| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melinda M Mulvihill, Daniel K Nomur. Therapeutic potential of monoacylglycerol lipase inhibitors. Life sciences. vol 92. issue 8-9. 2013-04-17. PMID:23142242. |
recent studies have uncovered that the serine hydrolase monoacylglycerol lipase (magl) links the endocannabinoid and eicosanoid systems together through hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-ag) to provide the major arachidonic acid (aa) precursor pools for pro-inflammatory eicosanoid synthesis in specific tissues. |
2013-04-17 |
2023-08-12 |
mouse |
| Silvia Carloni, Daniel Alonso-Alconada, Silvia Girelli, Andrea Duranti, Andrea Tontini, Daniele Piomelli, Enrique Hilario, Antonia Alvarez, Walter Balduin. Pretreatment with the monoacylglycerol lipase inhibitor URB602 protects from the long-term consequences of neonatal hypoxic-ischemic brain injury in rats. Pediatric research. vol 72. issue 4. 2013-03-05. PMID:22821058. |
this study was undertaken to assess whether preventing the deactivation of the endocannabinoid 2-arachidonoylglycerol (2-ag) with the monoacylglycerol lipase (magl) inhibitor urb602 can provide neuroprotective effects in hypoxia-ischemia (hi)-induced brain injury. |
2013-03-05 |
2023-08-12 |
rat |
| Mireille Alhouayek, Giulio G Mucciol. The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity. Trends in molecular medicine. vol 18. issue 10. 2013-02-15. PMID:22917662. |
anandamide and 2-arachidonoylglycerol are endogenous bioactive lipids that bind to and activate the cannabinoid receptors, and together with the enzymes responsible for their biosynthesis and degradation [fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl)] constitute the endocannabinoid system (ecs). |
2013-02-15 |
2023-08-12 |
Not clear |
| Su-Hyoun Chon, John D Douglass, Yin Xiu Zhou, Nashmia Malik, Joseph L Dixon, Anita Brinker, Loredana Quadro, Judith Storc. Over-expression of monoacylglycerol lipase (MGL) in small intestine alters endocannabinoid levels and whole body energy balance, resulting in obesity. PloS one. vol 7. issue 8. 2013-02-12. PMID:22937137. |
over-expression of monoacylglycerol lipase (mgl) in small intestine alters endocannabinoid levels and whole body energy balance, resulting in obesity. |
2013-02-12 |
2023-08-12 |
mouse |
| Alonso Vilches-Flores, Astrid C Hauge-Evans, Peter M Jones, Shanta J Persau. Chronic activation of cannabinoid receptors in vitro does not compromise mouse islet function. Clinical science (London, England : 1979). vol 124. issue 7. 2013-02-11. PMID:23078523. |
quantitative rt-pcr (reverse transcription-pcr) indicated that mrnas encoding synthesis [nape-pld (n-acyl-phosphatidyl ethanolamide-hydrolysing phospholipase d)] and degradation [faah (fatty acid amide hydrolase)] of the endocannabinoid aea (anandamide) were the most abundant ecs elements in mouse islets, with much lower levels of cb1r, cb2r, dagl (diacylglycerol lipase) and magl (monoacylglycerol lipase) mrnas. |
2013-02-11 |
2023-08-12 |
mouse |
| Chen Li, Alonso Vilches-Flores, Min Zhao, Stephanie A Amiel, Peter M Jones, Shanta J Persau. Expression and function of monoacylglycerol lipase in mouse β-cells and human islets of Langerhans. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 30. issue 2. 2012-11-20. PMID:22739267. |
the current study aimed to investigate the expression and function, in mouse and human β-cells, of monoacylglycerol lipase (mgl), an enzyme that facilitates degradation of the endocannabinoid 2-arachidonoylglycerol (2-ag). |
2012-11-20 |
2023-08-12 |
mouse |
