| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liang Zhao, Yan Xiao, Xiao-Liang Wang, Jinjing Pei, Zhi-Zhong Gua. Original Research: Influence of okadaic acid on hyperphosphorylation of tau and nicotinic acetylcholine receptors in primary neurons. Experimental biology and medicine (Maywood, N.J.). vol 241. issue 16. 2017-06-06. PMID:27190248. |
primary cultures of neurons isolated from the hippocampus of the brains of neonatal rats were exposed to okadaic acid or/and aβ1-42 tau phosphorylated at ser404 and ser202, and the protein expressions of α7, α4 and α3 nachr subunits were quantified by western blotting, and their corresponding mrnas by real-time pcr. |
2017-06-06 |
2023-08-13 |
rat |
| Ze-Fen Wang, Zhi-Yong Pan, Cheng-Shi Xu, Zhi-Qiang L. Activation of G-protein coupled estrogen receptor 1 improves early-onset cognitive impairment via PI3K/Akt pathway in rats with traumatic brain injury. Biochemical and biophysical research communications. vol 482. issue 4. 2017-06-06. PMID:27908726. |
early-onset cognitive impairment following a single tbi was closely associated with acute hippocampal neuronal loss rather than tau pathology. |
2017-06-06 |
2023-08-13 |
human |
| Sarada Subramanian, Ganesh Savanur, Sowmya Madhavada. Passive immunization targeting the N-terminal region of phosphorylated tau (residues 68-71) improves spatial memory in okadaic acid induced tauopathy model rats. Biochemical and biophysical research communications. vol 483. issue 1. 2017-06-06. PMID:27998769. |
the cognitive impairment in patients with ad is closely associated with loss of synapses and the formation of neurofibrillary tangles (nft) containing hyperphosphorylated tau in the hippocampus. |
2017-06-06 |
2023-08-13 |
rat |
| Xiaoguang Li, Zhihao Wang, Lu Tan, Yali Wang, Chengbiao Lu, Rongxiang Chen, Shujuan Zhang, Yuan Gao, Yanchao Liu, Yaling Yin, Xinghua Liu, Enjie Liu, Ying Yang, Yu Hu, Zhipeng Xu, Fuqiang Xu, Jie Wang, Gong-Ping Liu, Jian-Zhi Wan. Correcting miR92a-vGAT-Mediated GABAergic Dysfunctions Rescues Human Tau-Induced Anxiety in Mice. Molecular therapy : the journal of the American Society of Gene Therapy. vol 25. issue 1. 2017-06-06. PMID:28129110. |
here, we found that overexpression of human wild-type, full-length tau (termed htau) in hippocampus significantly decreased the extracellular γ-aminobutyric acid (gaba) level with inhibition of γ oscillation and the evoked inhibitory postsynaptic potential (eipsp). |
2017-06-06 |
2023-08-13 |
mouse |
| Xin You Tai, Matthias Koepp, John S Duncan, Nick Fox, Pamela Thompson, Sallie Baxendale, Joan Y W Liu, Cheryl Reeves, Zuzanna Michalak, Maria Tho. Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: a study of temporal lobe resections. Brain : a journal of neurology. vol 139. issue Pt 9. 2017-06-05. PMID:27497924. |
we also found unusual patterns of subpial tau deposition, sparing of the hippocampus and co-localization with mossy fibre sprouting, a feature of temporal lobe epilepsy. |
2017-06-05 |
2023-08-13 |
Not clear |
| Cyril Laurent, Guillaume Dorothée, Stéphane Hunot, Elodie Martin, Yann Monnet, Marie Duchamp, Yuan Dong, François-Pierre Légeron, Antoine Leboucher, Sylvie Burnouf, Emilie Faivre, Kévin Carvalho, Raphaëlle Caillierez, Nadège Zommer, Dominique Demeyer, Nathalie Jouy, Veronique Sazdovitch, Susanna Schraen-Maschke, Cécile Delarasse, Luc Buée, David Blu. Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain : a journal of neurology. vol 140. issue 1. 2017-06-05. PMID:27818384. |
to address this question, we took advantage of the thy-tau22 mouse model that progressively develops hippocampal tau pathology paralleling cognitive deficits and reappraised the interrelationship between tau pathology and brain immune responses. |
2017-06-05 |
2023-08-13 |
mouse |
| Cyril Laurent, Guillaume Dorothée, Stéphane Hunot, Elodie Martin, Yann Monnet, Marie Duchamp, Yuan Dong, François-Pierre Légeron, Antoine Leboucher, Sylvie Burnouf, Emilie Faivre, Kévin Carvalho, Raphaëlle Caillierez, Nadège Zommer, Dominique Demeyer, Nathalie Jouy, Veronique Sazdovitch, Susanna Schraen-Maschke, Cécile Delarasse, Luc Buée, David Blu. Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain : a journal of neurology. vol 140. issue 1. 2017-06-05. PMID:27818384. |
