| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Milan Aksic, Joko Poleksic, Dubravka Aleksic, Natasa Petronijevic, Nevena V Radonjic, Maja Jakovcevski, Slobodan Kapor, Nevena Divac, Branislav R Filipovic, Igor Jakovcevsk. Maternal Deprivation in Rats Decreases the Expression of Interneuron Markers in the Neocortex and Hippocampus. Frontiers in neuroanatomy. vol 15. 2021-06-26. PMID:34168541. |
we estimated numbers of various immunohistochemically defined interneuron subpopulations in several neocortical regions and in the hippocampus. |
2021-06-26 |
2023-08-13 |
rat |
| Lucas B Comeras, Noa Hörmer, Pradeepa Mohan Bethuraj, Ramon O Tasa. NPY Released From GABA Neurons of the Dentate Gyrus Specially Reduces Contextual Fear Without Affecting Cued or Trace Fear. Frontiers in synaptic neuroscience. vol 13. 2021-06-15. PMID:34122036. |
thus, these findings suggest that co-release of npy from specific interneuron populations of the dorsal dg modifies dedicated aspects of hippocampal processing by sharpening the activation of neural engrams and the consecutive fear response. |
2021-06-15 |
2023-08-13 |
Not clear |
| Vladislav Sekulić, Feng Yi, Tavita Garrett, Alexandre Guet-McCreight, J Josh Lawrence, Frances K Skinne. Integration of Within-Cell Experimental Data With Multi-Compartmental Modeling Predicts H-Channel Densities and Distributions in Hippocampal OLM Cells. Frontiers in cellular neuroscience. vol 14. 2021-06-10. PMID:33093823. |
the oriens-lacunosum/moleculare (olm) interneuron operates as a "gate" that controls incoming sensory and ongoing contextual information in the ca1 of the hippocampus, making it essential to understand how its biophysical properties contribute to memory function. |
2021-06-10 |
2023-08-13 |
mouse |
| Nabila Haji, Ilse Riebe, Argel Aguilar-Valles, Julien Artinian, Isabel Laplante, Jean-Claude Lacaill. Tsc1 haploinsufficiency in Nkx2.1 cells upregulates hippocampal interneuron mTORC1 activity, impairs pyramidal cell synaptic inhibition, and alters contextual fear discrimination and spatial working memory in mice. Molecular autism. vol 11. issue 1. 2021-05-28. PMID:32375878. |
tsc1 haploinsufficiency in nkx2.1 cells upregulates hippocampal interneuron mtorc1 activity, impairs pyramidal cell synaptic inhibition, and alters contextual fear discrimination and spatial working memory in mice. |
2021-05-28 |
2023-08-13 |
mouse |
| Felipe V Gomes, Anthony A Grac. Beyond Dopamine Receptor Antagonism: New Targets for Schizophrenia Treatment and Prevention. International journal of molecular sciences. vol 22. issue 9. 2021-05-28. PMID:33922888. |
an advanced understanding of the circuitry of scz has pointed to pathological origins in the excitation/inhibition balance in regions such as the hippocampus, and restoring function in this region, particularly as a means to compensate for parvalbumin (pv) interneuron loss and resultant hippocampal hyperactivity, may be a more efficacious approach to relieve a broad range of scz symptoms. |
2021-05-28 |
2023-08-13 |
Not clear |
| Haiquan Zhong, Jing Rong, Chunting Zhu, Min Liang, Yingchun Li, Rong Zho. Epigenetic Modifications of GABAergic Interneurons Contribute to Deficits in Adult Hippocampus Neurogenesis and Depression-Like Behavior in Prenatally Stressed Mice. The international journal of neuropsychopharmacology. vol 23. issue 4. 2021-05-19. PMID:32211762. |
gabaergic interneuron is a key modulator in adult hippocampal neurogenesis. |
2021-05-19 |
2023-08-13 |
mouse |
| Sara Hijazi, Tim S Heistek, Philip Scheltens, Ulf Neumann, Derya R Shimshek, Huibert D Mansvelder, August B Smit, Ronald E van Kestere. Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer's disease. Molecular psychiatry. vol 25. issue 12. 2021-05-14. PMID:31431685. |
