| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pablo Berríos-Cárcamo, Sarah Núñez, Justine Castañeda, Javiera Gallardo, María Rosa Bono, Fernando Ezque. Two-Month Voluntary Ethanol Consumption Promotes Mild Neuroinflammation in the Cerebellum but Not in the Prefrontal Cortex, Hippocampus, or Striatum of Mice. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673763. |
we found a significant increase in mcp1 mrna levels in the cerebellum of mice that consumed ethanol compared to controls, whereas no significant changes were observed in the prefrontal cortex, hippocampus, or striatum or in microglia isolated from the hippocampus and striatum. |
2024-04-27 |
2024-04-29 |
mouse |
| Astrid Wachter, Maya E Woodbury, Sylvia Lombardo, Aicha Abdourahman, Carolin Wuest, Emily McGlame, Timothy Pastika, Joseph Tamm, Nandini Romanul, Kiran Yanamandra, Rachel Bennett, Gen Lin, Taekyung Kwon, Fan Liao, Corinna Klein, Yelena Grinberg, Methasit Jaisa-Aad, Huan Li, Matthew P Frosch, Markus P Kummer, Sudeshna Das, Tammy Dellovade, Eric H Karran, Xavier Langlois, Janina S Ried, Alberto Serrano-Pozo, Robert V Talanian, Knut Biber, Bradley T Hyma. Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aβ and tau. Acta neuropathologica. vol 147. issue 1. 2024-04-01. PMID:38557897. |
here, we characterized 32 human donors along progression of ad pathology, both in time-from early to late pathology-and in space-from entorhinal cortex (ec), inferior temporal gyrus (itg), prefrontal cortex (pfc) to visual cortex (v2 and v1)-with biochemistry, immunohistochemistry, and single nuclei-rna-sequencing, profiling a total of 337,512 brain myeloid cells, including microglia. |
2024-04-01 |
2024-04-04 |
human |
| Lauren A Buck, Qiaowei Xie, Michelle Willis, Christine M Side, Laura L Giacometti, Peter J Gaskill, Kyewon Park, Farida Shaheen, Lili Guo, Santhi Gorantla, Jacqueline M Barke. Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation. Communications biology. vol 7. issue 1. 2024-03-30. PMID:38553542. |
behavioral alterations are accompanied by immune changes in hiv infected mice, including increased prefrontal cortex astrocyte immunoreactivity and brain-region specific effects on microglia number and reactivity. |
2024-03-30 |
2024-04-01 |
mouse |
| Hai-Long Zhang, Shufen Hu, Shu-Ting Qu, Meng-Dan Lv, Jun-Jun Wang, Xin-Ting Liu, Jia-He Yao, Yi-Yan Ding, Guang-Yin X. Inhibition of NKCC1 Ameliorates Anxiety and Autistic Behaviors Induced by Maternal Immune Activation in Mice. Current issues in molecular biology. vol 46. issue 3. 2024-03-27. PMID:38534737. |
we further demonstrated that mia offspring showed significant microglia activation, excessive dendritic spines, and narrow postsynaptic density (psd) in their prefrontal cortex (pfc). |
2024-03-27 |
2024-03-29 |
mouse |
| Gangjing Li, Li Hu, Xiangcheng Gu, Weijun Zhu, Xuechu Zhen, Xiaohui Su. Targeting Large-Conductance Calcium-Activated Potassium Channels to Ameliorate Lipopolysaccharide-Induced Depressive-Like Behavior in Mice. Neurochemical research. 2024-02-22. PMID:38383879. |
), a specific bk channel blocker, or bk shrna-aav effectively inhibited the activation of microglia, reduced the production of il-1β in the hippocampus and suppressed the expression and activity of ido in the hippocampus and prefrontal cortex, resulting in the amelioration of depressive-like behavior in mice. |
2024-02-22 |
2024-02-24 |
mouse |
| Ki-Joong Kim, Jinyeon Hwang, Kang-Woo Lee, Jieun Kim, Yunha Han, Uk Namgun. Neuron-Microglia Interaction is Involved in Anti-inflammatory Response by Vagus Nerve Stimulation in the Prefrontal Cortex of Rats Injected with Polyinosinic:Polycytidylic Acid. Molecular neurobiology. 2024-02-22. PMID:38383920. |
the microglia in the prefrontal cortex (pfc) displayed the activated form of morphology in poly(i:c)-injected rats and changed to a normal shape after acute vns (avns). |
