| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sharon L Eastwoo. The synaptic pathology of schizophrenia: is aberrant neurodevelopment and plasticity to blame? International review of neurobiology. vol 59. 2004-05-10. PMID:15006484. |
the aim of this review is to explore whether aberrant development and synaptic plasticity may underlie the synaptic pathology of schizophrenia. |
2004-05-10 |
2023-08-12 |
Not clear |
| Sharon L Eastwoo. The synaptic pathology of schizophrenia: is aberrant neurodevelopment and plasticity to blame? International review of neurobiology. vol 59. 2004-05-10. PMID:15006484. |
first, studies in schizophrenia of the expression of two synaptic genes important in synaptic remodeling and plasticity are reviewed, changes in which may be indicative of aberrant synaptic plasticity in the disorder. |
2004-05-10 |
2023-08-12 |
Not clear |
| Thomas J Raedle. Muscarinic receptors in schizophrenia: is there a role for synaptic plasticity? International review of neurobiology. vol 59. 2004-05-10. PMID:15006486. |
muscarinic receptors in schizophrenia: is there a role for synaptic plasticity? |
2004-05-10 |
2023-08-12 |
Not clear |
| Dorit Ben-Shachar, Daphna Laifenfel. Mitochondria, synaptic plasticity, and schizophrenia. International review of neurobiology. vol 59. 2004-05-10. PMID:15006492. |
mitochondria, synaptic plasticity, and schizophrenia. |
2004-05-10 |
2023-08-12 |
Not clear |
| Dorit Ben-Shachar, Daphna Laifenfel. Mitochondria, synaptic plasticity, and schizophrenia. International review of neurobiology. vol 59. 2004-05-10. PMID:15006492. |
the conceptualization of schizophrenia as a disorder of connectivity, i.e., of neuronal?synaptic plasticity, suggests abnormal synaptic modeling and neuronal signaling, possibly as a consequence of flawed interactions with the environment, as at least a secondary mechanism underlying the pathophysiology of this disorder. |
2004-05-10 |
2023-08-12 |
Not clear |
| N D Halim, C S Weickert, B W McClintock, T M Hyde, D R Weinberger, J E Kleinman, B K Lipsk. Presynaptic proteins in the prefrontal cortex of patients with schizophrenia and rats with abnormal prefrontal development. Molecular psychiatry. vol 8. issue 9. 2004-05-06. PMID:12931207. |
dysfunction of the prefrontal cortex in schizophrenia may be associated with abnormalities in synaptic structure and/or function and reflected in altered concentrations of proteins in presynaptic terminals and involved in synaptic plasticity (synaptobrevin/ vesicle-associated membrane protein (vamp), synaptosomal-associated protein-25 (snap-25), syntaxin, synaptophysin and growth-associated protein-43 (gap-43)). |
2004-05-06 |
2023-08-12 |
rat |
| Christine Konradi, Stephan Hecker. Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment. Pharmacology & therapeutics. vol 97. issue 2. 2003-05-21. PMID:12559388. |
abnormal neuronal development, abnormal synaptic plasticity, and neurodegeneration have been proposed to be causal or contributing factors in schizophrenia. |
2003-05-21 |
2023-08-12 |
Not clear |
| T Shinkai, O Ohmori, H Hori, J Nakamur. Allelic association of the neuronal nitric oxide synthase (NOS1) gene with schizophrenia. Molecular psychiatry. vol 7. issue 6. 2003-02-11. PMID:12140778. |
nitric oxide (no) has been identified as a widespread and multifunctional biological messenger molecule in the central nervous system (cns), with possible roles in neurotransmission, neurosecretion, synaptic plasticity, and tissue injury in many neurological disorders, including schizophrenia. |
2003-02-11 |
2023-08-12 |
human |
| Paula C Ashe, Jennifer Chlan-Fourney, Augusto V Juorio, Xin-Min L. Brain-derived neurotrophic factor (BDNF) mRNA in rats with neonatal ibotenic acid lesions of the ventral hippocampus. Brain research. vol 956. issue 1. 2003-01-29. PMID:12426055. |
the role of brain-derived neurotrophic factor (bdnf) in neurodevelopment, cell viability and synaptic plasticity led to the investigation of bdnf as a potential candidate molecule in the pathophysiology of schizophrenia. |
2003-01-29 |
2023-08-12 |
rat |
| Kazuhiko Toyooka, Koue Asama, Yuichiro Watanabe, Tatsuyuki Muratake, Makoto Takahashi, Toshiyuki Someya, Hiroyuki Naw. Decreased levels of brain-derived neurotrophic factor in serum of chronic schizophrenic patients. Psychiatry research. vol 110. issue 3. 2002-10-08. PMID:12127475. |
neurotrophic factors regulate neuronal development as well as synaptic plasticity, and their impairment is often implicated as a cause of schizophrenia. |
2002-10-08 |
2023-08-12 |
human |
| R S Devon, S Anderson, P W Teague, W J Muir, V Murray, A J Pelosi, D H Blackwood, D J Porteou. The genomic organisation of the metabotropic glutamate receptor subtype 5 gene, and its association with schizophrenia. Molecular psychiatry. vol 6. issue 3. 2001-07-26. PMID:11326300. |
(1-3) electrophysiological studies in grm subtype 5 knockout mice reveal, in one study, a sensorimotor gating deficit characteristic of schizophrenia and in another, a key rôle for this gene in the modulation of hippocampal nmda-dependent synaptic plasticity. |
2001-07-26 |
2023-08-12 |
mouse |
| J R Peláe. Towards a neural network based therapy for hallucinatory disorders. Neural networks : the official journal of the International Neural Network Society. vol 13. issue 8-9. 2001-03-15. PMID:11156194. |
pattern completion in a neural network model of the thalamus and a biologically plausible model of synaptic plasticity are the key concepts used in this paper for analyzing some cognitive disorders that involve hallucinations of several kinds: visual hallucinations in the charles bonnet syndrome and psychedelic drugs consumption, somatic hallucination in phantom limbs, cognitive hallucinations in schizophrenia and even in multiple personality disorders. |
2001-03-15 |
2023-08-12 |
Not clear |
| M J Wayner, D L Armstrong, C F Pheli. Nicotine blocks angiotensin II inhibition of LTP in the dentate gyrus. Peptides. vol 17. issue 7. 1997-03-14. PMID:8959746. |
nicotinic blocking of the ang ii inhibition of a frequency dependent type of synaptic plasticity provides a function for central nicotinic receptors and a possible mechanism of action a) to explain the enhancement of learning and memory by nicotine, b) an explanation for tobacco smoking while drinking alcohol, and c) a possible basis for the excessive use of tobacco in depression and schizophrenia that supports a possible therapeutic use of nicotine in some mental disorders. |
1997-03-14 |
2023-08-12 |
Not clear |
| N A Uranov. [Brain synaptic plasticity in schizophrenia]. Vestnik Rossiiskoi akademii meditsinskikh nauk. issue 4. 1996-10-23. PMID:8754075. |
[brain synaptic plasticity in schizophrenia]. |
1996-10-23 |
2023-08-12 |
Not clear |
| P Etienne, M Baudr. Calcium dependent aspects of synaptic plasticity, excitatory amino acid neurotransmission, brain aging and schizophrenia: a unifying hypothesis. Neurobiology of aging. vol 8. issue 4. 1987-10-05. PMID:2888032. |
calcium dependent aspects of synaptic plasticity, excitatory amino acid neurotransmission, brain aging and schizophrenia: a unifying hypothesis. |
1987-10-05 |
2023-08-11 |
Not clear |