| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Donna M McDade, Ann-Marie Conway, Allan B James, Brian J Morri. Activity-dependent gene transcription as a long-term influence on receptor signalling. Biochemical Society transactions. vol 37. issue Pt 6. 2010-01-05. PMID:19909279. |
this indirect regulation of receptor turnover is likely to contribute to the delayed, but long-lasting, phases of synaptic plasticity and also to the synaptic dysfunction associated with diseases such as schizophrenia and alzheimer's disease, where zif268 expression is reduced. |
2010-01-05 |
2023-08-12 |
Not clear |
| Maaike Alaerts, Shana Ceulemans, Diego Forero, Lotte N Moens, Sonia De Zutter, Lien Heyrman, An-Sofie Lenaerts, Karl-Fredrik Norrback, Peter De Rijk, Lars-Göran Nilsson, Dirk Goossens, Rolf Adolfsson, Jurgen Del-Faver. Support for NRG1 as a susceptibility factor for schizophrenia in a northern Swedish isolated population. Archives of general psychiatry. vol 66. issue 8. 2009-08-11. PMID:19652122. |
neuregulin 1 (nrg1), a growth factor involved in neurodevelopment, myelination, neurotransmitter receptor expression, and synaptic plasticity, first joined the list of candidate genes for schizophrenia when a 7-marker haplotype at the 5' end of the gene (hap(ice)) was shown to be associated with the disorder in the icelandic population. |
2009-08-11 |
2023-08-12 |
Not clear |
| Klaas E Stephan, Karl J Friston, Chris D Frit. Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring. Schizophrenia bulletin. vol 35. issue 3. 2009-06-11. PMID:19155345. |
dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring. |
2009-06-11 |
2023-08-12 |
Not clear |
| Klaas E Stephan, Karl J Friston, Chris D Frit. Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring. Schizophrenia bulletin. vol 35. issue 3. 2009-06-11. PMID:19155345. |
this theory postulates that the core pathology in schizophrenia resides in aberrant n-methyl-d-aspartate receptor (nmdar)-mediated synaptic plasticity due to abnormal regulation of nmdars by neuromodulatory transmitters like dopamine, serotonin, or acetylcholine. |
2009-06-11 |
2023-08-12 |
Not clear |
| Clarissa Severino Gama, Ana Cristina Andreazza, Maurício Kunz, Michael Berk, Paulo Silva Belmonte-de-Abreu, Flavio Kapczinsk. Serum levels of brain-derived neurotrophic factor in patients with schizophrenia and bipolar disorder. Neuroscience letters. vol 420. issue 1. 2009-06-02. PMID:17442489. |
there is evidence that major psychiatric discords such as schizophrenia (sz) and bipolar disorder (bd) are associated with dysregulation of synaptic plasticity with downstream alterations of neurotrophins. |
2009-06-02 |
2023-08-12 |
rat |
| CongJian Zhao, Rene Anand, Karl-Heinz Braunewel. Nicotine-induced Ca2+-myristoyl switch of neuronal Ca2+ sensor VILIP-1 in hippocampal neurons: a possible crosstalk mechanism for nicotinic receptors. Cellular and molecular neurobiology. vol 29. issue 2. 2009-05-08. PMID:18925431. |
the nachrs are associated with processes of synaptic plasticity in hippocampal neurons and they have been implicated in the pathology of cns disorders, including alzheimer's disease and schizophrenia. |
2009-05-08 |
2023-08-12 |
Not clear |
| Schahram Akbarian, Hsien-Sung Huan. Epigenetic regulation in human brain-focus on histone lysine methylation. Biological psychiatry. vol 65. issue 3. 2009-04-10. PMID:18814864. |
in addition, the h3k4-specific methyltransferase, mll1, is essential for hippocampal synaptic plasticity and might be involved in cortical dysfunction of some cases of schizophrenia. |
2009-04-10 |
2023-08-12 |
human |
| Wei Tang, Ke Huang, Ruqi Tang, Guoquan Zhou, Chao Fang, Jing Zhang, Lingzhen Du, Guoying Feng, Lin He, Yongyong Sh. Evidence for association between the 5' flank of the NOS1 gene and schizophrenia in the Chinese population. The international journal of neuropsychopharmacology. vol 11. issue 8. 2009-01-26. PMID:18544180. |
nitric oxide (no) plays an important role in the dopaminergic and serotonergic system as the second messenger of the nmda receptor and has possible roles in neurotransmission, neurosecretion, synaptic plasticity, and tissue injury in many neurological disorders, including schizophrenia. |
2009-01-26 |
2023-08-12 |
human |
| Haroldo Evangelista Vargas, Clarissa Severino Gama, Ana Cristina Andreazza, Dalton Medeiros, Laura Stertz, Gabriel Fries, Joana Palha, Keila Maria Cereser, Michael Berk, Flavio Kapczinski, Paulo Silva Belmonte-de-Abre. Decreased serum neurotrophin 3 in chronically medicated schizophrenic males. Neuroscience letters. vol 440. issue 3. 2008-11-05. PMID:18572319. |
there is evidence that major psychiatric disorders such as schizophrenia (sz) are associated with deregulation of synaptic plasticity with downstream alterations of neurotrophins. |
