| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinsong Hu, Nana Dang, Eline Menu, Elke De Bruyne, Elke De Bryune, Dehui Xu, Ben Van Camp, Els Van Valckenborgh, Karin Vanderkerke. Activation of ATF4 mediates unwanted Mcl-1 accumulation by proteasome inhibition. Blood. vol 119. issue 3. 2012-03-13. PMID:22128141. |
knocking down atf4 was paralleled by down-regulation of mcl-1 induction by bortezomib and significantly increased bortezomib-induced apoptosis. |
2012-03-13 |
2023-08-12 |
Not clear |
| Gordon P Meares, Marjelo A Mines, Eléonore Beurel, Tae-Yeon Eom, Ling Song, Anna A Zmijewska, Richard S Jop. Glycogen synthase kinase-3 regulates endoplasmic reticulum (ER) stress-induced CHOP expression in neuronal cells. Experimental cell research. vol 317. issue 11. 2011-08-09. PMID:21356208. |
apoptosis following upr activation can be mediated by activation of two transcription factors, atf4 and atf6, that activate expression of the death-inducing transcription factor c/ebp homologous protein (chop/gadd153) following er stress. |
2011-08-09 |
2023-08-12 |
Not clear |
| S M Kim, S Y Yoon, J E Choi, J S Park, J M Choi, T Nguyen, D H Ki. Activation of eukaryotic initiation factor-2 α-kinases in okadaic acid-treated neurons. Neuroscience. vol 169. issue 4. 2011-04-18. PMID:20600673. |
activating transcription factor (atf4) which induces apoptosis in response to eif2 alpha phosphorylation was increased and translocated to nuclei in oa-treated neurons. |
2011-04-18 |
2023-08-12 |
rat |
| Zohreh Galehdar, Patrick Swan, Benjamin Fuerth, Steven M Callaghan, David S Park, Sean P Crega. Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 50. 2011-02-09. PMID:21159964. |
specifically, we demonstrate that ectopic expression of atf4 sensitizes mouse cortical neurons to er-stress-induced apoptosis and that atf4-deficient neurons exhibit markedly reduced levels of puma expression and cell death. |
2011-02-09 |
2023-08-12 |
mouse |
| Souvik Dey, Thomas D Baird, Donghui Zhou, Lakshmi Reddy Palam, Dan F Spandau, Ronald C We. Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response. The Journal of biological chemistry. vol 285. issue 43. 2010-11-24. PMID:20732869. |
atf4 is a transcriptional activator of the integrated stress response, a program of gene expression involved in metabolism, nutrient uptake, anti-oxidation, and the activation of additional transcription factors, such as chop/gadd153, that can induce apoptosis. |
2010-11-24 |
2023-08-12 |
human |
| Kristine P Malabanan, Levon M Khachigia. Activation transcription factor-4 and the acute vascular response to injury. Journal of molecular medicine (Berlin, Germany). vol 88. issue 6. 2010-08-17. PMID:20306012. |
in this context, atf4 is thought to regulate pro-inflammatory signalling cascades and subsequent apoptosis. |
2010-08-17 |
2023-08-12 |
mouse |
| Tomasz Rzymski, Manuela Milani, Dean C Singleton, Adrian L Harri. Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia. Cell cycle (Georgetown, Tex.). vol 8. issue 23. 2010-02-03. PMID:19887912. |
atf4 decreases the antitumor activity of chemotherapy by mechanisms involving expression of genes involved in oxidative stress resistance, redox homeostasis and inhibitors of apoptosis. |
2010-02-03 |
2023-08-12 |
Not clear |
| Xiaoyan Zhang, Shibing Yu, Deborah L Galson, Min Luo, Jie Fan, Jian Zhang, Youfei Guan, Guozhi Xia. Activating transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts. Journal of cellular biochemistry. vol 105. issue 3. 2008-12-31. PMID:18729081. |
in addition, apoptosis was significantly increased in atf4(-/-) bmscs and calvarial periosteal osteoblasts relative to wt controls. |
2008-12-31 |
2023-08-12 |
mouse |
| Nima Niknejad, Melissa Morley, Jim Dimitroulako. Activation of the integrated stress response regulates lovastatin-induced apoptosis. The Journal of biological chemistry. vol 282. issue 41. 2007-11-27. PMID:17699156. |
furthermore, the eif2alpha kinase gcn2 mediates lovastatin induction of atf4 and lovastatin-induced apoptosis was also attenuated in gcn2(-/-) mefs. |
2007-11-27 |
2023-08-12 |
human |
| Daima Ord, Kati Meerits, Tõnis Or. TRB3 protects cells against the growth inhibitory and cytotoxic effect of ATF4. Experimental cell research. vol 313. issue 16. 2007-11-05. PMID:17707795. |
