| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mihaela Necula, Jeff Kure. Site-specific pseudophosphorylation modulates the rate of tau filament dissociation. FEBS letters. vol 579. issue 6. 2005-04-01. PMID:15733856. |
hyperphosphorylation of tau is of fundamental importance for neurofibrillary lesion development in alzheimer's disease, but the mechanisms through which it acts are not clear. |
2005-04-01 |
2023-08-12 |
Not clear |
| R Rademakers, M Cruts, C van Broeckhove. The role of tau (MAPT) in frontotemporal dementia and related tauopathies. Human mutation. vol 24. issue 4. 2005-03-31. PMID:15365985. |
abnormal filamentous tau deposits have been reported as a pathological characteristic in several other neurodegenerative diseases, including frontotemporal dementia, pick disease, alzheimer disease, argyrophilic grain disease, progressive supranuclear palsy, and corticobasal degeneration. |
2005-03-31 |
2023-08-12 |
mouse |
| Natalia Csokova, Rostislav Skrabana, Hans-Dieter Liebig, Anna Mederlyova, Peter Kontsek, Michal Nova. Rapid purification of truncated tau proteins: model approach to purification of functionally active fragments of disordered proteins, implication for neurodegenerative diseases. Protein expression and purification. vol 35. issue 2. 2005-03-29. PMID:15135415. |
truncated tau is of great interest because of its important role in neurofibrillary pathogenesis in alzheimer's disease (ad). |
2005-03-29 |
2023-08-12 |
Not clear |
| Carl W Cotman, Wayne W Poon, Robert A Rissman, Mathew Blurton-Jone. The role of caspase cleavage of tau in Alzheimer disease neuropathology. Journal of neuropathology and experimental neurology. vol 64. issue 2. 2005-03-29. PMID:15751224. |
the role of caspase cleavage of tau in alzheimer disease neuropathology. |
2005-03-29 |
2023-08-12 |
mouse |
| Salvatore Oddo, Antonella Caccamo, Kim N Green, Kevin Liang, Levina Tran, Yiling Chen, Frances M Leslie, Frank M LaFerl. Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 8. 2005-03-24. PMID:15705720. |
chronic nicotine administration exacerbates tau pathology in a transgenic model of alzheimer's disease. |
2005-03-24 |
2023-08-12 |
mouse |
| Marcus Pickhardt, Zuzana Gazova, Martin von Bergen, Inna Khlistunova, Yipeng Wang, Antje Hascher, Eva-Maria Mandelkow, Jacek Biernat, Eckhard Mandelko. Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells. The Journal of biological chemistry. vol 280. issue 5. 2005-03-22. PMID:15525637. |
anthraquinones inhibit tau aggregation and dissolve alzheimer's paired helical filaments in vitro and in cells. |
2005-03-22 |
2023-08-12 |
Not clear |
| Marcus Pickhardt, Zuzana Gazova, Martin von Bergen, Inna Khlistunova, Yipeng Wang, Antje Hascher, Eva-Maria Mandelkow, Jacek Biernat, Eckhard Mandelko. Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells. The Journal of biological chemistry. vol 280. issue 5. 2005-03-22. PMID:15525637. |
the abnormal aggregation of tau protein into paired helical filaments (phfs) is one of the hallmarks of alzheimer's disease. |
2005-03-22 |
2023-08-12 |
Not clear |
| Varun Rachakonda, Tian Hong Pan, Wei Dong L. Biomarkers of neurodegenerative disorders: how good are they? Cell research. vol 14. issue 5. 2005-03-22. PMID:15538967. |
the followings, for instance, are only a few of the many new biomarkers that have been recently identified: the phosphorylated tau protein and aggregated beta-amyloid peptide for alzheimer's disease (ad), alpha-synuclein contained lewy bodies and altered dopamine transporter (dat) imaging for parkinson's disease (pd), sod mutations for familial amyotrophic lateral sclerosis (als), and cag repeats resulted from huntington's gene mutations in huntington's disease (hd). |
2005-03-22 |
2023-08-12 |
Not clear |
| Mar Pérez, Raquel Cuadros, María J Benítez, Juan S Jiméne. Interaction of Alzheimer's disease amyloid beta peptide fragment 25-35 with tau protein, and with a tau peptide containing the microtubule binding domain. Journal of Alzheimer's disease : JAD. vol 6. issue 5. 2005-03-21. PMID:15505366. |
interaction of alzheimer's disease amyloid beta peptide fragment 25-35 with tau protein, and with a tau peptide containing the microtubule binding domain. |
2005-03-21 |
2023-08-12 |
Not clear |
| Mar Pérez, Raquel Cuadros, María J Benítez, Juan S Jiméne. Interaction of Alzheimer's disease amyloid beta peptide fragment 25-35 with tau protein, and with a tau peptide containing the microtubule binding domain. Journal of Alzheimer's disease : JAD. vol 6. issue 5. 2005-03-21. PMID:15505366. |
this interaction produces the aggregation of tau peptide and the concomitant disassembling of abeta 25-35, offering thus an explanation to the lack of co-localization of neurofibrillary tangles and senile plaques in alzheimer's disease, and suggesting the possibility that tau protein may have a protective action by preventing abeta from adopting the cytotoxic, aggregated form. |