2008-11-05 |
2023-08-12 |
Not clear |
| Bai Lu, Keri Martinowic. Cell biology of BDNF and its relevance to schizophrenia. Novartis Foundation symposium. vol 289. 2008-08-07. PMID:18497099. |
extending these studies to synaptic plasticity in other areas of the brain may help us to better understand how altered bdnf signalling could contribute to intermediate phenotypes associated with schizophrenia. |
2008-08-07 |
2023-08-12 |
Not clear |
| Lin Mei, Wen-Cheng Xion. Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. Nature reviews. Neuroscience. vol 9. issue 6. 2008-06-16. PMID:18478032. |
neuregulin 1 in neural development, synaptic plasticity and schizophrenia. |
2008-06-16 |
2023-08-12 |
Not clear |
| Katsuaki Suzuki, Kazuhiko Nakamura, Yasuhide Iwata, Yoshimoto Sekine, Masayoshi Kawai, Genichi Sugihara, Kenji J Tsuchiya, Shiro Suda, Hideo Matsuzaki, Nori Takei, Kenji Hashimoto, Norio Mor. Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients. Schizophrenia research. vol 98. issue 1-3. 2008-03-31. PMID:17936586. |
reelin, a secretory protease that plays major roles in neurodevelopment and synaptic plasticity, may also play a role in the pathogenesis of schizophrenia. |
2008-03-31 |
2023-08-12 |
Not clear |
| Graham M Pitcher, Simon Beggs, Ran-Sook Woo, Lin Mei, Michael W Salte. ErbB4 is a suppressor of long-term potentiation in the adult hippocampus. Neuroreport. vol 19. issue 2. 2008-03-24. PMID:18185097. |
our findings suggest that cognitive deficits in schizophrenia may be a consequence of hyperfunction of erbb4 signaling leading to suppressed glutamatergic synaptic plasticity, thus opening new approaches for the treatment of this disorder. |
2008-03-24 |
2023-08-12 |
mouse |
| George S Robertson, Sarah E Hori, Kelly J Powel. Schizophrenia: an integrative approach to modelling a complex disorder. Journal of psychiatry & neuroscience : JPN. vol 31. issue 3. 2007-02-13. PMID:16699601. |
a large number of candidate schizophrenia susceptibility genes have been identified that encode proteins implicated in the regulation of synaptic plasticity, neurotransmission, neuronal migration, cell adherence, signal transduction, energy metabolism and neurite outgrowth. |
2007-02-13 |
2023-08-12 |
mouse |
| George S Robertson, Sarah E Hori, Kelly J Powel. Schizophrenia: an integrative approach to modelling a complex disorder. Journal of psychiatry & neuroscience : JPN. vol 31. issue 3. 2007-02-13. PMID:16699601. |
in support of the importance of these processes in schizophrenia, mice that have reduced levels or completely lack proteins that control glutamatergic neurotransmission, neuronal migration, cell adherence, signal transduction, neurite outgrowth and synaptic plasticity display many features reminiscent of schizophrenia. |
2007-02-13 |
2023-08-12 |
mouse |
| Rodrigo W Grillo, Gustavo L Ottoni, Renata Leke, Diogo O Souza, Luiz V Portela, Diogo R Lar. Reduced serum BDNF levels in schizophrenic patients on clozapine or typical antipsychotics. Journal of psychiatric research. vol 41. issue 1-2. 2007-02-06. PMID:16546213. |
neurotrophic factors regulate neuronal development and synaptic plasticity, possibly playing a role in the pathophysiology of schizophrenia and other psychiatric disorders. |
2007-02-06 |
2023-08-12 |
human |
| Linda W Jurata, Paul Gallagher, Andrew L Lemire, Vinod Charles, Jeffrey A Brockman, Elizabeth Lindsay Illingworth, C Anthony Alta. Altered expression of hippocampal dentate granule neuron genes in a mouse model of human 22q11 deletion syndrome. Schizophrenia research. vol 88. issue 1-3. 2007-02-06. PMID:17008057. |
overlap of the 287 genes with the reportedly reduced expression of mitochondrial, ubiquitin/proteasome, and synaptic plasticity genes in schizophrenia dentate granule neurons, was not significant. |
2007-02-06 |
2023-08-12 |
mouse |
| Klaas E Stephan, Torsten Baldeweg, Karl J Fristo. Synaptic plasticity and dysconnection in schizophrenia. Biological psychiatry. vol 59. issue 10. 2006-08-02. PMID:16427028. |
synaptic plasticity and dysconnection in schizophrenia. |
2006-08-02 |
2023-08-12 |
human |
| Klaas E Stephan, Torsten Baldeweg, Karl J Fristo. Synaptic plasticity and dysconnection in schizophrenia. Biological psychiatry. vol 59. issue 10. 2006-08-02. PMID:16427028. |
we describe how theoretical and causal models of brain responses might contribute to a mechanistic understanding of synaptic plasticity in schizophrenia. |
2006-08-02 |
2023-08-12 |
human |
| P Steullet, H C Neijt, M Cuénod, K Q D. Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: relevance to schizophrenia. Neuroscience. vol 137. issue 3. 2006-04-12. PMID:16330153. |
synaptic plasticity impairment and hypofunction of nmda receptors induced by glutathione deficit: relevance to schizophrenia. |
2006-04-12 |
2023-08-12 |
rat |