| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Poppe, C Reimertz, H Düssmann, A J Krohn, C M Luetjens, D Böckelmann, A L Nieminen, D Kögel, J H Preh. Dissipation of potassium and proton gradients inhibits mitochondrial hyperpolarization and cytochrome c release during neural apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 13. 2001-07-26. PMID:11426445. |
our data suggest two distinct mechanisms for mitochondrial cytochrome c release: (1) active cytochrome c release associated with early mitochondrial hyperpolarization, leading to neuronal apoptosis, and (2) passive cytochrome c release secondary to mitochondrial depolarization and matrix swelling. |
2001-07-26 |
2023-08-12 |
human |
| R R Fogelholm, A V Alh. Smoking and intervertebral disc degeneration. Medical hypotheses. vol 56. issue 4. 2001-07-19. PMID:11339862. |
ischemia, apoptosis, faulty synthesis of disc macromolecules, and an imbalance between disc matrix proteinases and their inhibitors may be involved in the pathogenesis of disc degeneration. |
2001-07-19 |
2023-08-12 |
Not clear |
| J Dimberg, A Hugander, A Sirsj. Decreased levels of precursor transforming growth factor beta1 in human colorectal cancer. International journal of molecular medicine. vol 7. issue 6. 2001-07-19. PMID:11351271. |
transforming growth factor (tgf) beta1 is a growth factor with wide-ranging effects on proliferation, differentiation, immunosuppression, apoptosis and matrix remodelling. |
2001-07-19 |
2023-08-12 |
human |
| T L Woodward, A S Mienaltowski, R R Modi, J M Bennett, S Z Hasla. Fibronectin and the alpha(5)beta(1) integrin are under developmental and ovarian steroid regulation in the normal mouse mammary gland. Endocrinology. vol 142. issue 7. 2001-07-19. PMID:11416044. |
extracellular matrix (ecm) proteins have been shown to regulate mammary epithelial cell proliferation, differentiation, and apoptosis in vitro. |
2001-07-19 |
2023-08-12 |
mouse |
| C S Adams, K Mansfield, R L Perlot, I M Shapir. Matrix regulation of skeletal cell apoptosis. Role of calcium and phosphate ions. The Journal of biological chemistry. vol 276. issue 23. 2001-07-12. PMID:11278303. |
matrix regulation of skeletal cell apoptosis. |
2001-07-12 |
2023-08-12 |
Not clear |
| C S Adams, K Mansfield, R L Perlot, I M Shapir. Matrix regulation of skeletal cell apoptosis. Role of calcium and phosphate ions. The Journal of biological chemistry. vol 276. issue 23. 2001-07-12. PMID:11278303. |
previously, we noted that inorganic phosphate (p(i)), a major component of bone extracellular matrix, induced osteoblast apoptosis (meleti, z., shapiro, i. m., and adams, c. s. (2000) bone (ny) 27, 359-366). |
2001-07-12 |
2023-08-12 |
Not clear |
| A Frankel, K Rosen, J Filmus, R S Kerbe. Induction of anoikis and suppression of human ovarian tumor growth in vivo by down-regulation of Bcl-X(L). Cancer research. vol 61. issue 12. 2001-07-12. PMID:11406560. |
normal or immortal epithelial cells are sensitive to a form of apoptosis, commonly referred to as anoikis, which is induced by detachment from the extracellular matrix (ecm). |
2001-07-12 |
2023-08-12 |
mouse |
| S J Fortunato, R Meno. Distinct molecular events suggest different pathways for preterm labor and premature rupture of membranes. American journal of obstetrics and gynecology. vol 184. issue 7. 2001-07-12. PMID:11408859. |
this study was designed to determine differences between preterm labor and preterm premature rupture of membranes by using molecular markers of extracellular matrix degradation and apoptosis. |
2001-07-12 |
2023-08-12 |
Not clear |
| M H Barcellos-Hoff, K B Ewa. Transforming growth factor-beta and breast cancer: Mammary gland development. Breast cancer research : BCR. vol 2. issue 2. 2001-07-05. PMID:11250698. |
transforming growth factor (tgf)-beta1 is a pluripotent cytokine that profoundly inhibits epithelial proliferation, induces apoptosis, and influences morphogenesis by mediating extracellular matrix deposition and remodeling. |
2001-07-05 |
2023-08-12 |
Not clear |
| K Hishikawa, B S Oemar, T Nakak. Static pressure regulates connective tissue growth factor expression in human mesangial cells. The Journal of biological chemistry. vol 276. issue 20. 2001-07-05. PMID:11278731. |
high levels of ctgf in turn enhance extracellular matrix production and induce apoptosis in mesangial cells, and may contribute to remodeling of mesangium and ultimately glomerulosclerosis. |
2001-07-05 |
2023-08-12 |
human |
| S Niland, A Cremer, J Fluck, J A Eble, T Krieg, S Sollber. Contraction-dependent apoptosis of normal dermal fibroblasts. The Journal of investigative dermatology. vol 116. issue 5. 2001-07-05. PMID:11348456. |
