| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olivera M Mitrasinovic, Greer M Murph. Microglial overexpression of the M-CSF receptor augments phagocytosis of opsonized Abeta. Neurobiology of aging. vol 24. issue 6. 2003-10-29. PMID:12927763. |
the role of microglia in alzheimer's disease (ad) has come under intense scrutiny recently because microglia may clear amyloid beta (abeta) by phagocytosis after immunization of transgenic mice. |
2003-10-29 |
2023-08-12 |
mouse |
| Richard C Dodel, Harald Hampel, Yansheng D. Immunotherapy for Alzheimer's disease. The Lancet. Neurology. vol 2. issue 4. 2003-08-27. PMID:12849209. |
recent studies in murine models of alzheimer's disease (ad) have found that active immunisation with amyloid-beta peptide (abeta) or passive immunisation with abeta antibodies can lessen the severity of abeta-induced neuritic plaque pathology through the activation of microglia. |
2003-08-27 |
2023-08-12 |
Not clear |
| Magdalena Luca, Alexandra Chavez-Ross, Leah Edelstein-Keshet, Alex Mogilne. Chemotactic signaling, microglia, and Alzheimer's disease senile plaques: is there a connection? Bulletin of mathematical biology. vol 65. issue 4. 2003-08-21. PMID:12875339. |
chemotactic signaling, microglia, and alzheimer's disease senile plaques: is there a connection? |
2003-08-21 |
2023-08-12 |
Not clear |
| Magdalena Luca, Alexandra Chavez-Ross, Leah Edelstein-Keshet, Alex Mogilne. Chemotactic signaling, microglia, and Alzheimer's disease senile plaques: is there a connection? Bulletin of mathematical biology. vol 65. issue 4. 2003-08-21. PMID:12875339. |
chemotactic cells known as microglia are involved in the inflammation associated with pathology in alzheimer's disease (ad). |
2003-08-21 |
2023-08-12 |
Not clear |
| Joseph B El Khoury, Kathryn J Moore, Terry K Means, Josephine Leung, Kinya Terada, Michelle Toft, Mason W Freeman, Andrew D Luste. CD36 mediates the innate host response to beta-amyloid. The Journal of experimental medicine. vol 197. issue 12. 2003-08-05. PMID:12796468. |
accumulation of inflammatory microglia in alzheimer's senile plaques is a hallmark of the innate response to beta-amyloid fibrils and can initiate and propagate neurodegeneration characteristic of alzheimer's disease (ad). |
2003-08-05 |
2023-08-12 |
mouse |
| Wataru Matsunaga, Tetsuya Shirokawa, Kenichi Isob. Specific uptake of Abeta1-40 in rat brain occurs in astrocyte, but not in microglia. Neuroscience letters. vol 342. issue 1-2. 2003-07-31. PMID:12727334. |
in the brain of a patient with alzheimer's disease, beta amyloid peptide (abeta) is thought to be taken up by glial cells such as astrocyte and microglia to be degraded. |
2003-07-31 |
2023-08-12 |
rat |
| Kazuyuki Takata, Yoshihisa Kitamura, Daiju Tsuchiya, Toshiyuki Kawasaki, Takashi Taniguchi, Shun Shimoham. Heat shock protein-90-induced microglial clearance of exogenous amyloid-beta1-42 in rat hippocampus in vivo. Neuroscience letters. vol 344. issue 2. 2003-07-14. PMID:12782334. |
alzheimer's disease is characterized by the accumulation of extracellular amyloid-beta (a beta) fibrils with microglia. |
2003-07-14 |
2023-08-12 |
rat |
| Suman Deb, J Wenjun Zhang, Paul E Gottschal. Beta-amyloid induces the production of active, matrix-degrading proteases in cultured rat astrocytes. Brain research. vol 970. issue 1-2. 2003-07-08. PMID:12706262. |
the senile and neuritic plaque neuropathology of alzheimer's disease (ad) is accompanied by an inflammatory response that includes activated astrocytes and microglia. |
2003-07-08 |
2023-08-12 |
rat |
| C Holmes, M El-Okl, A L Williams, C Cunningham, D Wilcockson, V H Perr. Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 74. issue 6. 2003-07-08. PMID:12754353. |
activated microglia, the resident macrophages of the brain, are a feature of alzheimer's disease. |
2003-07-08 |
2023-08-12 |
human |
| Lav K Parvathenani, Svetlana Tertyshnikova, Corinne R Greco, Susan B Roberts, Barbara Robertson, Rand Posmantu. P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease. The Journal of biological chemistry. vol 278. issue 15. 2003-07-03. PMID:12551918. |
p2x7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of alzheimer's disease. |
2003-07-03 |
2023-08-12 |
mouse |
| Junko Irie-Sasaki, Takehiko Sasaki, Josef M Penninge. CD45 regulated signaling pathways. Current topics in medicinal chemistry. vol 3. issue 7. 2003-06-10. PMID:12678844. |
moreover, loss of cd45 can affect microglia activation in a mouse model for alzheimer's disease. |
2003-06-10 |
2023-08-12 |
mouse |
| Maria E Bamberger, Meera E Harris, Douglas R McDonald, Jens Husemann, Gary E Landret. A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 7. 2003-05-30. PMID:12684452. |
