All Relations between microtubule-associated protein tau and mesencephalon

Reference Sentence Publish Date Extraction Date Species
Aisan Farhadi, Mehdi Totonchi, Seyed Masood Nabavi, Hossein Baharvand, Hossein Pakdaman, Ensiyeh Hajizadeh-Saffar, Seyed Ahmad Mousavi, Fatemeh Hadi, Hamed Al-Sinawi, Quan Li, Jin-San Zhang, Yaser Tahamtani, Koorosh Shahpasan. P38 Initiates Degeneration of midbrain GABAergic and Glutamatergic Neurons in Diabetes Models. The European journal of neuroscience vol issue 2022 35513862 we showed that diabetes-related stresses and glucose metabolism deficiency could induce cis p-tau (an early driver of the tau pathology) accumulation in the midbrain and corpus callosum of the diabetic mice models and cells treated with 2-deoxy-d-glucose, respectively. 2022-05-05 2022-05-07 Not clear
Aisan Farhadi, Mehdi Totonchi, Seyed Masood Nabavi, Hossein Baharvand, Hossein Pakdaman, Ensiyeh Hajizadeh-Saffar, Seyed Ahmad Mousavi, Fatemeh Hadi, Hamed Al-Sinawi, Quan Li, Jin-San Zhang, Yaser Tahamtani, Koorosh Shahpasan. P38 Initiates Degeneration of midbrain GABAergic and Glutamatergic Neurons in Diabetes Models. The European journal of neuroscience vol issue 2022 35513862 we observed that oxidative stress activated p38, which directly and indirectly drove tau pathology in the gabaergic and glutamatergic neurons of the midbrain of the diabetic mice after 96 hours, which accumulated in the other neighboring brain areas after two months. 2022-05-05 2022-05-07 Not clear
Kaidong Wang, Baofu Zhang, Tian Tian, Bingyang Zhang, Ge Shi, Chunhui Zhang, Guoliang Li, Min Huan. Taurine protects dopaminergic neurons in paraquat-induced Parkinson's disease mouse model through PI3K/Akt signaling pathways. Amino acids vol issue 2021 34837554 in conclusion, our results suggest that tau may regulate microglia-mediated inflammatory responses through inhibition of the pi3k/akt pathway in the midbrain of pd mice, thereby reducing dac neurons damage. 2022-02-02 2022-01-13 Not clear
Kaidong Wang, Baofu Zhang, Tian Tian, Bingyang Zhang, Ge Shi, Chunhui Zhang, Guoliang Li, Min Huan. Taurine protects dopaminergic neurons in paraquat-induced Parkinson's disease mouse model through PI3K/Akt signaling pathways. Amino acids vol issue 2021 34837554 in conclusion, our results suggest that tau may regulate microglia-mediated inflammatory responses through inhibition of the pi3k/akt pathway in the midbrain of pd mice, thereby reducing dac neurons damage. 2021-11-27 2022-01-13 Not clear
Irene Sintini, Kenton Kaufman, Hugo Botha, Peter R Martin, Stacy R Loushin, Matthew L Senjem, Robert I Reid, Christopher G Schwarz, Clifford R Jack, Val J Lowe, Keith A Josephs, Jennifer L Whitwell, Farwa Al. Neuroimaging correlates of gait abnormalities in progressive supranuclear palsy. NeuroImage. Clinical vol 32 issue 2021 34655905 progressive supranuclear palsy is a neurodegenerative disorder characterized primarily by tau inclusions and neurodegeneration in the midbrain, basal ganglia, thalamus, premotor and frontal cortex. 2021-11-17 2022-01-13 Not clear
Naomi Kouri, Melissa E Murray, Joseph S Reddy, Daniel J Serie, Alexandra Soto-Beasley, Mariet Allen, Minerva M Carrasquillo, Xue Wang, Monica Casey Castanedes, Matthew C Baker, Rosa Rademakers, Ryan J Uitti, Neill R Graff-Radford, Zbigniew K Wszolek, Gerard D Schellenberg, Julia E Crook, Nil\\xc3\\xbcfer Ertekin-Taner, Owen A Ross, Dennis W Dickso. Latent trait modeling of tau neuropathology in progressive supranuclear palsy. Acta neuropathologica vol 141 issue 5 2021 33635380 top associations were identified at rs1768208 with midbrain tectum and red nucleus tau burden. 2021-11-16 2022-01-13 Not clear
