| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew N Hill, Erica J Carrier, Ryan J McLaughlin, Anna C Morrish, Sarah E Meier, Cecilia J Hillard, Boris B Gorzalk. Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment. Journal of neurochemistry. vol 106. issue 6. 2008-11-07. PMID:18643796. |
we determined the effects of cus, with or without concurrent treatment with the antidepressant imipramine (10 mg/kg), on cp55940 binding to the cannabinoid cb(1) receptor; whole tissue endocannabinoid content; and fatty acid amide hydrolase (faah) activity in the prefrontal cortex, hippocampus, hypothalamus, amygdala, midbrain and ventral striatum. |
2008-11-07 |
2023-08-12 |
rat |
| M Kurtuncu, N Battista, T Uz, A D'Agostino, N Dimitrijevic, N Pasquariello, R Manev, M Maccarrone, H Mane. Effects of cocaine in 5-lipoxygenase-deficient mice. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 3. 2008-07-01. PMID:18327533. |
since the 5-lox pathway may regulate the levels/metabolism of arachidonoylethanolamide (aea) we assayed the aea levels in the striatum, the binding of the endogenous aea to the cannabinoid receptor cb1r, and anandamide hydrolase (faah) activity in the striatum, hippocampus, and cortex. |
2008-07-01 |
2023-08-12 |
mouse |
| M Kurtuncu, N Battista, T Uz, A D'Agostino, N Dimitrijevic, N Pasquariello, R Manev, M Maccarrone, H Mane. Effects of cocaine in 5-lipoxygenase-deficient mice. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 3. 2008-07-01. PMID:18327533. |
cocaine also decreased cb1r binding in all brain regions studied and the only significant differences between 5-lox-deficient and control mice was the greater hippocampal faah activity in 5-lox-deficient mice. |
2008-07-01 |
2023-08-12 |
mouse |
| L Cristino, K Starowicz, L De Petrocellis, J Morishita, N Ueda, V Guglielmotti, V Di Marz. Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of the mouse brain. Neuroscience. vol 151. issue 4. 2008-06-12. PMID:18248904. |
in this study we used immunohistochemical techniques (single peroxidase and double immunofluorescence staining), and analyzed the localization of the trpv1 channel in mouse hippocampal and cerebellar neurons with respect to nape-pld, faah, 12-lox and comt. |
2008-06-12 |
2023-08-12 |
mouse |
| Matthew N Hill, Alasdair M Barr, W-S Vanessa Ho, Erica J Carrier, Boris B Gorzalka, Cecilia J Hillar. Electroconvulsive shock treatment differentially modulates cortical and subcortical endocannabinoid activity. Journal of neurochemistry. vol 103. issue 1. 2007-11-07. PMID:17561935. |
a single ecs session resulted in a general reduction in the binding affinity of the cb(1) receptor in all brain regions examined, as well as reductions in n-arachidonylethanolamine (anandamide) content in the prefrontal cortex and the hippocampus, reduced hydrolysis of anandamide by fatty acid amide hydrolase (faah) in the prefrontal cortex and an increase in the binding site density of the cb(1) receptor in the amygdala. |
2007-11-07 |
2023-08-12 |
Not clear |
| Ryan J McLaughlin, Matthew N Hill, Anna C Morrish, Boris B Gorzalk. Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect. Behavioural pharmacology. vol 18. issue 5-6. 2007-10-23. PMID:17762511. |
male sprague-dawley rats were bilaterally implanted with cannulae directed at the dentate gyrus of the dorsal hippocampus and subsequently received three infusions of either the cannabinoid cb1 receptor agonist hu-210 (1 and 2.5 microg), the fatty acid amide hydrolase inhibitor urb597 (0.5 and 1 microg), the cannabinoid cb1 receptor antagonist am251 (1 and 2.5 microg), or vehicle (dimethyl sulfoxide) and were assessed in the forced swim test. |
2007-10-23 |
2023-08-12 |
rat |
| Anuradha Nallapaneni, Jing Liu, Subramanya Karanth, Carey Pop. Modulation of paraoxon toxicity by the cannabinoid receptor agonist WIN 55,212-2. Toxicology. vol 227. issue 1-2. 2006-11-29. PMID:16956707. |
in vitro, paraoxon inhibited hippocampal cholinesterase and fatty acid amide hydrolase activities, and displaced specific binding to the cannabinoid receptor ligand ([(3)h]cp 55,940) in a concentration-dependent manner. |
2006-11-29 |
2023-08-12 |
rat |
| Anuradha Nallapaneni, Jing Liu, Subramanya Karanth, Carey Pop. Modulation of paraoxon toxicity by the cannabinoid receptor agonist WIN 55,212-2. Toxicology. vol 227. issue 1-2. 2006-11-29. PMID:16956707. |
four hours after dosing, paraoxon (0.4 mg/kg, sc) elicited classical signs of cholinergic toxicity and significantly reduced hippocampal cholinesterase and fatty acid amide hydrolase activities as well as [(3)h]cp 55,940 binding. |
