| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eva M Marco, Victor Echeverry-Alzate, Jose Antonio López-Moreno, Elena Giné, Sara Peñasco, Maria Paz Vivero. Consequences of early life stress on the expression of endocannabinoid-related genes in the rat brain. Behavioural pharmacology. vol 25. issue 5-6. 2015-03-31. PMID:25083571. |
for this, we analysed, by real-time quantitative pcr, the expression of genes encoding for cb1 and cb2 receptors, trpv1 and gpr55 (cnr1, cnr2a, cnr2b, trpv1, and gpr55), for the major enzymes of synthesis, n-acyl phosphatidyl-ethanolamine phospholipase d (nape-pld) and diacylglycerol lipase (dagl) (nape-pld, dagla and daglb), and degradation, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) (faah, magl and cox-2), in specific brain regions, that is, the frontal cortex, ventral and dorsal striatum, dorsal hippocampus and amygdala. |
2015-03-31 |
2023-08-13 |
human |
| Flaubert Tchantchou, Laura B Tucker, Amanda H Fu, Rebecca J Bluett, Joseph T McCabe, Sachin Patel, Yumin Zhan. The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury. Neuropharmacology. vol 85. 2015-03-30. PMID:24937045. |
using a tbi mouse model, we found that post-injury chronic treatment with pf3845, a selective and potent faah inhibitor, reversed tbi-induced impairments in fine motor movement, hippocampus dependent working memory and anxiety-like behavior. |
2015-03-30 |
2023-08-13 |
mouse |
| Rebecca J Henry, Daniel M Kerr, David P Finn, Michelle Roch. FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus. Journal of neuroimmunology. vol 276. issue 1-2. 2015-02-02. PMID:25245162. |
administration of the faah inhibitor urb597 increased hippocampal levels of the n-acylethanolamines palmitoylethanolamide and oleoylethanolamide, but not anandamide. |
2015-02-02 |
2023-08-13 |
rat |
| Patricia Rivera, Sergio Arrabal, Manuel Cifuentes, Jesús M Grondona, Margarita Pérez-Martín, Leticia Rubio, Antonio Vargas, Antonia Serrano, Francisco J Pavón, Juan Suárez, Fernando Rodríguez de Fonsec. Localization of the cannabinoid CB1 receptor and the 2-AG synthesizing (DAGLα) and degrading (MAGL, FAAH) enzymes in cells expressing the Ca(2+)-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus. Frontiers in neuroanatomy. vol 8. 2014-07-14. PMID:25018703. |
localization of the cannabinoid cb1 receptor and the 2-ag synthesizing (daglα) and degrading (magl, faah) enzymes in cells expressing the ca(2+)-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus. |
2014-07-14 |
2023-08-13 |
rat |
| Patricia Rivera, Sergio Arrabal, Manuel Cifuentes, Jesús M Grondona, Margarita Pérez-Martín, Leticia Rubio, Antonio Vargas, Antonia Serrano, Francisco J Pavón, Juan Suárez, Fernando Rodríguez de Fonsec. Localization of the cannabinoid CB1 receptor and the 2-AG synthesizing (DAGLα) and degrading (MAGL, FAAH) enzymes in cells expressing the Ca(2+)-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus. Frontiers in neuroanatomy. vol 8. 2014-07-14. PMID:25018703. |
for this purpose, we used double-label immunofluorescence and confocal laser scanning microscopy for the characterization of the expression of the 2-ag/cb1 signaling system (cb1 receptor, daglα, magl, and faah) and the cabps calbindin d28k, calretinin, and parvalbumin in the rat hippocampus. |
2014-07-14 |
2023-08-13 |
rat |
| Elizabeth Sabens Liedhegner, Amy Sasman, Cecilia J Hillar. Brain region-specific changes in N-acylethanolamine contents with time of day. Journal of neurochemistry. vol 128. issue 4. 2014-04-08. PMID:24138639. |
we measured concentrations of three naes, the km and vmax for fatty acid amide hydrolysis (faah), faah protein and faah mrna in prefrontal cortex, hippocampus, hypothalamus, amygdala, striatum, and cerebellum at 4 h intervals, starting at 03:00. |