2005-03-21 |
2023-08-12 |
Not clear |
| Laura A Robertson, Kenneth L Moya, Kieran C Bree. The potential role of tau protein O-glycosylation in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 6. issue 5. 2005-03-21. PMID:15505370. |
the potential role of tau protein o-glycosylation in alzheimer's disease. |
2005-03-21 |
2023-08-12 |
Not clear |
| Laura A Robertson, Kenneth L Moya, Kieran C Bree. The potential role of tau protein O-glycosylation in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 6. issue 5. 2005-03-21. PMID:15505370. |
as increased phosphorylation of the microtubule-associated protein tau is one of the pathological hallmarks of alzheimer's disease and glycosylation may play an influential role in this process. |
2005-03-21 |
2023-08-12 |
Not clear |
| M L Michaelis, S Ansar, Y Chen, E R Reiff, K I Seyb, R H Himes, K L Audus, G I Geor. {beta}-Amyloid-induced neurodegeneration and protection by structurally diverse microtubule-stabilizing agents. The Journal of pharmacology and experimental therapeutics. vol 312. issue 2. 2005-03-18. PMID:15375176. |
deposition of beta-amyloid peptide (abeta) and hyperphosphorylation of the tau protein are associated with neuronal dysfunction and cell death in alzheimer's disease. |
2005-03-18 |
2023-08-12 |
Not clear |
| Ichiro Tsujio, Tanweer Zaidi, Jiliu Xu, Leszek Kotula, Inge Grundke-Iqbal, Khalid Iqba. Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau. FEBS letters. vol 579. issue 2. 2005-03-15. PMID:15642345. |
inhibitors of protein phosphatase-2a from human brain structures, immunocytological localization and activities towards dephosphorylation of the alzheimer type hyperphosphorylated tau. |
2005-03-15 |
2023-08-12 |
human |
| Armelle Rametti, Françoise Esclaire, Catherine Yardin, Faraj Terr. Linking alterations in tau phosphorylation and cleavage during neuronal apoptosis. The Journal of biological chemistry. vol 279. issue 52. 2005-03-14. PMID:15475565. |
this mechanism may contribute to the aggregation of hyperphosphorylated tau into paired helical filaments in alzheimer's disease where reduced pp2a activity has been reported. |
2005-03-14 |
2023-08-12 |
Not clear |
| Jae-Hyeon Cho, Gail V W Johnso. Glycogen synthase kinase 3 beta induces caspase-cleaved tau aggregation in situ. The Journal of biological chemistry. vol 279. issue 52. 2005-03-14. PMID:15494420. |
tau is a substrate of caspases, and caspase-cleaved tau has been detected in alzheimer's disease brain but not in control brain. |
2005-03-14 |
2023-08-12 |
Not clear |
| Jae-Hyeon Cho, Gail V W Johnso. Glycogen synthase kinase 3 beta induces caspase-cleaved tau aggregation in situ. The Journal of biological chemistry. vol 279. issue 52. 2005-03-14. PMID:15494420. |
these data suggest that a combination of phosphorylation events and caspase activation contribute to the tau oligomerization process in alzheimer's disease, with gsk3 beta-mediated tau phosphorylation preceding caspase cleavage. |
2005-03-14 |
2023-08-12 |
Not clear |
| Katsuhiko Minoura, Fumie Mizushima, Mari Tokimasa, Shuko Hiraoka, Koji Tomoo, Miho Sumida, Taizo Taniguchi, Toshimasa Ishid. Structural evaluation of conformational transition state responsible for self-assembly of tau microtubule-binding domain. Biochemical and biophysical research communications. vol 327. issue 4. 2005-03-14. PMID:15652510. |
in the brains of alzheimer's disease patients, the tau protein abnormally aggregates to form an insoluble paired helical filament (phf). |
2005-03-14 |
2023-08-12 |
Not clear |
| Annika Olsson, Hugo Vanderstichele, Niels Andreasen, Geert De Meyer, Anders Wallin, Björn Holmberg, Lars Rosengren, Eugeen Vanmechelen, Kaj Blenno. Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology. Clinical chemistry. vol 51. issue 2. 2005-03-11. PMID:15563479. |
to simultaneously study several biomarkers for alzheimer disease (ad), we used the xmap technology to develop and evaluate a multiparametric bead-based assay for quantification of beta-amyloid((1-42)) [abeta((1-42))], total tau (t-tau), and hyperphosphorylated tau [p-tau((181p))] in cerebrospinal fluid (csf). |
2005-03-11 |
2023-08-12 |
Not clear |
| G O Ivy, Y Ihara, K Kitan. The protease inhibitor leupeptin induces several signs of aging in brain, retina and internal organs of young rats. Archives of gerontology and geriatrics. vol 12. issue 2-3. 2005-03-10. PMID:15374443. |
finally, both leupeptin treatment and normal aging led to the onset of immunoreactivity in purkinje cells to antibodies to the abnormal tau molecule of paired helical filaments from alzheimer's disease brain. |
2005-03-10 |
2023-08-12 |
rat |