| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Caroline Demangel, Stephen Hig. Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease. Biology of the cell. vol 110. issue 11. 2018-12-17. PMID:30055020. |
prolonged exposure to mycolactone is normally cytotoxic, since it triggers stress responses activating the transcription factor atf4 and ultimately inducing apoptosis. |
2018-12-17 |
2023-08-13 |
Not clear |
| Sandeep C Chaudhary, Mohammad Waseem, Mehtab Rana, Hui Xu, Levy Kopelovich, Craig A Elmets, Mohammad Atha. Naproxen Inhibits UVB-induced Basal Cell and Squamous Cell Carcinoma Development in Ptch1 Photochemistry and photobiology. vol 93. issue 4. 2018-12-11. PMID:28329421. |
in bcc and scc cells, naproxen-induced apoptosis and activated unfolded protein response (upr) signaling with increased expression of atf4, p-eif2α and chop. |
2018-12-11 |
2023-08-13 |
Not clear |
| Qifei Wang, Guangzhen Wu, Xiangyu Che, Quanlin Li, Zhiwei Zhang, Qizhen Tan. Sorafenib induces renal cell carcinoma apoptosis Die Pharmazie. vol 73. issue 3. 2018-12-11. PMID:29544563. |
meanwhile, overexpression of atf4 was demonstrated to induce achn cell cycle arrest and cell apoptosis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Qifei Wang, Guangzhen Wu, Xiangyu Che, Quanlin Li, Zhiwei Zhang, Qizhen Tan. Sorafenib induces renal cell carcinoma apoptosis Die Pharmazie. vol 73. issue 3. 2018-12-11. PMID:29544563. |
meanwhile, sorafenib-induced cell apoptosis may be dependent on the activation of atf4 since knockdown of atf4 partially reversed sorafenib-induced achn cell apoptosis. |
2018-12-11 |
2023-08-13 |
Not clear |
| X-Z Lu, Z-H Yang, H-J Zhang, L-L Zhu, X-L Mao, Y Yua. MiR-214 protects MC3T3-E1 osteoblasts against H2O2-induced apoptosis by suppressing oxidative stress and targeting ATF4. European review for medical and pharmacological sciences. vol 21. issue 21. 2018-08-07. PMID:29164589. |
mir-214 protects mc3t3-e1 osteoblasts against h2o2-induced apoptosis by suppressing oxidative stress and targeting atf4. |
2018-08-07 |
2023-08-13 |
Not clear |
| Janet M Menzie-Suderam, Payam Mohammad-Gharibani, Jigar Modi, Zea Ma, Rui Tao, Howard Prentice, Jang-Yen W. Granulocyte-colony stimulating factor protects against endoplasmic reticulum stress in an experimental model of stroke. Brain research. vol 1682. 2018-08-03. PMID:29277709. |
g-csf treatment significantly (p < .05) attenuated the expression of proteins involved in er stress apoptosis pathway; atf4, atf6, p-p38mapk, pjnk and chop. |
2018-08-03 |
2023-08-13 |
rat |
| Sung-Min Ju, Yong-Seok Jo, Yoo-Min Jeon, Hyun-Ock Pae, Dae-Gill Kang, Ho-Sub Lee, Jun-Sang Bae, Byung-Hun Jeo. Phosphorylation of eIF2α suppresses cisplatin-induced p53 activation and apoptosis by attenuating oxidative stress via ATF4-mediated HO-1 expression in human renal proximal tubular cells. International journal of molecular medicine. vol 40. issue 6. 2018-07-20. PMID:29039478. |
taken together, these results suggest that phosphorylation of eif2α suppresses cisplatin‑induced p53 activation and apoptosis by attenuating oxidative stress via atf4-mediated ho-1 expression in hk-2 cells, as atf4 expression is usually dependent on the phosphorylation of eif2α and may also transcriptionally induce the expression of ho-1 in response to oxidative stress. |
2018-07-20 |
2023-08-13 |
human |
