| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chun-Yen Wu, Da-Fong Song, Zhi-Jia Chen, Chao-Sheng Hu, David Pei-Cheng Lin, Han-Hsin Chan. Absence of the Klotho Function Causes Cornea Degeneration with Specific Features Resembling Fuchs Endothelial Corneal Dystrophy and Bullous Keratopathy. Biology. vol 13. issue 3. 2024-03-27. PMID:38534403. |
the mechanism analysis showed multi-fold abnormalities, including oxidative stress-induced cornea epithelium apoptosis and inflammation, extracellular matrix remodeling in the stroma, and a disruption of epithelial repair, presumably through the epithelial-mesenchymal transition. |
2024-03-27 |
2024-03-29 |
mouse |
| Kuangqi Chen, Le Jin, Yingying Wen, Qianjie Yang, Xiang Li, Liyue Zhang, Liyin Wang, Yutong Xia, Zhitong Chen, Chen Xie, Jianping Tong, Ye She. Blue light impairs cornea and corneal wound healing by downregulating VCAM1 partly. iScience. vol 26. issue 12. 2023-11-30. PMID:38034364. |
animal experiments confirmed that bl pollution caused similar effects on the rabbit cornea, including increased ros production, apoptosis, delayed wound healing, and decreased vcam1 expression. |
2023-11-30 |
2023-12-10 |
human |
| Minal Thacker, Abhishek Sahoo, A Aniruth Reddy, Kiran K Bokara, Swati Singh, Sayan Basu, Vivek Sing. Benzalkonium chloride-induced dry eye disease animal models: Current understanding and potential for translational research. Indian journal of ophthalmology. vol 71. issue 4. 2023-04-07. PMID:37026256. |
bac induces high levels of proinflammatory cytokines in the cornea and conjunctiva, along with epithelial cell apoptosis and reduction of mucins, which leads to tear film instability, thereby successfully simulating human ded. |
2023-04-07 |
2023-08-14 |
mouse |
| Zhen-Ning Zhang, Hai Liu, Mi-Mi Liu, Dan-Lei Yang, Jue Bi, Qian-Qian Chen, Wei Chen, Ping Xian. Effects of Nickel at Environmentally Relevant Concentrations on Human Corneal Epithelial Cells: Oxidative Damage and Cellular Apoptosis. Biomolecules. vol 12. issue 9. 2022-09-23. PMID:36139122. |
here, human corneal epithelial cells (hcec) were employed to analyze the toxicity of ni via detections of cell morphology, cell viability, reactive oxygen species production, cell apoptosis rate, and apoptotic gene expression levels after exposure for 24 h to uncover the damage of ni to the cornea. |
2022-09-23 |
2023-08-14 |
human |
| Sawetree Pakkarato, Hiroyuki Sakagami, Kaoru Goto, Masahiko Watanabe, Hisatake Kondo, Wiphawi Hipkaeo, Surang Chompho. Localization of phosphatidylinositol phosphate 5 kinase γ, phospholipase β3 and diacylglycerol kinase ζ in corneal epithelium in comparison with conjunctival epithelium of mice. Experimental eye research. 2022-08-13. PMID:35963308. |
dgkζ is involved in regulation from birth of the transcription in epithelial cells, including apoptosis as well as regulation of mitosis of epithelial cells in both cornea and conjunctiva, with the transcription involvement more apparent in the conjunctiva, although it does not work in stem cells of the corneal limbus. |
2022-08-13 |
2023-08-14 |
mouse |
| Yi-Jen Hsueh, Yen-Ning Chen, Yu-Ting Tsao, Chao-Min Cheng, Wei-Chi Wu, Hung-Chi Che. The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163178. |
we review the oxidative damage (e.g., lipid peroxidation, dna lesions, autophagy, and apoptosis) that occurs in different areas of the eye (e.g., cornea, anterior chamber, lens, retina, and optic nerve). |
2022-02-15 |
2023-08-13 |
Not clear |
