| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lijuan Zhang, Jinqiang Zhang, Zili Yo. Switching of the Microglial Activation Phenotype Is a Possible Treatment for Depression Disorder. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30459555. |
however, postmortem and animal studies have shown that overactivated microglia can inhibit neurogenesis in the hippocampus and induce depressive-like behaviors. |
2020-10-01 |
2023-08-13 |
Not clear |
| Wei Wang, Rui Wang, Jingjing Xu, Xiaqing Qin, Hong Jiang, Arslan Khalid, Dexiang Liu, Fang Pan, Cyrus S H Ho, Roger C M H. Minocycline Attenuates Stress-Induced Behavioral Changes via Its Anti-inflammatory Effects in an Animal Model of Post-traumatic Stress Disorder. Frontiers in psychiatry. vol 9. 2020-10-01. PMID:30459654. |
the effects of minocycline on pro-inflammatory cytokines, activation of microglia, and nf-κb in the pfc and hippocampus were also examined. |
2020-10-01 |
2023-08-13 |
rat |
| Wei Wang, Rui Wang, Jingjing Xu, Xiaqing Qin, Hong Jiang, Arslan Khalid, Dexiang Liu, Fang Pan, Cyrus S H Ho, Roger C M H. Minocycline Attenuates Stress-Induced Behavioral Changes via Its Anti-inflammatory Effects in an Animal Model of Post-traumatic Stress Disorder. Frontiers in psychiatry. vol 9. 2020-10-01. PMID:30459654. |
taken together, our results suggest that the anxiolytic effect of minocycline is related to its ability to decrease the levels of pro-inflammatory cytokines and inhibit activation of microglia and nf-κb in the pfc and hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Juan Bu, Shen Shi, Hui-Qin Wang, Xiao-Shan Niu, Zong-Feng Zhao, Wei-Dong Wu, Xiao-Ling Zhang, Zhi Ma, Yan-Jun Zhang, Hui Zhang, Yi Zh. Acacetin protects against cerebral ischemia-reperfusion injury Neural regeneration research. vol 14. issue 4. 2020-10-01. PMID:30632500. |
to understand the effect of acacetin on microglia-mediated inflammatory response after cerebral ischemia-reperfusion injury, immunohistochemistry for the microglia marker calcium adapter protein ionized calcium-binding adaptor molecule 1 (iba1) was examined in the hippocampus of ischemic brain tissue. |
2020-10-01 |
2023-08-13 |
mouse |
| Michele Malaguarnera, Marta Llansola, Tiziano Balzano, Belén Gómez-Giménez, Carles Antúnez-Muñoz, Núria Martínez-Alarcón, Rahebeh Mahdinia, Vicente Felip. Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:30858801. |
the effects of bicuculline on microglia and astrocyte activation, il-1β content, on membrane expression of ampa and nmda glutamate receptors subunits in the hippocampus and on spatial learning and memory as well as anxiety were assessed. |
2020-10-01 |
2023-08-13 |
rat |
| Michele Malaguarnera, Marta Llansola, Tiziano Balzano, Belén Gómez-Giménez, Carles Antúnez-Muñoz, Núria Martínez-Alarcón, Rahebeh Mahdinia, Vicente Felip. Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:30858801. |
treatment with bicuculline reduces astrocyte activation and il-1β but not microglia activation in the hippocampus of hyperammonemic rats. |
2020-10-01 |
2023-08-13 |
rat |
| Noelia Rodríguez-Iglesias, Amanda Sierra, Jorge Valer. Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia. Frontiers in cell and developmental biology. vol 7. 2020-10-01. PMID:30891446. |
herein we will focus on microglia, the resident immune cells of the cns, which modulate the production of new neurons in the adult hippocampus and are also well suited to participate in their circuit integration. |
2020-10-01 |
2023-08-13 |
Not clear |
| Noelia Rodríguez-Iglesias, Amanda Sierra, Jorge Valer. Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia. Frontiers in cell and developmental biology. vol 7. 2020-10-01. PMID:30891446. |
importantly, microglia are able to sense subtle changes in their environment and may use this information to differently modulate hippocampal wiring, ultimately impacting on memory function. |
2020-10-01 |
2023-08-13 |
Not clear |
| Noelia Rodríguez-Iglesias, Amanda Sierra, Jorge Valer. Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia. Frontiers in cell and developmental biology. vol 7. 2020-10-01. PMID:30891446. |
deciphering the role of microglia in hippocampal circuitry constant rewiring will help to better understand the influence of microglia on memory function. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xianliang Zhang, Qiang He, Tao Huang, Na Zhao, Fei Liang, Bo Xu, Xianghe Chen, Tuojian Li, Jianzhong B. Treadmill Exercise Decreases Aβ Deposition and Counteracts Cognitive Decline in APP/PS1 Mice, Possibly Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:31024293. |
treadmill exercise significantly inhibited neuroinflammation, which was characterized by a remarkably reduced expression of pro-inflammatory factors and increased expression of anti-inflammatory mediators in the hippocampus, resulting from a shift in activated microglia from the m1 to m2 phenotype. |
2020-10-01 |
2023-08-13 |
mouse |
| Huaiqing Luo, Yang Xiang, Xiangping Qu, Huijun Liu, Chi Liu, Guangyi Li, Li Han, Xiaoqun Qi. Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer's Disease Through Activation of BDNF-TrkB Signaling Pathway. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:31040784. |
