| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emi Hayashi-Park, Bria N Ozment, Chelsea M Griffith, Haiying Zhang, Peter R Patrylo, Gregory M Ros. Experimentally induced diabetes worsens neuropathology, but not learning and memory, in middle aged 3xTg mice. Behavioural brain research. vol 322. issue Pt B. 2017-11-30. PMID:27173425. |
subsequently, the hippocampal region was examined using immunohistochemistry (6e10 antibody for amyloid) and immunoblotting (at8 antibody for phosphorylated tau). |
2017-11-30 |
2023-08-13 |
mouse |
| Shinsuke Ishigaki, Yusuke Fujioka, Yohei Okada, Yuichi Riku, Tsuyoshi Udagawa, Daiyu Honda, Satoshi Yokoi, Kuniyuki Endo, Kensuke Ikenaka, Shinnosuke Takagi, Yohei Iguchi, Naruhiko Sahara, Akihiko Takashima, Hideyuki Okano, Mari Yoshida, Hitoshi Warita, Masashi Aoki, Hirohisa Watanabe, Haruo Okado, Masahisa Katsuno, Gen Sobu. Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes. Cell reports. vol 18. issue 5. 2017-11-28. PMID:28147269. |
hippocampus-specific fus- or sfpq-knockdown mice exhibit frontotemporal lobar degeneration (ftld)-like behaviors, reduced adult neurogenesis, accumulation of phosphorylated tau, and hippocampal atrophy with neuronal loss through an increased 4r-t/3r-t ratio. |
2017-11-28 |
2023-08-13 |
mouse |
| Glenn R Yamakawa, Connor Lengkeek, Sabrina Salberg, Simon C Spanswick, Richelle Mychasiu. Behavioral and pathophysiological outcomes associated with caffeine consumption and repetitive mild traumatic brain injury (RmTBI) in adolescent rats. PloS one. vol 12. issue 11. 2017-11-28. PMID:29108016. |
finally, modifications to expression of 12 genes (adora2a, app, aqp4, bdnf, bmal1, clock, cry, gfap, orx1, orx2, per, tau), in the prefrontal cortex, hippocampus, and/or the hypothalamus were assessed. |
2017-11-28 |
2023-08-13 |
rat |
| Xun-Hu Gu, Li-Jun Xu, Zhi-Qiang Liu, Bo Wei, Yuan-Jian Yang, Guo-Gang Xu, Xiao-Ping Yin, Wei Wan. The flavonoid baicalein rescues synaptic plasticity and memory deficits in a mouse model of Alzheimer's disease. Behavioural brain research. vol 311. 2017-11-27. PMID:27233830. |
changes in hippocampal 12/15 lipoxygenase (12/15lo) and glycogen synthase kinase 3β (gsk3β) activity, aβ production, tau phosphorylation, synaptic plasticity, and dendritic spine density were evaluated. |
2017-11-27 |
2023-08-13 |
mouse |
| Helena Soler, Jonatan Dorca-Arévalo, Marta González, Sara Esmeralda Rubio, Jesús Ávila, Eduardo Soriano, Marta Pascua. The GABAergic septohippocampal connection is impaired in a mouse model of tauopathy. Neurobiology of aging. vol 49. 2017-11-16. PMID:27743524. |
we show that pyramidal neurons, mossy cells, and some parvalbumin (parv)-positive hippocampal interneurons in 2- and 8-month-old (mo) vlw mice accumulate phosphorylated forms of tau (p-tau). |
2017-11-16 |
2023-08-13 |
mouse |
| Natalia A Stefanova, Natalia A Muraleva, Kseniya Yi Maksimova, Ekaterina A Rudnitskaya, Elena Kiseleva, Darya V Telegina, Nataliya G Kolosov. An antioxidant specifically targeting mitochondria delays progression of Alzheimer's disease-like pathology. Aging. vol 8. issue 11. 2017-11-16. PMID:27750209. |
via improvement of structural and functional state of mitochondria, treatment with skq1 alleviated the structural neurodegenerative alterations, prevented the neuronal loss and synaptic damage, increased the levels of synaptic proteins, enhanced neurotrophic supply, and decreased amyloid-β1-42 protein levels and tau hyperphosphorylation in the hippocampus of oxys rats, resulting in improvement of the learning ability and memory. |
2017-11-16 |
2023-08-13 |
human |
| Ane-Victoria Idland, Roser Sala-Llonch, Tom Borza, Leiv Otto Watne, Torgeir Bruun Wyller, Anne Brækhus, Henrik Zetterberg, Kaj Blennow, Kristine Beate Walhovd, Anders Martin Fjel. CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults. Neurobiology of aging. vol 49. 2017-11-16. PMID:27794264. |
