| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| José Ángel García-Pedraza, Mónica García, María Luisa Martín, Luis San Román, Asunción Morá. The role of endothelium-derived hyperpolarizing factor and cyclooxygenase pathways in the inhibitory serotonergic response to the pressor effect elicited by sympathetic stimulation in chronic sarpogrelate treated rats. European journal of pharmacology. vol 731. 2014-12-03. PMID:24675150. |
we have demonstrated that the antagonism of 5-ht2 receptors produces an enhancement of serotonergic sympathoinhibitory effect by 5-ht1d and 5-ht7 activation. |
2014-12-03 |
2023-08-12 |
rat |
| Ulrich W Laengle, Anne U Trendelenburg, Rudolf Markstein, Vicente Nogues, Anne Provencher-Bollinger, Danielle Roma. GLC756 decreases TNF-alpha via an alpha2 and beta2 adrenoceptor related mechanism. Experimental eye research. vol 83. issue 5. 2006-12-22. PMID:16938291. |
the receptors on which glc756 binds (d1, d2, d4, alpha-1, alpha-2, 5-ht1a, 5-ht2c, 5-ht1d, 5-ht2 a, beta-1, and beta-2) were suggested to play a role. |
2006-12-22 |
2023-08-12 |
rat |
| Mostafa El Mansari, Pierre Blie. Mechanisms of action of current and potential pharmacotherapies of obsessive-compulsive disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 30. issue 3. 2006-07-19. PMID:16427729. |
finally, based on this knowledge, new strategies aimed at producing more rapid, effective and safe anti-ocd drugs, such as a selective action on terminal 5-ht1d receptors, on 5-ht2 receptors as well as on the glutamate system, are discussed. |
2006-07-19 |
2023-08-12 |
rat |
| E Calama, A V Ortíz de Urbina, A Morán, M L Martín, L San Romá. Effect of 5-hydroxytryptamine on neurogenic vasoconstriction in the isolated, autoperfused hindquarters of the rat. Clinical and experimental pharmacology & physiology. vol 32. issue 10. 2006-01-05. PMID:16173953. |
the effects of 5-ht were mimicked by 5-carboxamidotryptamine (a 5-ht1 receptor agonist) and l-694 247 (a selective 5-ht1d receptor agonist), but not by 8-hydroxy-2-dipropylaminotetralin (a 5-ht1a receptor agonist), cgs-12066b (a 5-ht1b receptor agonist), alpha-methyl-5-ht (a 5-ht2 receptor agonist), 1-(3-chlorophenyl) piperazine (a 5-ht2c receptor agonist) or 1-phenylbiguanide (a 5-ht3 receptor agonist). |
2006-01-05 |
2023-08-12 |
rat |
| J S Sprouse, L S Reynolds, J P Braselton, H Rollema, S H Zor. Comparison of the novel antipsychotic ziprasidone with clozapine and olanzapine: inhibition of dorsal raphe cell firing and the role of 5-HT1A receptor activation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 5. 1999-11-15. PMID:10516958. |
ziprasidone is a novel antipsychotic agent which binds with high affinity to 5-ht1a receptors (ki = 3.4 nm), in addition to 5-ht1d, 5-ht2, and d2 sites. |
1999-11-15 |
2023-08-12 |
rat |
| E J Pappert, C G Goetz, G T Stebbins, M Belden, P M Carve. 5-Hydroxytryptophan-induced myoclonus in guinea pigs: mediation through 5-HT1/2 receptor subtypes. European journal of pharmacology. vol 347. issue 1. 1998-09-01. PMID:9650847. |
guinea pigs were pre-treated with carbidopa (50 mg) followed by one of eight 5-ht antagonists: (-)-n-tert-butyl-3-[4-(2-methoxyphenyl) piperazin-1-yl]-2-phenyl propionamide ((-)-way 100135) (5-ht1a), n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-ethyl]-n-(2-pyridyl)-cy clohexancarboxamide (way 100635) (5-ht1a), methiothepin mesylate (5-ht1/2), mesulergine hydrochloride (5-ht2a/2c), n[4-methoxy-3-(4-methyl-l-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2 ,4-oxadizol-3-yl) (gr 127935) (5-ht1d), trans-4-[(3z)3-(2-dimethylaminoethyl)oxyimino-3(2-fluorop hen yl) propen-1-yl]phenol, hemifumarate (sr 46349) (5-ht2), ondansetron hydrochloride (5-ht3), and [1-[2-[methylsulphonyl)amino]ethyl]-4-piperidinyl]methyl-5-fluoro-2-meth oxy-1h-indole-3-carboxylate (gr 125487) (5-ht4). |