moreover, apelin-13 inhibited microglia and astrocyte activation, reduced il-1β and tnf-α expression and hippocampal bdnf/trkb expression deficit in ad rats. |
2020-10-01 |
2023-08-13 |
rat |
| Nicholas Chaaya, Angela Jacques, Arnauld Belmer, Kate Beecher, Syed A Ali, Fatemeh Chehrehasa, Andrew R Battle, Luke R Johnson, Selena E Bartlet. Contextual Fear Conditioning Alter Microglia Number and Morphology in the Rat Dorsal Hippocampus. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31139053. |
contextual fear conditioning alter microglia number and morphology in the rat dorsal hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Nicholas Chaaya, Angela Jacques, Arnauld Belmer, Kate Beecher, Syed A Ali, Fatemeh Chehrehasa, Andrew R Battle, Luke R Johnson, Selena E Bartlet. Contextual Fear Conditioning Alter Microglia Number and Morphology in the Rat Dorsal Hippocampus. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31139053. |
the current study was designed to evaluate how two different contextual fear memories alter amygdala and hippocampus microglia, brain derived neurotrophic factor (bdnf), and phosphorylated cyclic-amp response element binding (pcreb). |
2020-10-01 |
2023-08-13 |
rat |
| Nicholas Chaaya, Angela Jacques, Arnauld Belmer, Kate Beecher, Syed A Ali, Fatemeh Chehrehasa, Andrew R Battle, Luke R Johnson, Selena E Bartlet. Contextual Fear Conditioning Alter Microglia Number and Morphology in the Rat Dorsal Hippocampus. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31139053. |
the unpaired fear conditioning procedure (whereby non-reinforced and non-overlapping auditory tones were provided at random intervals during conditioning), despite producing equivalent levels of fear as the standard procedure, did not alter microglia, bdnf or pcreb number in any dorsal hippocampus or lateral amygdala brain regions. |
2020-10-01 |
2023-08-13 |
rat |
| Teresa Joy, Muddanna S Rao, Sampath Madhyastha, Keshav Pa. Effect of N-Acetyl Cysteine on Intracerebroventricular Colchicine Induced Cognitive Deficits, Beta Amyloid Pathology, and Glial Cells. Neuroscience journal. vol 2019. 2020-10-01. PMID:31139638. |
cognitive function was evaluated in active avoidance test; beta amyloid protein, beta amyloid plaques, astrocytes, and microglia cells were quantified using immunohistochemistry in hippocampal and prefrontal cortices. |
2020-10-01 |
2023-08-13 |
human |
| Teresa Joy, Muddanna S Rao, Sampath Madhyastha, Keshav Pa. Effect of N-Acetyl Cysteine on Intracerebroventricular Colchicine Induced Cognitive Deficits, Beta Amyloid Pathology, and Glial Cells. Neuroscience journal. vol 2019. 2020-10-01. PMID:31139638. |
colchicine has resulted in significant cognitive loss, increased intraneuronal beta amyloid protein expression, increased reactive astrocytes, and activated microglia in all the regions of the hippocampus and prefrontal cortices. |
2020-10-01 |
2023-08-13 |
human |
| Sarah J Spencer, Aniko Korosi, Sophie Layé, Barbara Shukitt-Hale, Ruth M Barriento. Food for thought: how nutrition impacts cognition and emotion. NPJ science of food. vol 1. 2020-10-01. PMID:31304249. |
low dietary intake of omega-3 polyunsaturated fatty acids can also contribute to depression through its effects on endocannabinoid and inflammatory pathways in specific brain regions leading to synaptic phagocytosis by microglia in the hippocampus, contributing to memory loss. |
2020-10-01 |
2023-08-13 |
Not clear |
| Murad-Ali Shah, Dong-Ju Park, Ju-Bin Kang, Myeong-Ok Kim, Phil-Ok Ko. Baicalin alleviates lipopolysaccharide-induced neuroglial activation and inflammatory factors activation in hippocampus of adult mice. Laboratory animal research. vol 36. 2020-10-01. PMID:32983956. |
results from the present study showed that baicalin suppresses lps-induced neuroinflammation by regulating microglia and astrocyte activation and modulating inflammatory factors in the hippocampus. |
2020-10-01 |
2023-08-13 |
mouse |
| Murad-Ali Shah, Dong-Ju Park, Ju-Bin Kang, Myeong-Ok Kim, Phil-Ok Ko. Baicalin alleviates lipopolysaccharide-induced neuroglial activation and inflammatory factors activation in hippocampus of adult mice. Laboratory animal research. vol 36. 2020-10-01. PMID:32983956. |
thus, these results demonstrate that baicalin has neuroprotective effect by alleviates microglia and astrocyte activation and modulates inflammatory response by suppressing nf-κb expression in hippocampus with neuroinflammation caused by lps. |
2020-10-01 |
2023-08-13 |
mouse |
| Noemi Tonna, Fabio Bianco, Michela Matteoli, Cinzia Cagnoli, Flavia Antonucci, Amedea Manfredi, Nicolò Mauro, Elisabetta Ranucci, Paolo Ferrut. A soluble biocompatible guanidine-containing polyamidoamine as promoter of primary brain cell adhesion and Science and technology of advanced materials. vol 15. issue 4. 2020-09-30. PMID:27877708. |
in this work, it was found that agma1 surface-adsorbed on cell culturing coverslips exhibits excellent properties as adhesion and proliferation promoter of primary brain cells such as microglia, as well as of hippocampal neurons and astrocytes. |
2020-09-30 |
2023-08-13 |
Not clear |