| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rowan Pentz, M Florencia Iulit. The NGF Metabolic Pathway: New Opportunities for Biomarker Research and Drug Target Discovery : NGF Pathway Biomarkers and Drug Targets. Advances in experimental medicine and biology. vol 1331. 2021-08-31. PMID:34453291. |
a novel model that explains the preferential vulnerability of basal forebrain cholinergic neurons in ad as the result of pathological alterations to nerve growth factor (ngf) metabolism offers an integrated investigative platform for the development of such biomarkers and therapeutics. |
2021-08-31 |
2023-08-13 |
Not clear |
| Viviana Triaca, Francesca Ruberti, Nadia Can. NGF and the Amyloid Precursor Protein in Alzheimer's Disease: From Molecular Players to Neuronal Circuits. Advances in experimental medicine and biology. vol 1331. 2021-08-31. PMID:34453297. |
in addition, the neurotrophic factor hypothesis posits that the loss nerve growth factor (ngf) signalling in ad may account for the vulnerability to atrophy of bfcns and consequent impairment of cholinergic functions. |
2021-08-31 |
2023-08-13 |
mouse |
| Christian Humpe. NGF Released from Blood Cells or Collagen Hydrogels as a Therapeutic Target in Alzheimer's Disease? Advances in experimental medicine and biology. vol 1331. 2021-08-31. PMID:34453299. |
nerve growth factor (ngf) is the most potent growth factor to support the survival of these cholinergic neurons. |
2021-08-31 |
2023-08-13 |
Not clear |
| Sonia Do Carmo, Benjamin Kannel, A Claudio Cuell. Nerve Growth Factor Compromise in Down Syndrome. Frontiers in aging neuroscience. vol 13. 2021-08-27. PMID:34434101. |
the basal forebrain cholinergic system relies on trophic support by nerve growth factor (ngf) to maintain its phenotype and function. |
2021-08-27 |
2023-08-13 |
Not clear |
| Michael J Castle, Fernando C Baltanás, Imre Kovacs, Alan H Nagahara, David Barba, Mark H Tuszynsk. Postmortem Analysis in a Clinical Trial of AAV2-NGF Gene Therapy for Alzheimer's Disease Identifies a Need for Improved Vector Delivery. Human gene therapy. vol 31. issue 7-8. 2021-08-18. PMID:32126838. |
nerve growth factor (ngf) gene therapy rescues and stimulates cholinergic neurons, which degenerate in alzheimer's disease (ad). |
2021-08-18 |
2023-08-13 |
Not clear |
| Agustin Benitez, Raul Riquelme, Miguel Del Campo, Camila Araya, Hernan E Lar. Nerve Growth Factor: A Dual Activator of Noradrenergic and Cholinergic Systems of the Rat Ovary. Frontiers in endocrinology. vol 12. 2021-08-10. PMID:33716987. |
nerve growth factor: a dual activator of noradrenergic and cholinergic systems of the rat ovary. |
2021-08-10 |
2023-08-13 |
rat |
| Agustin Benitez, Raul Riquelme, Miguel Del Campo, Camila Araya, Hernan E Lar. Nerve Growth Factor: A Dual Activator of Noradrenergic and Cholinergic Systems of the Rat Ovary. Frontiers in endocrinology. vol 12. 2021-08-10. PMID:33716987. |
the nerve growth factor (ngf) was the first neurotrophic factor found to regulate ovarian noradrenergic neurons and the cholinergic neurons in the central nervous system. |
2021-08-10 |
2023-08-13 |
rat |
| Maria Eriksdotter, Sumonto Mitr. Gene and cell therapy for the nucleus basalis of Meynert with NGF in Alzheimer's disease. Handbook of clinical neurology. vol 179. 2021-07-28. PMID:34225964. |
in recent years, other approaches to influence the degenerating cholinergic system in ad focusing on nerve growth factor (ngf) have been undertaken. |
2021-07-28 |
2023-08-13 |
Not clear |
| Wei Zheng Eu, Yu-Ju Chen, Wei-Ting Chen, Kuan-Yu Wu, Cheng-Yu Tsai, Sin-Jhong Cheng, Roderick N Carter, Guo-Jen Huan. The effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervation. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33723225. |
the effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervation. |
2021-06-28 |
2023-08-13 |
mouse |
| Lan-Ting Zhou, Juan Zhang, Lu Tan, He-Zhou Huang, Yang Zhou, Zhi-Qiang Liu, Youming Lu, Ling-Qiang Zhu, Chengye Yao, Dan Li. Elevated Levels of miR-144-3p Induce Cholinergic Degeneration by Impairing the Maturation of NGF in Alzheimer's Disease. Frontiers in cell and developmental biology. vol 9. 2021-04-28. PMID:33898468. |
nerve growth factor (ngf) is secreted in brain regions that receive projections from the basal forebrain cholinergic neurons. |
2021-04-28 |
2023-08-13 |
mouse |
| Yinpei Luo, Yuwei Sun, Xuelong Tian, Xiaolin Zheng, Xing Wang, Weina Li, Xiaoying Wu, Bin Shu, Wensheng Ho. Deep Brain Stimulation for Alzheimer's Disease: Stimulation Parameters and Potential Mechanisms of Action. Frontiers in aging neuroscience. vol 13. 2021-03-30. PMID:33776742. |