senile plaques found in the alzheimer's disease brain are foci of local inflammatory reactions mediated by plaque-associated microglia. |
2003-05-30 |
2023-08-12 |
Not clear |
| Shigeko Uryu, Shinya Tokuhiro, Tomiichiro Od. beta-Amyloid-specific upregulation of stearoyl coenzyme A desaturase-1 in macrophages. Biochemical and biophysical research communications. vol 303. issue 1. 2003-05-22. PMID:12646202. |
beta-amyloid peptide (a beta), a major component of senile plaques, the formation of which is characteristic of alzheimer's disease (ad), is believed to induce inflammation of the brain mediated by microglia, leading to neuronal cell loss. |
2003-05-22 |
2023-08-12 |
Not clear |
| Robert Veerhuis, Mariëlle J Van Breemen, Jeroen M Hoozemans, Michela Morbin, Jamal Ouladhadj, Fabrizio Tagliavini, Piet Eikelenboo. Amyloid beta plaque-associated proteins C1q and SAP enhance the Abeta1-42 peptide-induced cytokine secretion by adult human microglia in vitro. Acta neuropathologica. vol 105. issue 2. 2003-04-23. PMID:12536224. |
pro-inflammatory cytokines released by activated microglia could be a driving force in alzheimer's disease (ad) pathology. |
2003-04-23 |
2023-08-12 |
human |
| Kazuyuki Takata, Yoshihisa Kitamura, Jun-ichi Kakimura, Keiichi Shibagaki, Daiju Tsuchiya, Takashi Taniguchi, Mark A Smith, George Perry, Shun Shimoham. Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis. Biochemical and biophysical research communications. vol 301. issue 3. 2003-04-14. PMID:12565837. |
in alzheimer's disease (ad), fibrillar amyloid-beta (abeta) peptides form senile plaques associated with activated microglia. |
2003-04-14 |
2023-08-12 |
Not clear |
| Corinna Trebst, Susan M Staugaitis, Pia Kivisäkk, Don Mahad, Martha K Cathcart, Barbara Tucky, Tao Wei, Mysore R Sandhya Rani, Richard Horuk, Kenneth D Aldape, Carlos A Pardo, Claudia F Lucchinetti, Hans Lassmann, Richard M Ransohof. CC chemokine receptor 8 in the central nervous system is associated with phagocytic macrophages. The American journal of pathology. vol 162. issue 2. 2003-04-11. PMID:12547701. |
ccr8 was consistently expressed on phagocytic macrophages and activated microglia in stroke and progressive multifocal leukoencephalopathy, but not expressed on microglia in pathologies that lacked phagocytic macrophages such as senile change of the alzheimer's type. |
2003-04-11 |
2023-08-12 |
human |
| Yoichi Nakamur. Regulating factors for microglial activation. Biological & pharmaceutical bulletin. vol 25. issue 8. 2003-04-04. PMID:12186424. |
pathological activation of microglia has been reported in a wide range of conditions such as cerebral ischemia, alzheimer's disease, prion diseases, multiple sclerosis, aids dementia, and others. |
2003-04-04 |
2023-08-12 |
Not clear |
| Teresa Wierzba-Bobrowicz, Elzbieta Gwiazda, Elzbieta Kosno-Kruszewska, Eliza Lewandowska, Waldemar Lechowicz, Ewa Bertrand, Grazyna M Szpak, Bogna Schmidt-Sido. Morphological analysis of active microglia--rod and ramified microglia in human brains affected by some neurological diseases (SSPE, Alzheimer's disease and Wilson's disease). Folia neuropathologica. vol 40. issue 3. 2003-03-07. PMID:12572918. |
morphological analysis of active microglia--rod and ramified microglia in human brains affected by some neurological diseases (sspe, alzheimer's disease and wilson's disease). |
2003-03-07 |
2023-08-12 |
human |
| Teresa Wierzba-Bobrowicz, Elzbieta Gwiazda, Elzbieta Kosno-Kruszewska, Eliza Lewandowska, Waldemar Lechowicz, Ewa Bertrand, Grazyna M Szpak, Bogna Schmidt-Sido. Morphological analysis of active microglia--rod and ramified microglia in human brains affected by some neurological diseases (SSPE, Alzheimer's disease and Wilson's disease). Folia neuropathologica. vol 40. issue 3. 2003-03-07. PMID:12572918. |
in the present study immunohistochemical identification of rod microglial phenotype against ramified microglia was performed on segments of 17 brains derived from 7 cases of encephalitis of viral aetiology (including 5 sspe cases), 6 cases of wilson's disease and 4 cases of alzheimer's disease. |
2003-03-07 |
2023-08-12 |
human |
| Gilles J Guillemin, Bruce J Bre. Implications of the kynurenine pathway and quinolinic acid in Alzheimer's disease. Redox report : communications in free radical research. vol 7. issue 4. 2003-03-04. PMID:12396664. |
senile plaques in alzheimer's disease are associated with evidence of chronic local inflammation (especially activated microglia) a major aspect of quin toxicity is lipid peroxidation and markers of lipid peroxidation are found in alzheimer's disease. |
2003-03-04 |
2023-08-12 |
Not clear |