Naomi Kouri, Melissa E Murray, Joseph S Reddy, Daniel J Serie, Alexandra Soto-Beasley, Mariet Allen, Minerva M Carrasquillo, Xue Wang, Monica Casey Castanedes, Matthew C Baker, Rosa Rademakers, Ryan J Uitti, Neill R Graff-Radford, Zbigniew K Wszolek, Gerard D Schellenberg, Julia E Crook, Nil\\xc3\\xbcfer Ertekin-Taner, Owen A Ross, Dennis W Dickso. Latent trait modeling of tau neuropathology in progressive supranuclear palsy. Acta neuropathologica vol 141 issue 5 2021 33635380 digital microscopy was employed to quantify phosphorylated tau burden in midbrain tectum and red nucleus in 795 psp cases and tau burdens were used as quantitative phenotypes in gwas. 2021-11-16 2022-01-13 Not clear
David Wallon, Susana Boluda, Anne Rovelet-Lecrux, Manon Thierry, Julien Lagarde, Laetitia Miguel, Magalie Lecourtois, Antoine Bonnevalle, Marie Sarazin, Michel Bottlaender, Mathieu Mula, Serge Marty, Natsuko Nakamura, Catherine Schramm, Fran\\xc3\\xa7ois Sellal, Th\\xc3\\xa9r\\xc3\\xa8se Jonveaux, Camille Heitz, Isabelle Le Ber, St\\xc3\\xa9phane Epelbaum, Eloi Magnin, Aline Zarea, St\\xc3\\xa9phane Rousseau, Olivier Quenez, Didier Hannequin, Florence Clavaguera, Dominique Campion, Charles Duyckaerts, Ga\\xc3\\xabl Nicola. Clinical and neuropathological diversity of tauopathy in MAPT duplication carriers. Acta neuropathologica vol 142 issue 2 2021 34095977 distribution, aspect and 4r/3r tau aggregates composition suggested a spectrum from predominantly 3r, mainly cortical deposits well correlating with cognitive and behavioral changes, to predominantly 4r deposits, mainly in the basal ganglia and midbrain, in patients with prominent extrapyramidal syndrome. 2021-08-16 2022-01-13 Not clear
Jordan Follett, Matthew J Farre. LRRK2; a dynamic regulator of cellular trafficking. Brain research vol 1761 issue 2021 33662339 nevertheless, the age-associated midbrain pathology observed post-mortem in lrrk2-parkinsonism may involve the abnormal accumulation of either \xce\xb1-synuclein or tau, or just the loss of dopaminergic neurons and gliosis. 2021-03-21 2022-01-13 Not clear
Luyan Jiao, Meige Zheng, Jinhai Duan, Ting Wu, Zhao Li, Lin Liu, Xianhong Xiang, Xiaolu Tang, Jinyang He, Xingjian Li, Guofeng Zhang, Jinhui Ding, Huaibin Cai, Xian Li. Tau knockout exacerbates degeneration of parvalbumin-positive neurons in substantia nigra pars reticulata in Parkinson's disease-related \\xce\\xb1-synuclein A53T mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 34 issue 9 2021 33000527 to investigate how the expression of tau affects \xce\xb1-syn-induced neurodegeneration in vivo, we generated triple transgenic mice that overexpressed \xce\xb1-syn a53t mutation in the midbrain dopaminergic neurons (mdans) with different expression levels of tau. 2021-03-16 2022-01-13 Not clear
Eun-Joo Kim, Ji-Hye L Hwang, Stephanie E Gaus, Alissa L Nana, Jersey Deng, Jesse A Brown, Salvatore Spina, Myung Jun Lee, Eliana Marisa Ramos, Lea T Grinberg, Joel H Kramer, Adam L Boxer, Maria Luisa Gorno-Tempini, Howard J Rosen, Bruce L Miller, William W Seele. Evidence of corticofugal tau spreading in patients with frontotemporal dementia. Acta neuropathologica vol 139 issue 1 2021 31542807 within each clinical syndrome, there were predicted relationships between cortical atrophy patterns and axonal tau deposition in midbrain cerebral peduncle and pontine base. 2021-01-19 2022-01-13 Not clear
