| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Willy L Bonkale, Gustavo Turecki, Mark C Austi. Increased tryptophan hydroxylase immunoreactivity in the dorsal raphe nucleus of alcohol-dependent, depressed suicide subjects is restricted to the dorsal subnucleus. Synapse (New York, N.Y.). vol 60. issue 1. 2006-08-04. PMID:16596624. |
in the present study, we measured the levels of tryptophan hydroxylase (tph), the main synthetic enzyme of 5-ht synthesis, in specific nuclei of the dorsal raphe (dr) in depressed suicide victims with alcohol dependence and matched psychiatrically normal controls. |
2006-08-04 |
2023-08-12 |
human |
| Zhiyuan Ma, Elliot Pearson, Ceylan Isgor, Rui Ta. Evidence of reuptake inhibition responsible for mecamylamine-evoked increases in extracellular serotonin. Brain research. vol 1073-1074. 2006-07-19. PMID:16458272. |
the present report using microdialysis approach investigates the neurochemical mechanism of mecamylamine in the regulation of extracellular serotonin in the dorsal raphe nucleus of freely behaving rats. |
2006-07-19 |
2023-08-12 |
rat |
| Aniko Korosi, Jan G Veening, Tamás Kozicz, Marloes Henckens, Jos Dederen, Lucianne Groenink, Jan van der Gugten, Berend Olivier, Eric W Roubo. Distribution and expression of CRF receptor 1 and 2 mRNAs in the CRF over-expressing mouse brain. Brain research. vol 1072. issue 1. 2006-06-30. PMID:16423327. |
on the basis of these results and the fact that crf-oe mice reveal a number of physiological and autonomic symptoms that may be related to chronic stress, we suggest that crf1 in the basal nuclei may be involved in disturbed information processing and that crf2 in the dorsal raphe nucleus may play a role in mediating stress-induced release of serotonin by crf. |
2006-06-30 |
2023-08-12 |
mouse |
| Jeanne Lanoir, Gerard Hilaire, Isabelle Sei. Reduced density of functional 5-HT1A receptors in the brain, medulla and spinal cord of monoamine oxidase-A knockout mouse neonates. The Journal of comparative neurology. vol 495. issue 5. 2006-06-26. PMID:16498683. |
abnormally high brain 5-ht levels in monoamine oxidase-a knockout (mao-a ko) mouse neonates raise the question of whether the distribution and density of the 5-ht1a receptors (5-ht1ar) expressed in the brain by postnatal day p7 are affected and, if so, whether the 5-ht1a autoreceptors in the dorsal raphe are modified in the same way as the postsynaptic 5-ht1ar present in raphe target structures. |
2006-06-26 |
2023-08-12 |
mouse |
| Snezana Kusljic, Jan Brosda, Maarten van den Buus. Effects of haloperidol and clozapine on sensorimotor gating deficits induced by 5-hydroxytryptamine depletion in the brain. British journal of pharmacology. vol 147. issue 7. 2006-06-19. PMID:16415909. |
in male sprague-dawley rats, selected parts of the brain 5-ht systems were lesioned by micro-injection of the 5-ht neurotoxin 5,7-dihydroxytryptamine into the dorsal raphe nucleus (drn) or median raphe nucleus (mrn). |
2006-06-19 |
2023-08-12 |
rat |
| Chloé Alexandre, Daniela Popa, Véronique Fabre, Saoussen Bouali, Patrice Venault, Klaus-Peter Lesch, Michel Hamon, Joëlle Adrie. Early life blockade of 5-hydroxytryptamine 1A receptors normalizes sleep and depression-like behavior in adult knock-out mice lacking the serotonin transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 20. 2006-06-08. PMID:16707806. |
possible adaptive changes in 5-ht(1a)r after neonatal treatment with way 100635 were investigated by measuring 5-ht(1a) binding sites and 5-ht(1a) mrna in various rems- and/or depression-related brain areas, as well as 5-ht(1a)r-mediated hypothermia and inhibition of neuronal firing in the dorsal raphe nucleus. |
2006-06-08 |
2023-08-12 |
mouse |
