| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuko Nagao, Kikuko Amo-Shiinoki, Hiroko Nakabayashi, Masayuki Hatanaka, Manabu Kondo, Kimie Matsunaga, Masahiro Emoto, Shigeru Okuya, Yukio Tanizawa, Katsuya Tanab. Gsk-3-Mediated Proteasomal Degradation of ATF4 Is a Proapoptotic Mechanism in Mouse Pancreatic β-Cells. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36362372. |
gsk-3 inhibition prevented proteasomal degradation of activating transcriptional factor 4 (atf4) and alleviated apoptosis. |
2022-11-11 |
2023-08-14 |
mouse |
| Longhao Wang, Tao Hu, Zhibo Shen, Yuanyuan Zheng, Qishun Geng, Lifeng Li, Beibei Sha, Miaomiao Li, Yaxin Sun, Yongjun Guo, Wenhua Xue, Dan Xuan, Ping Chen, Jie Zha. Inhibition of USP1 activates ER stress through Ubi-protein aggregation to induce autophagy and apoptosis in HCC. Cell death & disease. vol 13. issue 11. 2022-11-10. PMID:36357365. |
ml-323 treatment resulted in the accumulation of ubiquitinated proteins, induced er stress, and triggered noxa-dependent apoptosis, which was regulated by the activating transcription factor 4(atf4). |
2022-11-10 |
2023-08-14 |
Not clear |
| Yaping Chen, Zheming Chen, Weineng Cheng, Yajun Cao, Wen Xu, Wenfang Lai, Yuqin Zhang, Mei Huang, Lihong Na. The Role of the GRP78/PERK/ATF4 Pathway in the Ability of Gua Lou Gui Zhi Decoction to Attenuate Apoptosis by Inhibiting Endoplasmic Reticulum Stress after Ischemia-Reperfusion Injury. Frontiers in bioscience (Landmark edition). vol 27. issue 10. 2022-11-07. PMID:36336865. |
in addition, the unfolded protein response (upr) plays an important role in ers because it activates downstream apoptotic signal transduction and induces apoptosis through the glucose-regulated protein 78 (grp78)/protein kinase r (pkr)-like er kinase (perk)/activating transcription factor 4 (atf4) pathway. |
2022-11-07 |
2023-08-14 |
Not clear |
| Yuankang Zou, Ziyan Yuan, Yafei Sun, Maodeng Zhai, Zhice Tan, Ruili Guan, Michael Aschner, Wenjing Luo, Jianbin Zhan. Resetting Proteostasis of CIRBP with ISRIB Suppresses Neural Stem Cell Apoptosis under Hypoxic Exposure. Oxidative medicine and cellular longevity. vol 2022. 2022-10-10. PMID:36211820. |
interestingly, isrib, a small-molecule modulator of the perk-atf4 signaling pathway, could prevent the reduction and apoptosis of nscs in two steps: enhancing the expression of cirbp through the protein kinase r- (pkr-) like endoplasmic reticulum kinase (perk) and activating transcription factor 4 (atf4) axis. |
2022-10-10 |
2023-08-14 |
Not clear |
| Shuying Yuan, Yongfu Pan, Tong Xu, Li Zhang, Xihui Chen, Fengying Wang, Qian Liu, Lijun Ji. Daurisoline Inhibits ESCC by Inducing G1 Cell Cycle Arrest and Activating ER Stress to Trigger Noxa-Dependent Intrinsic and CHOP-DR5-Dependent Extrinsic Apoptosis via p-eIF2 Oxidative medicine and cellular longevity. vol 2022. 2022-08-15. PMID:35965681. |
the induction of apoptosis by das was largely dependent on the activation of the transcription factor atf4 and its downstream noxa-dependent intrinsic and chop-dr5-dependent extrinsic apoptotic pathway. |
2022-08-15 |
2023-08-14 |
human |
| Hossam El-Sheikh Ali, Kirsten Scoggin, Harutaka Murase, Jamie Norris, Bruno Menarim, Pouya Dini, Barry Bal. Transcriptomic and histochemical analysis reveal the complex regulatory networks in equine Chorioallantois during spontaneous term labor. Biology of reproduction. 2022-08-01. PMID:35913756. |
also, tl was associated with the upregulation of matrix metalloproteinase (mmp1, mmp2, mmp3, and mmp9) with subsequent extracellular matrix degradation and apoptosis, as reflected by upregulation of several apoptosis-related genes (atf3, atf4, fas, fos, and birc3). |
2022-08-01 |
2023-08-14 |
Not clear |
