| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Po-Chiao Chang, Hung-Wen Tsai, Ming-Tsai Chiang, Pei-Ling Huang, Song-Kun Shyue, Lee-Young Cha. TRC8 downregulation contributes to the development of non-alcoholic steatohepatitis by exacerbating hepatic endoplasmic reticulum stress. Biochimica et biophysica acta. vol 1852. issue 11. 2019-11-20. PMID:26319415. |
the hepatic er stress response, as evidenced by increased eif2α phosphorylation and expression of atf4 and chop, and the level of activated caspase 3, an apoptosis indicator, were augmented by trc8 deficiency. |
2019-11-20 |
2023-08-13 |
mouse |
| Fangfang Di, Jiansheng Liu, Shang Li, Guangxin Yao, Yan Hong, Zi-Jiang Chen, Weiping Li, Yanzhi D. ATF4 Contributes to Ovulation via Regulating COX2/PGE2 Expression: A Potential Role of ATF4 in PCOS. Frontiers in endocrinology. vol 9. 2019-11-20. PMID:30498475. |
previous studies have shown that atf4 plays critical role in apoptosis and glucose homeostasis, but its role in regulating reproductive function was not explored. |
2019-11-20 |
2023-08-13 |
human |
| Joy Ogbechi, Belinda S Hall, Thomas Sbarrato, Jack Taunton, Anne E Willis, Ronald C Wek, Rachel E Simmond. Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4. Cell death & disease. vol 9. issue 3. 2019-11-13. PMID:29540678. |
however, chronic activation without stress remediation enhances autophagy and apoptosis of cells by a pathway facilitated by atf4 and chop. |
2019-11-13 |
2023-08-13 |
Not clear |
| Juyi Zhang, Peng Zhang, Chengjie Meng, Baoqi Dang, Haiying Li, Haitao Shen, Zhong Wang, Xiang Li, Gang Che. The PERK Pathway Plays a Neuroprotective Role During the Early Phase of Secondary Brain Injury Induced by Experimental Intracerebral Hemorrhage. Acta neurochirurgica. Supplement. vol 127. 2019-10-28. PMID:31407071. |
inhibition of perk with gsk2606414 suppressed the protein levels of p-eif2α and atf4, resulting in increase of transcriptional activator ccaat/enhancer-binding protein homologous protein (chop) and caspase-12, which promoted apoptosis and reduced neuronal survival. |
2019-10-28 |
2023-08-13 |
rat |
| Yichun He, Hao Meng, Huadan Xu, Linghua Fan, Zijian Zhou, Bo Xu, Liankun Sun, Yufei Ga. Regulation of Integrated Stress Response Sensitizes U87MG Glioblastoma Cells to Temozolomide Through the Mitochondrial Apoptosis Pathway. Anatomical record (Hoboken, N.J. : 2007). vol 301. issue 8. 2019-10-24. PMID:29698579. |
salubrinal could upregulate the expression of atf4, a key factor in the isr, and enhance temozolomide-induced apoptosis. |
2019-10-24 |
2023-08-13 |
human |
| Yichun He, Hao Meng, Huadan Xu, Linghua Fan, Zijian Zhou, Bo Xu, Liankun Sun, Yufei Ga. Regulation of Integrated Stress Response Sensitizes U87MG Glioblastoma Cells to Temozolomide Through the Mitochondrial Apoptosis Pathway. Anatomical record (Hoboken, N.J. : 2007). vol 301. issue 8. 2019-10-24. PMID:29698579. |
atf4 transcriptionally regulated expression of the bh3-only protein noxa, thus inducing mitochondrial apoptosis. |
2019-10-24 |
2023-08-13 |
human |
| Wilson Max Almeida Monteiro De Moraes, Pamella Ramona Moraes de Souza, Nathalie Alves da Paixão, Luís Gustavo Oliveira de Sousa, Daniel Araki Ribeiro, Andrea G Marshall, Jonato Prestes, Maria Claudia Irigoyen, Patricia Chakur Brum, Alessandra Medeiro. Aerobic exercise training rescues protein quality control disruption on white skeletal muscle induced by chronic kidney disease in rats. Journal of cellular and molecular medicine. vol 22. issue 3. 2019-10-10. PMID:29265674. |
5/6nxs presented a trend towards to atrophy, with a reduction in motor performance, down-regulation of protein synthesis and up-regulation of apoptosis signalling; increases in ups activity, misfolded proteins, grp78, derlin, hsp27 and hsp70 protein levels, atf4 and grp78 genes; and increase in oxidative damage compared to cs group. |
2019-10-10 |
2023-08-13 |
