| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P J Goadsby, Y Knigh. Inhibition of trigeminal neurones after intravenous administration of naratriptan through an action at 5-hydroxy-tryptamine (5-HT(1B/1D)) receptors. British journal of pharmacology. vol 122. issue 5. 1998-09-24. PMID:9384509. |
furthermore, given that this inhibition could be reversed by the relatively selective 5-ht(1b/1d) receptor antagonist gr127935, it is highly likely that the anti-migraine effects of drugs of this class with central nervous system access are mediated, at least in part, by 5-ht(1b/1d) receptors within the trigeminal nucleus. |
1998-09-24 |
2023-08-12 |
Not clear |
| P J Goadsby, K L Hoski. Serotonin inhibits trigeminal nucleus activity evoked by craniovascular stimulation through a 5HT1B/1D receptor: a central action in migraine? Annals of neurology. vol 43. issue 6. 1998-06-25. PMID:9629840. |
serotonin inhibits trigeminal nucleus activity evoked by craniovascular stimulation through a 5ht1b/1d receptor: a central action in migraine? |
1998-06-25 |
2023-08-12 |
cat |
| P J Goadsby, K L Hoski. Serotonin inhibits trigeminal nucleus activity evoked by craniovascular stimulation through a 5HT1B/1D receptor: a central action in migraine? Annals of neurology. vol 43. issue 6. 1998-06-25. PMID:9629840. |
these data indicate that 5ht inhibits evoked trigeminal nucleus firing via the 5ht1b/1d receptor at which gr127935 is an antagonist. |
1998-06-25 |
2023-08-12 |
cat |
| P J Goadsby, K L Hoski. Serotonin inhibits trigeminal nucleus activity evoked by craniovascular stimulation through a 5HT1B/1D receptor: a central action in migraine? Annals of neurology. vol 43. issue 6. 1998-06-25. PMID:9629840. |
it is likely that some part of the effect of 5ht in migraine relates to inhibition of trigeminal nucleus activity, just as it is likely that some part of the effect of the triptans is also mediated at this central site and may be complementary to their nonneuronal actions. |
1998-06-25 |
2023-08-12 |
cat |
| E Knyihár-Csillik, J Tajti, M Samsam, G Sáry, S Slezák, L Vécse. Effect of a serotonin agonist (sumatriptan) on the peptidergic innervation of the rat cerebral dura mater and on the expression of c-fos in the caudal trigeminal nucleus in an experimental migraine model. Journal of neuroscience research. vol 48. issue 5. 1997-07-28. PMID:9185668. |
effect of a serotonin agonist (sumatriptan) on the peptidergic innervation of the rat cerebral dura mater and on the expression of c-fos in the caudal trigeminal nucleus in an experimental migraine model. |
1997-07-28 |
2023-08-12 |
rat |
| Maria Isabel Colado, Joaquín Del Rio, Enrique Peralt. Neonatal guanethidine sympathectomy suppresses autotomy and prevents changes in spinal and supraspinal monoamine levels induced by peripheral deafferentation in rats. Pain. vol 56. issue 1. 1994-05-19. PMID:7512708. |
changes in the content of 5-ht and its metabolite were also evident, at these time points, in periaqueductal gray matter and trigeminal nucleus. |
1994-05-19 |
2023-08-12 |
rat |
| A Kolta, R Dubuc, J P Lun. An immunocytochemical and autoradiographic investigation of the serotoninergic innervation of trigeminal mesencephalic and motor nuclei in the rabbit. Neuroscience. vol 53. issue 4. 1993-07-08. PMID:7685070. |
throughout the motor trigeminal nucleus, serotonin fibres were found in close proximity with cell bodies and with the proximal portions of axons and dendrites of labelled and unlabelled motoneurons. |
1993-07-08 |
2023-08-12 |
rabbit |
| F Nothias, B Onténiente, M Geffard, M Peschansk. Dissimilar responses of adult thalamic monoaminergic and somatosensory afferent fibers to implantation of thalamic fetal cells. Neuroscience. vol 37. issue 2. 1992-03-10. PMID:1723512. |
after various post-implantation delays, ranging from five to 30 days, two types of experiments were performed: (i) noradrenaline and serotonin immunohistochemistry with specific antibodies on alternate sections; and (ii) anterograde tracing using wheat germ agglutinin conjugated to horseradish peroxidase from the dorsal column nuclei and the principal sensory trigeminal nucleus. |
1992-03-10 |
2023-08-11 |
rat |
| N Yonehara, T Shibutani, Y Imai, Y Ooi, T Sawada, R Inok. Serotonin inhibits release of substance P evoked by tooth pulp stimulation in trigeminal nucleus caudalis in rabbits. Neuropharmacology. vol 30. issue 1. 1991-07-17. PMID:1710794. |
serotonin inhibits release of substance p evoked by tooth pulp stimulation in trigeminal nucleus caudalis in rabbits. |
1991-07-17 |
2023-08-11 |
Not clear |
| N Yonehara, T Shibutani, Y Imai, Y Ooi, T Sawada, R Inok. Serotonin inhibits release of substance P evoked by tooth pulp stimulation in trigeminal nucleus caudalis in rabbits. Neuropharmacology. vol 30. issue 1. 1991-07-17. PMID:1710794. |