| Daniele Missio, Alexandro Fritzen, Camila Cupper Vieira, Juliana Germano Ferst, Mariani Farias Fiorenza, Leonardo Guedes de Andrade, Bento Martins de Menezes, Monique Tomazele Rovani, Bernardo Gazieira Gasperin, Paulo Bayard Dias Gonçalves, Rogério Ferreir. Increased β-hydroxybutyrate (BHBA) concentration affect follicular growth in cattle. Animal reproduction science. vol 243. 2022-07-11. PMID:35816934. |
in addition, the relative abundance of genes involved in the ovulatory cascade (adam 17, areg, ereg, ptgs2), steroidogenesis (cyp19a1, 3bhsd, star), cellular stress (sod1, cat, gpx1, hspa5, xbp1s, xbp1u, atf4, atf6), monocarboxylic acid transporters (slc16a1, slc16a7) and apoptosis (xiap) was similar between groups. |
2022-07-11 |
2023-08-14 |
cat |
| K Zhang, X Liu, Y Tang, Z Liu, Q Yi, L Wang, B Geng, Y Xi. Fluid Shear Stress Promotes Osteoblast Proliferation and Suppresses Mitochondrial-Mediated Osteoblast Apoptosis Through the miR-214-3p-ATF4 Signaling Axis. Physiological research. 2022-06-30. PMID:35770472. |
moreover, mir-214 3p regulated osteoblast proliferation and apoptosis through targeting atf4. |
2022-06-30 |
2023-08-14 |
Not clear |
| Guang-Chen Zhang, Yi-Hao Wang, Pan-Pan Ruan, Zu-Qi Zhang, Ning-Ning Shen, Yu-Fu Liu, Yu-Guang Wang, Yue Ga. [Protective effect of ophiopogonin D against isoproterenol-induced cardiomyocyte injury and targets]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 10. 2022-06-19. PMID:35718492. |
cell count kit-8(cck-8) assay was used to detect viability of cells treated with opd and iso, western blot to examine the effect of opd and iso on the expression of endoplasmic reticulum stress-related bip, bax, perk, atf4, caspase-12, and chop, flow cytometry to determine cell apoptosis rate, and hoechst 33258 and tunel staining to observe cell apoptosis and morphological changes. |
2022-06-19 |
2023-08-14 |
rat |
| Z-L Yuan, Z-X Zhang, Y-Z Mo, D-L Li, L Xie, M-H Che. Inhibition of extracellular signal-regulated kinase downregulates endoplasmic reticulum stress-induced apoptosis and decreases brain injury in a cardiac arrest rat model. Physiological research. 2022-05-26. PMID:35616042. |
twenty-four hours after resuscitation, neural injury was assessed by survival rate, neurological deficit scores (nds) and nissl staining; apoptosis of brain cells was detected using terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) staining; mrna expression and protein levels of ers-related protein bip, perk, atf4 and chop were checked with rt-pcr and western blot. |
2022-05-26 |
2023-08-13 |
rat |
| Z-L Yuan, Z-X Zhang, Y-Z Mo, D-L Li, L Xie, M-H Che. Inhibition of extracellular signal-regulated kinase downregulates endoplasmic reticulum stress-induced apoptosis and decreases brain injury in a cardiac arrest rat model. Physiological research. 2022-05-26. PMID:35616042. |
pd98059 significantly improved survival rate and nds, increased the nissl bodies in neurons, reduced apoptosis, downregulated the mrna transcription and expression levels of bip, perk, atf4 and chop at 24 h after ca/cpr. |
2022-05-26 |
2023-08-13 |
rat |
| Ashlyn Parkhurst, Sabrina Z Wang, Tyler R Findlay, Kristen J Malebranche, Arman Odabas, Jesse Alt, Micah J Maxwell, Harpreet Kaur, Cody J Peer, William D Figg, Katherine E Warren, Barbara S Slusher, Charles G Eberhart, Eric H Raabe, Jeffrey A Ruben. Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors. Cell death & disease. vol 13. issue 4. 2022-04-28. PMID:35484114. |
combination therapy activates the integrative stress response as determined by increased expression of phosphorylated eif2α, atf4, and chop, and disrupts the protective noxa.mcl-1.bim axis, forcing stressed cells to undergo apoptosis. |
2022-04-28 |
2023-08-13 |
mouse |
| Gang Wu, Xi'an Zhang, Shijun Li, Lina Wang, Jie Bai, Hanxiang Wang, Qing Sh. Silencing ATF4 inhibits JMJD3-dependent JUNB/ETS1 axis and mitigates cerebral ischemic injury. Journal of biochemical and molecular toxicology. 2022-04-11. PMID:35403324. |
activating transcription factor 4 (atf4) is known to play an important role in cerebral ischemia through apoptosis and neuron regulation. |