2006-11-29 |
2023-08-12 |
rat |
| A I Gulyas, B F Cravatt, M H Bracey, T P Dinh, D Piomelli, F Boscia, T F Freun. Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala. The European journal of neuroscience. vol 20. issue 2. 2004-09-30. PMID:15233753. |
in the hippocampus, faah was present in somata and dendrites of principal cells, but not in interneurons. |
2004-09-30 |
2023-08-12 |
rat |
| Yury M Morozov, Yezekiel Ben-Ari, Tamas F Freun. The spatial and temporal pattern of fatty acid amide hydrolase expression in rat hippocampus during postnatal development. The European journal of neuroscience. vol 20. issue 2. 2004-09-30. PMID:15233754. |
the spatial and temporal pattern of fatty acid amide hydrolase expression in rat hippocampus during postnatal development. |
2004-09-30 |
2023-08-12 |
rat |
| Yury M Morozov, Yezekiel Ben-Ari, Tamas F Freun. The spatial and temporal pattern of fatty acid amide hydrolase expression in rat hippocampus during postnatal development. The European journal of neuroscience. vol 20. issue 2. 2004-09-30. PMID:15233754. |
during postnatal development of the hippocampus, the spatio-temporal expression of faah correlates well with the general pattern of neuronal maturation, but not with the arrival of afferent pathways, which suggests that faah - and its major endocannabinoid substrate, anandamide - is unlikely to be involved in the presynaptic control of neurotransmission. |
2004-09-30 |
2023-08-12 |
rat |
| M Egertová, B F Cravatt, M R Elphic. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770562. |
in the cerebellar cortex, hippocampus and neocortex of the rat brain, faah is located in the somata and dendrites of neurons that are postsynaptic to axon fibers expressing the cb(1) cannabinoid receptor [proc r soc lond b 265 (1998) 2081]. |
2003-07-30 |
2023-08-12 |
mouse |
| Angela B Clement, E Gregory Hawkins, Aron H Lichtman, Benjamin F Cravat. Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 9. 2003-06-19. PMID:12736361. |
anandamide-enhanced seizures in faah (-/-) mice resulted in significant neuronal damage in the ca1 and ca3 regions of the hippocampus for the bicuculline and kainate models, respectively. |
2003-06-19 |
2023-08-12 |
mouse |
| Angela B Clement, E Gregory Hawkins, Aron H Lichtman, Benjamin F Cravat. Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 9. 2003-06-19. PMID:12736361. |
notably, in the absence of anandamide treatment, faah (-/-) mice exhibited enhanced seizure responses to high doses of kainate that correlated with greatly elevated endogenous levels of anandamide in the hippocampus of these animals. |
2003-06-19 |
2023-08-12 |
mouse |
| b' Mauro Maccarrone, Olga Valverde, Maria L Barbaccia, Anna Casta\\xc3\\xb1\\xc3\\xa9, Rafael Maldonado, Catherine Ledent, Marc Parmentier, Alessandro Finazzi-Agr\\xc3\\xb. Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour. The European journal of neuroscience. vol 15. issue 7. 2002-06-21. PMID:11982628.' |
the age dependence of amt and faah activity were investigated in 1- or 4-month-old wt and ko animals, and found to increase with age in ko, but not wt, mice and to be higher in the hippocampus than in the cortex of all animals. |
2002-06-21 |
2023-08-12 |
mouse |
| A N Gifford, M Bruneus, S Lin, A Goutopoulos, A Makriyannis, N D Volkow, S J Gatle. Potentiation of the action of anandamide on hippocampal slices by the fatty acid amide hydrolase inhibitor, palmitylsulphonyl fluoride (AM 374). European journal of pharmacology. vol 383. issue 1. 2000-01-13. PMID:10556675. |
potentiation of the action of anandamide on hippocampal slices by the fatty acid amide hydrolase inhibitor, palmitylsulphonyl fluoride (am 374). |
2000-01-13 |
2023-08-12 |
Not clear |
| K Tsou, M I Nogueron, S Muthian, M C Sañudo-Pena, C J Hillard, D G Deutsch, J M Walke. Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry. Neuroscience letters. vol 254. issue 3. 1999-06-22. PMID:10214976. |
the large principal neurons, such as pyramidal cells in the cerebral cortex, the pyramidal cells the hippocampus, purkinje cells in the cerebellar cortex and the mitral cells in the olfactory bulb, showed the strongest faah immunoreactivity. |
1999-06-22 |
2023-08-12 |
rat |
| M Egertová, D K Giang, B F Cravatt, M R Elphic. A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain. Proceedings. Biological sciences. vol 265. issue 1410. 1998-12-22. PMID:9842734. |
high concentrations of faah activity were detected in the cerebellum, hippocampus and neocortex, regions of the rat brain which are enriched with cannabinoid receptors. |
1998-12-22 |
2023-08-12 |
rat |