| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olga Krizanova, Iveta Steliarova, Lucia Csaderova, Michal Pastorek, Sona Hudecov. Capsaicin induces apoptosis in PC12 cells through ER stress. Oncology reports. vol 31. issue 2. 2014-09-03. PMID:24337105. |
these results were correlated with endoplasmic reticulum (er) stress markers chop, atf4 and x-box binding protein 1 (xbp1), as well as with apoptosis induction. |
2014-09-03 |
2023-08-12 |
rat |
| Kazuya Takahashi, Fumihiko Furuya, Hiroki Shimura, Masahiro Kaneshige, Tetsuro Kobayash. Impaired oxidative endoplasmic reticulum stress response caused by deficiency of thyroid hormone receptor α. The Journal of biological chemistry. vol 289. issue 18. 2014-08-02. PMID:24644288. |
in hfd-treated trα-deficient mice, atf4 was not induced, and apoptosis was enhanced compared with hfd-treated wt mice. |
2014-08-02 |
2023-08-12 |
mouse |
| Kazuya Takahashi, Fumihiko Furuya, Hiroki Shimura, Masahiro Kaneshige, Tetsuro Kobayash. Impaired oxidative endoplasmic reticulum stress response caused by deficiency of thyroid hormone receptor α. The Journal of biological chemistry. vol 289. issue 18. 2014-08-02. PMID:24644288. |
these results indicate that endogenous trα plays an important role for the expression of atf4 and facilitates reduced apoptosis in pancreatic β-cells under er stress. |
2014-08-02 |
2023-08-12 |
mouse |
| Xiaobo Zhang, Seong-Ho Lee, Kyung-Won Min, Michael F McEntee, Jin Boo Jeong, Qingwang Li, Seung Joon Bae. The involvement of endoplasmic reticulum stress in the suppression of colorectal tumorigenesis by tolfenamic acid. Cancer prevention research (Philadelphia, Pa.). vol 6. issue 12. 2014-07-31. PMID:24104354. |
moreover, the perk-eif2α-atf4 branch of the upr pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells, as silencing atf4 attenuates tolfenamic acid-induced apoptosis. |
2014-07-31 |
2023-08-12 |
mouse |
| Xiao-Hui Duan, Jin-Rui Chang, Jing Zhang, Bao-Hong Zhang, Yu-Lin Li, Xu Teng, Yi Zhu, Jie Du, Chao-Shu Tang, Yong-Fen Q. Activating transcription factor 4 is involved in endoplasmic reticulum stress-mediated apoptosis contributing to vascular calcification. Apoptosis : an international journal on programmed cell death. vol 18. issue 9. 2014-03-17. PMID:23686245. |
activating transcription factor 4 (atf4) is a critical transcription factor in osteoblastogenesis and ers-induced apoptosis. |
2014-03-17 |
2023-08-12 |
rat |
| Xiao-Hui Duan, Jin-Rui Chang, Jing Zhang, Bao-Hong Zhang, Yu-Lin Li, Xu Teng, Yi Zhu, Jie Du, Chao-Shu Tang, Yong-Fen Q. Activating transcription factor 4 is involved in endoplasmic reticulum stress-mediated apoptosis contributing to vascular calcification. Apoptosis : an international journal on programmed cell death. vol 18. issue 9. 2014-03-17. PMID:23686245. |
however, whether atf4 is involved in ers-mediated apoptosis contributing to vc remains unclear. |
2014-03-17 |
2023-08-12 |
rat |
| Xiao-Hui Duan, Jin-Rui Chang, Jing Zhang, Bao-Hong Zhang, Yu-Lin Li, Xu Teng, Yi Zhu, Jie Du, Chao-Shu Tang, Yong-Fen Q. Activating transcription factor 4 is involved in endoplasmic reticulum stress-mediated apoptosis contributing to vascular calcification. Apoptosis : an international journal on programmed cell death. vol 18. issue 9. 2014-03-17. PMID:23686245. |