2022-04-11 |
2023-08-13 |
mouse |
| Gang Wu, Xi'an Zhang, Shijun Li, Lina Wang, Jie Bai, Hanxiang Wang, Qing Sh. Silencing ATF4 inhibits JMJD3-dependent JUNB/ETS1 axis and mitigates cerebral ischemic injury. Journal of biochemical and molecular toxicology. 2022-04-11. PMID:35403324. |
specifically, the regulatory function of atf4 and demethylase jmjd3 on the ischemic injury was explored via using ectopic expression and depletion by determination of modified neurologic severity score, blood-brain barrier, brain water content, apoptosis, infarct size, oxidative stress, and inflammation. |
2022-04-11 |
2023-08-13 |
mouse |
| Yujin Jin, Diem Thi Ngoc Huynh, Kyung-Sun He. Ginsenoside Rh1 inhibits tumor growth in MDA-MB-231 breast cancer cells via mitochondrial ROS and ER stress-mediated signaling pathway. Archives of pharmacal research. 2022-03-24. PMID:35325393. |
inhibition of atf4 by sirna transfection significantly inhibited rh1-mediated apoptosis and calcium production. |
2022-03-24 |
2023-08-13 |
Not clear |
| Nicholas R Liguori, Ashley Sanchez Sevilla Uruchurtu, Leiqing Zhang, Abbas E Abbas, Young S Lee, Lanlan Zhou, Christopher G Azzoli, Wafik S El-Deir. Preclinical studies with ONC201/TIC10 and lurbinectedin as a novel combination therapy in small cell lung cancer (SCLC). American journal of cancer research. vol 12. issue 2. 2022-03-09. PMID:35261798. |
induction of the integrated stress response mediator atf4 and chop was observed with onc201 and lurbinectedin along with induction of parp cleavage indicative of apoptosis in response to cellular stress. |
2022-03-09 |
2023-08-13 |
Not clear |
| Bereket Molla Tanga, Xun Fang, Seonggyu Bang, Gyeonghwan Seong, Mahanama De Zoysa, Islam M Saadeldin, Sanghoon Lee, Jongki Ch. MiRNA-155 inhibition enhances porcine embryo preimplantation developmental competence by upregulating ZEB2 and downregulating ATF4. Theriogenology. vol 183. 2022-03-01. PMID:35231827. |
the relative gene expression level analysis showed downregulation of mrnas related to stress and apoptosis, bax, and the stress-induced autophagy gene atf4, and tnf-ɑ in the mirna-155 inhibitor group. |
2022-03-01 |
2023-08-13 |
Not clear |
| V N Mal'tseva, M V Goltyaev, S V Novoselov, E G Varlamov. [Effects of Sodium Selenite and Dithiothreitol on Expression of Endoplasmic Reticulum Selenoproteins and Apoptosis Markers in MSF7 Breast Adenocarcinoma Cells]. Molekuliarnaia biologiia. vol 56. issue 1. 2022-01-27. PMID:35082262. |
when the ss concentration was increased to 0.1 μm, an increase in expression was observed for key er stress genes and apoptosis markers, including chop, gadd34, puma, bim, atf4, sxbp, uxbp, akt1, bax, and bak. |
2022-01-27 |
2023-08-13 |
Not clear |
| Xiaogang Zheng, Bingtao Liu, Xiongxiong Liu, Ping Li, Pengcheng Zhang, Fei Ye, Ting Zhao, Yanbei Kuang, Weiqiang Chen, Xiaodong Jin, Qiang L. PERK Regulates the Sensitivity of Hepatocellular Carcinoma Cells to High-LET Carbon Ions via either Apoptosis or Ferroptosis. Journal of Cancer. vol 13. issue 2. 2022-01-24. PMID:35069910. |
on the one hand, perk promoted autophagy via regulating atf4 expression; on the other hand, perk regulated p53 expression, and the latter either induced autophagy through up-regulating dram, or directly promoting apoptosis through the mitochondrial pathway or facilitating ferroptosis via down-regulating |
2022-01-24 |
2023-08-13 |
Not clear |
| Dandan Yan, Na Wang, Jianling Yao, Xu Wu, Jingping Yuan, Hong Ya. Curcumin Attenuates the PERK-eIF2α Signaling to Relieve Acrylamide-Induced Neurotoxicity in SH‑SY5Y Neuroblastoma Cells. Neurochemical research. 2022-01-17. PMID:35037165. |
moreover, curcumin pretreatment inhibited perk-dependent eif2α phosphorylation, further suppressed gsk-3β and atf4 function, and abolished abnormal tau phosphorylation, p-creb reduction, and chop-induced apoptosis in sh-sy5y cells. |
2022-01-17 |
2023-08-13 |
Not clear |