| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hossein Sendi, Ivy Mead, Meimei Wan, Marjan Mehrab-Mohseni, Kenneth Koch, Anthony Atala, Herbert L Bonkovsky, Colin E Bisho. miR-122 inhibition in a human liver organoid model leads to liver inflammation, necrosis, steatofibrosis and dysregulated insulin signaling. PloS one. vol 13. issue 7. 2019-01-22. PMID:30024933. |
this was associated with increase in inflammatory cytokines (il6, tnf), chemokines (ccl2, ccl3) and increase in a subset of matrix metaloproteinases (mmp8, mmp9). |
2019-01-22 |
2023-08-13 |
human |
| Swati Jaiswal, Prashant Mishr. Co-delivery of curcumin and serratiopeptidase in HeLa and MCF-7 cells through nanoparticles show improved anti-cancer activity. Materials science & engineering. C, Materials for biological applications. vol 92. 2018-12-11. PMID:30184794. |
structural similarity of serratiopeptidase to matrix metallo proteases (mmps), particularly mmp8, have been found (based on low rmsd values) to induce tnfα production and play tumour suppressive role in certain cancers. |
2018-12-11 |
2023-08-13 |
Not clear |
| Emily B Lurier, Donald Dalton, Will Dampier, Pichai Raman, Sina Nassiri, Nicole M Ferraro, Ramakrishan Rajagopalan, Mahdi Sarmady, Kara L Spille. Transcriptome analysis of IL-10-stimulated (M2c) macrophages by next-generation sequencing. Immunobiology. vol 222. issue 7. 2018-03-26. PMID:28318799. |
many of the identified m2c-specific genes are associated with angiogenesis, matrix remodeling, and phagocytosis, including cd163, mmp8, timp1, vcan, serpina1, marco, plod2, pcocle2 and f5. |
2018-03-26 |
2023-08-13 |
human |
| Meghan C Daly, Sarah J Atkinson, Brian M Varisco, Lindsey Klingbeil, Paul Hake, Patrick Lahni, Giovanna Piraino, David Wu, Simon P Hogan, Basilia Zingarelli, Hector R Won. Role of matrix metalloproteinase-8 as a mediator of injury in intestinal ischemia and reperfusion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 10. 2017-09-08. PMID:27435263. |
inhibition of mmp8 is a potential therapeutic strategy in this setting.-daly, m. c., atkinson, s. j., varisco, b. m., klingbeil l., hake, p., lahni, p., piraino, g., wu, d., hogan, s. p., zingarelli, b., wong, h. r. role of matrix metalloproteinase-8 as a mediator of injury in intestinal ischemia and reperfusion. |
2017-09-08 |
2023-08-13 |
mouse |
| Athanasia Tsaousi, Ellen Witte, Katrin Witte, Hans-Joachim Röwert-Huber, Hans-Dieter Volk, Wolfram Sterry, Kerstin Wolk, Sylke Schneider-Burrus, Robert Saba. MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations. Mediators of inflammation. vol 2016. 2017-08-11. PMID:27843200. |
here, we demonstrate that one of the most highly upregulated molecules in ai lesions is matrix metalloproteinase 8 (mmp8), an enzyme specialized in the degradation of extracellular matrix components and the hdl component apolipoprotein a-i. |
2017-08-11 |
2023-08-13 |
Not clear |
| Mingcui Xu, Feng Zhang, Aixiu Wang, Chen Wang, Yu Cao, Ming Zhang, Mingming Zhang, Min Su, Xiaoping Zou, Guifang Xu, Yuzheng Zhug. Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Promotes Hepatic Stellate Cells Migration via Canonical NF-κB/MMP9 Pathway. PloS one. vol 11. issue 12. 2017-07-06. PMID:27907201. |
cell migration was detected by transwell assay; cell viability was evaluated by cell counting kit-8; the expression of mmp1, mmp2, mmp3, mmp7, mmp8, mmp9, mmp10, mmp11, mmp12, mmp13 gene was identified by quantitative real-time polymerase chain reaction and western blotting; the activity of matrix metalloproteinases (mmps) was tested by enzyme-linked immuno sorbent assay; small interfering rna transfection was applied for depletion of mmp9 and p65. |
2017-07-06 |
2023-08-13 |
human |