| Guanqun Ge, Yan Yan, Hui Ca. Ginsenoside Rh2 Inhibited Proliferation by Inducing ROS Mediated ER Stress Dependent Apoptosis in Lung Cancer Cells. Biological & pharmaceutical bulletin. vol 40. issue 12. 2018-07-17. PMID:28966297. |
activating transcription factor 4 (atf4), ccaat/enhancer-binding protein homologous protein (chop), and caspase-4 were involved in g-rh2-induced apoptosis of h1299 cells. |
2018-07-17 |
2023-08-13 |
Not clear |
| Guanqun Ge, Yan Yan, Hui Ca. Ginsenoside Rh2 Inhibited Proliferation by Inducing ROS Mediated ER Stress Dependent Apoptosis in Lung Cancer Cells. Biological & pharmaceutical bulletin. vol 40. issue 12. 2018-07-17. PMID:28966297. |
in addition, nac (n-acetylcysteine, a reactive oxygen species (ros) scavenger) treatment dramatically decreased ros generation in h1299 cells; both of nac and 4-pba (4-phenylbutyrate, a specific endoplasmic reticulum (er) stress inhibitor) administration impaired apoptosis and expression levels of atf4, chop and caspase-4 in g-rh2 incubated h1299 cells. |
2018-07-17 |
2023-08-13 |
Not clear |
| Ritesh K Srivastava, Changzhao Li, Zhiping Weng, Anupam Agarwal, Craig A Elmets, Farrukh Afaq, Mohammad Atha. Defining cutaneous molecular pathobiology of arsenicals using phenylarsine oxide as a prototype. Scientific reports. vol 6. 2018-07-02. PMID:27725709. |
similar to its effects in murine epidermis, a dose- and time-dependent upregulation of ros, cytokines, upr proteins (grp78, p-perk, p-eif2α, atf4 and chop) and apoptosis were observed in pao-treated human skin keratinocytes nhek and hacat. |
2018-07-02 |
2023-08-13 |
human |
| Pingping Liang, Lin Zhong, Lei Gong, Jiahui Wang, Yujie Zhu, Weifeng Liu, Jun Yan. Fibroblast growth factor 21 protects rat cardiomyocytes from endoplasmic reticulum stress by promoting the fibroblast growth factor receptor 1-extracellular signal‑regulated kinase 1/2 signaling pathway. International journal of molecular medicine. vol 40. issue 5. 2018-05-30. PMID:28949374. |
however, excessive er stress (tm ≥10 µm) activated the er stress-mediated apoptosis signaling pathways, including pkr-like er kinase (perk)-eukaryotic translational initiation factor 2α (eif2α)-activating transcription factor 4 (atf4)-ccaat/-enhancer-binding protein homologous protein (chop) and inositol-requiring kinase 1α (ire1α)-c-jun n-terminal kinases (jnk), as well as inhibited the expression of fgf21 and its primary receptors. |
2018-05-30 |
2023-08-13 |
rat |
| Xiaowen Gong, Hui Xie, Xiaoyong Li, Ji Wu, Yi Li. Bisphenol A induced apoptosis and transcriptome differences of spermatogonial stem cells in vitro. Acta biochimica et biophysica Sinica. vol 49. issue 9. 2018-05-23. PMID:28910977. |
among the cluster of degs associated with the kyoto encyclopedia of genes and genomes (kegg) apoptosis pathway, activating transcription factor 4 (atf4) and dna damage inducible transcript 3 (ddit3) genes were significantly up-regulated in bpa-treated sscs, which were proved by qpcr. |
2018-05-23 |
2023-08-13 |
mouse |
| Ravyn M Thompson, Dominik Dytfeld, Leticia Reyes, Reeder M Robinson, Brittany Smith, Yefim Manevich, Andrzej Jakubowiak, Mieczyslaw Komarnicki, Anna Przybylowicz-Chalecka, Tomasz Szczepaniak, Amit K Mitra, Brian G Van Ness, Magdalena Luczak, Nathan G Dollof. Glutaminase inhibitor CB-839 synergizes with carfilzomib in resistant multiple myeloma cells. Oncotarget. vol 8. issue 22. 2018-03-26. PMID:28415782. |