2014-04-08 |
2023-08-12 |
Not clear |
| Elizabeth Sabens Liedhegner, Amy Sasman, Cecilia J Hillar. Brain region-specific changes in N-acylethanolamine contents with time of day. Journal of neurochemistry. vol 128. issue 4. 2014-04-08. PMID:24138639. |
faah km values are significantly affected by time of day in pfc, hippocampus and amygdala and faah vmax values are significantly affected in pfc, hippocampus and cerebellum. |
2014-04-08 |
2023-08-12 |
Not clear |
| D M Kerr, L Downey, M Conboy, D P Finn, M Roch. Alterations in the endocannabinoid system in the rat valproic acid model of autism. Behavioural brain research. vol 249. 2013-10-21. PMID:23643692. |
furthermore, tissue levels of the fatty acid amide hydrolase substrates, aea, oleoylethanolamide and palmitoylethanolamide, were higher in the hippocampus of vpa-exposed rats immediately following social exposure. |
2013-10-21 |
2023-08-12 |
rat |
| Laura E Wise, Kelly A Long, Rehab A Abdullah, Jonathan Z Long, Benjamin F Cravatt, Aron H Lichtma. Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice. ACS chemical neuroscience. vol 3. issue 5. 2013-08-20. PMID:22860205. |
jzl184 increased 2-ag levels in the hippocampus, prefrontal cortex, and cerebellum to a similar degree in faah -/- and +/+ mice. |
2013-08-20 |
2023-08-12 |
mouse |
| Tiffany T-Y Lee, Matthew N Hill, Cecilia J Hillard, Boris B Gorzalk. Temporal changes in N-acylethanolamine content and metabolism throughout the peri-adolescent period. Synapse (New York, N.Y.). vol 67. issue 1. 2013-05-07. PMID:22987804. |
thus, this study characterized temporal changes in nae content (aea, oleoylethanolamine [oea], and palmitoylethanolamide [pea]) and faah activity across the peri-adolescent period, in four corticolimbic structures (amygdala, hippocampus, prefrontal cortex, and hypothalamus). |
2013-05-07 |
2023-08-12 |
rat |
| Niamh Murphy, Thelma R Cowley, Christoph W Blau, Colin N Dempsey, Janis Noonan, Aoife Gowran, Riffat Tanveer, Weredeselam M Olango, David P Finn, Veronica A Campbell, Marina A Lync. The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation. Journal of neuroinflammation. vol 9. 2013-01-17. PMID:22537429. |
the fatty acid amide hydrolase inhibitor urb597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation. |
2013-01-17 |
2023-08-12 |
rat |
| N P Bowles, M N Hill, S M Bhagat, I N Karatsoreos, C J Hillard, B S McEwe. Chronic, noninvasive glucocorticoid administration suppresses limbic endocannabinoid signaling in mice. Neuroscience. vol 204. 2012-07-23. PMID:21939741. |
more precisely, we explored the effects of a 4-week exposure to cort dissolved in the drinking water of mice (100 μg/ml) and measured cannabinoid cb(1) receptor binding, endocannabinoid content, activity of the endocannabinoid degrading enzyme fatty acid amide hydrolase (faah), and mrna expression of both the cb(1) receptor and faah in both the hippocampus and amygdala. |
2012-07-23 |
2023-08-12 |
mouse |
| N P Bowles, M N Hill, S M Bhagat, I N Karatsoreos, C J Hillard, B S McEwe. Chronic, noninvasive glucocorticoid administration suppresses limbic endocannabinoid signaling in mice. Neuroscience. vol 204. 2012-07-23. PMID:21939741. |
our data demonstrate that cort decreases cb(1) receptor binding site density in both the hippocampus and amygdala and also reduced anandamide (aea) content and increased faah activity within both structures. |
2012-07-23 |
2023-08-12 |
mouse |
| Anushka V Goonawardena, John Sesay, Cheryl Ann Sexton, Gernot Riedel, Robert E Hampso. Pharmacological elevation of anandamide impairs short-term memory by altering the neurophysiology in the hippocampus. Neuropharmacology. vol 61. issue 5-6. 2012-02-16. PMID:21767554. |
