| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tae-Soo Kim, Il-Gyu Ko, Yun-Hee Sung, Sung-Eun Kim, Bo-Kyun Kim, Seung-Kook Park, Mal-Soon Shin, Chang-Ju Kim, Sang-Jin Yoon, Khae-Hawn Ki. Vardenafil increases cell proliferation in the dentate gyrus through enhancement of serotonin expression in the rat dorsal raphe. Journal of Korean medical science. vol 24. issue 6. 2010-01-27. PMID:19949666. |
the findings demonstrate that the increasing effect of vardenafil on cell proliferation is closely associated with the enhancing effect of vardenafil on serotonin expression under normal conditions. |
2010-01-27 |
2023-08-12 |
rat |
| Amélie Soumier, Mounira Banasr, Sylviane Lortet, Frédérique Masmejean, Nathalie Bernard, Lydia Kerkerian-Le-Goff, Cecilia Gabriel, Mark J Millan, Elisabeth Mocaer, Annie Daszut. Mechanisms contributing to the phase-dependent regulation of neurogenesis by the novel antidepressant, agomelatine, in the adult rat hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 11. 2009-12-07. PMID:19571795. |
only the 5-ht(2c) receptor antagonists, sb243,213 or s32006, but not melatonin, mimicked the effects of agomelatine on cell proliferation in vh. |
2009-12-07 |
2023-08-12 |
rat |
| Luigi M Pavone, Simona Tafuri, Roberta Lo Muto, Anna Spina, Alla E Lychkova, Vincenzo Mastellone, Alfredo Vittoria, Luigi Avallone, Norma Staian. Expression of the serotonin transporter SERT in the genital tract of cattle. Regulatory peptides. vol 154. issue 1-3. 2009-06-22. PMID:19323988. |
serotonin mediates a wide range of physiological functions by binding to multiple receptors on cell surface. |
2009-06-22 |
2023-08-12 |
cattle |
| Tim D Werry, Richard Loiacono, Patrick M Sexton, Arthur Christopoulo. RNA editing of the serotonin 5HT2C receptor and its effects on cell signalling, pharmacology and brain function. Pharmacology & therapeutics. vol 119. issue 1. 2008-12-02. PMID:18554725. |
rna editing of the serotonin 5ht2c receptor and its effects on cell signalling, pharmacology and brain function. |
2008-12-02 |
2023-08-12 |
Not clear |
| Kristofer Thorslund, Klas Nordlin. Serotonergic drugs--a possible role in the treatment of psoriasis? Drug news & perspectives. vol 20. issue 8. 2008-03-27. PMID:18080039. |
serotonin (5-ht) is a monoamine which besides general effects also has an impact on cell proliferation, migration and apoptosis. |
2008-03-27 |
2023-08-12 |
Not clear |
| Yuan-Shan Cheng, Yuan-Sheng Liu, Mo Yan. [Effect of 5-hydroxtryptamine on megakaryocytopoiesis--review]. Zhongguo shi yan xue ye xue za zhi. vol 14. issue 2. 2007-12-14. PMID:16638226. |
5-ht mainly binds to 5-ht(2) receptors or 5-ht(1) receptors on cell surface to stimulate cell proliferation through ras or mapk pathway in many cell types. |
2007-12-14 |
2023-08-12 |
Not clear |
| Yuan-Sheng Liu, Mo Yan. The effect of 5-hydroxtryptamine on the regulation of megakaryocytopoiesis. Hematology (Amsterdam, Netherlands). vol 11. issue 1. 2006-12-27. PMID:16522551. |
5-ht mainly binds to 5-ht2 receptors or 5-ht1 receptors on cell surfaces to stimulate cell proliferation through ras or mapk (mitogen-activated protein kinase) pathways in many cell types. |
2006-12-27 |
2023-08-12 |
Not clear |
| G-J Huang, J Herber. The role of 5-HT1A receptors in the proliferation and survival of progenitor cells in the dentate gyrus of the adult hippocampus and their regulation by corticoids. Neuroscience. vol 135. issue 3. 2005-12-22. PMID:16129565. |
depleting 5-ht with p-chlorophenylalanine (300 mg/kg initially followed by 100 mg/kg/day) or stimulating 5-ht1a receptors with 8-oh-dpat (1 mg/kg or 2 mg/kg, s.c. injections twice daily) for 14 days had no effect on cell proliferation as measured by ki-67 or brdu (5-bromo-3-deoxyuridine) immunocytochemistry in the dentate gyrus. |
2005-12-22 |
2023-08-12 |
rat |
| Satoshi Matsusaka, Ichiro Wakabayash. 5-Hydroxytryptamine augments migration of human aortic smooth muscle cells through activation of RhoA and ERK. Biochemical and biophysical research communications. vol 337. issue 3. 2005-12-15. PMID:16219295. |
the enhancing effect of 5-ht on cell migration was markedly inhibited in the presence of ketanserin, a 5-ht2 receptor antagonist, but not by gr 55562, a 5-ht1 receptor antagonist. |
2005-12-15 |
2023-08-12 |
human |
| Andrzej Slominski, Alexander Pisarchik, Blazej Zbytek, Desmond J Tobin, Söbia Kauser, Jacobo Wortsma. Functional activity of serotoninergic and melatoninergic systems expressed in the skin. Journal of cellular physiology. vol 196. issue 1. 2003-07-16. PMID:12767050. |
testing for functional activity of these receptors with serotonin and melatonin (10(-14) to 10(-10) m) showed variable effects depending on cell type and culture conditions. |