further, apoptosis in a mechanically relaxed collagen matrix could be abrogated by depolymerization of f-actin using cytochalasin d and also by disturbing actin-myosin interaction using 2,3-butanedione monoxime, indicating a possible dependence of apoptosis on mechanical forces and/or cell shape. |
2001-07-05 |
2023-08-12 |
human |
| W Wick, C Grimmel, C Wild-Bode, M Platten, M Arpin, M Welle. Ezrin-dependent promotion of glioma cell clonogenicity, motility, and invasion mediated by BCL-2 and transforming growth factor-beta2. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 10. 2001-06-21. PMID:11331365. |
glioma cells expressing dominant-negative ezrins exhibit a shift of the bcl-2/bax rheostat toward apoptosis, reduced alpha(v)beta(3) integrin expression and reduced matrix metalloproteinase (mmp) expression and activity. |
2001-06-21 |
2023-08-12 |
mouse |
| M Horlitz, U Sigwart, J Niebaue. [Statins do not prevent restenosis after coronary angioplasty: where to go from here?]. Herz. vol 26. issue 2. 2001-06-21. PMID:11349614. |
known mechanisms of restenotic lesion formation are smooth muscle cell proliferation, extracellular matrix production, remodeling and decreased programmed cell death (apoptosis). |
2001-06-21 |
2023-08-12 |
Not clear |
| S L Hsu, C C Cheng, Y R Shi, C W Chian. Proteolysis of integrin alpha5 and beta1 subunits involved in retinoic acid-induced apoptosis in human hepatoma Hep3B cells. Cancer letters. vol 167. issue 2. 2001-06-21. PMID:11369141. |
in this study, we examined the influence of cell-extracellular matrix interaction on the ability of atra to induce apoptosis. |
2001-06-21 |
2023-08-12 |
human |
| J L Contreras, G Bilbao, C A Smyth, X L Jiang, D E Eckhoff, S M Jenkins, F T Thomas, D T Curiel, J M Thoma. Cytoprotection of pancreatic islets before and soon after transplantation by gene transfer of the anti-apoptotic Bcl-2 gene. Transplantation. vol 71. issue 8. 2001-06-21. PMID:11374395. |
islet apoptosis has been documented after extracellular matrix disruption and exposure to proinflammatory cytokines, and during hypoxia before islet revascularization and rejection. |
2001-06-21 |
2023-08-12 |
mouse |
| J L Contreras, G Bilbao, C A Smyth, X L Jiang, D E Eckhoff, S M Jenkins, F T Thomas, D T Curiel, J M Thoma. Cytoprotection of pancreatic islets before and soon after transplantation by gene transfer of the anti-apoptotic Bcl-2 gene. Transplantation. vol 71. issue 8. 2001-06-21. PMID:11374395. |
bcl-2 transfection ex vivo protects these islets from apoptosis induced by disruption of the islet extracellular matrix during pancreatic digestion. |
2001-06-21 |
2023-08-12 |
mouse |
| F Remoué, D To Van, A M Schacht, M Picquet, O Garraud, J Vercruysse, A Ly, A Capron, G Rivea. Gender-dependent specific immune response during chronic human Schistosomiasis haematobia. Clinical and experimental immunology. vol 124. issue 1. 2001-06-14. PMID:11359443. |
a significantly higher nuclear matrix protein 41/7 secretion, an apoptosis marker, was specifically observed in mononuclear blood cell cultures of females suggesting that a specific cell death process was engaged in a gender-dependent manner. |
2001-06-14 |
2023-08-12 |
human |
| Y K Zhu, T Umino, X D Liu, H J Wang, D J Romberger, J R Spurzem, S I Rennar. Contraction of fibroblast-containing collagen gels: initial collagen concentration regulates the degree of contraction and cell survival. In vitro cellular & developmental biology. Animal. vol 37. issue 1. 2001-06-07. PMID:11249200. |
remodeling of extracellular matrix involves a number of steps including the recruitment, accumulation, and eventual apoptosis of parenchymal cells as well as the production, organization, and rearrangement of extracellular matrix produced by these cells. |
2001-06-07 |
2023-08-12 |
human |
| Y K Zhu, T Umino, X D Liu, H J Wang, D J Romberger, J R Spurzem, S I Rennar. Contraction of fibroblast-containing collagen gels: initial collagen concentration regulates the degree of contraction and cell survival. In vitro cellular & developmental biology. Animal. vol 37. issue 1. 2001-06-07. PMID:11249200. |
if the gels were maintained in the attached state which largely prevents contraction, apoptosis was significantly reduced, suggesting that contraction rather than matrix composition was a requirement for the increased apoptosis. |
2001-06-07 |
2023-08-12 |
human |
| J T Yu, R G Foster, D C Dea. Transcriptional repression by RB-E2F and regulation of anchorage-independent survival. Molecular and cellular biology. vol 21. issue 10. 2001-06-07. PMID:11313458. |
it is not until igf-1 expression diminishes (~16 h after loss of matrix contact) that epithelial cells deprived of matrix contact undergo apoptosis. |
2001-06-07 |
2023-08-12 |
Not clear |