1998-09-01 |
2023-08-12 |
Not clear |
| A Merzak, S Koochekpour, M P Fillion, G Fillion, G J Pilkingto. Expression of serotonin receptors in human fetal astrocytes and glioma cell lines: a possible role in glioma cell proliferation and migration. Brain research. Molecular brain research. vol 41. issue 1-2. 1997-02-20. PMID:8883928. |
expression of seven serotonin or 5-hydroxytryptamine (5-ht) receptors (5-ht1d alpha, 5-ht1e, 5-ht2, 5-ht1a, 5-ht1c, 5-ht1d beta, and 5-ht6) was investigated in human normal fetal astrocytes and eight glioma cell lines by reverse transcription and polymerase chain reaction (rt-pcr). |
1997-02-20 |
2023-08-12 |
human |
| T Wurch, C Palmier, F C Colpaert, P J Pauwel. Sequence and functional analysis of cloned guinea pig and rat serotonin 5-HT1D receptors: common pharmacological features within the 5-HT1D receptor subfamily. Journal of neurochemistry. vol 68. issue 1. 1997-01-27. PMID:8978753. |
the cyclic amp data show some common pharmacological features for the 5-ht1d receptors of guinea pig, rat, and human: an almost similar rank order of potency for the investigated 5-ht1d receptor agonists, stereoselectivity for the binding affinity and agonist potency of r(+)-8-hydroxy-2-(di-n-propylamino)tetralin, and equal 5-ht1d receptor-mediated antagonist potency for methiothepin and the 5-ht2 receptor antagonists ritanserin and ketanserin. |
1997-01-27 |
2023-08-12 |
mouse |
| D Hoyer, G R Marti. Classification and nomenclature of 5-HT receptors: a comment on current issues. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788515. |
at the time of the serotonin satellite meeting in chicago, the iuphar classification of receptors for 5-ht recognised four distinct receptor classes (5-ht1, 5-ht2, 5-ht3 and 5-ht4), comprising seven fully characterised functional receptor subtypes and four recombinant receptors (5-ht1d alpha, 5-ht1d beta, 5-ht1e and 5-ht1f). |
1996-12-04 |
2023-08-12 |
Not clear |
| R B Raffa, E E Cod. Lack of binding of acetaminophen to 5-HT receptor or uptake sites (or eleven other binding/uptake assays). Life sciences. vol 59. issue 2. 1996-08-30. PMID:8699917. |
in the present study, we measured the affinity of acetaminophen at 5-ht3, as well as 5-ht1a, 5-ht1b, 5-ht1d, 5-ht2, 5-ht2c, 5-ht4, 5-ht6, 5-ht7 and eleven other receptor sites and at serotonin and norepinephrine reuptake sites. |
1996-08-30 |
2023-08-12 |
Not clear |
| D Baldwin, S Rudg. The role of serotonin in depression and anxiety. International clinical psychopharmacology. vol 9 Suppl 4. 1995-08-31. PMID:7622823. |
however, we do know that 5-ht1a agonists are involved in the treatment of certain anxiety disorders, that 5-ht1c and 5-ht2 receptor antagonists may be indicated for the treatment of generalized anxiety disorder, and that 5-ht1d receptor agonists are used in the treatment of migraine. |
1995-08-31 |
2023-08-12 |
Not clear |
| D S Choi, G Birraux, J M Launay, L Maroteau. The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors. FEBS letters. vol 352. issue 3. 1994-11-07. PMID:7926008. |
