| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P J Byrd, P R Cooper, T Stankovic, H S Kullar, G D Watts, P J Robinson, M R Taylo. A gene transcribed from the bidirectional ATM promoter coding for a serine rich protein: amino acid sequence, structure and expression studies. Human molecular genetics. vol 5. issue 11. 1997-03-11. PMID:8923007. |
in an earlier report we showed that the 5' end of the gene for ataxia telangiectasia atm is within 700 bp of the 5' end of a novel gene e14, and suggested that the cpg island that separates these genes functions as a bidirectional promoter. |
1997-03-11 |
2023-08-12 |
mouse |
| F Kerangueven, F Eisinger, T Noguchi, F Allione, V Wargniez, C Eng, G Padberg, C Theillet, J Jacquemier, M Longy, H Sobol, D Birnbau. Loss of heterozygosity in human breast carcinomas in the ataxia telangiectasia, Cowden disease and BRCA1 gene regions. Oncogene. vol 14. issue 3. 1997-02-27. PMID:9018120. |
one of them may be the ataxia telangiectasia (atm) gene which is located in one of the affected regions. |
1997-02-27 |
2023-08-12 |
human |
| N D Lakin, P Weber, T Stankovic, S T Rottinghaus, A M Taylor, S P Jackso. Analysis of the ATM protein in wild-type and ataxia telangiectasia cells. Oncogene. vol 13. issue 12. 1997-02-11. PMID:9000145. |
analysis of the atm protein in wild-type and ataxia telangiectasia cells. |
1997-02-11 |
2023-08-12 |
human |
| G Chen, Lee EYH. The product of the ATM gene is a 370-kDa nuclear phosphoprotein. The Journal of biological chemistry. vol 271. issue 52. 1997-01-28. PMID:8969240. |
neuronal degeneration, gonadal abnormalities, and immune deficiency are some of the major manifestations of the hereditary disease ataxia telangiectasia, which is caused by mutations in a single gene, designated atm. |
1997-01-28 |
2023-08-12 |
mouse |
| M Jung, A Kondratyev, S A Lee, A Dimtchev, A Dritschil. ATM gene product phosphorylates I kappa B-alpha. Cancer research. vol 57. issue 1. 1997-01-28. PMID:8988033. |
the recently cloned atm gene is mutated in patients with ataxia telangiectasia, but its biological functions remain to be experimentally determined. |
1997-01-28 |
2023-08-12 |
rabbit |
| W K Rathmell, W K Kaufmann, J C Hurt, L L Byrd, G Ch. DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage. Cancer research. vol 57. issue 1. 1997-01-28. PMID:8988043. |
dna-pk has several characteristics that support this hypothesis: ku binds to dna damaged by nicks or double-strand breaks, dna-pkcs is activated when ku binds to dna, dna-pk will phosphorylate p53 and other cell cycle regulatory proteins in vitro, and dna-pkcs shares homology with atm, which is mutated in ataxia telangiectasia and involved in signaling the p53 response to ionizing radiation. |
1997-01-28 |
2023-08-12 |
mouse |
| N J Bentley, D A Holtzman, G Flaggs, K S Keegan, A DeMaggio, J C Ford, M Hoekstra, A M Car. The Schizosaccharomyces pombe rad3 checkpoint gene. The EMBO journal. vol 15. issue 23. 1997-01-27. PMID:8978690. |
rad3 is an inessential member of the 'lipid kinase' subclass of kinases which includes the atm protein defective in ataxia telangiectasia patients. |
1997-01-27 |
2023-08-12 |
human |
| M Liyanage, A Coleman, S du Manoir, T Veldman, S McCormack, R B Dickson, C Barlow, A Wynshaw-Boris, S Janz, J Wienberg, M A Ferguson-Smith, E Schröck, T Rie. Multicolour spectral karyotyping of mouse chromosomes. Nature genetics. vol 14. issue 3. 1996-12-16. PMID:8896561. |
we have applied spectral karyotyping (sky) to chemically induced plasmocytomas, mammary gland tumours from transgenic mice overexpressing the c-myc oncogene and thymomas from mice deficient for the ataxia telangiectasia (atm) gene. |
1996-12-16 |
2023-08-12 |
mouse |
| S Stilgenbauer, P Liebisch, M R James, M Schröder, B Schlegelberger, K Fischer, M Bentz, P Lichter, H Döhne. Molecular cytogenetic delineation of a novel critical genomic region in chromosome bands 11q22.3-923.1 in lymphoproliferative disorders. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 21. 1996-12-04. PMID:8876224. |
in the 41 tumors exhibiting deletions, we identified a commonly deleted segment in band 11q22.3-923.1; this region is approximately 2-3 mb in size and contains the genes coding for atm (ataxia telangiectasia mutated), rdx (radixin), and fdx1 (ferredoxin 1). |
1996-12-04 |
2023-08-12 |
Not clear |
| W Siede, J B Allen, S J Elledge, E C Friedber. The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment. Journal of bacteriology. vol 178. issue 19. 1996-11-26. PMID:8824640. |