importantly, we demonstrate that early intervention aimed at restoring pv interneuron activity has long-term beneficial effects on memory and hippocampal network activity, and reduces amyloid plaque deposition, a hallmark of ad pathology. |
2021-05-14 |
2023-08-13 |
mouse |
| Cristina Rosell-Valle, Magdalena Martínez-Losa, Elisa Matas-Rico, Estela Castilla-Ortega, Emma Zambrana-Infantes, Ana Isabel Gómez-Conde, Lourdes Sánchez-Salido, David Ladrón de Guevara-Miranda, Carmen Pedraza, Pedro Jesús Serrano-Castro, Jerold Chun, Fernando Rodríguez de Fonseca, Manuel Álvarez-Dolado, Luis Javier Santín, Guillermo Estivill-Torrú. GABAergic deficits in absence of LPA Brain structure & function. vol 226. issue 5. 2021-05-05. PMID:33792787. |
therapeutic strategies using the transplantation of gabaergic interneuron progenitors derived from the medial ganglionic eminence (mge) into the adult hippocampus reversed the symptomatology in multiple rodent models of interneuron-related pathologies. |
2021-05-05 |
2023-08-13 |
Not clear |
| Annika Mehr, Meike Hick, Susann Ludewig, Michaela Müller, Ulrike Herrmann, Jakob von Engelhardt, David P Wolfer, Martin Korte, Ulrike C Mülle. Lack of APP and APLP2 in GABAergic Forebrain Neurons Impairs Synaptic Plasticity and Cognition. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 7. 2021-05-04. PMID:32219307. |
here, we show that app is also widely expressed in several interneuron subtypes, both in hippocampus and cortex. |
2021-05-04 |
2023-08-13 |
mouse |
| Jie Zheng, Hong-Lian Li, Na Tian, Fei Liu, Lu Wang, Yaling Yin, Lupeng Yue, Longyu Ma, You Wan, Jian-Zhi Wan. Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission. Cell stem cell. vol 26. issue 3. 2021-04-27. PMID:31978364. |
interneuron accumulation of phosphorylated tau impairs adult hippocampal neurogenesis by suppressing gabaergic transmission. |
2021-04-27 |
2023-08-13 |
mouse |
| John T Madden, Shannon M Thompson, Christy M Magcalas, Jennifer L Wagner, Derek A Hamilton, Daniel D Savage, Benjamin J Clark, Nathan S Pentkowsk. Moderate prenatal alcohol exposure reduces parvalbumin expressing GABAergic interneurons in the dorsal hippocampus of adult male and female rat offspring. Neuroscience letters. vol 718. 2021-03-01. PMID:31874217. |
to explore the effects of moderate pae on gabaergic interneuron expression, this study used a rat model of moderate pae to examine the effects of pae on parvalbumin (parv)-positive cells in fields ca1, ca3 and the dentate gyrus (dg) of the dorsal hippocampus (dhc). |
2021-03-01 |
2023-08-13 |
rat |
| John T Madden, Shannon M Thompson, Christy M Magcalas, Jennifer L Wagner, Derek A Hamilton, Daniel D Savage, Benjamin J Clark, Nathan S Pentkowsk. Moderate prenatal alcohol exposure reduces parvalbumin expressing GABAergic interneurons in the dorsal hippocampus of adult male and female rat offspring. Neuroscience letters. vol 718. 2021-03-01. PMID:31874217. |
the results are discussed in relation to hippocampal gabaergic interneuron function, pae and behavior. |
2021-03-01 |
2023-08-13 |
rat |
| Tristan Geiller, Bert Vancura, Satoshi Terada, Eirini Troullinou, Spyridon Chavlis, Grigorios Tsagkatakis, Panagiotis Tsakalides, Katalin Ócsai, Panayiota Poirazi, Balázs J Rózsa, Attila Losoncz. Large-Scale 3D Two-Photon Imaging of Molecularly Identified CA1 Interneuron Dynamics in Behaving Mice. Neuron. vol 108. issue 5. 2021-01-27. PMID:33022227. |
yet little is known about the functional properties and activity dynamics of the major hippocampal interneuron classes in behaving animals. |
2021-01-27 |
2023-08-13 |
mouse |
| Megha Sah, Amy N Shore, Sabrina Petri, Ayla Kanber, Mu Yang, Matthew C Weston, Wayne N Franke. Altered excitatory transmission onto hippocampal interneurons in the IQSEC2 mouse model of X-linked neurodevelopmental disease. Neurobiology of disease. vol 137. 2021-01-15. PMID:31978606. |