in addition to conventional astroglial and microglial responses, we identified a cd8-positive t cell infiltration in the hippocampus of tau transgenic mice associated with an early chemokine response, notably involving ccl3. |
2017-06-05 |
2023-08-13 |
mouse |
| Cyril Laurent, Guillaume Dorothée, Stéphane Hunot, Elodie Martin, Yann Monnet, Marie Duchamp, Yuan Dong, François-Pierre Légeron, Antoine Leboucher, Sylvie Burnouf, Emilie Faivre, Kévin Carvalho, Raphaëlle Caillierez, Nadège Zommer, Dominique Demeyer, Nathalie Jouy, Veronique Sazdovitch, Susanna Schraen-Maschke, Cécile Delarasse, Luc Buée, David Blu. Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain : a journal of neurology. vol 140. issue 1. 2017-06-05. PMID:27818384. |
such anti-cd3 treatment prevented hippocampal t cell infiltration in tau transgenic animals and reverted spatial memory deficits, in absence of tau pathology modulation. |
2017-06-05 |
2023-08-13 |
mouse |
| Lucas T Woods, Deepa Ajit, Jean M Camden, Laurie Erb, Gary A Weisma. Purinergic receptors as potential therapeutic targets in Alzheimer's disease. Neuropharmacology. vol 104. 2017-05-26. PMID:26519903. |
many of the pathological characteristics associated with ad are revealed post-mortem, including amyloid-β plaque deposition, neurofibrillary tangles containing hyperphosphorylated tau proteins and neuronal loss in the hippocampus and cortex. |
2017-05-26 |
2023-08-13 |
human |
| Richard Kvetnansky, Petr Novak, Peter Vargovic, Katarina Lejavova, Lubica Horvathova, Katarina Ondicova, George Manz, Peter Filipcik, Michal Novak, Boris Mrave. Exaggerated phosphorylation of brain tau protein in CRH KO mice exposed to repeated immobilization stress. Stress (Amsterdam, Netherlands). vol 19. issue 4. 2017-05-18. PMID:27484105. |
we assessed expression of phosphorylated tau (p-tau) at the phf-1 epitope and ne concentrations in the locus coeruleus (lc), a1/c1 and a2/c2 catecholaminergic cell groups, hippocampus, amygdala, nucleus basalis magnocellularis, and frontal cortex of unstressed, singly stressed or repeatedly stressed mice. |
2017-05-18 |
2023-08-13 |
mouse |
| Marta Nesteruk, Tomasz Nesteruk, Maria Styczyńska, Monika Mandecka, Anna Barczak, Maria Barcikowsk. Combined use of biochemical and volumetric biomarkers to assess the risk of conversion of mild cognitive impairment to Alzheimer's disease. Folia neuropathologica. vol 54. issue 4. 2017-05-09. PMID:28139818. |
the aim of our study was to evaluate the usefulness of several biomarkers in predicting the conversion of mild cognitive impairment (mci) to alzheimer's disease (ad): β-amyloid and tau proteins in cerebrospinal fluid and the volumetric evaluation of brain structures including the hippocampus in magnetic resonance imaging (mri). |
2017-05-09 |
2023-08-13 |
Not clear |
| Hong-Chun Li, Jie Xiao, Yi-Long Huang, Long-Jun Li, Hong Jiang, Li-Xuan Huang, Ting Yang, Ling Yang, Fan L. [Reduction in hypoxia-derived neuroinflammation and dysfunctional glutamate transporters by minocycline may restore hypoxia-injured cognition of neonatal rat]. Sheng li xue bao : [Acta physiologica Sinica]. vol 68. issue 2. 2017-04-28. PMID:27108901. |
inflammatory mediators (iba-1, il-1β, tnf-α and tgf-β1), glutamate transporters (eaat1 and eaat2), total tau and phosphorylated tau (phosphorylation sites: tyr18, thr205, thr231, ser396 and ser404) protein expressions in the hippocampus were detected by western blot 7 d after hypoxic exposure. |
2017-04-28 |
2023-08-13 |
rat |
| Hong-Chun Li, Jie Xiao, Yi-Long Huang, Long-Jun Li, Hong Jiang, Li-Xuan Huang, Ting Yang, Ling Yang, Fan L. [Reduction in hypoxia-derived neuroinflammation and dysfunctional glutamate transporters by minocycline may restore hypoxia-injured cognition of neonatal rat]. Sheng li xue bao : [Acta physiologica Sinica]. vol 68. issue 2. 2017-04-28. PMID:27108901. |