| Po-Yen Lee, Yu-Hung Lai, Po-Len Liu, Ching-Chih Liu, Chia-Cheng Su, Fang-Yen Chiu, Wei-Chung Cheng, Shiuh-Liang Hsu, Kai-Chun Cheng, Li-Yi Chiu, Tzu-En Kao, Chia-Ching Lin, Yo-Chen Chang, Shu-Chi Wang, Chia-Yang L. Toxicity of amantadine hydrochloride on cultured bovine cornea endothelial cells. Scientific reports. vol 11. issue 1. 2021-11-10. PMID:34531501. |
in the present study, the effects of amantadine hcl on cell growth, proliferation, and apoptosis in bovine cornea endothelial cells, and in vitro endothelial permeability were examined. |
2021-11-10 |
2023-08-13 |
cattle |
| Po-Yen Lee, Yu-Hung Lai, Po-Len Liu, Ching-Chih Liu, Chia-Cheng Su, Fang-Yen Chiu, Wei-Chung Cheng, Shiuh-Liang Hsu, Kai-Chun Cheng, Li-Yi Chiu, Tzu-En Kao, Chia-Ching Lin, Yo-Chen Chang, Shu-Chi Wang, Chia-Yang L. Toxicity of amantadine hydrochloride on cultured bovine cornea endothelial cells. Scientific reports. vol 11. issue 1. 2021-11-10. PMID:34531501. |
results showed that lower doses of amantadine hcl do not affect cell growth (≤ 20 μΜ), whereas higher doses of amantadine hcl inhibits cell growth (≥ 50 μΜ), induces apoptosis (2000 μΜ), increases sub-g1 phase growth arrest (2000 μΜ), causes dna damage (≥ 1000 μΜ), and induces endothelial hyperpermeability (≥ 1000 μΜ) in bovine cornea endothelial cells; additionally, we also found that amantadine hcl attenuates the proliferation (≥ 200 μΜ) and arrests cell cycle at g1 phase (≥ 200 μΜ) in bovine cornea endothelial cells. |
2021-11-10 |
2023-08-13 |
cattle |
| Juan Li, Guangwei Zhang, Shen Nian, Yali Lv, Yi Shao, Nini Qiao, Rongbin Liang, Lihua Huang, Ali Lu. Dry eye induced by exposure to cigarette smoke pollution: An in vivo and in vitro study. Free radical biology & medicine. vol 153. 2021-06-18. PMID:32320747. |
apoptosis and ki67 increased in both the conjunctiva and the cornea of cs-exposed animals. |
2021-06-18 |
2023-08-13 |
mouse |
| Qing-Yang Feng, Zi-Xuan Hu, Xi-Ling Song, Hong-Wei Pa. Aberrant expression of genes and proteins in pterygium and their implications in the pathogenesis. International journal of ophthalmology. vol 10. issue 6. 2020-10-01. PMID:28730091. |
in this review, we summarize the aberrant expression of a range of genes and proteins in pterygium compared with normal conjunctiva or cornea, including growth factors, matrix metalloproteinases and tissue inhibitors of metalloproteinases, interleukins, tumor suppressor genes, proliferation related proteins, apoptosis related proteins, cell adhesion molecules, extracellular matrix proteins, heat shock proteins and tight junction proteins. |
2020-10-01 |
2023-08-13 |
human |
| Wen Yi Fan, Yun Long Sui, Ting Jun Fa. Proparacaine induces cytotoxicity and mitochondria-dependent apoptosis in corneal stromal cells both Toxicology research. vol 5. issue 5. 2020-09-30. PMID:30090447. |
proparacaine induces cytotoxicity and mitochondria-dependent apoptosis in corneal stromal cells both proparacaine (ppc) is a widely used topical anaesthetic in the eye clinic; its abuse may damage the cornea and result in impairment of vision. |
2020-09-30 |
2023-08-13 |
human |
| Mohammed Ziaei, Akilesh Gokul, Hans Vellara, Dipika Patel, Charles Nj McGhe. Peripheral Cornea Crosslinking Before Deep Anterior Lamellar Keratoplasty. Medical hypothesis, discovery & innovation ophthalmology journal. vol 9. issue 2. 2020-09-28. PMID:32490019. |
since cornea crosslinking (cxl) has been proven to halt progression and biomechanically stabilize keratoconus, we hypothesized that cxl of the corneal periphery 3 months prior to corneal transplantation can reduce the incidence of recurrent ectasia by strengthening the peripheral corneal tissue and causing apoptosis of diseased peripheral host keratocytes. |
