| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dina Medina-Vera, Juan Antonio Navarro, Patricia Rivera, Cristina Rosell-Valle, Alfonso Gutiérrez-Adán, Carlos Sanjuan, Antonio Jesús López-Gambero, Rubén Tovar, Juan Suárez, Francisco Javier Pavón, Elena Baixeras, Juan Decara, Fernando Rodríguez de Fonsec. D-Pinitol promotes Tau dephosphorylation through a Cyclin-dependent kinase 5 regulation mechanism: a new potential approach for Tauopathies? British journal of pharmacology. 2022-06-27. PMID:35760415. |
recent evidence links brain insulin resistance with neurodegenerative diseases where hyperphosphorylated tau protein contributes to neuronal cell death. |
2022-06-27 |
2023-08-14 |
Not clear |
| Antonia Moll, Lisa Marie Ramirez, Momchil Ninov, Juliane Schwarz, Henning Urlaub, Markus Zweckstette. Hsp multichaperone complex buffers pathologically modified Tau. Nature communications. vol 13. issue 1. 2022-06-27. PMID:35760815. |
because phosphorylated tau binds the hsp70/hsp90 machinery but is not recognized by hsp90 alone, the data establish the hsp70/hsp90 multichaperone complex as a critical regulator of tau in neurodegenerative diseases. |
2022-06-27 |
2023-08-14 |
human |
| Cécilia Tremblay, Geidy E Serrano, Anthony J Intorcia, Monica R Mariner, Lucia I Sue, Richard A Arce, Alireza Atri, Charles H Adler, Christine M Belden, Holly A Shill, Erika Driver-Dunckley, Shyamal H Mehta, Thomas G Beac. Olfactory Bulb Amyloid-β Correlates With Brain Thal Amyloid Phase and Severity of Cognitive Impairment. Journal of neuropathology and experimental neurology. 2022-06-25. PMID:35751438. |
the alzheimer disease (ad) neuropathological hallmarks amyloid β (aβ) and tau neurofibrillary (nf) pathology have been reported in the olfactory bulb (ob) in aging and in different neurodegenerative diseases, which coincides with frequently reported olfactory dysfunction in these conditions. |
2022-06-25 |
2023-08-14 |
Not clear |
| Kristian F Odfalk, Kevin F Bieniek, Sarah C Hop. Microglia: Friend and Foe in Tauopathy. Progress in neurobiology. 2022-06-17. PMID:35714860. |
aggregation of misfolded microtubule associated protein tau into abnormal intracellular inclusions defines a class of neurodegenerative diseases known as tauopathies. |
2022-06-17 |
2023-08-14 |
Not clear |
| Julie A Schneide. Neuropathology of Dementia Disorders. Continuum (Minneapolis, Minn.). vol 28. issue 3. 2022-06-09. PMID:35678405. |
this article also discusses the underlying proteinopathies of neurodegenerative diseases (eg, amyloid-β, paired helical filament tau, α-synuclein, and tdp-43 pathology) and vascular pathologies, including tissue injury (eg, infarcts, hemorrhages) with or without vessel disease. |
2022-06-09 |
2023-08-14 |
Not clear |
| Fuyuki Kametani, Masato Hasegaw. Structures of tau and α-synuclein filaments from brains of patients with neurodegenerative diseases. Neurochemistry international. 2022-06-06. PMID:35659527. |
structures of tau and α-synuclein filaments from brains of patients with neurodegenerative diseases. |
2022-06-06 |
2023-08-14 |
Not clear |
| Wade Self, Khader Awwad, John Paul Savaryn, Michael Schul. An immuno-enrichment free, validated quantification of tau protein in human CSF by LC-MS/MS. PloS one. vol 17. issue 6. 2022-06-02. PMID:35653415. |
tau protein is a key target of interest in developing therapeutics for neurodegenerative diseases. |
2022-06-02 |
2023-08-14 |
human |
| Lara Blömeke, Marlene Pils, Victoria Kraemer-Schulien, Alexandra Dybala, Anja Schaffrath, Andreas Kulawik, Fabian Rehn, Anneliese Cousin, Volker Nischwitz, Johannes Willbold, Rebecca Zack, Thomas F Tropea, Tuyen Bujnicki, Gültekin Tamgüney, Daniel Weintraub, David Irwin, Murray Grossman, David A Wolk, John Q Trojanowski, Oliver Bannach, Alice Chen-Plotkin, Dieter Willbol. Quantitative detection of α-Synuclein and Tau oligomers and other aggregates by digital single particle counting. NPJ Parkinson's disease. vol 8. issue 1. 2022-06-02. PMID:35655068. |
the pathological hallmark of neurodegenerative diseases is the formation of toxic oligomers by proteins such as alpha-synuclein (asyn) or microtubule-associated protein tau (tau). |
2022-06-02 |
2023-08-14 |
human |
| Lara Blömeke, Marlene Pils, Victoria Kraemer-Schulien, Alexandra Dybala, Anja Schaffrath, Andreas Kulawik, Fabian Rehn, Anneliese Cousin, Volker Nischwitz, Johannes Willbold, Rebecca Zack, Thomas F Tropea, Tuyen Bujnicki, Gültekin Tamgüney, Daniel Weintraub, David Irwin, Murray Grossman, David A Wolk, John Q Trojanowski, Oliver Bannach, Alice Chen-Plotkin, Dieter Willbol. Quantitative detection of α-Synuclein and Tau oligomers and other aggregates by digital single particle counting. NPJ Parkinson's disease. vol 8. issue 1. 2022-06-02. PMID:35655068. |
our results demonstrate that asyn and tau aggregate concentrations measured by sfida differentiate neurodegenerative disease diagnostic groups. |
2022-06-02 |
2023-08-14 |
human |
