| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Santiago Canals, Maria José Casarejos, Sonsoles de Bernardo, Rosa Maria Solano, Maria Angeles Men. Selective and persistent activation of extracellular signal-regulated protein kinase by nitric oxide in glial cells induces neuronal degeneration in glutathione-depleted midbrain cultures. Molecular and cellular neurosciences. vol 24. issue 4. 2004-02-27. PMID:14697665. |
intracellular glutathione (gsh) levels determine whether nitric oxide (no) is neurotrophic for dopamine neurons or triggers a cell death cascade in primary midbrain cultures. |
2004-02-27 |
2023-08-12 |
Not clear |
| Santiago Canals, Maria José Casarejos, Sonsoles de Bernardo, Eulalia Rodríguez-Martín, Maria Angeles Men. Nitric oxide triggers the toxicity due to glutathione depletion in midbrain cultures through 12-lipoxygenase. The Journal of biological chemistry. vol 278. issue 24. 2003-07-22. PMID:12679339. |
nitric oxide triggers the toxicity due to glutathione depletion in midbrain cultures through 12-lipoxygenase. |
2003-07-22 |
2023-08-12 |
Not clear |
| Santiago Canals, Maria José Casarejos, Sonsoles de Bernardo, Eulalia Rodríguez-Martín, Maria Angeles Men. Nitric oxide triggers the toxicity due to glutathione depletion in midbrain cultures through 12-lipoxygenase. The Journal of biological chemistry. vol 278. issue 24. 2003-07-22. PMID:12679339. |
we have previously shown that non-toxic inhibition of gsh synthesis with l-buthionine-(s,r)-sulfoximine in primary midbrain cultures transforms a nitric oxide (no) neurotrophic effect, selective for dopamine neurons, into a toxic effect with participation of guanylate cyclase (gc) and cgmp-dependent protein kinase (pkg) (canals, s., casarejos, m. j., de bernardo, s., rodríguez-martín, e., and mena, m. a. |
2003-07-22 |
2023-08-12 |
Not clear |
| Mohamed B Abou-Donia, Anjelika M Dechkovskaia, Larry B Goldstein, Deepti U Shah, Sarah L Bullman, Wasiuddin A Kha. Uranyl acetate-induced sensorimotor deficit and increased nitric oxide generation in the central nervous system in rats. Pharmacology, biochemistry, and behavior. vol 72. issue 4. 2003-01-08. PMID:12062578. |
a significant increase in nitric oxide was seen at 0.1 mg/kg dose in cortex and midbrain, whereas brainstem and cerebellum showed an insignificant decrease at both the doses. |
2003-01-08 |
2023-08-12 |
rat |
| S Canals, M J Casarejos, S de Bernardo, E Rodríguez-Martín, M A Men. Glutathione depletion switches nitric oxide neurotrophic effects to cell death in midbrain cultures: implications for Parkinson's disease. Journal of neurochemistry. vol 79. issue 6. 2002-01-16. PMID:11752059. |
glutathione depletion switches nitric oxide neurotrophic effects to cell death in midbrain cultures: implications for parkinson's disease. |
2002-01-16 |
2023-08-12 |
Not clear |
| S Canals, M J Casarejos, S de Bernardo, E Rodríguez-Martín, M A Men. Glutathione depletion switches nitric oxide neurotrophic effects to cell death in midbrain cultures: implications for Parkinson's disease. Journal of neurochemistry. vol 79. issue 6. 2002-01-16. PMID:11752059. |
nitric oxide (no) exerts neurotrophic and neurotoxic effects on dopamine (da) function in primary midbrain cultures. |
2002-01-16 |
2023-08-12 |
Not clear |
| J E Tongren, C Yang, W E Collins, J S Sullivan, A A Lal, L Xia. Expression of proinflammatory cytokines in four regions of the brain in Macaque mulatta (rhesus) monkeys infected with Plasmodium coatneyi. The American journal of tropical medicine and hygiene. vol 62. issue 4. 2001-03-01. PMID:11220773. |
eleven days after parasite inoculation, the rhesus monkeys were killed and tissue samples from 4 regions of the brain (cortex and white matter of the cerebrum, cerebellum, and midbrain) were collected for quantitation of mrna expression of cytokines, adhesion molecules, and inducible nitric oxide synthetase (inos) by reverse transcriptase-polymerase chain reaction (rt-pcr). |
2001-03-01 |
2023-08-12 |
monkey |
| S Canals, M J Casarejos, E Rodríguez-Martín, S de Bernardo, M A Men. Neurotrophic and neurotoxic effects of nitric oxide on fetal midbrain cultures. Journal of neurochemistry. vol 76. issue 1. 2001-02-08. PMID:11145978. |
neurotrophic and neurotoxic effects of nitric oxide on fetal midbrain cultures. |
2001-02-08 |
2023-08-12 |
Not clear |
| B Liu, L Du, J S Hon. Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation. The Journal of pharmacology and experimental therapeutics. vol 293. issue 2. 2000-06-21. PMID:10773035. |
treatment of rat mesencephalic mixed neuron-glia cultures with lipopolysaccharide (lps)-activated microglia, resident immune cells of the brain, to release proinflammatory and neurotoxic factors tumor necrosis factor-alpha, interleukin-1beta, nitric oxide, and superoxide and subsequently caused damage to midbrain neurons, including dopaminergic neurons. |