rat |
| Wei Liu, Tianyao Yang, Zhaofa Xu, Bin Xu, Yu Den. Methyl-mercury induces apoptosis through ROS-mediated endoplasmic reticulum stress and mitochondrial apoptosis pathways activation in rat cortical neurons. Free radical research. vol 53. issue 1. 2019-07-26. PMID:30513015. |
results showed that mehg induced neuronal oxidative stress, apoptosis, up-regulating glucose-regulated protein (grp78, grp94), spliced xbp1, activating transcription factor 4 (atf4) mrna, with activation of upr including pkr-like er kinase-eif2α, inositol-requiring enzyme 1, and atf6 pathways, as well as c/ebp homologous transcription factor protein and cleaved caspase-12 up-regulation. |
2019-07-26 |
2023-08-13 |
rat |
| Tao Hu, Jingyang Zhang, Beibei Sha, Miaomiao Li, Longhao Wang, Yi Zhang, Xingge Liu, Ziming Dong, Zhenzhen Liu, Pei Li, Ping Che. Targeting the overexpressed USP7 inhibits esophageal squamous cell carcinoma cell growth by inducing NOXA-mediated apoptosis. Molecular carcinogenesis. vol 58. issue 1. 2019-07-05. PMID:30182448. |
mechanistically, inhibition of usp7 accumulated poly-ubiquitinated proteins, activated endoplasmic reticulum stress, and increased expression of atf4, which transcriptionally upregulated expression of noxa and induced noxa-mediated apoptosis. |
2019-07-05 |
2023-08-13 |
Not clear |
| Haixia Zhao, Na Ma, Zhaoqi Liu, Ting Wang, Chengfu Yuan, Yumin He, Yaoyan Dun, Zhiyong Zhou, Ding Yuan, Changcheng Zhan. Protective effect of Wuzi Yanzong recipe on testicular dysfunction through inhibition of germ cell apoptosis in ageing rats via endoplasmic reticulum stress. Andrologia. vol 51. issue 2. 2019-05-29. PMID:30393883. |
in addition, wz significantly activated the onset of ers and prevented germ cell apoptosis by upregulating the expression levels of ers-responsive proteins grp78, phospho-perk, phospho-eif2α, atf4, phospho-ire-1α, xbp1 and atf6α, and downregulating the expression levels of pro-apoptotic proteins p-jnk, caspase12 and chop in testicular germ cell of ageing rats. |
2019-05-29 |
2023-08-13 |
rat |
| Hairong Xin, Yintian Deng, Jie Ca. Proviral insertion in murine lymphomas 2 promotes stomach cancer progression by regulating apoptosis via reactive oxygen species-triggered endoplasmic reticulum stress. Biochemical and biophysical research communications. vol 506. issue 1. 2019-05-21. PMID:30340823. |
knockdown of pim2 induced apoptosis in gastric cancer cells, which was regulated by endoplasmic reticulum (er) stress, as evidenced by the increased expression levels of activating transcription factor (atf) 6, atf4, x-box- binding protein-1 (xbp-1) and c/ebp homologous protein (chop). |
2019-05-21 |
2023-08-13 |
Not clear |
| Yuan Gao, Xiaochun Wu, Shuqin Zhao, Yujun Zhang, Hailong Ma, Zhen Yang, Wanghao Yang, Chen Zhao, Li Wang, Quanwei Zhan. Melatonin receptor depletion suppressed hCG-induced testosterone expression in mouse Leydig cells. Cellular & molecular biology letters. vol 24. 2019-05-17. PMID:30915128. |
to further investigate the potential roles of melatonin receptors in hcg-induced regulation of er stress and apoptosis, we examined expression of some crucial er stress markers, including grp78, chop, atf4, xbp1, and ire1. |
2019-05-17 |
2023-08-13 |
mouse |
| Anita Skakic, Marina Andjelkovic, Natasa Tosic, Kristel Klaassen, Maja Djordjevic, Sonja Pavlovic, Maja Stojiljkovi. CRISPR/Cas9 genome editing of SLC37A4 gene elucidates the role of molecular markers of endoplasmic reticulum stress and apoptosis in renal involvement in glycogen storage disease type Ib. Gene. vol 703. 2019-05-17. PMID:30951856. |
in this model system we used rt-qpcr analysis to investigate the expression of molecular markers of the upr response (atf4, ddit3, hspa5, and xbp1s) and apoptosis (bcl2, bax). |
2019-05-17 |
2023-08-13 |
human |