| Alessia Ligresti, Rosaria Villano, Marco Allarà, István Ujváry, Vincenzo Di Marz. Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB₁ receptor ligand. Pharmacological research. vol 66. issue 2. 2012-10-25. PMID:22525682. |
these compounds were investigated for assessing their cannabinoid receptor binding affinity and capability of inhibiting the activity of the two major metabolic enzymes of the endocannabinoid system, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl). |
2012-10-25 |
2023-08-12 |
human |
| Jae Won Chang, Micah J Niphakis, Kenneth M Lum, Armand B Cognetta, Chu Wang, Megan L Matthews, Sherry Niessen, Matthew W Buczynski, Loren H Parsons, Benjamin F Cravat. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chemistry & biology. vol 19. issue 5. 2012-09-24. PMID:22542104. |
highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. |
2012-09-24 |
2023-08-12 |
Not clear |
| Coco N Kapanda, Julien Masquelier, Geoffray Labar, Giulio G Muccioli, Jacques H Poupaert, Didier M Lamber. Synthesis and pharmacological evaluation of 2,4-dinitroaryldithiocarbamate derivatives as novel monoacylglycerol lipase inhibitors. Journal of medicinal chemistry. vol 55. issue 12. 2012-09-07. PMID:22651858. |
monoacylglycerol lipase (magl) is responsible for signal termination of 2-arachidonoylglycerol (2-ag), an endocannabinoid neurotransmitter endowed with several physiological effects. |
2012-09-07 |
2023-08-12 |
Not clear |
| Jenny L Wilkerson, Katherine R Gentry, Ellen C Dengler, James A Wallace, Audra A Kerwin, Megan N Kuhn, Alexander M Zvonok, Ganesh A Thakur, Alexandros Makriyannis, Erin D Milliga. Immunofluorescent spectral analysis reveals the intrathecal cannabinoid agonist, AM1241, produces spinal anti-inflammatory cytokine responses in neuropathic rats exhibiting relief from allodynia. Brain and behavior. vol 2. issue 2. 2012-08-23. PMID:22574283. |
am1241 produced profound anti-allodynia with corresponding immunoreactive levels of p38 mitogen-activated kinase, il-1β, il-10, the endocannabinoid enzyme monoacylglycerol lipase, and astrocyte activation markers that were similar to nonneuropathic controls. |
2012-08-23 |
2023-08-12 |
rat |
| Joshua J Sumislawski, Teniel S Ramikie, Sachin Pate. Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 13. 2012-08-14. PMID:21849983. |
reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation. |
2012-08-14 |
2023-08-12 |
Not clear |
| Jenny L Wilkerson, Katherine R Gentry, Ellen C Dengler, James A Wallace, Audra A Kerwin, Leisha M Armijo, Megan N Kuhn, Ganesh A Thakur, Alexandros Makriyannis, Erin D Milliga. Intrathecal cannabilactone CB(2)R agonist, AM1710, controls pathological pain and restores basal cytokine levels. Pain. vol 153. issue 5. 2012-08-13. PMID:22425445. |
in cci animals, lumbar dorsal spinal cord and corresponding dorsal root ganglia (drg) were evaluated by immunohistochemistry for expression of il-10, il-1β, phosphorylated p38-mitogen-activated-kinase (p-p38mapk), a pathway associated with proinflammatory cytokine production, glial cell markers, and degradative endocannabinoid enzymes, including monoacylglycerol lipase (magl). |
2012-08-13 |
2023-08-12 |
human |
| Kwang-Mook Jung, Jason R Clapper, Jin Fu, Giuseppe D'Agostino, Ana Guijarro, Dean Thongkham, Agnesa Avanesian, Giuseppe Astarita, Nicholas V DiPatrizio, Andrea Frontini, Saverio Cinti, Sabrina Diano, Daniele Piomell. 2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism. Cell metabolism. vol 15. issue 3. 2012-07-03. PMID:22405068. |