the human serotonin 5-ht2b receptor: pharmacological link between 5-ht2 and 5-ht1d receptors. |
1994-11-07 |
2023-08-12 |
human |
| A J Kaumann, M Frenken, H Posival, A M Brow. Variable participation of 5-HT1-like receptors and 5-HT2 receptors in serotonin-induced contraction of human isolated coronary arteries. 5-HT1-like receptors resemble cloned 5-HT1D beta receptors. Circulation. vol 90. issue 3. 1994-10-18. PMID:8087924. |
we assessed the relative participation of 5-ht1-like and 5-ht2 receptors and attempted to identify whether vasoconstrictor 5-ht1-like receptors are 5-ht1d alpha or 5-ht1d beta. |
1994-10-18 |
2023-08-12 |
human |
| F Hery, M Hamo. [Neuroleptics and serotonin]. L'Encephale. vol 19. issue 5. 1994-03-14. PMID:7905821. |
these studies not only demonstrate the existence of several classes of serotonin receptors called 5-ht1a, 5-ht1b, 5-ht1c, 5-ht1d, 5-ht2, 5-ht3 and 5-ht4, but led also to the development of novel agonists and antagonists for the stimulation or blockade of each of them. |
1994-03-14 |
2023-08-12 |
Not clear |
| A A Alhaide. Anticholinergic, antihistaminic and cardiovascular effects of two new congeners of quipazine and trazodone. Arzneimittel-Forschung. vol 43. issue 11. 1994-02-24. PMID:7904818. |
binding studies at 5-ht receptors indicated that the quipazine analogue, compound i, has moderate affinity for the selective 5-ht1d ligand while the trazodone analogue, compound ii, binds to 5-ht2 receptors. |
1994-02-24 |
2023-08-12 |
rabbit |
| B Arranz, A Eriksson, E Mellerup, P Plenge, J Marcusso. Effect of aging in human cortical pre- and postsynaptic serotonin binding sites. Brain research. vol 620. issue 1. 1993-11-09. PMID:8402192. |
5-ht1a, 5-ht1d, 5-ht2 binding sites and affinity and 5-ht uptake sites were simultaneously determined in frontal cortex samples from 23 control subjects, aged 16-75 years. |
1993-11-09 |
2023-08-12 |
human |
| M G Erlander, T W Lovenberg, B M Baron, L de Lecea, P E Danielson, M Racke, A L Slone, B W Siegel, P E Foye, K Canno. Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 8. 1993-05-17. PMID:7682702. |
both were insensitive to 5-ht1a, 5-ht1d or 5-ht2 serotonergic ligands [8-hydroxy-2-(di-n-propylamino)tetralin, sumatriptan, and 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane]. |
1993-05-17 |
2023-08-12 |
rat |
| M R Pranzatelli, P T Tailor, P Raz. Brainstem serotonin receptors in the guinea pig: implications for myoclonus. Neuropharmacology. vol 32. issue 3. 1993-05-17. PMID:8474616. |
in guinea pig brainstem, the rank order of binding site density was: 5-ht transporter site >> 5-ht1d > antagonist-labeled 5-ht2 > 5-ht1a, 5-ht1c > 5-ht1e > agonist-labeled 5-ht2 binding site. |
1993-05-17 |
2023-08-12 |
rat |
| M R Pranzatelli, P T Tailor, P Raz. Brainstem serotonin receptors in the guinea pig: implications for myoclonus. Neuropharmacology. vol 32. issue 3. 1993-05-17. PMID:8474616. |
there were fewer 5-ht1a and 5-ht1c binding sites and 5-ht uptake sites in guinea pig than rat brainstem, more 5-ht1d and antagonist-labeled 5-ht2 sites, but the differences were 2-fold or less. |
1993-05-17 |
2023-08-12 |
rat |
| F J Monsma, Y Shen, R P Ward, M W Hamblin, D R Sible. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Molecular pharmacology. vol 43. issue 3. 1993-04-13. PMID:7680751. |
within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-ht)] receptors: 5-ht2 > 5-ht1d > 5-ht1c > 5-ht1b > 5-ht1a > 5-ht1e. |
1993-04-13 |
2023-08-12 |
rat |