2020-09-28 |
2023-08-13 |
Not clear |
| Can Zhao, Wenjing Li, Haoyun Duan, Zongyi Li, Yanni Jia, Songmei Zhang, Xin Wang, Qingjun Zhou, Weiyun Sh. NAD American journal of physiology. Cell physiology. vol 318. issue 4. 2020-08-04. PMID:32049549. |
here we hypothesize that nic may possess the capacity to protect the cornea from uvb-induced endothelial apoptosis. |
2020-08-04 |
2023-08-13 |
mouse |
| Guang Wang, Ling-Min Jiang, Bao-Yi Tan, Pei-Zhi Li, Pei-Ling Zhang, Yu Zhang, Xin Cheng, Zheng-Lai Ma, Zhi-Jie Li, Beate Brand-Saberi, Xuesong Yan. Cell survival controlled by lens-derived Sema3A-Nrp1 is vital on caffeine-suppressed corneal innervation during chick organogenesis. Journal of cellular physiology. vol 234. issue 6. 2020-04-13. PMID:30362583. |
taken together, we speculate here that caffeine-enhanced reactive oxygen species upregulates sema3a-nrp1 expression in the lens and periocular tissues, resulting in corneal cell apoptosis, accompanied by its chemorepellent role on the invasion of the developing cornea by trigeminal sensory fibers. |
2020-04-13 |
2023-08-13 |
chicken |
| Ufuk Ozkan, Ali Akal, Kudret Ozkan, Omer Faruk Yilmaz, Fatih Mehmet Adıbell. Investigating the effect of intracameral cefuroxime on oxidative stress and apoptosis in the rat cornea. Arquivos brasileiros de oftalmologia. vol 82. issue 4. 2020-01-14. PMID:31116319. |
investigating the effect of intracameral cefuroxime on oxidative stress and apoptosis in the rat cornea. |
2020-01-14 |
2023-08-13 |
rat |
| Fengge Liu, Hui Kong, Xiangfeng Kon. Transforming growth factor-β blocks glucose-induced inflammation and apoptosis in corneal epithelial cells. FEBS open bio. vol 8. issue 12. 2019-11-20. PMID:30524944. |
this study aimed to identify the effect of transforming growth factor-β (tgf-β) on biological events, such as apoptosis and inflammation, in the diabetic cornea. |
2019-11-20 |
2023-08-13 |
human |
| Fengge Liu, Hui Kong, Xiangfeng Kon. Transforming growth factor-β blocks glucose-induced inflammation and apoptosis in corneal epithelial cells. FEBS open bio. vol 8. issue 12. 2019-11-20. PMID:30524944. |
in conclusion, tgf-β can ameliorate the enhancement of apoptosis and inflammation in diabetic cornea in |
2019-11-20 |
2023-08-13 |
human |
| M Izadi, N Jonaidi-Jafari, M Pourazizi, M H Alemzadeh-Ansari, M J Hoseinpourfar. Photokeratitis induced by ultraviolet radiation in travelers: A major health problem. Journal of postgraduate medicine. vol 64. issue 1. 2019-10-11. PMID:29067921. |
the results show that uvr at 300 nm causes apoptosis in all three layers of the cornea and induces keratitis. |
2019-10-11 |
2023-08-13 |
Not clear |
| M Izadi, N Jonaidi-Jafari, M Pourazizi, M H Alemzadeh-Ansari, M J Hoseinpourfar. Photokeratitis induced by ultraviolet radiation in travelers: A major health problem. Journal of postgraduate medicine. vol 64. issue 1. 2019-10-11. PMID:29067921. |
apoptosis in all layers of the cornea occurs 5 h after exposure. |
2019-10-11 |
2023-08-13 |
Not clear |
| He Jin, Liangping Liu, Hui Ding, Miao He, Chi Zhang, Xingwu Zhon. Small Incision Femtosecond Laser-assisted X-ray-irradiated Corneal Intrastromal Xenotransplantation in Rhesus Monkeys: A Preliminary Study. Current molecular medicine. vol 18. issue 9. 2019-10-03. PMID:30698112. |
gamma-ray irradiation could significantly induce widespread apoptosis in corneas and reduced the allogenicity of donor cornea. |
2019-10-03 |
2023-08-13 |
monkey |