also, the coexpression of trb3 rescues postmitotic neuronally differentiated pc12 cells from the apoptosis evoked by atf4 overexpression. |
2007-11-05 |
2023-08-12 |
Not clear |
| Kazuyoshi Kumagai, Yosuke Ando, Naoki Kiyosawa, Kazumi Ito, Ryota Kawai, Takashi Yamoto, Sunao Manabe, Munehiro Teranish. Toxicoproteomic investigation of the molecular mechanisms of cycloheximide-induced hepatocellular apoptosis in rat liver. Toxicology. vol 228. issue 2-3. 2007-01-04. PMID:17067731. |
in the gene expression assay using quantitative rt-pcr, the genes related to chop-mediated apoptosis such as the c/ebpbeta, atf3 and atf4 genes were significantly increased corresponding to the induction of hepatocellular apoptosis in rats treated with chx. |
2007-01-04 |
2023-08-12 |
rat |
| Reshma Shringarpure, Laurence Catley, Deepak Bhole, Renate Burger, Klaus Podar, Yu-Tzu Tai, Benedikt Kessler, Paul Galardy, Hidde Ploegh, Pierfrancesco Tassone, Teru Hideshima, Constantine Mitsiades, Nikhil C Munshi, Dharminder Chauhan, Kenneth C Anderso. Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib. British journal of haematology. vol 134. issue 2. 2006-08-04. PMID:16846475. |
we showed that overexpression of activating transcription factor 3 (atf3), atf4, atf5, c-jun, jund and caspase-3 is associated with sensitivity to bortezomib-induced apoptosis, whereas overexpression of heat shock protein (hsp)27, hsp70, hsp90 and t-cell factor 4 is associated with bortezomib resistance. |
2006-08-04 |
2023-08-12 |
Not clear |
| Elizabeth Karaskov, Cameron Scott, Liling Zhang, Tracy Teodoro, Mariella Ravazzola, Allen Volchu. Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. Endocrinology. vol 147. issue 7. 2006-07-24. PMID:16601139. |
ins-1 cells exposed to palmitate for 16-24 h under serum-free conditions showed marked apoptosis and increased protein levels of phosphorylated eukaryotic translation initiation factor 2alpha (eif2alpha), activating transcription factor 4 (atf4), x box-binding protein 1 (xbp-1), and c/ebp homologous transcription factor (chop) compared with control cells. |
2006-07-24 |
2023-08-12 |
Not clear |
| R C Wek, H-Y Jiang, T G Anthon. Coping with stress: eIF2 kinases and translational control. Biochemical Society transactions. vol 34. issue Pt 1. 2006-03-27. PMID:16246168. |
atf4 also enhances the expression of additional transcription factors, atf3 and chop (ccaat/enhancer-binding protein homologous protein)/gadd153 (growth arrest and dna-damage-inducible protein), that assist in the regulation of genes involved in metabolism, the redox status of the cells and apoptosis. |
2006-03-27 |
2023-08-12 |
mouse |
| Soo Jung Kim, Kyung Mi Park, Nayoung Kim, Young Il Yeo. Doxorubicin prevents endoplasmic reticulum stress-induced apoptosis. Biochemical and biophysical research communications. vol 339. issue 2. 2006-02-07. PMID:16298333. |
in contrast to another topoisomerase inhibitor, etoposide, doxorubicin markedly decreased apoptosis induced by thapsigargin; this doxorubicin effect was accompanied by reduced expression of the upr-specific proapoptotic protein, c/ebp-homologous protein, and its upstream transcription factor, atf4. |
2006-02-07 |
2023-08-12 |
human |
| Melissa L Fishel, Cara A Rabik, Wasim K Bleibel, Xinmin Li, Robert C Moschel, M Eileen Dola. Role of GADD34 in modulation of cisplatin cytotoxicity. Biochemical pharmacology. vol 71. issue 3. 2006-02-03. PMID:16325149. |
among the overexpressed probe sets were genes involved in dna damage and apoptosis, including gadd34, ddit4, atf4, and pthlh. |
2006-02-03 |
2023-08-12 |
Not clear |
| S Jean, C Bideau, L Bellon, G Halimi, M De Méo, T Orsière, G Dumenil, J L Bergé-Lefranc, A Bott. The expression of genes induced in melanocytes by exposure to 365-nm UVA: study by cDNA arrays and real-time quantitative RT-PCR. Biochimica et biophysica acta. vol 1522. issue 2. 2002-02-05. PMID:11750059. |
these genes included genes involved in cell cycle regulation (gadd45, cip1/waf1), in stress response (hsp70, hsp40, hsp86), in apoptosis (gadd153, tristetraproline) and genes encoding transcription factors (egr-1, etr-101, c-jun, atf4). |
2002-02-05 |
2023-08-12 |
human |