we tested whether csf nfl levels predict hippocampal atrophy rate in cognitively healthy older adults independently of the established csf alzheimer's disease (ad) biomarkers, β-amyloid 1-42, and phosphorylated tau (p-tau). |
2017-11-16 |
2023-08-13 |
human |
| C Dioli, P Patrício, R Trindade, L G Pinto, J M Silva, M Morais, E Ferreiro, S Borges, A Mateus-Pinheiro, A J Rodrigues, N Sousa, J M Bessa, L Pinto, I Sotiropoulo. Tau-dependent suppression of adult neurogenesis in the stressed hippocampus. Molecular psychiatry. vol 22. issue 8. 2017-11-13. PMID:28555078. |
these data establish tau as a critical regulator of the cellular cascades underlying stress deficits on hippocampal neurogenesis in the adult brain. |
2017-11-13 |
2023-08-13 |
mouse |
| Yipeng Wang, Varun Balaji, Senthilvelrajan Kaniyappan, Lars Krüger, Stephan Irsen, Katharina Tepper, RamReddy Chandupatla, Walter Maetzler, Anja Schneider, Eckhard Mandelkow, Eva-Maria Mandelko. The release and trans-synaptic transmission of Tau via exosomes. Molecular neurodegeneration. vol 12. issue 1. 2017-11-09. PMID:28086931. |
tau pathology in ad spreads in a hierarchical pattern, whereby it first appears in the entorhinal cortex, then spreads to the hippocampus and later to the surrounding areas. |
2017-11-09 |
2023-08-13 |
Not clear |
| Deyan Kong, Qian Liu, Guangxu Xu, Zhenhua Huang, Ning Luo, Yuanheng Huang, Keshu Ca. Synergistic effect of tanshinone IIA and mesenchymal stem cells on preventing learning and memory deficits via anti-apoptosis, attenuating tau phosphorylation and enhancing the activity of central cholinergic system in vascular dementia. Neuroscience letters. vol 637. 2017-10-31. PMID:27845241. |
the combined administration of tsa and mscs demonstrated a synergistic effect on suppressing neuronal apoptosis in the hippocampus, attenuating tau phosphorylation and enhancing the activity of central cholinergic system. |
2017-10-31 |
2023-08-13 |
rat |
| Sosuke Yagishita, Seiya Suzuki, Keisuke Yoshikawa, Keiko Iida, Ayako Hirata, Masahiko Suzuki, Akihiko Takashima, Kei Maruyama, Akira Hirasawa, Takeo Awaj. Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging. Molecular brain. vol 10. issue 1. 2017-10-30. PMID:28057021. |
treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging. |
2017-10-30 |
2023-08-13 |
mouse |
| Núbia Broetto, Fernanda Hansen, Giovana Brolese, Cristiane Batassini, Franciane Lirio, Fabiana Galland, João Paulo Almeida Dos Santos, Márcio Ferreira Dutra, Carlos-Alberto Gonçalve. Intracerebroventricular administration of okadaic acid induces hippocampal glucose uptake dysfunction and tau phosphorylation. Brain research bulletin. vol 124. 2017-10-26. PMID:27108544. |
intracerebroventricular administration of okadaic acid induces hippocampal glucose uptake dysfunction and tau phosphorylation. |
2017-10-26 |
2023-08-13 |
rat |
| Núbia Broetto, Fernanda Hansen, Giovana Brolese, Cristiane Batassini, Franciane Lirio, Fabiana Galland, João Paulo Almeida Dos Santos, Márcio Ferreira Dutra, Carlos-Alberto Gonçalve. Intracerebroventricular administration of okadaic acid induces hippocampal glucose uptake dysfunction and tau phosphorylation. Brain research bulletin. vol 124. 2017-10-26. PMID:27108544. |
we herein investigated the effect of intracerebroventricular (icv) infusion of oka (100 and 200ng) on hippocampal tau phosphorylation at ser396, which is considered an important fibrillogenic tau protein site, and on glucose uptake, which is reduced early in ad. |
2017-10-26 |
2023-08-13 |
rat |
| Núbia Broetto, Fernanda Hansen, Giovana Brolese, Cristiane Batassini, Franciane Lirio, Fabiana Galland, João Paulo Almeida Dos Santos, Márcio Ferreira Dutra, Carlos-Alberto Gonçalve. Intracerebroventricular administration of okadaic acid induces hippocampal glucose uptake dysfunction and tau phosphorylation. Brain research bulletin. vol 124. 2017-10-26. PMID:27108544. |