in the present study, we developed transgenic mice that overexpress in forebrain neurons the presynaptic hydrolase, monoacylglycerol lipase (mgl), which deactivates the endocannabinoid 2-arachidonoyl-sn-glycerol (2-ag). |
2012-07-03 |
2023-08-12 |
mouse |
| Marion Feledziak, Didier M Lambert, Jacqueline Marchand-Brynaert, Giulio G Mucciol. Inhibitors of the endocannabinoid-degrading enzymes, or how to increase endocannabinoid's activity by preventing their hydrolysis. Recent patents on CNS drug discovery. vol 7. issue 1. 2012-06-04. PMID:22280341. |
to date four enzymes - fatty acid amide hydrolase (faah), n-acylethanolamine-hydrolyzing acid amidase (naaa), monoacylglycerol lipase (magl), α/β-hydrolase domain 6 (abhd6) - were shown to control endocannabinoid levels in tissues or in intact cells. |
2012-06-04 |
2023-08-12 |
Not clear |
| Monika Szabo, Mark Agostino, Daniel T Malone, Elizabeth Yuriev, Ben Capuan. The design, synthesis and biological evaluation of novel URB602 analogues as potential monoacylglycerol lipase inhibitors. Bioorganic & medicinal chemistry letters. vol 21. issue 22. 2012-02-13. PMID:21982493. |
we have synthesised an extensive series of urb602 analogues as inhibitors of monoacylglycerol lipase (magl), which is the major enzyme responsible for metabolising the endocannabinoid 2-arachidonylglycerol. |
2012-02-13 |
2023-08-12 |
human |
| Peng Zhong, Bin Pan, Xiu-ping Gao, Jacqueline L Blankman, Benjamin F Cravatt, Qing-song Li. Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum. The Journal of physiology. vol 589. issue Pt 20. 2012-02-07. PMID:21911610. |
the endocannabinoid (ecb) 2-arachidonoylglycerol (2-ag) is hydrolysed primarily by monoacylglycerol lipase (magl). |
2012-02-07 |
2023-08-12 |
mouse |
| Josée Guindon, Ana Guijarro, Daniele Piomelli, Andrea G Hohman. Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. British journal of pharmacology. vol 163. issue 7. 2012-01-18. PMID:21198549. |
background and purpose the endocannabinoid 2-arachidonoylglycerol (2-ag) is degraded primarily by monoacylglycerol lipase (mgl). |
2012-01-18 |
2023-08-12 |
rat |
| Bin Pan, Wei Wang, Peng Zhong, Jacqueline L Blankman, Benjamin F Cravatt, Qing-song Li. Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 38. 2011-12-07. PMID:21940435. |
alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice. |
2011-12-07 |
2023-08-12 |
mouse |
| Daniel K Nomura, Bradley E Morrison, Jacqueline L Blankman, Jonathan Z Long, Steven G Kinsey, Maria Cecilia G Marcondes, Anna M Ward, Yun Kyung Hahn, Aron H Lichtman, Bruno Conti, Benjamin F Cravat. Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation. Science (New York, N.Y.). vol 334. issue 6057. 2011-11-29. PMID:22021672. |
here, we show that a distinct pathway exists in brain, where monoacylglycerol lipase (magl) hydrolyzes the endocannabinoid 2-arachidonoylglycerol to generate a major arachidonate precursor pool for neuroinflammatory prostaglandins. |
2011-11-29 |
2023-08-12 |
mouse |
| Divya Ramesh, Gracious R Ross, Joel E Schlosburg, Robert A Owens, Rehab A Abdullah, Steven G Kinsey, Jonathan Z Long, Daniel K Nomura, Laura J Sim-Selley, Benjamin F Cravatt, Hamid I Akbarali, Aron H Lichtma. Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice. The Journal of pharmacology and experimental therapeutics. vol 339. issue 1. 2011-11-22. PMID:21719468. |
the endogenous cannabinoids, n-arachidonoylethanolamine (anandamide; aea) and 2-arachidonylglycerol (2-ag), activate both cannabinoid receptors but are rapidly metabolized by fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), respectively. |
2011-11-22 |
2023-08-12 |
mouse |