| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yongle Cai, Jingliu Liu, Bin Wang, Miao Sun, Hao Yan. Microglia in the Neuroinflammatory Pathogenesis of Alzheimer's Disease and Related Therapeutic Targets. Frontiers in immunology. vol 13. 2022-05-13. PMID:35558075. |
alzheimer's disease (ad) is the most prevalent neurodegenerative disease worldwide, characterized by progressive neuron degeneration or loss due to excessive accumulation of β-amyloid (aβ) peptides, formation of neurofibrillary tangles (nfts), and hyperphosphorylated tau. |
2022-05-13 |
2023-08-13 |
Not clear |
| Mauro Montalbano, Elizabeth Jaworski, Stephanie Garcia, Anna Ellsworth, Salome McAllen, Andrew Routh, Rakez Kaye. Tau modulates mRNA transcription, alternative polyadenylation (APA) profiles of hnRNPs, chromatin remodeling and spliceosome complexes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560478. |
tau protein is a known contributor in several neurodegenerative diseases, including alzheimer 's disease (ad) and frontotemporal dementia (ftd). |
2022-05-13 |
2023-08-13 |
human |
| Airi Tarutani, Tadashi Adachi, Hiroyasu Akatsu, Yoshio Hashizume, Kazuko Hasegawa, Yuko Saito, Andrew C Robinson, David M A Mann, Mari Yoshida, Shigeo Murayama, Masato Hasegaw. Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43. Acta neuropathologica. 2022-05-05. PMID:35513543. |
in this review, we summarize the ultrastructural and biochemical features of pathogenic proteins extracted from the brains of patients with neurodegenerative diseases that accumulate abnormal forms of tau, α-synuclein, and tdp-43, and we discuss how these disease-specific properties are maintained in the brain, based on recent experimental insights. |
2022-05-05 |
2023-08-13 |
Not clear |
| Benjamin J Tuck, Lauren V C Miller, Taxiarchis Katsinelos, Annabel E Smith, Emma L Wilson, Sophie Keeling, Shi Cheng, Marina J Vaysburd, Claire Knox, Lucy Tredgett, Emmanouil Metzakopian, Leo C James, William A McEwa. Cholesterol determines the cytosolic entry and seeded aggregation of tau. Cell reports. vol 39. issue 5. 2022-05-04. PMID:35508140. |
our findings establish entry as a rate-limiting step to seeded aggregation and demonstrate that dysregulated cholesterol, a feature of several neurodegenerative diseases, potentiates tau aggregation by promoting entry of tau assemblies into the cell interior. |
2022-05-04 |
2023-08-13 |
Not clear |
| Harish Kumar, Jayant B Udgaonka. Elongation of Fibrils Formed by a Tau Fragment is Inhibited by a Transient Dimeric Intermediate. The journal of physical chemistry. B. 2022-05-03. PMID:35503811. |
the formation and propagation of aggregates of the tau protein in the brain are associated with the tauopathy group of neurodegenerative diseases. |
2022-05-03 |
2023-08-13 |
Not clear |
| Luka Culig, Xixia Chu, Vilhelm A Boh. Neurogenesis in Aging and Age-related Neurodegenerative Diseases. Ageing research reviews. 2022-05-01. PMID:35490966. |
in this review, we describe the involvement of adult neurogenesis in neurodegenerative diseases and address the molecular mechanistic aspects of neurogenesis that involve some of the key aggregation-prone proteins in the brain (i.e., tau, aβ, α-synuclein, …). |
2022-05-01 |
2023-08-13 |
human |
| Eric Shao, Che-Wei Chang, Zhiyong Li, Xinxing Yu, Kaitlyn Ho, Michelle Zhang, Xin Wang, Jeffrey Simms, Iris Lo, Jessica Speckart, Julia Holtzman, Gui-Qiu Yu, Erik D Roberson, Lennart Muck. TAU ablation in excitatory neurons and postnatal TAU knockdown reduce epilepsy, SUDEP, and autism behaviors in a Dravet syndrome model. Science translational medicine. vol 14. issue 642. 2022-04-27. PMID:35476595. |
intracellular accumulation of tau aggregates is a hallmark of several neurodegenerative diseases. |
2022-04-27 |
2023-08-13 |
mouse |
| Eleonora Virgilio, Fabiola De Marchi, Elena Contaldi, Umberto Dianzani, Roberto Cantello, Letizia Mazzini, Cristoforo Com. The Role of Tau beyond Alzheimer's Disease: A Narrative Review. Biomedicines. vol 10. issue 4. 2022-04-23. PMID:35453510. |
this narrative review summarizes current knowledge regarding non-ad neurodegenerative diseases and the tau protein. |
2022-04-23 |
2023-08-13 |
Not clear |
| Taha F S Ali, Halil I Ciftci, Mohamed O Radwan, Eslam Roshdy, Ahmed M Shawky, Mohammed A S Abourehab, Hiroshi Tateishi, Masami Otsuka, Mikako Fujit. Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity. Pharmaceuticals (Basel, Switzerland). vol 15. issue 4. 2022-04-23. PMID:35455423. |
similarly, abnormal tau aggregate accumulation in neurons is a hallmark of various neurodegenerative diseases. |
2022-04-23 |
2023-08-13 |
Not clear |
| Zhuang Zhuang Han, Sang-Gyun Kang, Luis Arce, David Westawa. Prion-like strain effects in tauopathies. Cell and tissue research. 2022-04-23. PMID:35460367. |
in the realm of dementia, tau protein misfolding is associated with a wide spectrum of clinicopathologically diverse neurodegenerative diseases, collectively known as tauopathies. |
2022-04-23 |
2023-08-13 |
Not clear |
| Urmi Sengupta, Rakez Kaye. Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases. Progress in neurobiology. 2022-04-21. PMID:35447272. |