| Siva S V P Sakamuri, Abhijit Takawale, Ratnadeep Basu, Paul W M Fedak, Darren Freed, Consolato Sergi, Gavin Y Oudit, Zamaneh Kassir. Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure. Translational research : the journal of laboratory and clinical medicine. vol 172. 2017-06-26. PMID:26963743. |
matrix metalloproteinases (mmp1, mmp2, mmp8, mmp13, and mt1-mmp/mmp14) were comparable between dcm hearts. |
2017-06-26 |
2023-08-13 |
human |
| Delphine Demeestere, Eline Dejonckheere, Sophie Steeland, Paco Hulpiau, Jurgen Haustraete, Nick Devoogdt, Rielana Wichert, Christoph Becker-Pauly, Elien Van Wonterghem, Sylviane Dewaele, Griet Van Imschoot, Jeroen Aerts, Lutgarde Arckens, Yvan Saeys, Claude Libert, Roosmarijn E Vandenbrouck. Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8. Molecular therapy : the journal of the American Society of Gene Therapy. vol 24. issue 5. 2017-06-16. PMID:26775809. |
a detrimental role for matrix metalloproteinase 8 (mmp8) has been identified in several pathological conditions, e.g., lethal hepatitis and the systemic inflammatory response syndrome. |
2017-06-16 |
2023-08-13 |
mouse |
| Delphine Demeestere, Eline Dejonckheere, Sophie Steeland, Paco Hulpiau, Jurgen Haustraete, Nick Devoogdt, Rielana Wichert, Christoph Becker-Pauly, Elien Van Wonterghem, Sylviane Dewaele, Griet Van Imschoot, Jeroen Aerts, Lutgarde Arckens, Yvan Saeys, Claude Libert, Roosmarijn E Vandenbrouck. Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8. Molecular therapy : the journal of the American Society of Gene Therapy. vol 24. issue 5. 2017-06-16. PMID:26775809. |
since matrix mmp8-deficient mice are protected in the above-mentioned diseases, specific mmp8 inhibitors could be of clinical value. |
2017-06-16 |
2023-08-13 |
mouse |
| Limei Geng, Zhiqiang Chen, Hong Ren, Xiaoyan Niu, Xiangyan Yu, Hongqian Ya. Effects of an early intervention using human amniotic epithelial cells in a COPD rat model. Pathology, research and practice. vol 212. issue 11. 2017-03-17. PMID:27667559. |
il-8 was measured using a radioimmunoassay, surfactant protein d (sp-d) was measured by elisa, and matrix metalloproteinase (mmp)2 and mmp8 expression was assessed by pcr. |
2017-03-17 |
2023-08-13 |
human |
| Stefania Moz, Daniela Basso, Andrea Padoan, Dania Bozzato, Paola Fogar, Carlo-Federico Zambon, Michela Pelloso, Cosimo Sperti, Saula Vigili de Kreutzenberg, Claudio Pasquali, Sergio Pedrazzoli, Angelo Avogaro, Mario Pleban. Blood expression of matrix metalloproteinases 8 and 9 and of their inducers S100A8 and S100A9 supports diagnosis and prognosis of PDAC-associated diabetes mellitus. Clinica chimica acta; international journal of clinical chemistry. vol 456. 2016-12-20. PMID:26923392. |
based on the knowledge that matrix metalloproteinases (mmps) and s100a8/a9 synergistically work in causing pdac-associated type 2 diabetes mellitus (t2dm), we verified whether tissue and blood mmp8, mmp9, s100a8 and s100a9 expression might help in distinguishing pdac among diabetics. |
2016-12-20 |
2023-08-13 |
Not clear |
| Annu Näkki, Cristina Rodriguez-Fontenla, Antonio Gonzalez, Arsi Harilainen, Päivi Leino-Arjas, Markku Heliövaara, Johan G Eriksson, Kaj Tallroth, Tapio Videman, Jaakko Kaprio, Janna Saarela, Urho M Kujal. Association study of MMP8 gene in osteoarthritis. Connective tissue research. vol 57. issue 1. 2016-11-10. PMID:26577236. |
there is a prior functional evidence for different matrix metalloproteinases (mmps), such as mmp8 and mmp9, having a role in the breakdown of cartilage extracellular matrix in oa. |
2016-11-10 |
2023-08-13 |
Not clear |
| Jeong Eun Han, Eun-Jung Lee, Eunjung Moon, Jong Hoon Ryu, Ji Woong Choi, Hee-Sun Ki. Matrix Metalloproteinase-8 is a Novel Pathogenetic Factor in Focal Cerebral Ischemia. Molecular neurobiology. vol 53. issue 1. 2016-10-10. PMID:25421209. |
the neutrophil collagenase matrix metalloproteinase-8 (mmp8) is a recently identified member of mmps that have important roles in various inflammation-related disorders. |