Onder Albayram, Bryce MacIver, John Mathai, Anne Verstegen, Sean Baxley, Chenxi Qiu, Carter Bell, Barbara J Caldarone, Xiao Zhen Zhou, Kun Ping Lu, Mark Zeide. Traumatic Brain Injury-related voiding dysfunction in mice is caused by damage to rostral pathways, altering inputs to the reflex pathways. Scientific reports vol 9 issue 1 2020 31201348 hyperphosphorylated tau deposition and neural tangle-like pathology occurred in cortical and hippocampal regions only of igg control mice accompanied with post-traumatic neuroinflammation and was not seen in midbrain and hindbrain regions associated with bladder filling and voiding reflex arcs. 2020-10-15 2022-01-13 Not clear
Adnan A Hirad, Jeffrey J Bazarian, Kian Merchant-Borna, Frank E Garcea, Sarah Heilbronner, David Paul, Eric B Hintz, Edwin van Wijngaarden, Giovanni Schifitto, David W Wright, Tamara R Espinoza, Bradford Z Maho. A common neural signature of brain injury in concussion and subconcussion. Science advances vol 5 issue 8 2020 31457074 we then replicate the observation of reduced midbrain white matter integrity in a retrospective cohort of individuals with frank concussion, and further show that variance in white matter integrity is correlated with levels of serum-based tau, a marker of blood-brain barrier disruption. 2020-05-05 2022-01-13 Not clear
Bennet Omalu, Gary W Small, Julian Bailes, Linda M Ercoli, David A Merrill, Koon-Pong Wong, Sung-Cheng Huang, Nagichettiar Satyamurthy, Jennifer L Hammers, John Lee, Robert P Fitzsimmons, Jorge R Barri. Postmortem Autopsy-Confirmation of Antemortem [F-18]FDDNP-PET Scans in a Football Player With Chronic Traumatic Encephalopathy. Neurosurgery vol 82 issue 2 2019 29136240 [f-18]fddnp-pet signals may be consistent with neuropathological patterns of tau deposition in cte, involving areas that receive the maximal shearing, angular-rotational acceleration-deceleration forces in american football players, consistent with distinctive and differential topographic vulnerability and selectivity of cte beyond brain cortices, also involving midbrain and limbic areas. 2019-09-04 2022-01-13 Not clear
Melinda Barkhuizen, Fleur J P van Dijck, Reint K Jellema, Ruth Gussenhoven, Imke Engelbertink, Ralph van Mechelen, Jack P M Cleutjens, Matthias Seehase, Harry W M Steinbusch, Luc J Zimmermann, A W Danilo Gavilanes, Boris W Krame. The influence of anesthetics on substantia nigra tyrosine hydroxylase expression and tau phosphorylation in the hypoxic-ischemic near-term lamb. Pediatric research vol 83 issue 6 2019 29741516 the overall microglial response and tau phosphorylation were also measured in the sn, surrounding the midbrain gray matter structures and the hippocampal white matter.resultsthe isoflurane-treated uco group had fewer tyrosine hydroxylase-expressing neurons in the sn at 8\xe2\x80\x89h after the insult than the propofol-treated uco or sham-operated groups (p<0.05). 2019-08-12 2022-01-13 Not clear