amyloid β, tau, and α-synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases. |
2022-04-21 |
2023-08-13 |
Not clear |
| Urmi Sengupta, Rakez Kaye. Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases. Progress in neurobiology. 2022-04-21. PMID:35447272. |
aggregation of specific proteins are histopathological hallmarks of several neurodegenerative diseases, such as, amyloid β (aβ) plaques and tau neurofibrillary tangles in alzheimer's disease (ad); morphologically different inclusions of ratiometric 3 repeat (3r) and 4 repeat (4r) tau isoforms in progressive supranuclear palsy (psp), corticobasal degeneration (cbd), and pick's disease (pid); α-synuclein (α-syn) containing lewy bodies (lbs) and dystrophic lewy neurites (lns) in parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2022-04-21 |
2023-08-13 |
Not clear |
| Urmi Sengupta, Rakez Kaye. Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases. Progress in neurobiology. 2022-04-21. PMID:35447272. |
interestingly, studies have also shown synergistic interplay among aβ, tau, and α-syn in several neurodegenerative diseases, suggesting a protein triumvirate. |
2022-04-21 |
2023-08-13 |
Not clear |
| Urmi Sengupta, Rakez Kaye. Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases. Progress in neurobiology. 2022-04-21. PMID:35447272. |
in this review, we summarize the emerging evidence of aβ, tau, and α-syn aggregation in pathophysiology, and their overlap in a spectrum of neurodegenerative diseases including ad, psp, pid, cbd, pd and dlb. |
2022-04-21 |
2023-08-13 |
Not clear |
| Maria João Botelho, Jelena Milinovic, Narcisa M Bandarra, Carlos Val. Alzheimer's Disease and Toxins Produced by Marine Dinoflagellates: An Issue to Explore. Marine drugs. vol 20. issue 4. 2022-04-21. PMID:35447926. |
this study focused on yessotoxins (ytxs), gymnodimine (gym), spirolides (spxs), and gambierol, all toxins that have been shown to reduce β-amyloid plaques and tau hyperphosphorylation, thus preventing the neuronal or synaptic dysfunction that ultimately causes the cell death associated with ad (or other neurodegenerative diseases). |
2022-04-21 |
2023-08-13 |
zebrafish |
| Keiji Wakamatsu, Yoichi Chiba, Ryuta Murakami, Yumi Miyai, Koichi Matsumoto, Masaki Kamada, Wakako Nonaka, Naoya Uemura, Ken Yanase, Masaki Uen. Metabolites and Biomarker Compounds of Neurodegenerative Diseases in Cerebrospinal Fluid. Metabolites. vol 12. issue 4. 2022-04-21. PMID:35448530. |
in this paper, we show the significance of glucose- and neurotransmitter-related csf metabolites, considering their transporters in the choroid plexus; summarize the reported candidates of csf biomarkers for neurodegenerative diseases, including amyloid-β, tau, α-synuclein, micrornas, and mitochondrial dna; and evaluate their potential as efficient diagnostic tools. |
2022-04-21 |
2023-08-13 |
Not clear |
| Romain La Rocca, Philipp O Tsvetkov, Andrey V Golovin, Diane Allegro, Pascale Barbier, Soazig Malesinski, Françoise Guerlesquin, François Devre. Identification of the three zinc-binding sites on tau protein. International journal of biological macromolecules. 2022-04-14. PMID:35421417. |
tau protein has been extensively studied due to its key roles in microtubular cytoskeleton regulation and in the formation of aggregates found in some neurodegenerative diseases. |
2022-04-14 |
2023-08-13 |
Not clear |
| Zahra Moeini, Zahra Seraj, Toktam Zohoorian Abootorabi, Mohammadreza Ashrafi-Kooshk, Gholamhossein Riazi, Ali Akbar Saboury, Arefeh Seyedarab. Unravelling the Novel Effects of Three Volatile Compounds in Preventing Fibril Formation of Disease Related Tau and α-Synuclein Proteins- Towards Identifying Candidate Aromatic Substances for Treating Neurodegenerative Diseases. Frontiers in pharmacology. vol 13. 2022-04-08. PMID:35392564. |
unravelling the novel effects of three volatile compounds in preventing fibril formation of disease related tau and α-synuclein proteins- towards identifying candidate aromatic substances for treating neurodegenerative diseases. |
2022-04-08 |
2023-08-13 |
Not clear |
| Nakul Ravi Raval, Arafat Nasser, Clara Aabye Madsen, Natalie Beschorner, Emily Eufaula Beaman, Morten Juhl, Szabolcs Lehel, Mikael Palner, Claus Svarer, Pontus Plavén-Sigray, Louise Møller Jørgensen, Gitte Moos Knudse. An Frontiers in neuroscience. vol 16. 2022-04-04. PMID:35368260. |
an positron emission tomography (pet) has become an essential clinical tool for diagnosing neurodegenerative diseases with abnormal accumulation of proteins like amyloid-β or tau. |
2022-04-04 |
2023-08-13 |
human |
| Lukas S Stelzl, Lisa M Pietrek, Andrea Holla, Javier Oroz, Mateusz Sikora, Jürgen Köfinger, Benjamin Schuler, Markus Zweckstetter, Gerhard Humme. Global Structure of the Intrinsically Disordered Protein Tau Emerges from Its Local Structure. JACS Au. vol 2. issue 3. 2022-04-04. PMID:35373198. |
the paradigmatic disordered protein tau plays an important role in neuronal function and neurodegenerative diseases. |
2022-04-04 |
2023-08-13 |
Not clear |