| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ilona Hübner, Jacek Hübner, Sławomir Kroczk. Comparative assessment of limb function and conduction parameters in peripheral nerves in the course of two forms of amyotrophic lateral sclerosis. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 45. issue 266. 2018-11-20. PMID:30240369. |
amyotrophic lateral sclerosis (als) is a progressive, incurable, neurodegenerative disease affecting the upper and lower motor neuron, which inevitably leads to the impaired fitness of patients and therefore deterioration of their quality of life. |
2018-11-20 |
2023-08-13 |
Not clear |
| Rosa Campopiano, Larisa Ryskalin, Emiliano Giardina, Stefania Zampatti, Carla L Busceti, Francesca Biagioni, Rosangela Ferese, Marianna Storto, Stefano Gambardella, Francesco Forna. Next Generation Sequencing and ALS: known genes, different phenotyphes. Archives italiennes de biologie. vol 155. issue 4. 2018-08-28. PMID:29405028. |
amyotrophic lateral sclerosis (als) is fatal neurodegenerative disease clinically characterized by upper and lower motor neuron dysfunction resulting in rapidly progressive paralysis and death from respiratory failure. |
2018-08-28 |
2023-08-13 |
Not clear |
| Fulvio Zaccagna, Giulia Lucignani, Eytan Raz, Claudio Colonnes. Imaging techniques in ALS. Archives italiennes de biologie. vol 155. issue 4. 2018-08-28. PMID:29405031. |
amyotrophic lateral sclerosis (als) is a progressive neurodegenerative disease characterized by degeneration of both upper and lower motor neuron located in the spinal cord and brainstem. |
2018-08-28 |
2023-08-13 |
Not clear |
| E Broussalis, S Grinzinger, A B Kunz, M Killer-Oberpfalzer, E Haschke-Becher, H-P Hartung, J Krau. Late age onset of amyotrophic lateral sclerosis is often not considered in elderly people. Acta neurologica Scandinavica. vol 137. issue 3. 2018-06-28. PMID:29148035. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease causing an upper and lower motor neuron loss. |
2018-06-28 |
2023-08-13 |
Not clear |
| Ken Ikeda, Yasuo Iwasak. Edaravone, a Free Radical Scavenger, Delayed Symptomatic and Pathological Progression of Motor Neuron Disease in the Wobbler Mouse. PloS one. vol 10. issue 10. 2016-06-08. PMID:26469273. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease that affects the upper and the lower motor neuron, leading to death within 3-5 years after onset. |
2016-06-08 |
2023-08-13 |
mouse |
| Paulo Victor Sgobbi de Souza, Wladimir Bocca Vieira de Rezende Pinto, Marco Antônio Troccoli Chieia, Acary Souza Bulle Oliveir. Clinical and genetic basis of familial amyotrophic lateral sclerosis. Arquivos de neuro-psiquiatria. vol 73. issue 12. 2016-06-02. PMID:26465287. |
amyotrophic lateral sclerosis represents the most common neurodegenerative disease leading to upper and lower motor neuron compromise. |
2016-06-02 |
2023-08-13 |
Not clear |
| Catherine A Blizzard, K M Lee, Tracey C Dickso. Inducing Chronic Excitotoxicity in the Mouse Spinal Cord to Investigate Lower Motor Neuron Degeneration. Frontiers in neuroscience. vol 10. 2016-03-14. PMID:26973454. |
lower motor neuron, and distal neuromuscular junction, degeneration are pathological hallmarks of the devastating neurodegenerative disease amyotrophic lateral sclerosis (als). |
2016-03-14 |
2023-08-13 |
mouse |
| Hong-Fu Li, Zhi-Ying W. Genotype-phenotype correlations of amyotrophic lateral sclerosis. Translational neurodegeneration. vol 5. 2016-02-04. PMID:26843957. |
amyotrophic lateral sclerosis (als) is a devastating neurodegenerative disease characterized by progressive neuronal loss and degeneration of upper motor neuron (umn) and lower motor neuron (lmn). |
2016-02-04 |
2023-08-13 |
Not clear |
| Diogo Fernandes dos Santos, José Luiz Pedroso, Pedro Braga-Neto, Giselle Melo Fontes Silva, Luciane Bizari Coin de Carvalho, Lucila B F Prado, Orlando Graziani P Barsottini, Gilmar Fernandes do Prad. Excessive fragmentary myoclonus in Machado-Joseph disease. Sleep medicine. vol 15. issue 3. 2014-11-24. PMID:24518960. |
machado-joseph disease (mjd) is a neurodegenerative disease which usually presents several clinical findings including cerebellar ataxia and other extracerebellar features, such as parkinsonism, dystonia, peripheral neuropathy, and lower motor neuron disease. |
2014-11-24 |
2023-08-12 |
Not clear |
| Fei Song, Pohung Chiang, John Ravits, Jeffrey A Loe. Activation of microglial neuregulin1 signaling in the corticospinal tracts of ALS patients with upper motor neuron signs. Amyotrophic lateral sclerosis & frontotemporal degeneration. vol 15. issue 1-2. 2014-10-22. PMID:24229388. |
since the connection between upper and lower motor neuron (lmn) systems in als patients is not readily seen in the sod1 mouse, we examined the lateral and ventral csts for nrg1 receptor activation and nrg1 expression in als patients with umn symptoms compared to control patients with no evidence of neurodegenerative disease. |
