| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Saeed Solouki, Farzad Mehrabi, Iraj Mirzaii-Dizga. Localization of long-term synaptic plasticity defects in cerebellar circuits using optokinetic reflex learning profile. Journal of neural engineering. 2022-06-08. PMID:35675762. |
localization of long-term synaptic plasticity defects in cerebellar circuits using optokinetic reflex learning profile. |
2022-06-08 |
2023-08-14 |
Not clear |
| Saeed Solouki, Farzad Mehrabi, Iraj Mirzaii-Dizga. Localization of long-term synaptic plasticity defects in cerebellar circuits using optokinetic reflex learning profile. Journal of neural engineering. 2022-06-08. PMID:35675762. |
in this study, investigating the effect of long-term synaptic changes on cerebellar motor learning, we intend to provide quantitative criteria for localizing defects in the major forms of synaptic plasticity in the cerebellum. |
2022-06-08 |
2023-08-14 |
Not clear |
| Natasha Saviuk, Yumaine Chong, Peng Wang, Sara Bermudez, Zhe Zhao, Arjun A Bhaskaran, Derek Bowie, Nahum Sonenberg, Ellis Cooper, A Pejmun Haghigh. Loss of 4E-BP converts cerebellar long-term depression to long-term potentiation. Cell reports. vol 39. issue 10. 2022-06-08. PMID:35675781. |
we show that genetic removal of 4e-bp, a translational suppressor and target of mammalian target of rapamycin complex 1, results in a striking change in cerebellar synaptic plasticity. |
2022-06-08 |
2023-08-14 |
mouse |
| Natasha Saviuk, Yumaine Chong, Peng Wang, Sara Bermudez, Zhe Zhao, Arjun A Bhaskaran, Derek Bowie, Nahum Sonenberg, Ellis Cooper, A Pejmun Haghigh. Loss of 4E-BP converts cerebellar long-term depression to long-term potentiation. Cell reports. vol 39. issue 10. 2022-06-08. PMID:35675781. |
biochemical and pharmacological experiments suggest that increased phosphatase activity largely accounts for the defects in ltd. our results point to a model in which translational regulation through the action of 4e-bp plays a critical role in establishing the appropriate kinase/phosphatase balance required for normal synaptic plasticity in the cerebellum. |
2022-06-08 |
2023-08-14 |
mouse |
| Marialuisa Tognolina, Anita Monteverdi, Egidio D'Angel. Discovering Microcircuit Secrets With Multi-Spot Imaging and Electrophysiological Recordings: The Example of Cerebellar Network Dynamics. Frontiers in cellular neuroscience. vol 16. 2022-04-04. PMID:35370553. |
here, we review what is known about cerebellar network organization, neural dynamics and synaptic plasticity and point out what is still missing and would require experimental assessments. |
2022-04-04 |
2023-08-13 |
Not clear |
| Haian Mao, Tomás Mediavilla, Héctor Estévez-Silva, Daniel Marcellino, Fahad Sulta. Increase of vesicular glutamate transporter 2 co-expression in the deep cerebellar nuclei related to skilled reach learning. Brain research. 2022-02-22. PMID:35192848. |
synaptic plasticity in the excitatory collaterals to the cerebellar output, the deep cerebellar nuclei (dcn), have recently been shown to be an important part of motor learning. |
2022-02-22 |
2023-08-13 |
mouse |
| Hiroshi Mitoma, Jerome Honnorat, Kazuhiko Yamaguchi, Mario Mant. Cerebellar long-term depression and auto-immune target of auto-antibodies: the concept of LTDpathies. Molecular biomedicine. vol 2. issue 1. 2022-01-10. PMID:35006439. |
interestingly, these autoantigens are all involved in molecular cascades for induction of long-term depression (ltd) of synaptic transmissions between parallel fibers (pfs) and purkinje cells (pcs), a crucial mechanism of synaptic plasticity in the cerebellum. |
2022-01-10 |
2023-08-13 |
Not clear |
| Masahiko Fujit. Associative anticipatory learning and control of the cerebellar cortex based on the spike-timing-dependent plasticity of the parallel fiber-Purkinje cell synapses. Neural networks : the official journal of the International Neural Network Society. vol 147. 2021-12-25. PMID:34953298. |
for the associative learning of temporally continuous signals, this study integrates the universal function approximation capability of the cerebellar cortex model and temporally asymmetric synaptic plasticity to create the theory of associative anticipatory learning of the cerebellum. |
2021-12-25 |
2023-08-13 |
Not clear |
| Hoda Ranjbar, Monavareh Soti, Mohammad Banazadeh, Kiarash Saleki, Kristi A Kohlmeier, Mohammad Shaban. Addiction and the cerebellum with a focus on actions of opioid receptors. Neuroscience and biobehavioral reviews. vol 131. 2021-12-03. PMID:34555385. |
further, the presence of perineural nets (pnns) in the cerebellum which contain proteins known to alter synaptic plasticity could contribute to addiction. |
2021-12-03 |
2023-08-13 |
Not clear |
| Alexander S Fanning, Amin Md Shakhawat, Jennifer L Raymon. Population calcium responses of Purkinje cells in the oculomotor cerebellum driven by nonvisual input. Journal of neurophysiology. vol 126. issue 4. 2021-11-17. PMID:34346783. |
the climbing fiber input to the cerebellum conveys instructive signals that can induce synaptic plasticity and learning by triggering complex spikes accompanied by large calcium transients in purkinje cells. |
2021-11-17 |
2023-08-13 |
mouse |