local application of 5-ht (10(-6) m) inhibited the release of immunoreactive substance p induced by stimulation and this inhibition was antagonized by methysergide (10(-4) m) applied concomitantly to the superficial layers of the trigeminal nucleus. |
1991-07-17 |
2023-08-11 |
Not clear |
| N Yonehara, T Shibutani, Y Imai, Y Ooi, T Sawada, R Inok. Serotonin inhibits release of substance P evoked by tooth pulp stimulation in trigeminal nucleus caudalis in rabbits. Neuropharmacology. vol 30. issue 1. 1991-07-17. PMID:1710794. |
these results suggest a functional interaction between substance p and 5-ht in the superficial layers of the trigeminal nucleus for regulation of transmission of dental pain. |
1991-07-17 |
2023-08-11 |
Not clear |
| J M Fritschy, W E Lyons, M E Molliver, R Grzann. Neurotoxic effects of p-chloroamphetamine on the serotoninergic innervation of the trigeminal motor nucleus: a retrograde transport study. Brain research. vol 473. issue 2. 1989-05-10. PMID:2466523. |
the present study was conducted to determine (i) whether the motor nucleus of the trigeminal nerve is innervated by overlapping projections from multiple serotonin cell groups and (ii) whether a particular subset of serotoninergic axon terminals in the trigeminal motor nucleus are sensitive to the neurotoxic effects of pca. |
1989-05-10 |
2023-08-11 |
rat |
| J M Fritschy, W E Lyons, M E Molliver, R Grzann. Neurotoxic effects of p-chloroamphetamine on the serotoninergic innervation of the trigeminal motor nucleus: a retrograde transport study. Brain research. vol 473. issue 2. 1989-05-10. PMID:2466523. |
these results demonstrate that pca selectively lesions serotonin axon terminals arising from the dorsal raphe nucleus, while sparing projections from the raphe obscurus and raphe pallidus to the trigeminal motor nucleus. |
1989-05-10 |
2023-08-11 |
rat |
| M A Matthews, T V Hernandez, S L Lile. Immunocytochemistry of enkephalin and serotonin distribution in restricted zones of the rostral trigeminal spinal subnuclei: comparisons with subnucleus caudalis. Synapse (New York, N.Y.). vol 1. issue 6. 1988-10-20. PMID:3455561. |
both enkephalin (enk) and serotonin (5-ht) are present in rostral trigeminal nuclei and these regions receive inputs from the raphe complex. |
1988-10-20 |
2023-08-11 |
cat |
| J C Pearson, L Jenne. Localization of serotonin- and substance P-like immunofluorescence in the caudal spinal trigeminal nucleus of the rat. Neuroscience letters. vol 88. issue 2. 1988-07-22. PMID:2454433. |
the 5-ht- and sp-immunoreactive fibers share extensive topographical overlap within the superficial laminae of the caudal trigeminal nucleus; however, the majority of stained fibers are immunoreactive for either 5-ht or sp, but not both simultaneously. |
1988-07-22 |
2023-08-11 |
rat |
| L Brodin, J T Buchanan, T Hökfelt, S Grillner, A A Verhofsta. A spinal projection of 5-hydroxytryptamine neurons in the lamprey brainstem; evidence from combined retrograde tracing and immunohistochemistry. Neuroscience letters. vol 67. issue 1. 1986-08-13. PMID:3725200. |
two groups of these cells, one within the posterior reticular nucleus of the rhombencephalon and another rostral to the trigeminal motor nucleus, were labelled after incubation with 5-ht antiserum. |
1986-08-13 |
2023-08-11 |
Not clear |
| E C Cropper, J S Eisenman, E C Azmiti. 5-HT-Immunoreactive fibers in the trigeminal nuclear complex of the rat. Experimental brain research. vol 55. issue 3. 1984-10-12. PMID:6381083. |
the distribution of serotonin immunoreactive (5-ht-ir) fibers in the trigeminal nuclear complex of the rat was mapped. |
1984-10-12 |
2023-08-12 |
rat |
| N Schaffar, A Jean, A Cala. Radioautographic study of serotoninergic axon terminals in the rat trigeminal motor nucleus. Neuroscience letters. vol 44. issue 1. 1984-06-14. PMID:6717849. |
serotonin (5-ht) axon terminals were demonstrated in the rat trigeminal motor nucleus (vmn) using radioautography following local injection of tritiated 5-ht. |
1984-06-14 |
2023-08-12 |
rat |
| H J Haigle. Characteristics of extravascular serotonin receptors in the brain. Advances in neurology. vol 33. 1982-03-26. PMID:7055009. |
a decrease in the amount of 5-ht released by projections from the mpr to the trigeminal nucleus could be partially responsible for the pain experienced in migraine headache. |
1982-03-26 |
2023-08-12 |
Not clear |
| H J Haigle. Characteristics of extravascular serotonin receptors in the brain. Advances in neurology. vol 33. 1982-03-26. PMID:7055009. |
drugs useful in treating migraine headache may mimic 5-ht at synapses in the trigeminal nucleus that are associated with projections from the mpr. |
1982-03-26 |
2023-08-12 |
Not clear |