2016-10-10 |
2023-08-13 |
Not clear |
| Luciana Batalha de Miranda de Araujo, Casie E Horgan, Abraham Aron, Renato V Iozzo, Beatrice E Lechne. Compensatory fetal membrane mechanisms between biglycan and decorin in inflammation. Molecular reproduction and development. vol 82. issue 5. 2016-04-12. PMID:25914258. |
furthermore, our findings suggest that biglycan and decorin play discrete roles in fetal membrane signaling pathways during inflammation, leading to changes in the abundance of mmp8 and collagen α1vi, two components of the fetal membrane extracellular matrix that influence the pathophysiology of pprom. |
2016-04-12 |
2023-08-13 |
mouse |
| Clélia Le Gallic, Yohann Phalente, Line Manens, Isabelle Dublineau, Marc Benderitter, Yann Gueguen, Stephanie Lehoux, Teni G Ebrahimia. Chronic Internal Exposure to Low Dose 137Cs Induces Positive Impact on the Stability of Atherosclerotic Plaques by Reducing Inflammation in ApoE-/- Mice. PloS one. vol 10. issue 6. 2016-03-04. PMID:26046630. |
lesions of mice exposed to 137cs were also characterized by enhanced collagen and smooth muscle cell content, concurrent with reduced matrix metalloproteinase mmp8 and mmp13 expression. |
2016-03-04 |
2023-08-13 |
mouse |
| Guanmei Wen, Cheng Zhang, Qishan Chen, Le Anh Luong, Arif Mustafa, Shu Ye, Qingzhong Xia. A Novel Role of Matrix Metalloproteinase-8 in Macrophage Differentiation and Polarization. The Journal of biological chemistry. vol 290. issue 31. 2015-10-19. PMID:26092731. |
matrix metalloproteinase-8 (mmp8) has been shown to influence various cellular functions. |
2015-10-19 |
2023-08-13 |
mouse |
| Jungsil Kim, Jesse D Procknow, Hiromi Yanagisawa, Jessica E Wagensei. Differences in genetic signaling, and not mechanical properties of the wall, are linked to ascending aortic aneurysms in fibulin-4 knockout mice. American journal of physiology. Heart and circulatory physiology. vol 309. issue 1. 2015-09-15. PMID:25934097. |
additional genes in both pathways, as well as matrix metalloprotease-8 (mmp8), are upregulated specifically in fbln4(-/-) aa compared with fbln4(+/+) aa and fbln4(-/-) da. |
2015-09-15 |
2023-08-13 |
mouse |
| Nikolaus Fortelny, Jennifer H Cox, Reinhild Kappelhoff, Amanda E Starr, Philipp F Lange, Paul Pavlidis, Christopher M Overal. Network analyses reveal pervasive functional regulation between proteases in the human protease web. PLoS biology. vol 12. issue 5. 2015-05-28. PMID:24865846. |
predictions from the protease web on the activity of matrix metalloproteinase 8 (mmp8) and neutrophil elastase being linked by an inactivating cleavage of serpina1 by mmp8 were validated and explain perplexing mmp8-/- versus wild-type polymorphonuclear chemokine cleavages in vivo. |
2015-05-28 |
2023-08-13 |
human |
| Christian E Oberkofler, Perparim Limani, Jae-Hwi Jang, Andreas Rickenbacher, Kuno Lehmann, Dimitri A Raptis, Udo Ungethuem, Yinghua Tian, Kamile Grabliauskaite, Rok Humar, Rolf Graf, Bostjan Humar, Pierre-Alain Clavie. Systemic protection through remote ischemic preconditioning is spread by platelet-dependent signaling in mice. Hepatology (Baltimore, Md.). vol 60. issue 4. 2015-05-11. PMID:24700614. |
models of interleukin-10 (il10) and matrix metalloproteinase 8 (mmp8) deficiency were used to assess downstream effectors of organ protection. |
2015-05-11 |
2023-08-13 |
mouse |
| Xiao-Zeng Wang, Xiao-Mo Du, Quan-Min Jing, Xing-Xing Li, Ruo-Xi Gu, Jiao Wang, Ya-Ling Ha. Impact of matrix metalloproteinase-8 gene variations on the risk of thoracic aortic dissection in a Chinese Han population. Molecular biology reports. vol 40. issue 10. 2014-06-07. PMID:24065531. |
the importance of matrix metalloproteinase 8 (mmp8) expression during the progression of thoracic aortic dissection (tad) has been recently emphasized. |
2014-06-07 |
2023-08-12 |
human |