the saccharomyces cerevisiae gene mec1 represents a structural homolog of the human gene atm mutated in ataxia telangiectasia patients. |
1996-11-26 |
2023-08-12 |
human |
| W Jongmans, M Artuso, M Vuillaume, H Brésil, S P Jackson, J Hal. The role of Ataxia telangiectasia and the DNA-dependent protein kinase in the p53-mediated cellular response to ionising radiation. Oncogene. vol 13. issue 6. 1996-11-08. PMID:8808686. |
the dna-dependent protein kinase (dna-pk), whose catalytic subunit shows structural similarities to the ataxia telangiectasia (at) gene product (atm), has also been implicated in the p53-mediated signal transduction pathway that activates the cellular response to dna damage produced by ionizing radiation. |
1996-11-08 |
2023-08-12 |
Not clear |
| M Rybczyńska, A L Pawlak, E Sikorska, R Ignatowic. Ataxia telangiectasia heterozygotes and patients display increased fluidity and decrease in contents of sulfhydryl groups in red blood cell membranes. Biochimica et biophysica acta. vol 1302. issue 3. 1996-09-19. PMID:8765144. |
in red blood cell membranes of ataxia telangiectasia mutated (atm) homozygotes and heterozygotes, decreased values of the corrected fluorescence anisotropy and the anisotropy parameter were found, indicating increased fluidity and decreased microviscosity, respectively. |
1996-09-19 |
2023-08-12 |
Not clear |
| A Baumer, U Bernthaler, W Wolz, H Hoehn, D Schindle. New mutations in the ataxia telangiectasia gene. Human genetics. vol 98. issue 2. 1996-09-05. PMID:8698354. |
we report the detection of four new mutations in the ataxia telangiectasia gene (atm). |
1996-09-05 |
2023-08-12 |
Not clear |
| C Barlow, S Hirotsune, R Paylor, M Liyanage, M Eckhaus, F Collins, Y Shiloh, J N Crawley, T Ried, D Tagle, A Wynshaw-Bori. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell. vol 86. issue 1. 1996-08-26. PMID:8689683. |
a murine model of ataxia telangiectasia was created by disrupting the atm locus via gene targeting. |
1996-08-26 |
2023-08-12 |
mouse |
| M P Wymann, G Bulgarelli-Leva, M J Zvelebil, L Pirola, B Vanhaesebroeck, M D Waterfield, G Panayoto. Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. Molecular and cellular biology. vol 16. issue 4. 1996-07-29. PMID:8657148. |
at higher concentrations, wortmannin inhibits the ataxia telangiectasia gene (atm)-related dna-dependent protein kinase (dna-pkcs). |
1996-07-29 |
2023-08-12 |
Not clear |
| Y Miki, T Katagiri, F Kasumi, T Yoshimoto, Y Nakamur. Mutation analysis in the BRCA2 gene in primary breast cancers. Nature genetics. vol 13. issue 2. 1996-07-16. PMID:8640237. |
3) or ataxia telangiectasia (atm) genes, each of which is considered to be a tumour suppressor. |
1996-07-16 |
2023-08-12 |
Not clear |
| K A Cimprich, T B Shin, C T Keith, S L Schreibe. cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 7. 1996-05-24. PMID:8610130. |
one of the members of this family, human atm, is defective in the cells of patients with ataxia telangiectasia and is involved in detection and response of cells to damaged dna. |
1996-05-24 |
2023-08-12 |
human |
| N C Walworth, R Bernard. rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint. Science (New York, N.Y.). vol 271. issue 5247. 1996-02-21. PMID:8553071. |
thus, p56chk1 appears to function downstream of several of the known schizosaccharomyces pombe checkpoint gene products, including that encoded by rad3+, a gene with sequence similarity to the atm gene mutated in patients with ataxia telangiectasia. |
1996-02-21 |
2023-08-12 |
Not clear |
| Y Sanchez, B A Desany, W J Jones, Q Liu, B Wang, S J Elledg. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science (New York, N.Y.). vol 271. issue 5247. 1996-02-21. PMID:8553072. |
mutants of the saccharomyces cerevisiae ataxia telangiectasia mutated (atm) homolog mec1/sad3/esr1 were identified that could live only if the rad53/sad1 checkpoint kinase was overproduced. |
1996-02-21 |
2023-08-12 |
human |
| N Mukaid. [Primary immunodeficiency diseases]. Nihon rinsho. Japanese journal of clinical medicine. vol 53. issue 11. 1996-02-06. PMID:8538051. |
the cloning of the atm gene demonstrated that the mutations in this gene were observed in the members of all the families affected with ataxia telangiectasia (at), indicating the crucial role of this gene in the pathogenesis of at. |
1996-02-06 |
2023-08-12 |
Not clear |