atf4 knockdown attenuated ers-induced apoptosis in calcified vsmcs. |
2014-03-17 |
2023-08-12 |
rat |
| Xiao-Hui Duan, Jin-Rui Chang, Jing Zhang, Bao-Hong Zhang, Yu-Lin Li, Xu Teng, Yi Zhu, Jie Du, Chao-Shu Tang, Yong-Fen Q. Activating transcription factor 4 is involved in endoplasmic reticulum stress-mediated apoptosis contributing to vascular calcification. Apoptosis : an international journal on programmed cell death. vol 18. issue 9. 2014-03-17. PMID:23686245. |
our results demonstrate that atf4 was involved at least in part in the process of ers-mediated apoptosis contributing to vc. |
2014-03-17 |
2023-08-12 |
rat |
| Soledad Matus, Estefanía Lopez, Vicente Valenzuela, Melissa Nassif, Claudio Het. Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis. PloS one. vol 8. issue 7. 2014-02-13. PMID:23874395. |
atf4 is a key er stress transcription factor that plays a role in both adaptation to stress and the activation of apoptosis. |
2014-02-13 |
2023-08-12 |
mouse |
| Liang Wu, You-Yong Tian, Jing-Ping Shi, Wei Xie, Jian-Quan Shi, Jie Lu, Ying-Dong Zhan. Inhibition of endoplasmic reticulum stress is involved in the neuroprotective effects of candesartan cilexitil in the rotenone rat model of Parkinson's disease. Neuroscience letters. vol 548. 2014-02-07. PMID:23774475. |
moreover, candesartan cilexetil has been found to play a protective role via down-regulating the expression of activating transcription factor 4 (atf4), the ccaat-enhancer-binding protein (c/ebp) homologous protein (chop), and p53 upregulated modulator of apoptosis (puma). |
2014-02-07 |
2023-08-12 |
rat |
| Hiroki Matsumoto, Shuichi Miyazaki, Satoshi Matsuyama, Masayuki Takeda, Makoto Kawano, Hiroshi Nakagawa, Kazuhiko Nishimura, Saburo Matsu. Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression. Biology open. vol 2. issue 10. 2013-10-29. PMID:24167719. |
selection of autophagy or apoptosis in cells exposed to er-stress depends on atf4 expression pattern with or without chop expression. |
2013-10-29 |
2023-08-12 |
Not clear |
| Hiroki Matsumoto, Shuichi Miyazaki, Satoshi Matsuyama, Masayuki Takeda, Makoto Kawano, Hiroshi Nakagawa, Kazuhiko Nishimura, Saburo Matsu. Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression. Biology open. vol 2. issue 10. 2013-10-29. PMID:24167719. |
thapsigargin-induced er-stress caused only apoptosis after ∼2 hr with ire1 phosphorylation, and grp78, atf4, and chop expressions. |
2013-10-29 |
2023-08-12 |
Not clear |
| Hiroki Matsumoto, Shuichi Miyazaki, Satoshi Matsuyama, Masayuki Takeda, Makoto Kawano, Hiroshi Nakagawa, Kazuhiko Nishimura, Saburo Matsu. Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression. Biology open. vol 2. issue 10. 2013-10-29. PMID:24167719. |
atf4-sirna completely inhibited the autophagy induced by naf or tunicamycin with suppressed atf4 protein and mrna expressions, and also inhibited apoptosis by thapsigargin with suppression of both atf4 and chop. |
2013-10-29 |
2023-08-12 |
Not clear |
| Hiroki Matsumoto, Shuichi Miyazaki, Satoshi Matsuyama, Masayuki Takeda, Makoto Kawano, Hiroshi Nakagawa, Kazuhiko Nishimura, Saburo Matsu. Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression. Biology open. vol 2. issue 10. 2013-10-29. PMID:24167719. |
on the other hand, chop-sirna activated autophagy in thapsigargin-induced er-stress with significant atf4 expression, and suppressed apoptosis with chop suppression. |