| Malika Robichaud, Guy Debonne. Allopregnanolone and ganaxolone increase the firing activity of dorsal raphe nucleus serotonergic neurons in female rats. The international journal of neuropsychopharmacology. vol 9. issue 2. 2006-05-25. PMID:16174428. |
we have previously shown that a 7-d treatment with 3alpha,5alpha-thp drastically increases the spontaneous firing activity of dorsal raphe nucleus (drn) 5-ht neurons in female rats. |
2006-05-25 |
2023-08-12 |
rat |
| Chad J Swanson, Thomas P Blackburn, Xuexiang Zhang, Kang Zheng, Zhi-Qing David Xu, Tomas Hökfelt, Toni D Wolinsky, Michael J Konkel, Heidi Chen, Huailing Zhong, Mary W Walker, Douglas A Craig, Christophe P G Gerald, Theresa A Branche. Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 48. 2006-05-22. PMID:16287967. |
these results indicate that gal(3)-selective antagonists produce anxiolytic- and antidepressant-like effects, possibly by attenuating the inhibitory influence of galanin on 5-ht transmission at the level of the dorsal raphe nucleus. |
2006-05-22 |
2023-08-12 |
mouse |
| Dorota Maciag, Kimberly L Simpson, David Coppinger, Yuefeng Lu, Yue Wang, Rick C S Lin, Ian A Pau. Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 1. 2006-05-12. PMID:16012532. |
here, we show that chronic neonatal (postnatal days 8-21) exposure to citalopram (5 mg/kg, twice daily, s.c.), a potent and highly selective ssri, results in profound reductions in both the rate-limiting serotonin synthetic enzyme (tryptophan hydroxylase) in dorsal raphe and in serotonin transporter expression in cortex that persist into adulthood. |
2006-05-12 |
2023-08-12 |
rat |
| Cynthia L Bethea, Arubala P Reddy, Lisa J Smit. Nuclear factor kappa B in the dorsal raphe of macaques: an anatomical link for steroids, cytokines and serotonin. Journal of psychiatry & neuroscience : JPN. vol 31. issue 2. 2006-05-12. PMID:16575426. |
nuclear factor kappa b in the dorsal raphe of macaques: an anatomical link for steroids, cytokines and serotonin. |
2006-05-12 |
2023-08-12 |
Not clear |
| Cynthia L Bethea, Arubala P Reddy, Lisa J Smit. Nuclear factor kappa B in the dorsal raphe of macaques: an anatomical link for steroids, cytokines and serotonin. Journal of psychiatry & neuroscience : JPN. vol 31. issue 2. 2006-05-12. PMID:16575426. |
we questioned (1) whether serotonin neurons contain nfkappab, (2) whether nfkappab detection with immunocytochemistry is changed in the dorsal raphe nucleus (drn) by ovarian hormone treatment and (3) whether ovarian hormones regulate midbrain nfkappab gene or protein expression. |
2006-05-12 |
2023-08-12 |
Not clear |
| Cindy K J Lieben, Harry W M Steinbusch, Arjan Bloklan. 5,7-DHT lesion of the dorsal raphe nuclei impairs object recognition but not affective behavior and corticosterone response to stressor in the rat. Behavioural brain research. vol 168. issue 2. 2006-05-09. PMID:16360222. |
the substantial reduction in neuronal 5-ht markers in the dorsal raphe did not affect anxiety-related, depressive-like or impulsive behavior. |
2006-05-09 |
2023-08-12 |
rat |
| Sadamu Nakai, Wataru Matsunaga, Kenichi Isobe, Tetsuya Shirokaw. Age-dependent interactive changes in serotonergic and noradrenergic cortical axon terminals in F344 rats. Neuroscience research. vol 54. issue 3. 2006-04-28. PMID:16406149. |
the serotonergic (5-ht) axons originating from the dorsal raphe (dr) share the same cortical area and their age-dependent changes and interactions with na axons were still unclear. |
2006-04-28 |
2023-08-12 |
rat |
| Sarah J Judge, Sarah E Gartsid. Firing of 5-HT neurones in the dorsal and median raphe nucleus in vitro shows differential alpha1-adrenoceptor and 5-HT1A receptor modulation. Neurochemistry international. vol 48. issue 2. 2006-04-24. PMID:16256247. |