Thomas E Cope, Timothy Rittman, Robin J Borchert, P Simon Jones, Deniz Vatansever, Kieren Allinson, Luca Passamonti, Patricia Vazquez Rodriguez, W Richard Bevan-Jones, John T O'Brien, James B Row. Tau burden and the functional connectome in Alzheimer's disease and progressive supranuclear palsy. Brain : a journal of neurology vol 141 issue 2 2019 29293892 further, we demonstrate that in psp increasing tau burden in midbrain and deep nuclei was associated with strengthened cortico-cortical functional connectivity. 2019-05-30 2022-01-13 Not clear
Xiaolu Tang, Luyan Jiao, Meige Zheng, Yan Yan, Qi Nie, Ting Wu, Xiaomei Wan, Guofeng Zhang, Yonglin Li, Song Wu, Bin Jiang, Huaibin Cai, Pingyi Xu, Jinhai Duan, Xian Li. Tau Deficiency Down-Regulated Transcription Factor Orthodenticle Homeobox 2 Expression in the Dopaminergic Neurons in Ventral Tegmental Area and Caused No Obvious Motor Deficits in Mice. Neuroscience vol 373 issue 2018 29337233 in this study, we examined motor functions and analyzed several proteins implicated in the maintenance of midbrain dopaminergic (da) neurons (mdans) function of adult and aged tau 2018-11-26 2022-01-13 Not clear
Marta Marqui\\xc3\\xa9, Eline E Verwer, Avery C Meltzer, Sally Ji Who Kim, Cinthya Ag\\xc3\\xbcero, Jose Gonzalez, Sara J Makaretz, Michael Siao Tick Chong, Prianca Ramanan, Ana C Amaral, Marc D Normandin, Charles R Vanderburg, Stephen N Gomperts, Keith A Johnson, Matthew P Frosch, Teresa G\\xc3\\xb3mez-Isl. Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson's case. Acta neuropathologica communications vol 5 issue 1 2018 29047416 in vivo uptake has also consistently been observed in midbrain, basal ganglia and choroid plexus in elderly individuals regardless of their clinical diagnosis, including clinically normal whose brains are not expected to harbor tau pathology in those areas. 2018-06-13 2022-01-13 Not clear
Annachiara Cagnin, Sara Mariotto, Michele Fiorini, Marina Gaule, Nicola Bonetto, Matteo Tagliapietra, Emanuele Buratti, Gianluigi Zanusso, Sergio Ferrari, Salvatore Monac. Microglial and Neuronal TDP-43 Pathology in Anti-IgLON5-Related Tauopathy. Journal of Alzheimer's disease : JAD vol 59 issue 1 2018 28550263 postmortem brain examination disclosed neuronal tau pathology prevailing in the hippocampus, amygdala, and locus coeruleus, in addition to microglial/neuronal tdp-43 pathology, with overexpression of aberrantly phosphorylated forms and neurotoxic truncated fragments, in basal ganglia, nucleus basalis, thalamus, and midbrain. 2018-04-06 2022-01-13 Not clear
Sara Garcia-Rat\\xc3\\xa9s, Paul Morrill, Henry Tu, Gwenael Pottiez, Antoine-Scott Badin, Cristina Tormo-Garcia, Catherine Heffner, Clive W Coen, Susan A Greenfiel. (I) Pharmacological profiling of a novel modulator of the \\xce\\xb17 nicotinic receptor: Blockade of a toxic acetylcholinesterase-derived peptide increased in Alzheimer brains. Neuropharmacology vol 105 issue 2017 26867503 here we show for the first time that (1) a peptide derived from acetylcholinesterase, with independent trophic functions that turn toxic in maturity, is significantly raised in the alzheimer midbrain and cerebrospinal fluid; (2) a synthetic version of this peptide enhances calcium influx and eventual production of amyloid beta and tau phosphorylation via an allosteric site on the \xce\xb17 nicotinic receptor; (3) a synthetic cyclic version of this peptide is neuroprotective against the toxicity not only of its linear counterpart but also of amyloid beta, thereby opening up the prospect of a novel therapeutic approach. 2017-06-21 2022-01-12 Not clear
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