2013-10-29 |
2023-08-12 |
Not clear |
| Hiroki Matsumoto, Shuichi Miyazaki, Satoshi Matsuyama, Masayuki Takeda, Makoto Kawano, Hiroshi Nakagawa, Kazuhiko Nishimura, Saburo Matsu. Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression. Biology open. vol 2. issue 10. 2013-10-29. PMID:24167719. |
these results showed that atf4 is the key signal for autophagy induced by er-stress, and that autophagy is switched to apoptosis by subsequent chop upregulation, suggesting that the changeover switch between autophagy and apoptosis is located between atf4 to chop in the perk pathway. |
2013-10-29 |
2023-08-12 |
Not clear |
| Qian Jiang, Feng Li, Kejian Shi, Pa Wu, Jiajia An, Yang Yang, Caimin X. ATF4 activation by the p38MAPK-eIF4E axis mediates apoptosis and autophagy induced by selenite in Jurkat cells. FEBS letters. vol 587. issue 15. 2013-10-22. PMID:23792164. |
atf4 activation by the p38mapk-eif4e axis mediates apoptosis and autophagy induced by selenite in jurkat cells. |
2013-10-22 |
2023-08-12 |
Not clear |
| Qian Jiang, Feng Li, Kejian Shi, Pa Wu, Jiajia An, Yang Yang, Caimin X. ATF4 activation by the p38MAPK-eIF4E axis mediates apoptosis and autophagy induced by selenite in Jurkat cells. FEBS letters. vol 587. issue 15. 2013-10-22. PMID:23792164. |
upregulated atf4 results in the transcriptional initiation of the apoptosis-related chop gene and autophagy-related map1lc3b gene, through which selenite links er stress to apoptosis and autophagy during leukemia treatment. |
2013-10-22 |
2023-08-12 |
Not clear |
| Ji Hoon Jang, Taha Iqbal, Kyoung-Jin Min, Shin Kim, Jong-Wook Park, Eun-Ik Son, Tae-Jin Lee, Taeg Kyu Kwo. Helenalin-induced apoptosis is dependent on production of reactive oxygen species and independent of induction of endoplasmic reticulum stress in renal cell carcinoma. Toxicology in vitro : an international journal published in association with BIBRA. vol 27. issue 2. 2013-08-20. PMID:23123298. |
however, down-regulation of atf4 and/or chop expression by sirna had no effect on helenalin-induced apoptosis in caki and hct116 cells. |
2013-08-20 |
2023-08-12 |
human |
| Justin T Babcock, Hoa B Nguyen, Yujun He, Jeremiah W Hendricks, Ronald C Wek, Lawrence A Quillia. Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response. The Journal of biological chemistry. vol 288. issue 22. 2013-08-06. PMID:23612979. |
consistent with this notion, exogenously expressed c-myc reversed the ability of rapamycin to prevent bortezomib-induced chop and atf4 expression as well as apoptosis. |
2013-08-06 |
2023-08-12 |
rat |
| Daniela Beck, Heike Niessner, Keiran S M Smalley, Keith Flaherty, Kim H T Paraiso, Christian Busch, Tobias Sinnberg, Sophie Vasseur, Juan Lucio Iovanna, Stefan Drießen, Björn Stork, Sebastian Wesselborg, Martin Schaller, Tilo Biedermann, Jürgen Bauer, Konstantinos Lasithiotakis, Benjamin Weide, Jürgen Eberle, Birgit Schittek, Dirk Schadendorf, Claus Garbe, Dagmar Kulms, Friedegund Meie. Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells. Science signaling. vol 6. issue 260. 2013-07-12. PMID:23362240. |
knockdown of the er stress response protein activating transcription factor 4 (atf4) significantly reduced vemurafenib-induced apoptosis. |
2013-07-12 |
2023-08-12 |
Not clear |