2014-10-22 |
2023-08-12 |
mouse |
| Stephen Rose, Kerstin Pannek, Christopher Bell, Fusun Baumann, Nicole Hutchinson, Alan Coulthard, Pamela McCombe, Robert Henderso. Direct evidence of intra- and interhemispheric corticomotor network degeneration in amyotrophic lateral sclerosis: an automated MRI structural connectivity study. NeuroImage. vol 59. issue 3. 2012-05-17. PMID:21893207. |
our novel findings, many of which are consistent with known pathology, show extensive involvement and degeneration of multiple corticomotor pathways in patients with upper and lower motor neuron signs and provide support for the use of automated structural connectivity techniques for studying neurodegenerative disease processes. |
2012-05-17 |
2023-08-12 |
human |
| T Siddique, S Ajroud-Dris. Familial amyotrophic lateral sclerosis, a historical perspective. Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology. vol 30. issue 2. 2012-01-10. PMID:22106714. |
amyotrophic lateral sclerosis is a fatal neurodegenerative disease of the upper and lower motor neuron of unknown etiology. |
2012-01-10 |
2023-08-12 |
Not clear |
| Albert C Ludolph, Sarah Jess. Evidence-based drug treatment in amyotrophic lateral sclerosis and upcoming clinical trials. Therapeutic advances in neurological disorders. vol 2. issue 5. 2011-07-14. PMID:21180622. |
amyotrophic lateral sclerosis/motor neuron disease is a severe neurodegenerative disease characterized by upper and lower motor neuron degeneration for which there is no truly effective treatment. |
2011-07-14 |
2023-08-12 |
human |
| Zhiye Chen, Lin M. Grey matter volume changes over the whole brain in amyotrophic lateral sclerosis: A voxel-wise meta-analysis of voxel based morphometry studies. Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases. vol 11. issue 6. 2011-02-28. PMID:20929296. |
amyotrophic lateral sclerosis (als) is a progressive neurodegenerative disease with selected both upper and lower motor neuron involvement. |
2011-02-28 |
2023-08-12 |
Not clear |
| Tomoyuki Awano, Gary S Johnson, Claire M Wade, Martin L Katz, Gayle C Johnson, Jeremy F Taylor, Michele Perloski, Tara Biagi, Izabella Baranowska, Sam Long, Philip A March, Natasha J Olby, G Diane Shelton, Shahnawaz Khan, Dennis P O'Brien, Kerstin Lindblad-Toh, Joan R Coate. Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 8. 2009-04-06. PMID:19188595. |
sod1 was considered a regional candidate gene because mutations in human sod1 can cause amyotrophic lateral sclerosis (als), an adult-onset fatal paralytic neurodegenerative disease with both upper and lower motor neuron involvement. |
2009-04-06 |
2023-08-12 |
human |
| Gerardo Morfini, Gustavo Pigino, Györgyi Szebenyi, Yimei You, Sarah Pollema, Scott T Brad. JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport. Nature neuroscience. vol 9. issue 7. 2006-09-05. PMID:16751763. |
expansion of the polyglutamine (polyq) stretch in the androgen receptor (ar) protein leads to spinal and bulbar muscular atrophy (sbma), a neurodegenerative disease characterized by lower motor neuron degeneration. |
2006-09-05 |
2023-08-12 |
human |
| Thais Federici, Nicholas M Bouli. Gene-based treatment of motor neuron diseases. Muscle & nerve. vol 33. issue 3. 2006-04-12. PMID:16228969. |
motor neuron diseases (mnd), such as amyotrophic lateral sclerosis (als) and spinal muscular atrophy (sma), are progressive neurodegenerative diseases that share the common characteristic of upper and/or lower motor neuron degeneration. |
2006-04-12 |
2023-08-12 |
Not clear |
| S Hadano, Y Yanagisawa, J Skaug, K Fichter, J Nasir, D Martindale, B F Koop, S W Scherer, D W Nicholson, G A Rouleau, J Ikeda, M R Hayde. Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2. Genomics. vol 71. issue 2. 2001-07-05. PMID:11161814. |
amyotrophic lateral sclerosis is a progressive neurodegenerative disease that manifests as selective upper and lower motor neuron degeneration. |
2001-07-05 |
2023-08-12 |
human |
| M Keep, E Elmér, K S Fong, K Csisza. Intrathecal cyclosporin prolongs survival of late-stage ALS mice. Brain research. vol 894. issue 2. 2001-06-07. PMID:11251210. |
amyotrophic lateral sclerosis (als) is a neurodegenerative disease characterized by upper and lower motor neuron death with ascending paralysis leading to death. |
2001-06-07 |
2023-08-12 |
mouse |
| C L Lin, L A Bristol, L Jin, M Dykes-Hoberg, T Crawford, L Clawson, J D Rothstei. Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis. Neuron. vol 20. issue 3. 1998-04-23. PMID:9539131. |
amyotrophic lateral sclerosis (als) is a neurodegenerative disease that is characterized by selective upper and lower motor neuron degeneration, the pathogenesis of which is unknown. |
1998-04-23 |
2023-08-12 |
Not clear |