| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tarja M Malm, Milla Koistinaho, Maria Pärepalo, Tero Vatanen, Andreas Ooka, Stefan Karlsson, Jari Koistinah. Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice. Neurobiology of disease. vol 18. issue 1. 2005-05-16. PMID:15649704. |
the role of microglia recruited from bone marrow (bm) into the cns during the progression of alzheimer's disease (ad) is poorly understood. |
2005-05-16 |
2023-08-12 |
mouse |
| Sachiko Ito, Makoto Sawada, Masataka Haneda, Satoshi Fujii, Kentaro Oh-Hashi, Kazutoshi Kiuchi, Masahide Takahashi, Ken-Ichi Isob. Amyloid-beta peptides induce cell proliferation and macrophage colony-stimulating factor expression via the PI3-kinase/Akt pathway in cultured Ra2 microglial cells. FEBS letters. vol 579. issue 9. 2005-05-11. PMID:15792809. |
alzheimer's disease is characterized by numerous amyloid-beta peptide (abeta) plaques surrounded by microglia. |
2005-05-11 |
2023-08-12 |
mouse |
| Nahed S Elsisi, Selina Darling-Reed, Eunsook Y Lee, Ebenezer T Oriaku, Karam F Solima. Ibuprofen and apigenin induce apoptosis and cell cycle arrest in activated microglia. Neuroscience letters. vol 375. issue 2. 2005-04-22. PMID:15670648. |
evidence suggests that microglia proliferate by cell division to create gliosis at the site of pathological conditions such as the amyloid plaques in alzheimer's disease and the substantia nigra of parkinson's disease patients. |
2005-04-22 |
2023-08-12 |
Not clear |
| Robert E Mrak, W Sue T Griffi. Glia and their cytokines in progression of neurodegeneration. Neurobiology of aging. vol 26. issue 3. 2005-04-19. PMID:15639313. |
all of these conditions are associated with early and often dramatic activation of, and cytokine overexpression in, microglia and astrocytes, sometimes decades before pathological changes consistent with a diagnosis of alzheimer's disease are apparent, as in patients with down's syndrome or head injury. |
2005-04-19 |
2023-08-12 |
Not clear |
| Kirk P Townsend, Terrence Town, Takashi Mori, Lih-Fen Lue, Doug Shytle, Paul R Sanberg, David Morgan, Francisco Fernandez, Richard A Flavell, Jun Ta. CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide. European journal of immunology. vol 35. issue 3. 2005-04-19. PMID:15688347. |
although deposition of amyloid beta-peptide (abeta) as abeta plaques involves activation of microglia-mediated inflammatory responses, activated microglia ultimately fail to clear abeta plaques in the brains of either alzheimer's disease (ad) patients or ad mouse models. |
2005-04-19 |
2023-08-12 |
mouse |
| Clive Bate, Alun William. Detoxified lipopolysaccharide reduces microglial cell killing of prion-infected neurons. Neuroreport. vol 15. issue 18. 2005-03-29. PMID:15597050. |
these results suggest that some compounds that bind to cd14 might reduce microglial cell activation and increase neuronal survival in prion and alzheimer's diseases. |
2005-03-29 |
2023-08-12 |
Not clear |
| Imrich Blasko, Michaela Stampfer-Kountchev, Peter Robatscher, Robert Veerhuis, Piet Eikelenboom, Beatrix Grubeck-Loebenstei. How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes. Aging cell. vol 3. issue 4. 2005-03-15. PMID:15268750. |
how chronic inflammation can affect the brain and support the development of alzheimer's disease in old age: the role of microglia and astrocytes. |
2005-03-15 |
2023-08-12 |
Not clear |
| Angela M Bodles, Steven W Barge. Secreted beta-amyloid precursor protein activates microglia via JNK and p38-MAPK. Neurobiology of aging. vol 26. issue 1. 2005-03-14. PMID:15585341. |
reactive microglia are thought to play a role in the pathogenesis of alzheimer's disease (ad) and are localized to the senile plaques that are associated with cognitive decline. |
2005-03-14 |
2023-08-12 |
Not clear |
| Kazuyuki Takata, Yoshihisa Kitamura, Daiju Tsuchiya, Toshiyuki Kawasaki, Takashi Taniguchi, Shun Shimoham. High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity. Journal of neuroscience research. vol 78. issue 6. 2005-03-07. PMID:15499593. |
one pathogenic characteristic of alzheimer's disease (ad) is the formation of extracellular senile plaques with accumulated microglia. |
2005-03-07 |
2023-08-12 |
mouse |
| Xiaoning Bi, Michel Baudry, Jihua Liu, Yueqin Yao, Lawrence Fu, Fernando Brucher, Gary Lync. Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia. The Journal of biological chemistry. vol 279. issue 46. 2005-01-21. PMID:15364922. |
inflammatory responses involving microglia, the resident macrophages of the brain, are thought to contribute importantly to the progression of alzheimer's disease (ad) and possibly other neurodegenerative disorders. |
2005-01-21 |
2023-08-12 |
rat |