mechanistically, cb-839 enhanced crflz-induced er stress and apoptosis, characterized by a robust induction of atf4 and chop and the activation of caspases. |
2018-03-26 |
2023-08-13 |
Not clear |
| Juhyun Song, Oh Yoen Ki. Melatonin Modulates Neuronal Cell Death Induced by Endoplasmic Reticulum Stress under Insulin Resistance Condition. Nutrients. vol 9. issue 6. 2018-03-19. PMID:28604593. |
apoptosis cell death signaling markers (cleaved poly [adp-ribose] polymerase 1 (parp), p53, and bax) and er stress markers (phosphorylated eif2α (p-eif2α), atf4, chop, |
2018-03-19 |
2023-08-13 |
Not clear |
| Zhimeng Wu, Meiling Li, Wei Zheng, Qin Hu, Zhi Cheng, Fengjin Gu. Silencing of both ATF4 and PERK inhibits cell cycle progression and promotes the apoptosis of differentiating chondrocytes. International journal of molecular medicine. vol 40. issue 1. 2018-03-16. PMID:28498443. |
silencing of both atf4 and perk inhibits cell cycle progression and promotes the apoptosis of differentiating chondrocytes. |
2018-03-16 |
2023-08-13 |
Not clear |
| Zhimeng Wu, Meiling Li, Wei Zheng, Qin Hu, Zhi Cheng, Fengjin Gu. Silencing of both ATF4 and PERK inhibits cell cycle progression and promotes the apoptosis of differentiating chondrocytes. International journal of molecular medicine. vol 40. issue 1. 2018-03-16. PMID:28498443. |
on the whole, these findings reveal a new crucial combined effect of the silencing of perk and atf4 in modulating er stress‑mediated apoptosis during chondrocyte differentiation and proliferation. |
2018-03-16 |
2023-08-13 |
Not clear |
| Jeffrey J Rodvold, Kevin T Chiu, Nobuhiko Hiramatsu, Julia K Nussbacher, Valentina Galimberti, Navin R Mahadevan, Karl Willert, Jonathan H Lin, Maurizio Zanett. Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells. Science signaling. vol 10. issue 482. 2018-03-12. PMID:28588081. |
however, ters-induced enhancement of cell survival was predominantly mediated by the upr kinase perk and a reduction in the abundance of the transcription factor atf4, which prevented the activation of the transcription factor chop and, consequently, the induction of apoptosis. |
2018-03-12 |
2023-08-13 |
mouse |
| Zhenjiang Liu, Huihui Gu, Lu Gan, Yatao Xu, Fei Feng, Muhammad Saeed, Chao Su. Reducing Smad3/ATF4 was essential for Sirt1 inhibiting ER stress-induced apoptosis in mice brown adipose tissue. Oncotarget. vol 8. issue 6. 2018-02-26. PMID:28030827. |
further analysis revealed that sirt1 overexpression alleviated er stress-induced brown adipocyte apoptosis by inhibiting smad3 and atf4. |
2018-02-26 |
2023-08-13 |
mouse |
| Zhenjiang Liu, Huihui Gu, Lu Gan, Yatao Xu, Fei Feng, Muhammad Saeed, Chao Su. Reducing Smad3/ATF4 was essential for Sirt1 inhibiting ER stress-induced apoptosis in mice brown adipose tissue. Oncotarget. vol 8. issue 6. 2018-02-26. PMID:28030827. |
our data also confirmed that sirt1 reduced early apoptotic cells and blocked the mitochondrial apoptosis pathway by directly interacting with atf4. |
2018-02-26 |
2023-08-13 |
mouse |
| Inge M N Wortel, Laurens T van der Meer, Michael S Kilberg, Frank N van Leeuwe. Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells. Trends in endocrinology and metabolism: TEM. vol 28. issue 11. 2018-02-26. PMID:28797581. |
however, under persistent stress conditions, atf4 promotes the induction of apoptosis. |
2018-02-26 |
2023-08-13 |
Not clear |