the median raphe nucleus and dorsal raphe nucleus together are the major source of ascending 5-ht projections. |
2006-04-24 |
2023-08-12 |
rat |
| Sarah J Judge, Sarah E Gartsid. Firing of 5-HT neurones in the dorsal and median raphe nucleus in vitro shows differential alpha1-adrenoceptor and 5-HT1A receptor modulation. Neurochemistry international. vol 48. issue 2. 2006-04-24. PMID:16256247. |
here, using in vitro extracellular single unit electrophysiology we examined the responses of individual neurones in the rat median raphe nucleus and dorsal raphe nucleus to alpha(1)-adrenoceptor and 5-ht(1a) receptor activation and made comparisons between the two nuclei. |
2006-04-24 |
2023-08-12 |
rat |
| Sarah J Judge, Sarah E Gartsid. Firing of 5-HT neurones in the dorsal and median raphe nucleus in vitro shows differential alpha1-adrenoceptor and 5-HT1A receptor modulation. Neurochemistry international. vol 48. issue 2. 2006-04-24. PMID:16256247. |
compared to those in the dorsal raphe nucleus, the neurones in the median raphe nucleus which were inhibited by 5-ht had: (1) lower basal firing rates in the continuous presence of phenylephrine (1microm), (2) smaller excitatory responses to higher concentrations of phenylephrine (3-10microm), (3) smaller excitatory responses to brief application of norepinephrine (10-100microm) and (4) smaller inhibitory responses to 5-ht (10-50microm). |
2006-04-24 |
2023-08-12 |
rat |
| Alessia Lanari, Francesco Amenta, Giorgio Silvestrelli, Daniele Tomassoni, Lucilla Parnett. Neurotransmitter deficits in behavioural and psychological symptoms of Alzheimer's disease. Mechanisms of ageing and development. vol 127. issue 2. 2006-04-21. PMID:16297434. |
imbalance of different neurotransmitters (acetylcholine, dopamine, noradrenaline and serotonin), involvement of specific brain regions responsible for emotional activities (parahippocampal gyrus, dorsal raphe and locus coeruleus) and cortical hypometabolism have been proposed as neurobiological substrate of bpsd. |
2006-04-21 |
2023-08-12 |
Not clear |
| Alexis Evrard, Nicolas Barden, Michel Hamon, Joëlle Adrie. Glucocorticoid receptor-dependent desensitization of 5-HT1A autoreceptors by sleep deprivation: studies in GR-i transgenic mice. Sleep. vol 29. issue 1. 2006-04-14. PMID:16453979. |
in animals, sleep deprivation and pharmacologic treatment with antidepressants exert similar effects on 5-ht neurotransmission, notably functional desensitization of 5-ht1a autoreceptors located on 5-ht neurons in the dorsal raphe nucleus (drn). |
2006-04-14 |
2023-08-12 |
mouse |
| Jaime M Monti, Héctor Janto. Effects of the 5-HT(7) receptor antagonist SB-269970 microinjected into the dorsal raphe nucleus on REM sleep in the rat. Behavioural brain research. vol 167. issue 2. 2006-04-04. PMID:16290281. |
effects of the 5-ht(7) receptor antagonist sb-269970 microinjected into the dorsal raphe nucleus on rem sleep in the rat. |
2006-04-04 |
2023-08-12 |
rat |
| Ouissame Mnie-Filali, Mostafa El Mansari, Agnès Espana, Connie Sànchez, Nasser Haddjer. Allosteric modulation of the effects of the 5-HT reuptake inhibitor escitalopram on the rat hippocampal synaptic plasticity. Neuroscience letters. vol 395. issue 1. 2006-03-29. PMID:16330146. |
the present in vivo electrophysiological studies in anesthetized rat were undertaken to assess the effects of the selective serotonin (5-ht) reuptake inhibitor (ssri) escitalopram alone or in combination with the r-citalopram (the s- and r-enantiomers of citalopram), on both long-term potentiation (ltp) in the ca(1) region of dorsal hippocampus and spontaneous firing activity of dorsal raphe (dr) 5-ht neurons. |
2006-03-29 |
2023-08-12 |
rat |