the protein expression levels of iba-1, il-1β, tnf-α, eaat2 and tau phosphorylated at t231 were increased, but the total tau expression was decreased in the hippocampus of the rats from hy group 7 d after hypoxia exposure. |
2017-04-28 |
2023-08-13 |
rat |
| Marta Fernández-Nogales, María Santos-Galindo, Jesús Merchán-Rubira, Jeroen J M Hoozemans, Alberto Rábano, Isidro Ferrer, Jesús Avila, Félix Hernández, José J Luca. Tau-positive nuclear indentations in P301S tauopathy mice. Brain pathology (Zurich, Switzerland). vol 27. issue 3. 2017-04-24. PMID:27338164. |
initial detection of rod-shaped tau immunostaining in nuclei of cortical and striatal neurons of hd brains and in hippocampal neurons of early braak stage ad led us to coin the term "tau nuclear rods (tnrs)." |
2017-04-24 |
2023-08-13 |
mouse |
| Gabor G Kovacs, Jasmin Rahimi, Thomas Ströbel, Mirjam I Lutz, Günther Regelsberger, Nathalie Streichenberger, Armand Perret-Liaudet, Romana Höftberger, Pawel P Liberski, Herbert Budka, Beata Sikorsk. Tau pathology in Creutzfeldt-Jakob disease revisited. Brain pathology (Zurich, Switzerland). vol 27. issue 3. 2017-04-24. PMID:27377321. |
to determine the spectrum of tau pathologies in cjd, we assessed phospho-tau (ptau) immunoreactivities in 75 sporadic cjd cases including an evaluation of the entorhinal cortex and six hippocampal subregions. |
2017-04-24 |
2023-08-13 |
human |
| Gabor G Kovacs, Jasmin Rahimi, Thomas Ströbel, Mirjam I Lutz, Günther Regelsberger, Nathalie Streichenberger, Armand Perret-Liaudet, Romana Höftberger, Pawel P Liberski, Herbert Budka, Beata Sikorsk. Tau pathology in Creutzfeldt-Jakob disease revisited. Brain pathology (Zurich, Switzerland). vol 27. issue 3. 2017-04-24. PMID:27377321. |
however, the pattern of hippocampal tau pathology often deviates from the stages of braak. |
2017-04-24 |
2023-08-13 |
human |
| Robert John Hatch, Yan Wei, Di Xia, Jürgen Göt. Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment. Acta neuropathologica. vol 133. issue 5. 2017-04-20. PMID:28091722. |
a critical role for tau is supported by studies in transgenic mouse models that express the p301l tau mutation found in cases of familial frontotemporal dementia, with the accumulation of hyperphosphorylated tau in the hippocampus causing reductions in hippocampal long-term potentiation and impairments in spatial learning and memory. |
2017-04-20 |
2023-08-13 |
mouse |
| Robert John Hatch, Yan Wei, Di Xia, Jürgen Göt. Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment. Acta neuropathologica. vol 133. issue 5. 2017-04-20. PMID:28091722. |
furthermore, using mutagenesis and primary hippocampal neuronal cultures, we reveal that this reduction in neuronal excitability results from the relocation of the axon initial segment (ais) down the axon in a tau phosphorylation-dependent manner. |
2017-04-20 |
2023-08-13 |
mouse |
| Keith A Josephs, Melissa E Murray, Nirubol Tosakulwong, Jennifer L Whitwell, David S Knopman, Mary M Machulda, Stephen D Weigand, Bradley F Boeve, Kejal Kantarci, Leonard Petrucelli, Val J Lowe, Clifford R Jack, Ronald C Petersen, Joseph E Parisi, Dennis W Dickso. Tau aggregation influences cognition and hippocampal atrophy in the absence of beta-amyloid: a clinico-imaging-pathological study of primary age-related tauopathy (PART). Acta neuropathologica. vol 133. issue 5. 2017-04-20. PMID:28160067. |
tau aggregation influences cognition and hippocampal atrophy in the absence of beta-amyloid: a clinico-imaging-pathological study of primary age-related tauopathy (part). |
2017-04-20 |
2023-08-13 |
Not clear |
| Zhao-Xu Zhang, Rui-Ping Zhao, De-Sheng Wang, Yan-Bing L. Fuzhisan Ameliorates the Memory Deficits in Aged SAMP8 Mice via Decreasing Aβ Production and Tau Hyperphosphorylation of the Hippocampus. Neurochemical research. vol 41. issue 11. 2017-04-05. PMID:27518086. |
fuzhisan ameliorates the memory deficits in aged samp8 mice via decreasing aβ production and tau hyperphosphorylation of the hippocampus. |
2017-04-05 |
2023-08-13 |
mouse |