2024-02-22 |
2024-02-24 |
rat |
| Ming-Lei Guo, Yan Cheng, Damian Martinez Pineda, Rachael E Dempsey, Lifang Yan. Lipid Droplets Accumulation in the Brain of HIV Transgenic Rat: Implication in the Accelerated Aging of HIV Infected Individuals. Aging and disease. 2024-02-20. PMID:38377024. |
increased lds are mainly presented in microglia in the hp but largely co-localized with astrocytes in the pfc. |
2024-02-20 |
2024-02-23 |
human |
| Aaron Y Lai, Dustin Loren V Almanza, Jessica A Ribeiro, Mary E Hill, Matthew Mandrozos, Margaret M Koletar, Bojana Stefanovic, JoAnne McLauri. Obesity Facilitates Sex-Specific Improvement In Cognition And Neuronal Function In A Rat Model Of Alzheimer's Disease. bioRxiv : the preprint server for biology. 2024-02-08. PMID:38328066. |
pathological analyses of prefrontal cortex and hippocampus showed that obesity in tgf344-ad rats produced varied effects, with increased density of myelin and oligodendrocytes, lowered density and activation of microglia that we propose contributes to the cognitive improvement. |
2024-02-08 |
2024-02-10 |
human |
| Mohit Kumar, Babita Bhatt, Chitralekha Gusain, Nayan Mahajan, Mahendra Bishno. Sex-Specific Effects of Ketogenic Diet on Anxiety-like Behavior and Neuroimmune Response in C57Bl/6J Mice. The Journal of nutritional biochemistry. 2024-02-04. PMID:38311044. |
kd suppressed the mrna expression of the putative microglial markers (cd68, p2ry12, nox2) and induced morphological changes in the male pfc microglia. |
2024-02-04 |
2024-02-07 |
mouse |
| Jingwei Zhao, Mingming Zhang, Huamin Zhang, Ying Wang, Bingyu Chen, Jing Sha. Diosmin ameliorates LPS-induced depression-like behaviors in mice: inhibition of inflammation and oxidative stress in the prefrontal cortex. Brain research bulletin. 2023-12-13. PMID:38092305. |
specifically, diosmin treatment significantly suppressed the secretion of pro-inflammatory cytokines (tnf-α, il-6 and il-1β), reduced the activation of microglia, and inhibited the expression of nlrp3 inflammasome and its downstream effector caspase-1 in both pfc of mice and bv2 microglial cells exposed to lps. |
2023-12-13 |
2023-12-17 |
mouse |
| Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Sing. S1PR2 inhibition mitigates cognitive deficit in diabetic mice by modulating microglial activation via Akt-p53-TIGAR pathway. International immunopharmacology. vol 126. 2023-11-27. PMID:38011768. |
it further enhanced anti-inflammatory microglia in the hippocampus and prefrontal cortex (pfc), as evidenced by increased arg-1, cd206, and ym-1 levels and decreased inos, cd16, and mhcii levels. |
2023-11-27 |
2023-11-29 |
mouse |
| Marcia Spoelder, Yami Bright, Martine C Morrison, Veerle van Kempen, Lilian de Groodt, Malvina Begalli, Nikita Schuijt, Eva Kruiger, Ronald Bulthuis, Gabriele Gross, Robert Kleemann, Janna A van Diepen, Judith R Homber. Cognitive Performance during the Development of Diabetes in the Zucker Diabetic Fatty Rat. Cells. vol 12. issue 20. 2023-10-27. PMID:37887307. |
histological analyses in early adulthood showed no group differences in the number of prefrontal cortex neurons and microglia, nor psd95 and sirt1 mrna expression levels. |
2023-10-27 |
2023-11-08 |
rat |
| Jacqueline Barker, Lauren Buck, Qiaowei Xie, Michelle Willis, Christine Side, Laura Giacometti, Peter Gaskill, Kyewon Park, Farida Shaheen, Lili Guo, Santhi Gorantl. Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation. Research square. 2023-10-16. PMID:37841842. |
behavioral alterations were accompanied by immune changes in hiv infected mice, including increased prefrontal cortex astrocyte immunoreactivity and brain-region specific effects on microglia number and reactivity. |
2023-10-16 |
2023-11-08 |
mouse |