| Md Ataur Rahman, M D Hasanur Rahman, A N M Mamun-Or-Rashid, Hongik Hwang, Sooyoung Chung, Bonglee Kim, Hyewhon Rhi. Autophagy Modulation in Aggresome Formation: Emerging Implications and Treatments of Alzheimer's Disease. Biomedicines. vol 10. issue 5. 2022-05-28. PMID:35625764. |
alzheimer's disease (ad) is one of the most prevailing neurodegenerative diseases in the world, which is characterized by memory dysfunction and the formation of tau and amyloid β (aβ) aggregates in multiple brain regions, including the hippocampus and cortex. |
2022-05-28 |
2023-08-13 |
Not clear |
| Juan S Jiméne. Macromolecular structures and proteins interacting with the microtubule associated tau protein. Neuroscience. 2022-05-24. PMID:35609757. |
it is well established that neurodegenerative diseases known as tauopathies are characterized by the presence of filamentous forms of phosphorylated tau protein inside neurons. |
2022-05-24 |
2023-08-13 |
Not clear |
| Alexander D Law, Marlène Cassar, Dani M Long, Eileen S Chow, Jadwiga M Giebultowicz, Anjana Venkataramanan, Roland Strauss, Doris Kretzschma. FTD-associated mutations in Tau result in a combination of dominant and recessive phenotypes. Neurobiology of disease. 2022-05-19. PMID:35588988. |
although mutations in the microtubules-associated protein tau have long been connected with several neurodegenerative diseases, the underlying molecular mechanisms causing these tauopathies are still not fully understood. |
2022-05-19 |
2023-08-13 |
human |
| Vera I Wiersma, Ruben Rigort, Magdalini Polymenido. Tau: a phase in the crowd. The EMBO journal. 2022-05-17. PMID:35578810. |
from the management of microtubules to the production of pathological species: liquid-liquid phase separation may tune the behavior of the protein tau in health and neurodegenerative disease. |
2022-05-17 |
2023-08-13 |
Not clear |
| Isidro Ferrer, Pol Andrés-Benito, Paula Garcia-Esparcia, Irene López-Gonzalez, Diego Valiente, Mónica Jordán-Pirla, Margarita Carmona, Julia Sala-Jarque, Vanessa Gil, José Antonio Del Ri. Differences in Tau Seeding in Newborn and Adult Wild-Type Mice. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563179. |
alzheimer's disease (ad) and other tauopathies are common neurodegenerative diseases in older adults; in contrast, abnormal tau deposition in neurons and glial cells occurs only exceptionally in children. |
2022-05-14 |
2023-08-13 |
mouse |
| S Tok, H Maurin, C Delay, D Crauwels, N V Manyakov, W Van Der Elst, D Moechars, W H I M Drinkenbur. Neurophysiological effects of human-derived pathological tau conformers in the APPKM670/671NL.PS1/L166P amyloid mouse model of Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-05-13. PMID:35546164. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by two main pathological hallmarks: amyloid plaques and intracellular tau neurofibrillary tangles. |
2022-05-13 |
2023-08-13 |
mouse |
| Heng Lin, Carol A Deaton, Gail V W Johnso. Commentary: BAG3 as a mediator of endosome function and tau clearance. Neuroscience. 2022-05-13. PMID:35550160. |
the underlying mechanisms that contribute to the accumulation of tau in these neurodegenerative diseases are multifactorial; nonetheless, there is a growing awareness that dysfunction of endosome-lysosome pathways is a pivotal factor. |
2022-05-13 |
2023-08-13 |
mouse |
| Yuxing Xia, Stefan Prokop, Brach M Bell, Kimberly-Marie M Gorion, Cara L Croft, Lith Nasif, Guilian Xu, Cara J Riffe, Alyssa N Manaois, Kevin H Strang, Stephan S Quintin, Giavanna Paterno, Malú Gámez Tansey, David R Borchelt, Todd E Golde, Benoit I Giasso. Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice. Communications biology. vol 5. issue 1. 2022-05-13. PMID:35550593. |
pathological tau inclusions are neuropathologic hallmarks of many neurodegenerative diseases. |
2022-05-13 |
2023-08-13 |
mouse |
| Ishani Pidara, Koyuki Yamad. The Structure of Tau Proteins and Its Role in Neurodegenerative Disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553522. |
the structure of tau proteins and its role in neurodegenerative disease. |
2022-05-13 |
2023-08-13 |
Not clear |
| Ishani Pidara, Koyuki Yamad. The Structure of Tau Proteins and Its Role in Neurodegenerative Disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553522. |
irregular interaction between tau proteins and microtubules can lead to associated neurodegenerative diseases called tauopathies. |
2022-05-13 |
2023-08-13 |
Not clear |
| Yongle Cai, Jingliu Liu, Bin Wang, Miao Sun, Hao Yan. Microglia in the Neuroinflammatory Pathogenesis of Alzheimer's Disease and Related Therapeutic Targets. Frontiers in immunology. vol 13. 2022-05-13. PMID:35558075. |
alzheimer's disease (ad) is the most prevalent neurodegenerative disease worldwide, characterized by progressive neuron degeneration or loss due to excessive accumulation of β-amyloid (aβ) peptides, formation of neurofibrillary tangles (nfts), and hyperphosphorylated tau. |
2022-05-13 |
2023-08-13 |
Not clear |