2000-06-21 |
2023-08-12 |
rat |
| C Scheiner, R Arceneaux, W Guido, K Kratz, R Miz. Nitric oxide synthase distribution in the cat superior colliculus and co-localization with choline acetyltransferase. Journal of chemical neuroanatomy. vol 18. issue 4. 2000-06-21. PMID:10781733. |
we conclude that nitric oxide is contained in a variety of cell types in sc and that both nitric oxide and ach likely serve as co-modulators in this midbrain structure. |
2000-06-21 |
2023-08-12 |
cat |
| P Lingor, K Unsicker, K Krieglstei. GDNF and NT-4 protect midbrain dopaminergic neurons from toxic damage by iron and nitric oxide. Experimental neurology. vol 163. issue 1. 2000-06-13. PMID:10785444. |
gdnf and nt-4 protect midbrain dopaminergic neurons from toxic damage by iron and nitric oxide. |
2000-06-13 |
2023-08-12 |
rat |
| A R West, A A Grac. Striatal nitric oxide signaling regulates the neuronal activity of midbrain dopamine neurons in vivo. Journal of neurophysiology. vol 83. issue 4. 2000-05-15. PMID:10758092. |
striatal nitric oxide signaling regulates the neuronal activity of midbrain dopamine neurons in vivo. |
2000-05-15 |
2023-08-12 |
rat |
| H Katsuki, T Kume, S Kaneko, A Akaik. [Factors regulating survival and death of midbrain dopamine neurons]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 114 Suppl 1. 2000-02-16. PMID:10629879. |
dopaminergic neurons in midbrain--striatum co-cultures were more resistant to the cytotoxic actions of nmda and a nitric oxide donor noc-18, than the same neuronal population in single midbrain cultures. |
2000-02-16 |
2023-08-12 |
Not clear |
| S M Gomez-Urquijo, T Hökfelt, R Ubink, G Lubec, M Herrera-Marschit. Neurocircuitries of the basal ganglia studied in organotypic cultures: focus on tyrosine hydroxylase, nitric oxide synthase and neuropeptide immunocytochemistry. Neuroscience. vol 94. issue 4. 2000-02-14. PMID:10625053. |
local networks were especially prominent in the mesencephalon, where both tyrosine hydroxylase-positive axons spread from the "substantia nigra" to the rest of the tissue, and where nitric oxide synthase-positive networks also surrounded tyrosine hydroxylase-positive neurons. |
2000-02-14 |
2023-08-12 |
rat |
| B A Cox, S W Johnso. Nitric oxide facilitates N-methyl-D-aspartate-induced burst firing in dopamine neurons from rat midbrain slices. Neuroscience letters. vol 255. issue 3. 1999-02-10. PMID:9832190. |
nitric oxide facilitates n-methyl-d-aspartate-induced burst firing in dopamine neurons from rat midbrain slices. |
1999-02-10 |
2023-08-12 |
rat |
| K U Johansson, D Mello. Nitric oxide as a putative messenger molecule in the crayfish olfactory midbrain. Brain research. vol 807. issue 1-2. 1998-12-10. PMID:9757052. |
nitric oxide as a putative messenger molecule in the crayfish olfactory midbrain. |
1998-12-10 |
2023-08-12 |
Not clear |
| C W Hall, M M Behbehan. Synaptic effects of nitric oxide on enkephalinergic, GABAergic, and glutamatergic networks of the rat periaqueductal gray. Brain research. vol 805. issue 1-2. 1998-11-25. PMID:9733923. |
previous studies have shown that the injection of nitric oxide (no) donating compounds into the dorsal periaqueductal gray region of the midbrain (pag) decreases mean arterial pressure (map), while the injection of no synthase (nos) inhibitors increases map. |
1998-11-25 |
2023-08-12 |
rat |
| C W Hall, M M Behbehan. The medial preoptic nucleus of the hypothalamus modulates activity of nitric oxide sensitive neurons in the midbrain periaqueductal gray. Brain research. vol 765. issue 2. 1997-11-13. PMID:9313893. |
the medial preoptic nucleus of the hypothalamus modulates activity of nitric oxide sensitive neurons in the midbrain periaqueductal gray. |
1997-11-13 |
2023-08-12 |
Not clear |
| M M Hämäläinen, T A Lovic. Involvement of nitric oxide and serotonin in modulation of antinociception and pressor responses evoked by stimulation in the dorsolateral region of the periaqueductal gray matter in the rat. Neuroscience. vol 80. issue 3. 1997-10-27. PMID:9276497. |
nitric oxide may act in association with 5-hydroxytryptamine to control the excitability of the aversive system in the midbrain. |
1997-10-27 |
2023-08-12 |
rat |
| M M Hamalainen, T A Lovic. Role of nitric oxide and serotonin in modulation of the cardiovascular defence response evoked by stimulation in the periaqueductal grey matter in rats. Neuroscience letters. vol 229. issue 2. 1997-09-16. PMID:9223602. |
the results suggest that serotonin exerts an inhibitory modulation on the excitability of the midbrain defence area by a mechanism which involves nitric oxide. |
1997-09-16 |
2023-08-12 |
rat |