| Yinghui Ju, Yong Su, Qingqing Chen, Keke Ma, Tianjiao Ji, Zhongyuan Wang, Weizu Li, Weiping L. Protective effects of Astragaloside IV on endoplasmic reticulum stress-induced renal tubular epithelial cells apoptosis in type 2 diabetic nephropathy rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-03-22. PMID:30396095. |
taken together, our study suggests that the protective effects of as-iv may be related to inhibit er stress-induced apoptosis through down-regulating the expression of p-perk, atf4 and chop. |
2019-03-22 |
2023-08-13 |
rat |
| Zhiqiang Ma, Yang Yang, Shouyin Di, Xiao Feng, Dong Liu, Shuai Jiang, Wei Hu, Zhigang Qin, Yue Li, Jianjun Lv, Chongxi Fan, Xiaolong Yan, Xiaofei L. Pterostilbene exerts anticancer activity on non-small-cell lung cancer via activating endoplasmic reticulum stress. Scientific reports. vol 7. issue 1. 2019-03-06. PMID:28808300. |
in this study, we show that pt treatment time- and dose-dependently enhanced the endoplasmic reticulum stress (ers) signaling (i.e., p-perk, ire1, atf4, chop), thus decreasing the cell viability and inducing apoptosis in human pc9 and a549 nsclc cell lines. |
2019-03-06 |
2023-08-13 |
human |
| Xian-Qiang Ni, Wei-Wei Lu, Jin-Sheng Zhang, Qing Zhu, Jin-Ling Ren, Yan-Rong Yu, Xiu-Ying Liu, Xiu-Jie Wang, Mei Han, Qing Jing, Jie Du, Chao-Shu Tang, Yong-Fen Q. Inhibition of endoplasmic reticulum stress by intermedin1-53 attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE KO Mice. Endocrine. vol 62. issue 1. 2019-02-18. PMID:29943223. |
imd sirna aggravated the chop, caspase12-mediated vsmc apoptosis, which was abolished by atf4 silencing. |
2019-02-18 |
2023-08-13 |
mouse |
| Leah Persaud, Jason Mighty, Xuelin Zhong, Ashleigh Francis, Marifer Mendez, Hilal Muharam, Stephen M Redenti, Dibash Das, Bertal Huseyin Aktas, Moira Sauan. IL-24 Promotes Apoptosis through cAMP-Dependent PKA Pathways in Human Breast Cancer Cells. International journal of molecular sciences. vol 19. issue 11. 2019-02-08. PMID:30424508. |
in particular, er stress-induced apoptosis is primarily regulated through the extent of eif2α phosphorylation and activating transcription factor 4 (atf4) action. |
2019-02-08 |
2023-08-13 |
human |
| Yifan Jia, Zeyu Li, Yang Feng, Ruixia Cui, Yanyan Dong, Xing Zhang, Xiaohong Xiang, Kai Qu, Chang Liu, Jingyao Zhan. Methane-Rich Saline Ameliorates Sepsis-Induced Acute Kidney Injury through Anti-Inflammation, Antioxidative, and Antiapoptosis Effects by Regulating Endoplasmic Reticulum Stress. Oxidative medicine and cellular longevity. vol 2018. 2019-01-22. PMID:30581532. |
in addition, the endoplasmic reticulum (er) stress-related glucose-regulated protein 78 (grp78)/activating transcription factor 4 (atf4)/c/ebp homologous protein (chop)/caspase-12 apoptosis signaling pathway was significantly suppressed in the clp + mrs group. |
2019-01-22 |
2023-08-13 |
mouse |
| Zhaohui Li, Jia Wu, Lei Shen. Ibrutinib improves the development of acute lymphoblastic leukemia by activating endoplasmic reticulum stress-induced cell death. Die Pharmazie. vol 73. issue 5. 2019-01-17. PMID:29724297. |
more importantly, once er-stress was suppressed by tauroursodeoxycholic acid (tudca), an er-stress inhibitor, the upregulation of bip, atf4, chop, cleaved-caspase3 and cleaved-parp after ibrutinib treatment was partially reversed, suggesting that induction of all cell apoptosis by ibrutinib was partially attributed to activation of er stress. |
2019-01-17 |
2023-08-13 |
Not clear |
| Zhang Zhao, Guo-Chang Liu, Wen F. Role of PERK-eIF2α signaling pathway in fetal male rats with hypospadias induced by di-n-butyl phthalate. The Kaohsiung journal of medical sciences. vol 34. issue 9. 2019-01-02. PMID:30173778. |
further, p-perk, p-eif2α and atf4 protein expressions and the ratio of lc3-ii/lc3-i were greatly increased in the gts of fetal rats, while apoptosis index (ai) and p62 protein expression were evidently decreased (all p < 0.05). |
2019-01-02 |
2023-08-13 |
rat |