stm task) and concomitant hippocampal ensemble activity were assessed following administration of either urb597 (0.3, 3.0 mg/kg), an inhibitor of the fatty acid amide hydrolase (faah), am404 (1.5, 10.0 mg/kg), a putative anandamide uptake/faah inhibitor, or r-methanandamide (3.0, 10.0 mg/kg), a stable analog of anandamide. |
2012-02-16 |
2023-08-12 |
rat |
| Francis Rodriguez Bambico, Tommaso Cassano, Sergio Dominguez-Lopez, Noam Katz, Claire Dominique Walker, Daniele Piomelli, Gabriella Gobb. Genetic deletion of fatty acid amide hydrolase alters emotional behavior and serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 10. 2010-12-06. PMID:20571484. |
genetic deletion of fatty acid amide hydrolase alters emotional behavior and serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus. |
2010-12-06 |
2023-08-12 |
mouse |
| Sherrye T Glaser, Martin Kaczoch. Cyclooxygenase-2 mediates anandamide metabolism in the mouse brain. The Journal of pharmacology and experimental therapeutics. vol 335. issue 2. 2010-11-23. PMID:20702753. |
although aea is hydrolyzed primarily by fatty acid amide hydrolase (faah), ex vivo autoradiography revealed that cox-2 inhibition by nimesulide redirected [(3)h]aea substrate from cox-2 to faah in the cortex, hippocampus, thalamus, and periaqueductal gray. |
2010-11-23 |
2023-08-12 |
mouse |
| Christian G Reich, Michael E Taylor, Margaret M McCarth. Differential effects of chronic unpredictable stress on hippocampal CB1 receptors in male and female rats. Behavioural brain research. vol 203. issue 2. 2009-09-10. PMID:19460405. |
following cms, cb1 receptor and fatty-acid-amide-hydrolase (faah) expression levels in the hippocampus were assessed by western blot analysis. |
2009-09-10 |
2023-08-12 |
rat |
| Ricardo Llorente, Alvaro Llorente-Berzal, Stefania Petrosino, Eva-María Marco, Carmen Guaza, Carmen Prada, Meritxell López-Gallardo, Vincenzo Di Marzo, María-Paz Vivero. Gender-dependent cellular and biochemical effects of maternal deprivation on the hippocampus of neonatal rats: a possible role for the endocannabinoid system. Developmental neurobiology. vol 68. issue 11. 2009-07-15. PMID:18666205. |
in addition, we investigated the putative involvement of the endocannabinoid system by evaluating (a) the effects of md on hippocampal levels of endocannabinoids (b) the modulation of md effects by two inhibitors of endocannabinoids inactivation, the fatty acid amide hydrolase inhibitor n-arachidonoyl-serotonin (aa-5-ht), and the endocannabinoid reuptake inhibitor, omdm-2. |
2009-07-15 |
2023-08-12 |
rat |
| Anuradha Nallapaneni, Jing Liu, Subramanya Karanth, Carey Pop. Pharmacological enhancement of endocannabinoid signaling reduces the cholinergic toxicity of diisopropylfluorophosphate. Neurotoxicology. vol 29. issue 6. 2009-03-26. PMID:18765251. |
we first evaluated the relative in vitro and in vivo (2.5mg/kg, sc) effects of dfp on cholinesterase, fatty acid amide hydrolase (faah, an endocannabinoid degrading enzyme), monoacylglycerol lipase (magl, another endocannabinoid degrading enzyme) and cannabinoid receptor (cb1) binding in rat hippocampus. |
2009-03-26 |
2023-08-12 |
rat |
| Anuradha Nallapaneni, Jing Liu, Subramanya Karanth, Carey Pop. Pharmacological enhancement of endocannabinoid signaling reduces the cholinergic toxicity of diisopropylfluorophosphate. Neurotoxicology. vol 29. issue 6. 2009-03-26. PMID:18765251. |
in vivo, dfp inhibited hippocampal cholinesterase (89%) and faah (42%), but had no significant effect on magl or cb1 binding. |
2009-03-26 |
2023-08-12 |
rat |