D M Morrow, D A Tagle, Y Shiloh, F S Collins, P Hiete. TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell. vol 82. issue 5. 1995-10-13. PMID:7545545. |
patients with the genetic disorder ataxia telangiectasia (at) have mutations in the at mutated (atm) gene, which is homologous to tel1 and the checkpoint gene mec1. |
1995-10-13 |
2023-08-12 |
human |
K Savitsky, A Bar-Shira, S Gilad, G Rotman, Y Ziv, L Vanagaite, D A Tagle, S Smith, T Uziel, S Sfez, M Ashkenazi, I Pecker, M Frydman, R Harnik, S R Patanjali, A Simmons, G A Clines, A Sartiel, R A Gatti, L Chessa, O Sanal, M F Lavin, N G Jaspers, A M Taylor, C F Arlett, T Miki, S M Weissman, M Lovett, F S Collins, Y Shilo. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science (New York, N.Y.). vol 268. issue 5218. 1995-07-27. PMID:7792600. |
a gene, atm, that is mutated in the autosomal recessive disorder ataxia telangiectasia (at) was identified by positional cloning on chromosome 11q22-23. |
1995-07-27 |
2023-08-12 |
Not clear |