| D Ramonet, M J Rodríguez, M Pugliese, N Mah. Putative glucosensing property in rat and human activated microglia. Neurobiology of disease. vol 17. issue 1. 2004-12-21. PMID:15350960. |
this study analyses activated microglia in an in vivo rat neurodegenerative model based on acute hippocampal glutamate receptor overactivation and in postmortem samples from patients with alzheimer's disease. |
2004-12-21 |
2023-08-12 |
human |
| Sung-Soo Kim, Pil-Jae Kong, Bong-Seog Kim, Dong-Hyuk Sheen, Su-Youn Nam, Wanjoo Chu. Inhibitory action of minocycline on lipopolysaccharide-induced release of nitric oxide and prostaglandin E2 in BV2 microglial cells. Archives of pharmacal research. vol 27. issue 3. 2004-11-04. PMID:15089037. |
microglia are the major inflammatory cells in the central nervous system and become activated in response to brain injuries such as ischemia, trauma, and neurodegenerative diseases including alzheimer's disease (ad). |
2004-11-04 |
2023-08-12 |
Not clear |
| Lucía Rodero, Jon Infante, Enrique Palacio, Javier Llorca, José Berciano, Onofre Combarro. Polymorphism at codon 469 of the intercellular adhesion molecule-1 gene is not associated with sporadic Alzheimer's disease. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 126B. issue 1. 2004-10-19. PMID:15048650. |
activation of microglia is a central part of the chronic inflammatory response in alzheimer's disease (ad). |
2004-10-19 |
2023-08-12 |
human |
| A Hayes, E K Green, A Pritchard, J M Harris, Y Zhang, J C Lambert, M C Chartier-Harlin, S M Pickering-Brown, C L Lendon, D M A Man. A polymorphic variation in the interleukin 1A gene increases brain microglial cell activity in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 75. issue 10. 2004-10-19. PMID:15377701. |
a polymorphic variation in the interleukin 1a gene increases brain microglial cell activity in alzheimer's disease. |
2004-10-19 |
2023-08-12 |
Not clear |
| A Hayes, E K Green, A Pritchard, J M Harris, Y Zhang, J C Lambert, M C Chartier-Harlin, S M Pickering-Brown, C L Lendon, D M A Man. A polymorphic variation in the interleukin 1A gene increases brain microglial cell activity in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 75. issue 10. 2004-10-19. PMID:15377701. |
to investigate the impact of possession of the -889 c/t polymorphism of the interleukin 1a gene (il-1a) and the -511 c/t polymorphism of the interleukin 1b gene (il-1b) on the extent of neuroinflammation in the brain in alzheimer's disease (ad), as demonstrated by the degree of microglial cell activity associated with each il-1a and il-1b genotype. |
2004-10-19 |
2023-08-12 |
Not clear |
| Onofre Combarros, Jon Infante, Javier Llorca, Nicolás Peña, Carlos Fernández-Viadero, José Bercian. The chemokine receptor CCR5-Delta32 gene mutation is not protective against Alzheimer's disease. Neuroscience letters. vol 366. issue 3. 2004-10-08. PMID:15288441. |
chronic local inflammatory reaction involving reactive microglia is one of the major pathological events in alzheimer's disease (ad). |
2004-10-08 |
2023-08-12 |
Not clear |
| Gaia Novarino, Cinzia Fabrizi, Raffaella Tonini, Michela A Denti, Fiorella Malchiodi-Albedi, Giuliana M Lauro, Benedetto Sacchetti, Silvia Paradisi, Arnaldo Ferroni, Paul M Curmi, Samuel N Breit, Michele Mazzant. Involvement of the intracellular ion channel CLIC1 in microglia-mediated beta-amyloid-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 23. 2004-09-24. PMID:15190104. |
alzheimer's disease, for example, is characterized by an accumulation of beta-amyloid protein (abeta) in neuritic plaques that are infiltrated by reactive microglia and astrocytes. |
2004-09-24 |
2023-08-12 |
rat |
| Clive Bate, Robert Veerhuis, Piet Eikelenboom, Alun William. Microglia kill amyloid-beta1-42 damaged neurons by a CD14-dependent process. Neuroreport. vol 15. issue 9. 2004-09-16. PMID:15194867. |
activated microglia are closely associated with neuronal damage in alzheimer's disease. |
2004-09-16 |
2023-08-12 |
mouse |
| H Slawik, B Volk, B Fiebich, M Hül. Microglial expression of prostaglandin EP3 receptor in excitotoxic lesions in the rat striatum. Neurochemistry international. vol 45. issue 5. 2004-09-16. PMID:15234107. |
this change in ep3-receptor expression in microglia might participate in acute or chronic microglial activation in a variety of brain diseases such as ischemia or alzheimer's disease (ad). |
2004-09-16 |
2023-08-12 |
rat |
| Pattie S Green, Armando J Mendez, Jason S Jacob, Jan R Crowley, Whit Growdon, Bradley T Hyman, Jay W Heineck. Neuronal expression of myeloperoxidase is increased in Alzheimer's disease. Journal of neurochemistry. vol 90. issue 3. 2004-09-10. PMID:15255951. |
consistent with expression in phagocytic cells, myeloperoxidase immunoreactivity was present in some activated microglia in alzheimer brains. |
2004-09-10 |
2023-08-12 |
human |