| Giulia Galimberti, Giada Amodeo, Giulia Magni, Benedetta Riboldi, Gianfranco Balboni, Valentina Onnis, Stefania Ceruti, Paola Sacerdote, Silvia Franch. Prokineticin System Is a Pharmacological Target to Counteract Pain and Its Comorbid Mood Alterations in an Osteoarthritis Murine Model. Cells. vol 12. issue 18. 2023-09-28. PMID:37759478. |
in addition, pk upregulation and reactive astrogliosis in the hippocampus and microglia reactivity in the prefrontal cortex were detected. |
2023-09-28 |
2023-10-07 |
mouse |
| Hsiao-Yun Lin, Flurin Cathomas, Long Li, Romain Durand-de Cuttoli, Christopher Guevara, Cigdem Sevim Bayrak, Qian Wang, Swati Gupta, Kenny L Chan, Yusuke Shimo, Lyonna F Parise, Chongzhen Yuan, Antonio V Aubry, Fiona Chen, Jean Wong, Carole Morel, George W Huntley, Bin Zhang, Scott J Russo, Jun Wan. Chemokine receptor 5 signaling in PFC mediates stress susceptibility in female mice. bioRxiv : the preprint server for biology. 2023-09-04. PMID:37662400. |
in the brain, stress-susceptible mice displayed increased expression of c-c chemokine receptor 5 (ccr5), a receptor for ccl5, in microglia in the prefrontal cortex (pfc). |
2023-09-04 |
2023-09-07 |
mouse |
| Lauren A Buck, Qiaowei Xie, Michelle Willis, Christine M Side, Laura L Giacometti, Peter J Gaskill, Kyewon Park, Farida Shaheen, Lili Guo, Santhi Gorantla, Jacqueline M Barke. Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645889. |
these behavioral alterations were accompanied by immune changes in hiv infected mice, including increased prefrontal cortex astrocyte immunoreactivity and brain-region specific effects on microglia number and reactivity. |
2023-08-30 |
2023-09-07 |
mouse |
| Qing-Ren Liu, Cui-Na Shi, Fei Wang, Jian-Hua Ton. Neuroinflammation-induced parvalbumin interneuron and oscillation deficits might contribute to neurobehavioral abnormities in a two-hit model of depression. Heliyon. vol 9. issue 8. 2023-08-09. PMID:37554823. |
these behavioral alternations were related to enhanced neuroinflammation, as reflected by significantly increased il-1β and il-6 levels and microglia activation in the prefrontal cortex (pfc). |
2023-08-09 |
2023-08-16 |
mouse |
| Wataru Nagata, Mari Gotoh, Akiho Koizumi, Keiko Fukasawa, Keiichi Nakagawa, Yasushi Satoh, Toshiaki Ishizuk. Two-carba cyclic phosphatidic acid treatment promotes phenotypic switch from M1 to M2 microglia and prevents behavioral abnormalities in a mouse model of neuropsychiatric systemic lupus erythematosus. Human cell. 2023-08-04. PMID:37540445. |
the expression of cd68, an m1 phenotypic marker of microglia, was significantly elevated in the prefrontal cortex and hippocampus of mrl/lpr mice, which was significantly suppressed by 2ccpa treatment. |
2023-08-04 |
2023-08-14 |
mouse |
| Miquel Martin, Matteo M Pusceddu, Joan Teichenné, Teresa Negra, Alan Connolly, Xavier Escoté, Helena Torrell Galceran, Adrià Cereto Massagué, Iris Samarra Mestre, Antoni Del Pino Rius, Jordi Romero-Gimenez, Cristina Egea, Juan Maria Alcaide-Hidalgo, Josep Maria Del Ba. Preventive Treatment with Astaxanthin Microencapsulated with Spirulina Powder, Administered in a Dose Range Equivalent to Human Consumption, Prevents LPS-Induced Cognitive Impairment in Rats. Nutrients. vol 15. issue 13. 2023-07-14. PMID:37447181. |
our results demonstrate that lps modified long-term memory in the mwm and increased microglia activation in the hippocampus and prefrontal cortex. |
2023-07-14 |
2023-08-14 |
human |
| Shuhan Li, Zhanpeng Zhu, Tian Lan, Yuhan Wu, Ye Li, Changmin Wang, Wencheng Jian, Shu Yan Y. Levomilnacipran ameliorates lipopolysaccharide-induced depression-like behaviors and suppressed the TLR4/Ras signaling pathway. International immunopharmacology. vol 122. 2023-07-06. PMID:37413934. |
furthermore, we found that levomilnacipran could decrease the number of microglia and suppress its activation in prefrontal cortex of rats. |
2023-07-06 |
2023-08-14 |
rat |