electrophysiological recordings of hippocampal neurons reveal increased excitatory drive specifically onto interneurons, and significant alterations in intrinsic electrical properties specific to the interneuron population. |
2021-01-15 |
2023-08-13 |
mouse |
| Megha Sah, Amy N Shore, Sabrina Petri, Ayla Kanber, Mu Yang, Matthew C Weston, Wayne N Franke. Altered excitatory transmission onto hippocampal interneurons in the IQSEC2 mouse model of X-linked neurodevelopmental disease. Neurobiology of disease. vol 137. 2021-01-15. PMID:31978606. |
these findings point to a novel role of iqsec2 in hippocampal interneuron synaptic function and development with implications for a class of intractable neurodevelopmental diseases. |
2021-01-15 |
2023-08-13 |
mouse |
| Hyowon Chung, Kyerl Park, Hyun Jae Jang, Michael M Kohl, Jeehyun Kwa. Dissociation of somatostatin and parvalbumin interneurons circuit dysfunctions underlying hippocampal theta and gamma oscillations impaired by amyloid β oligomers in vivo. Brain structure & function. vol 225. issue 3. 2021-01-08. PMID:32107637. |
our results reveal frequency-specific and interneuron subtype-specific presynaptic dysfunctions of sst and pv interneurons' input to ca1 pc as the synaptic mechanisms underlying aβo-induced impairments of hippocampal network oscillations and identify them as potential therapeutic targets for restoring hippocampal network oscillations in early ad. |
2021-01-08 |
2023-08-13 |
mouse |
| Rachel Anne Hill, Adrienne Mary Grech, Michael J Notaras, Mauricio Sepulveda, Maarten van den Buus. Brain-Derived Neurotrophic Factor Val66Met polymorphism interacts with adolescent stress to alter hippocampal interneuron density and dendritic morphology in mice. Neurobiology of stress. vol 13. 2020-12-22. PMID:33344708. |
brain-derived neurotrophic factor val66met polymorphism interacts with adolescent stress to alter hippocampal interneuron density and dendritic morphology in mice. |
2020-12-22 |
2023-08-13 |
mouse |
| Rachel Anne Hill, Adrienne Mary Grech, Michael J Notaras, Mauricio Sepulveda, Maarten van den Buus. Brain-Derived Neurotrophic Factor Val66Met polymorphism interacts with adolescent stress to alter hippocampal interneuron density and dendritic morphology in mice. Neurobiology of stress. vol 13. 2020-12-22. PMID:33344708. |
the current study used a humanized mouse model of the bdnf val66met polymorphism to determine how reduced activity-dependent release of bdnf, both on its own, and in combination with chronic adolescent stress hormone, impact hippocampal gabaergic interneuron cell density and dendrite morphology. |
2020-12-22 |
2023-08-13 |
mouse |
| Swechhya Shrestha, Nickesha C Anderson, Laura B Grabel, Janice R Naegele, Gloster B Aaro. Development of electrophysiological and morphological properties of human embryonic stem cell-derived GABAergic interneurons at different times after transplantation into the mouse hippocampus. PloS one. vol 15. issue 8. 2020-10-13. PMID:32813731. |
to address this gap, we transplanted hesc-derived human gabaergic interneuron progenitors into the mouse hippocampus, and then characterized their electrophysiological properties and dendritic arborizations after transplantation by means of ex vivo whole-cell patch clamp recording, followed by biocytin staining, confocal imaging and neuron reconstruction software. |
2020-10-13 |
2023-08-13 |
mouse |
| Ian Mahar, Marilia Silva Albuquerque, Siddhartha Mondragon-Rodriguez, Chelsea Cavanagh, Maria Antonietta Davoli, Jean-Guy Chabot, Sylvain Williams, Naguib Mechawar, Rémi Quirion, Slavica Kranti. Phenotypic Alterations in Hippocampal NPY- and PV-Expressing Interneurons in a Presymptomatic Transgenic Mouse Model of Alzheimer's Disease. Frontiers in aging neuroscience. vol 8. 2020-10-01. PMID:28154533. |
taken together, our results identify for the first time ad-related alterations in hippocampal interneuron function as early as at 1 month of age. |
2020-10-01 |
2023-08-13 |
mouse |