icv infusion of oka (at 200ng) induced a spatial cognitive deficit, hippocampal astrogliosis (based on gfap increment) and increase in tau phosphorylation at site 396 in this model. |
2017-10-26 |
2023-08-13 |
rat |
| Núbia Broetto, Fernanda Hansen, Giovana Brolese, Cristiane Batassini, Franciane Lirio, Fabiana Galland, João Paulo Almeida Dos Santos, Márcio Ferreira Dutra, Carlos-Alberto Gonçalve. Intracerebroventricular administration of okadaic acid induces hippocampal glucose uptake dysfunction and tau phosphorylation. Brain research bulletin. vol 124. 2017-10-26. PMID:27108544. |
in vitro exposure of hippocampal slices to oka altered tau phosphorylation at site 396, without any associated change in glucose uptake activity. |
2017-10-26 |
2023-08-13 |
rat |
| Maud Gratuze, Emmanuel Plane. Regulation of brain insulin signaling: A new function for tau. The Journal of experimental medicine. vol 214. issue 8. 2017-10-26. PMID:28652305. |
they find that tau deletion impairs hippocampal response to insulin through irs-1 and pten dysregulation and suggest that, in alzheimer's disease, impairment of brain insulin signaling might occur via tau loss of function. |
2017-10-26 |
2023-08-13 |
Not clear |
| Masaki Takao, Nobuyoshi Hirose, Yasumichi Arai, Ban Mihara, Masaru Mimur. Neuropathology of supercentenarians - four autopsy case studies. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27590044. |
in particular, we focused on the pathology of alzheimer's disease and lewy body disease, as well as the status of hippocampal sclerosis, tdp-43 pathology, aging-related tau astrogliopathy, and cerebrovascular diseases. |
2017-10-25 |
2023-08-13 |
human |
| Toshiki Uchihara, Kentaro Endo, Hiromi Kondo, Sachi Okabayashi, Nobuhiro Shimozawa, Yasuhiro Yasutomi, Eijiro Adachi, Nobuyuki Kimur. Tau pathology in aged cynomolgus monkeys is progressive supranuclear palsy/corticobasal degeneration- but not Alzheimer disease-like -Ultrastructural mapping of tau by EDX. Acta neuropathologica communications. vol 4. issue 1. 2017-10-24. PMID:27842611. |
we found, 1) extensive deposition of aβ in brains of cynomolgus monkeys over 25 years of age, 2) selective deposition of 4-repeat tau as pretangles in neurons, and as coiled body-like structures in oligodendroglia-like cells and astrocytes, 3) preferential distribution of tau in the basal ganglia and neocortex rather than the hippocampus, and 4) age-associated increases in 30-34 kda at8- and rd4-positive tau fragments in sarkosyl-insoluble fractions. |
2017-10-24 |
2023-08-13 |
human |
| Keith A Josephs, Dennis W Dickson, Nirubol Tosakulwong, Stephen D Weigand, Melissa E Murray, Leonard Petrucelli, Amanda M Liesinger, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Joseph E Parisi, Ronald C Petersen, Clifford R Jack, Jennifer L Whitwel. Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer's disease: a longitudinal retrospective study. The Lancet. Neurology. vol 16. issue 11. 2017-10-20. PMID:28919059. |
post-mortem studies have not identified an association between β-amyloid or tau and rates of hippocampal atrophy in patients with alzheimer's disease. |
2017-10-20 |
2023-08-13 |
Not clear |
| Ji Hyeon Kim, Eunkyoung Kim, Won Hoon Choi, Jeeyoung Lee, Jung Hoon Lee, Hyojin Lee, Dong-Eun Kim, Young Ho Suh, Min Jae Le. Inhibitory RNA Aptamers of Tau Oligomerization and Their Neuroprotective Roles against Proteotoxic Stress. Molecular pharmaceutics. vol 13. issue 6. 2017-10-19. PMID:27120117. |
moreover, the tau aptamers significantly alleviated synthetic tau oligomer-mediated neurotoxicity and dendritic spine loss in primary hippocampal neurons. |
2017-10-19 |
2023-08-13 |
human |