| Alexander S Fanning, Amin Md Shakhawat, Jennifer L Raymon. Population calcium responses of Purkinje cells in the oculomotor cerebellum driven by nonvisual input. Journal of neurophysiology. vol 126. issue 4. 2021-11-17. PMID:34346783. |
thus, population calcium responses of purkinje cells in the cerebellar flocculus to visual and nonvisual input are similar to what has been reported previously for complex spikes, suggesting that multimodal instructive signals control the synaptic plasticity supporting oculomotor learning. |
2021-11-17 |
2023-08-13 |
mouse |
| Hari Teja Kalidindi, Lorenzo Vannucci, Cecilia Laschi, Egidio Falotic. Cerebellar adaptive mechanisms explain the optimal control of saccadic eye movements. Bioinspiration & biomimetics. vol 16. issue 1. 2021-11-01. PMID:33150874. |
cerebellar synaptic plasticity is vital for adaptability and fine tuning of goal-directed movements. |
2021-11-01 |
2023-08-13 |
Not clear |
| Raghavendra Y Nagaraja, David M Sherry, Jennifer L Fessler, Megan A Stiles, Feng Li, Karanpreet Multani, Albert Orock, Mohiuddin Ahmad, Richard S Brush, Robert E Anderson, Martin-Paul Agbaga, Ferenc Deá. W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34. Molecular neurobiology. vol 58. issue 10. 2021-10-27. PMID:34227061. |
these results point to elovl4 as essential for motor function and cerebellar synaptic plasticity. |
2021-10-27 |
2023-08-13 |
rat |
| Raghavendra Y Nagaraja, David M Sherry, Jennifer L Fessler, Megan A Stiles, Feng Li, Karanpreet Multani, Albert Orock, Mohiuddin Ahmad, Richard S Brush, Robert E Anderson, Martin-Paul Agbaga, Ferenc Deá. W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34. Molecular neurobiology. vol 58. issue 10. 2021-10-27. PMID:34227061. |
the results further suggest that ataxia in sca34 patients may arise from a primary impairment of synaptic plasticity and cerebellar network desynchronization before onset of neurodegeneration and progression of the disease at a later age. |
2021-10-27 |
2023-08-13 |
rat |
| Chihiro Nakamoto, Kohtarou Konno, Taisuke Miyazaki, Ena Nakatsukasa, Rie Natsume, Manabu Abe, Meiko Kawamura, Yugo Fukazawa, Ryuichi Shigemoto, Miwako Yamasaki, Kenji Sakimura, Masahiko Watanab. Expression mapping, quantification, and complex formation of GluD1 and GluD2 glutamate receptors in adult mouse brain. The Journal of comparative neurology. vol 528. issue 6. 2021-10-18. PMID:31625608. |
in the cerebellum, glud2 is exclusively expressed in purkinje cells, where it regulates synapse formation and regeneration, synaptic plasticity, and motor learning. |
2021-10-18 |
2023-08-13 |
mouse |
| Elaine E Guevara, William D Hopkins, Patrick R Hof, John J Ely, Brenda J Bradley, Chet C Sherwoo. Comparative analysis reveals distinctive epigenetic features of the human cerebellum. PLoS genetics. vol 17. issue 5. 2021-09-22. PMID:33956822. |
we found greater human-specific methylation in the cerebellum than the dorsolateral prefrontal cortex, with differentially methylated regions overlapping genes involved in several conditions or processes relevant to human neurobiology, including synaptic plasticity, lipid metabolism, neuroinflammation and neurodegeneration, and neurodevelopment, including developmental disorders. |
2021-09-22 |
2023-08-13 |
human |
| F Locatelli, T Soda, I Montagna, S Tritto, L Botta, F Prestori, E D'Angel. Calcium Channel-Dependent Induction of Long-Term Synaptic Plasticity at Excitatory Golgi Cell Synapses of Cerebellum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 15. 2021-08-20. PMID:33500277. |
calcium channel-dependent induction of long-term synaptic plasticity at excitatory golgi cell synapses of cerebellum. |
2021-08-20 |
2023-08-13 |
mouse |
| Pellegrino Lippiello, Eriola Hoxha, Filippo Tempia, Maria Concetta Miniac. GIRK1-Mediated Inwardly Rectifying Potassium Current Is a Candidate Mechanism Behind Purkinje Cell Excitability, Plasticity, and Neuromodulation. Cerebellum (London, England). vol 19. issue 6. 2021-08-19. PMID:32617840. |
using patch-clamp recordings in mice cerebellar slices, we examined the properties of the girk currents in purkinje cells (pcs) and investigated the effects of a selective agonist of girk1-containing channels, ml297 (ml), on pc firing and synaptic plasticity. |
2021-08-19 |
2023-08-13 |
mouse |
| Marco Canepar. Is Purkinje Neuron Hyperpolarisation Important for Cerebellar Synaptic Plasticity? A Retrospective and Prospective Analysis. Cerebellum (London, England). vol 19. issue 6. 2021-08-19. PMID:32654026. |
is purkinje neuron hyperpolarisation important for cerebellar synaptic plasticity? |
2021-08-19 |
2023-08-13 |
Not clear |
| Stefano Casali, Marialuisa Tognolina, Daniela Gandolfi, Jonathan Mapelli, Egidio D'Angel. Cellular-resolution mapping uncovers spatial adaptive filtering at the rat cerebellum input stage. Communications biology. vol 3. issue 1. 2021-07-02. PMID:33128000. |
long-term synaptic plasticity created effective spatial filters tuning the time-delay and gain of spike retransmission at the cerebellum input stage and provided a plausible basis for the spatiotemporal recoding of input spike patterns anticipated by the motor learning theory. |
2021-07-02 |
2023-08-13 |
rat |