| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Subramanian K Vadivel, Sundararaman Vardarajan, Richard I Duclos, JodiAnne T Wood, Jianxin Guo, Alexandros Makriyanni. Conformationally constrained analogues of 2-arachidonoylglycerol. Bioorganic & medicinal chemistry letters. vol 17. issue 21. 2008-02-05. PMID:17826996. |
these head group constrained and conformationally restricted analogues of 2-ag as well as the 1-keto precursors were evaluated as substrates for the endocannabinoid deactivating hydrolytic enzymes monoacylglycerol lipase (mgl) and fatty acid amide hydrolase (faah), and also were tested for their affinities for cb1 and cb2 cannabinoid receptors. |
2008-02-05 |
2023-08-12 |
Not clear |
| Geoffray Labar, Cédric Bauvois, Giulio G Muccioli, Johan Wouters, Didier M Lamber. Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling. Chembiochem : a European journal of chemical biology. vol 8. issue 11. 2007-09-14. PMID:17579916. |
monoacylglycerol lipase (magl) is a key enzyme responsible for the termination of endocannabinoid signaling. |
2007-09-14 |
2023-08-12 |
human |
| Gianna Rossi, Valeria Gasperi, Rita Paro, Daniela Barsacchi, Sandra Cecconi, Mauro Maccarron. Follicle-stimulating hormone activates fatty acid amide hydrolase by protein kinase A and aromatase-dependent pathways in mouse primary Sertoli cells. Endocrinology. vol 148. issue 3. 2007-04-04. PMID:17110429. |
we also show that diacylglycerol lipase and monoacylglycerol lipase, which respectively synthesize and degrade 2-arachidonoyl-glycerol, were not regulated by fsh, neither was the membrane transport of this endocannabinoid. |
2007-04-04 |
2023-08-12 |
mouse |
| Haibin Wang, Huirong Xie, Xiaofei Sun, Philip J Kingsley, Lawrence J Marnett, Benjamin F Cravatt, Sudhansu K De. Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. Prostaglandins & other lipid mediators. vol 83. issue 1-2. 2007-03-29. PMID:17259073. |
we also provide evidence that region- and stage-specific uterine expression of n-acylphosphatidylethanolamine-specific phospholipase d (nape-pld) and fatty acid amide hydrolase (faah), and sn-1-diacylglycerol (dag) lipase alpha (daglalpha) and monoacylglycerol lipase (magl) for synthesis and hydrolysis of anandamide and 2-ag, respectively, creates endocannabinoid gradients conducive to implantation. |
2007-03-29 |
2023-08-12 |
mouse |
| Yuki Hashimotodani, Takako Ohno-Shosaku, Masanobu Kan. Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 5. 2007-03-16. PMID:17267577. |
presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus. |
2007-03-16 |
2023-08-12 |
Not clear |
| Yuki Hashimotodani, Takako Ohno-Shosaku, Masanobu Kan. Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 5. 2007-03-16. PMID:17267577. |
the major endocannabinoid 2-arachidonoylglycerol (2-ag) is hydrolyzed by monoacylglycerol lipase (mgl), which is shown to be localized at axon terminals. |
2007-03-16 |
2023-08-12 |
Not clear |
| Anuradha Nallapaneni, Jing Liu, Subramanya Karanth, Carey Pop. Modulation of paraoxon toxicity by the cannabinoid receptor agonist WIN 55,212-2. Toxicology. vol 227. issue 1-2. 2006-11-29. PMID:16956707. |
several studies suggest that some organophosphorus toxicants can potentially modify cannabinergic signaling by direct binding to cannabinoid receptors and inhibition of enzymes responsible for cannabinoid degradation (i.e., fatty acid amide hydrolase and monoacylglycerol lipase). |
2006-11-29 |
2023-08-12 |
rat |
| Tiziana Bisogno, Maria Grazia Cascio, Bijali Saha, Anu Mahadevan, Paolo Urbani, Alberto Minassi, Giovanni Appendino, Carmela Saturnino, Billy Martin, Raj Razdan, Vincenzo Di Marz. Development of the first potent and specific inhibitors of endocannabinoid biosynthesis. Biochimica et biophysica acta. vol 1761. issue 2. 2006-05-31. PMID:16466961. |
enzymes for the biosynthesis and degradation of the endocannabinoid 2-arachidonoyl glycerol (2-ag) have been cloned and are the sn-1-selective-diacylglycerol lipases alpha and beta (daglalpha and beta) and the monoacylglycerol lipase (magl), respectively. |
2006-05-31 |
2023-08-12 |
human |
| Alessia Ligresti, Maria Grazia Cascio, Vincenzo Di Marz. Endocannabinoid metabolic pathways and enzymes. Current drug targets. CNS and neurological disorders. vol 4. issue 6. 2006-02-07. PMID:16375679. |
five endocannabinoid enzymes have been cloned to date: two are responsible for the biosynthesis and degradation of anandamide, the nape-selective phospholipase d and the fatty acid amide hydrolase, respectively; the other three catalyse the biosynthesis and degradation of 2-ag, the sn-1-selective diacylglycerol lipases alpha and beta and the monoacylglycerol lipase, respectively. |
2006-02-07 |
2023-08-12 |
human |
| Séverine Vandevoorde, Bijali Saha, Anu Mahadevan, Raj K Razdan, Roger G Pertwee, Billy R Martin, Christopher J Fowle. Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase. Biochemical and biophysical research communications. vol 337. issue 1. 2005-11-14. PMID:16181610. |
little is known as to the structural requirements of the acyl side chain for interaction of acylglycerols with monoacylglycerol lipase (magl), the enzyme chiefly responsible for the metabolism of the endocannabinoid 2-arachidonoylglycerol (2-ag) in the brain. |
2005-11-14 |
2023-08-12 |
Not clear |
| Thien P Dinh, Satish Kathuria, Daniele Piomell. RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol. Molecular pharmacology. vol 66. issue 5. 2004-12-06. PMID:15272052. |
rna interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol. |
2004-12-06 |
2023-08-12 |
rat |