| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M T Barrús, J Marín, J Villamor, G Balfagó. Receptors involved in the modulation of 5-hydroxytryptamine release in bovine cerebral arteries. The Journal of pharmacy and pharmacology. vol 44. issue 10. 1993-01-04. PMID:1360508. |
electrically-stimulated tritium release was decreased by tetrodotoxin (0.8 microm), ca-free medium, denervation with 6-ohda (1.46 mm, 10 min), 5-ht (10 microm), noradrenaline (1 microm) and the agonist of alpha 2-adrenoceptors b-ht 920 (0.1 and 1 microm), enhanced by metitepine (1 microm, antagonists of presynaptic 5-ht1 receptors) and rauwolscine (1 microm, antagonist at alpha 2-adrenoceptors, and also of 5-ht1d receptors) and not affected by ketanserin (1 microm, antagonist of 5-ht2 receptors), methysergide (0.1 microm, antagonist of 5-ht1 and 5-ht2 receptors) and phentolamine (1 and 3 microm antagonist of alpha-adrenoceptors and less potent of 5-ht1 receptors). |
1993-01-04 |
2023-08-11 |
cattle |
| M O Den Boer, C M Villalón, P R Saxen. 5-HT1-like receptor mediated changes in porcine carotid haemodynamics: are 5-HT1D receptors involved? Naunyn-Schmiedeberg's archives of pharmacology. vol 345. issue 5. 1992-10-22. PMID:1326717. |
the effect of metergoline (1 mg.kg-1), a substance with a very high affinity for the 5-ht1d receptor as well as for the 5-ht1a, 5-ht1b, 5-ht1c and 5-ht2 receptors, was studied on the responses to 5-ht and sumatriptan. |
1992-10-22 |
2023-08-11 |
Not clear |
| A Dumuis, H Gozlan, M Sebben, H Ansanay, C A Rizzi, M Turconi, E Monferini, E Giraldo, P Schiantarelli, H Ladinsk. Characterization of a novel 5-HT4 receptor antagonist of the azabicycloalkyl benzimidazolone class: DAU 6285. Naunyn-Schmiedeberg's archives of pharmacology. vol 345. issue 3. 1992-08-05. PMID:1320204. |
no significant binding (ki greater than 10 mumol/l) of dau 6285 to serotonergic 5-ht1a, 5-ht1b, 5-ht1c, 5-ht1d, and 5-ht2 receptors as well as to adrenergic alpha 1, alpha 2, dopaminergic d1, d2 or muscarinic m1-m3 receptor subtypes was found. |
1992-08-05 |
2023-08-11 |
mouse |
| M R Pranzatelli, J Ballett. Serotonin receptors in human neuroblastoma: a possible biologic tumor marker. Experimental neurology. vol 115. issue 3. 1992-04-02. PMID:1537397. |
no 5-ht1a, 5-ht1b, 5-ht1c, 5-ht1d, 5-ht2, or 5-ht uptake sites were found in any of the tumors, although all were detected in human or rat brain. |
1992-04-02 |
2023-08-11 |
human |
| G Gross, X Xin, M Gastpa. Trimipramine: pharmacological reevaluation and comparison with clozapine. Neuropharmacology. vol 30. issue 11. 1992-03-05. PMID:1663593. |
in radioligand binding studies, d,l-trimipramine showed fairly high affinities (ki 10-60 nm) for some dopamine (da), noradrenaline and 5-hydroxytryptamine (5-ht) receptor subtypes (5-ht2 receptors = alpha 1a/b-adrenoceptors greater than or equal to d2 receptors), intermediate affinities (300-550 nm) for d1 receptors, alpha 2b-adrenoceptors and 5-ht1c receptors but only low affinities (greater than 1000 nm) for alpha 2a-adrenoceptors, 5-ht1a, 5-ht1d and 5-ht3 receptors. |
1992-03-05 |
2023-08-11 |
rat |
| F P Zemlan, E F Schwa. Characterization of a novel serotonin receptor subtype (5-HT1S) in rat CNS: interaction with a GTP binding protein. Journal of neurochemistry. vol 57. issue 6. 1991-12-18. PMID:1834802. |
[3h]5-ht competition studies performed in the presence of 100 nm 8-oh-dpat and 10 nm ru 24969 (to block 5-ht1a and 5-ht1b receptors, respectively) indicated that the remaining 49% of [3h]5-ht binding did not possess the pharmacologic profile previous reported for 5-ht1c, 5-ht1d, 5-ht1e, 5-ht2, or 5-ht3 receptors. |
1991-12-18 |
2023-08-11 |
rat |
| R A Glennon, C Chaurasia, M Titele. Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region. Journal of medicinal chemistry. vol 33. issue 10. 1990-11-20. PMID:2213830. |
whereas tryptamine derivatives generally display little selectivity for the various populations of 5-ht receptors, n1-n-propyl-5-methoxy-alpha-methyltryptamine (3h) binds with significant affinity (ki = 12 nm) and selectivity at 5-ht2 receptors relative to 5-ht1a (ki = 7100 nm), 5-ht1b (ki = 5000 nm), 5-ht1c (ki = 120 nm), and 5-ht1d (ki greater than 10,000 nm) receptors. |
1990-11-20 |
2023-08-11 |
Not clear |
| W C Xiong, D L Nelso. Characterization of a [3H]-5-hydroxytryptamine binding site in rabbit caudate nucleus that differs from the 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D subtypes. Life sciences. vol 45. issue 16. 1989-12-05. PMID:2811600. |
the present findings demonstrate the presence of a high-affinity [3h]5-ht binding site in rabbit cn, designated 5-ht1r, that is different from previously defined 5-ht1a, 5-ht1b, 5-ht1c, 5-ht1d, and 5-ht2 sites. |
1989-12-05 |
2023-08-11 |
rabbit |
| P Schoeffter, D Hoye. How selective is GR 43175? Interactions with functional 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 340. issue 1. 1989-11-08. PMID:2552330. |
gr 43175 displayed the following order of affinity for 5-ht recognition sites (pkd values, -log mol/l, in parentheses): 5-ht1d (7.54) greater than 5-ht1b (6.35) greater than 5-ht1a (6.13) much greater than 5-ht1c (4.13) greater than 5-ht2 (3.67). |
1989-11-08 |
2023-08-11 |
human |