2003-07-16 |
2023-08-12 |
human |
| Abel Hiol, Penelope C Davey, James L Osterhout, Abdul A Waheed, Elizabeth R Fischer, Ching-Kang Chen, Graeme Milligan, Kirk M Druey, Teresa L Z Jone. Palmitoylation regulates regulators of G-protein signaling (RGS) 16 function. I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue. The Journal of biological chemistry. vol 278. issue 21. 2003-07-07. PMID:12642593. |
for rgs16, mutation of cys-2 and cys-12 blocks its incorporation of [3h]palmitate and ability to turn-off gi and gq signaling and significantly inhibited its gtpase activating protein activity toward ag alpha subunit fused to the 5-hydroxytryptamine receptor 1a, but did not reduce its plasma membrane localization based on cell fractionation studies and immunoelectron microscopy. |
2003-07-07 |
2023-08-12 |
rat |
| Jason J Radley, Barry L Jacob. 5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus. Brain research. vol 955. issue 1-2. 2003-01-31. PMID:12419546. |
this study investigated the action of 5-ht(1a) receptor antagonists on cell proliferation in the dentate gyrus of adult rats. |
2003-01-31 |
2023-08-12 |
rat |
| E C Azmiti. Modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis. Brain research bulletin. vol 56. issue 5. 2002-02-01. PMID:11750787. |
modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis. |
2002-02-01 |
2023-08-12 |
Not clear |
| P C Guest, K Salim, H A Skynner, S E George, J N Bresnick, G McAlliste. Identification and characterization of a truncated variant of the 5-hydroxytryptamine(2A) receptor produced by alternative splicing. Brain research. vol 876. issue 1-2. 2000-10-18. PMID:10973616. |
western blot analysis of hek-293 cells transfected transiently with a 5-ht(2a-tr) construct showed that a 30-kda protein was expressed on cell membranes. |
2000-10-18 |
2023-08-12 |
human |
| J M Brezun, A Daszut. Depletion in serotonin decreases neurogenesis in the dentate gyrus and the subventricular zone of adult rats. Neuroscience. vol 89. issue 4. 1999-07-22. PMID:10362289. |
since neuronal activity may also influence cellular development and plasticity in brain, we investigated the effects of serotonin depletion on cell proliferation occurring in these regions. |
1999-07-22 |
2023-08-12 |
human |
| J Eugen-Olsen, P Afzelius, L Andresen, J Iversen, G Kronborg, P Aabech, J O Nielsen, B Hofman. Serotonin modulates immune function in T cells from HIV-seropositive subjects. Clinical immunology and immunopathology. vol 84. issue 2. 1997-09-02. PMID:9245541. |
changes in the expression of 5ht1a receptors as judged by the expression of mrna could not explain why serotonin in vitro had a stronger enhancing effect on cell proliferation in some hiv-seropositive individuals than in others. |
1997-09-02 |
2023-08-12 |
human |
| A R Mercer, P Kloppenburg, J G Hildebran. Serotonin-induced changes in the excitability of cultured antennal-lobe neurons of the sphinx moth Manduca sexta. Journal of comparative physiology. A, Sensory, neural, and behavioral physiology. vol 178. issue 1. 1996-03-01. PMID:8568722. |
these cells were used to examine effects of 5ht (5 x 10(-6) to 5 x 10(-4) m) on cell excitability and action-potential waveform. |
1996-03-01 |
2023-08-12 |
Not clear |
| M G Cattaneo, E Palazzi, G Bondiolotti, L M Vicentin. 5-HT1D receptor type is involved in stimulation of cell proliferation by serotonin in human small cell lung carcinoma. European journal of pharmacology. vol 268. issue 3. 1995-01-30. PMID:7805767. |
the 5-ht1d agonist sumatriptan is capable of mimicking 5-ht action on cell proliferation. |
1995-01-30 |
2023-08-12 |
human |
| P A Rittenhouse, Q Li, A D Levy, L D Van de Ka. Neurons in the hypothalamic paraventricular nucleus mediate the serotonergic stimulation of renin secretion. Brain research. vol 593. issue 1. 1993-01-08. PMID:1458311. |
thus, these results are consistent with the hypothesis that 5-ht receptors located on cell bodies in the paraventricular nucleus mediate the renin response to a serotonin agonist and releaser. |
1993-01-08 |
2023-08-11 |
rat |
| H T Chen, M Clark, D Goldma. Quantitative autoradiography of 3H-paroxetine binding sites in rat brain. Journal of pharmacological and toxicological methods. vol 27. issue 4. 1992-11-27. PMID:1421530. |
although lesioning of 5-ht neurons with p-chloroamphetamine (pca) drastically eliminated 3h-paroxetine binding in most regions of the rat brain, significant binding remained in the raphe nuclei and medial forebrain bundle suggesting that 3h-paroxetine binding in these regions was to presynaptic sites on cell bodies or axons relatively resistant to pca. |
1992-11-27 |
2023-08-11 |
rat |