we analyzed the current stimulation parameters of dbs in ad from stimulation target, stimulation frequency, stimulation start time, stimulation duration, unilateral/bilateral treatment and current intensity, etc., and we also discussed its potential mechanism of action from multiple aspects, including regulating related neural networks, promoting nerve oscillation, reducing β-amyloid and tau levels, reducing neuroinflammation, regulating the cholinergic system, inducing the synthesis of nerve growth factor. |
2021-03-30 |
2023-08-13 |
human |
| Joseph M Hall, Fernando Gomez-Pinilla, Lisa M Savag. Nerve Growth Factor Is Responsible for Exercise-Induced Recovery of Septohippocampal Cholinergic Structure and Function. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30443202. |
nerve growth factor is responsible for exercise-induced recovery of septohippocampal cholinergic structure and function. |
2020-10-01 |
2023-08-13 |
rat |
| Joseph M Hall, Fernando Gomez-Pinilla, Lisa M Savag. Nerve Growth Factor Is Responsible for Exercise-Induced Recovery of Septohippocampal Cholinergic Structure and Function. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30443202. |
to determine which neurotrophin, brain-derived neurotrophic factor (bdnf) or nerve growth factor (ngf), is critical for exercise-induced cholinergic improvements, control and amnestic rats had either ngf or bdnf sequestered by trka-igg or trkb-igg coated microbeads placed within the dorsal hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Kenneth E Miller, Gregory E Frierdich, Robert H Dillard, Robert H Soriano, Dikla G Rouf. Intermittent vs Continuous Administration of Nerve Growth Factor to Injured Medial Septal Cholinergic Neurons in Rat Basal Forebrain. Neuroscience and medicine. vol 5. issue 2. 2020-10-01. PMID:30473908. |
intermittent vs continuous administration of nerve growth factor to injured medial septal cholinergic neurons in rat basal forebrain. |
2020-10-01 |
2023-08-13 |
rat |
| Kenneth E Miller, Gregory E Frierdich, Robert H Dillard, Robert H Soriano, Dikla G Rouf. Intermittent vs Continuous Administration of Nerve Growth Factor to Injured Medial Septal Cholinergic Neurons in Rat Basal Forebrain. Neuroscience and medicine. vol 5. issue 2. 2020-10-01. PMID:30473908. |
many medial septal neurons of the basal forebrain are dependent on nerve growth factor (ngf) from the hippocampus for survival and maintenance of a cholinergic phenotype. |
2020-10-01 |
2023-08-13 |
rat |
| Valentina Latina, Silvia Caioli, Cristina Zona, Maria Teresa Ciotti, Antonella Borreca, Pietro Calissano, Giuseppina Amador. NGF-Dependent Changes in Ubiquitin Homeostasis Trigger Early Cholinergic Degeneration in Cellular and Animal AD-Model. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30618634. |
basal forebrain cholinergic neurons (bfcns) depend on nerve growth factor (ngf) for their survival/differentiation and innervate cortical and hippocampal regions involved in memory/learning processes. |
2020-10-01 |
2023-08-13 |
Not clear |
| Sumonto Mitra, Homira Behbahani, Maria Eriksdotte. Innovative Therapy for Alzheimer's Disease-With Focus on Biodelivery of NGF. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:30804738. |
the neurotrophic molecule, nerve growth factor (ngf), plays a major role in the maintenance of cholinergic neurons integrity and function, both during development and adulthood. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xu-Qiao Chen, William C Moble. Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31133787. |
a second hypothesis, prompted by the selective loss of cholinergic neurons and the discovery of central nervous system (cns) neurotrophic factors, including nerve growth factor (ngf), prompted the "deficient neurotrophic hypothesis" (chen et al., 2018). |
2020-10-01 |
2023-08-13 |
Not clear |
| Viviana Triaca, Pietro Calissan. Impairment of the nerve growth factor pathway driving amyloid accumulation in cholinergic neurons: the incipit of the Alzheimer's disease story? Neural regeneration research. vol 11. issue 10. 2020-09-30. PMID:27904476. |
impairment of the nerve growth factor pathway driving amyloid accumulation in cholinergic neurons: the incipit of the alzheimer's disease story? |
2020-09-30 |
2023-08-13 |
Not clear |
| Viviana Triaca, Pietro Calissan. Impairment of the nerve growth factor pathway driving amyloid accumulation in cholinergic neurons: the incipit of the Alzheimer's disease story? Neural regeneration research. vol 11. issue 10. 2020-09-30. PMID:27904476. |
this could be also true in the case of nerve growth factor (ngf) alterations in sporadic alzheimer's disease (ad), an age-related pathology characterized by cholinergic loss, amyloid plaques and neurofibrillary tangles. |
2020-09-30 |
2023-08-13 |
Not clear |