| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helga Eyjolfsdottir, Maria Eriksdotter, Bengt Linderoth, Göran Lind, Bengt Juliusson, Philip Kusk, Ove Almkvist, Niels Andreasen, Kaj Blennow, Daniel Ferreira, Eric Westman, Inger Nennesmo, Azadeh Karami, Taher Darreh-Shori, Ahmadul Kadir, Agneta Nordberg, Erik Sundström, Lars-Olof Wahlund, Anders Wall, Maria Wiberg, Bengt Winblad, Åke Seiger, Lars Wahlberg, Per Almqvis. Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer's disease patients: application of a second-generation encapsulated cell biodelivery device. Alzheimer's research & therapy. vol 8. issue 1. 2017-10-13. PMID:27389402. |
targeted delivery of nerve growth factor (ngf) has emerged as a potential therapy for alzheimer's disease (ad) due to its regenerative effects on basal forebrain cholinergic neurons. |
2017-10-13 |
2023-08-13 |
Not clear |
| Brian Spencer, Paula A Desplats, Cassia R Overk, Elvira Valera-Martin, Robert A Rissman, Chengbiao Wu, Michael Mante, Anthony Adame, Jazmin Florio, Edward Rockenstein, Eliezer Maslia. Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 30. 2017-07-10. PMID:27466341. |
here, we found that reducing endogenous α-syn in an app transgenic mouse model of ad prevented the degeneration of cholinergic neurons, ameliorated corresponding deficits, and recovered the levels of rab3a and rab5 proteins involved in intracellular transport and sorting of nerve growth factor and brain-derived neurotrophic factor. |
2017-07-10 |
2023-08-13 |
mouse |
| Yoku Hayakawa, Kosuke Sakitani, Mitsuru Konishi, Samuel Asfaha, Ryota Niikura, Hiroyuki Tomita, Bernhard W Renz, Yagnesh Tailor, Marina Macchini, Moritz Middelhoff, Zhengyu Jiang, Takayuki Tanaka, Zinaida A Dubeykovskaya, Woosook Kim, Xiaowei Chen, Aleksandra M Urbanska, Karan Nagar, Christoph B Westphalen, Michael Quante, Chyuan-Sheng Lin, Michael D Gershon, Akira Hara, Chun-Mei Zhao, Duan Chen, Daniel L Worthley, Kazuhiko Koike, Timothy C Wan. Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling. Cancer cell. vol 31. issue 1. 2017-06-13. PMID:27989802. |
nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling. |
2017-06-13 |
2023-08-13 |
Not clear |
| Stephen D Skape. Nerve growth factor: a neuroimmune crosstalk mediator for all seasons. Immunology. vol 151. issue 1. 2017-05-31. PMID:28112808. |
the prototypical example and best-characterized neurotrophic factor is nerve growth factor (ngf), which is widely recognized as a target-derived factor responsible for the survival and maintenance of the phenotype of specific subsets of peripheral neurons and basal forebrain cholinergic nuclei during development and maturation. |
2017-05-31 |
2023-08-13 |
Not clear |
| H Hott. Neurogenic control of parenchymal arterioles in the cerebral cortex. Progress in brain research. vol 225. 2017-04-20. PMID:27130409. |
recent studies illuminate the physiological role of the cholinergic vasodilator system related to neurovascular coupling, neuroprotection, and promotion of the secretion of nerve growth factor. |
2017-04-20 |
2023-08-13 |
Not clear |
| N K Isaev, E V Stelmashook, E E Genrikh. Role of Nerve Growth Factor in Plasticity of Forebrain Cholinergic Neurons. Biochemistry. Biokhimiia. vol 82. issue 3. 2017-03-22. PMID:28320270. |
role of nerve growth factor in plasticity of forebrain cholinergic neurons. |
2017-03-22 |
2023-08-13 |
Not clear |
| Maria Florencia Iulita, Filippo Caraci, Augusto Claudio Cuell. A Link Between Nerve Growth Factor Metabolic Deregulation and Amyloid-β-Driven Inflammation in Down Syndrome. CNS & neurological disorders drug targets. vol 15. issue 4. 2016-12-30. PMID:26996175. |
in the mature and fully differentiated central nervous system, the phenotype of forebrain cholinergic neurons and their nerve terminals in cortex and hippocampus depend on the continuous endogenous supply of nerve growth factor (ngf). |
2016-12-30 |
2023-08-13 |
Not clear |
| Azadeh Karami, Helga Eyjolfsdottir, Swetha Vijayaraghavan, Göran Lind, Per Almqvist, Ahmadul Kadir, Bengt Linderoth, Niels Andreasen, Kaj Blennow, Anders Wall, Eric Westman, Daniel Ferreira, Maria Kristoffersen Wiberg, Lars-Olof Wahlund, Åke Seiger, Agneta Nordberg, Lars Wahlberg, Taher Darreh-Shori, Maria Eriksdotte. Changes in CSF cholinergic biomarkers in response to cell therapy with NGF in patients with Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 11. issue 11. 2016-08-26. PMID:25676388. |
the extensive loss of central cholinergic functions in alzheimer's disease (ad) brain is linked to impaired nerve growth factor (ngf) signaling. |
2016-08-26 |
2023-08-13 |
Not clear |
| Marzia Soligo, Virginia Protto, Fulvio Florenzano, Luisa Bracci-Laudiero, Fabrizio De Benedetti, Antonio Chiaretti, Luigi Mann. The mature/pro nerve growth factor ratio is decreased in the brain of diabetic rats: Analysis by ELISA methods. Brain research. vol 1624. 2016-08-10. PMID:26282349. |
nerve growth factor (ngf) is essential for the survival and functional maintenance of forebrain cholinergic neurons projecting mainly to the cortex and hippocampus. |
2016-08-10 |
2023-08-13 |
human |
| Luigi Aloe, Maria Luisa Rocco, Bijorn Omar Balzamino, Alessandra Micer. Nerve Growth Factor: A Focus on Neuroscience and Therapy. Current neuropharmacology. vol 13. issue 3. 2016-08-09. PMID:26411962. |
nerve growth factor (ngf) is the firstly discovered and best characterized neurotrophic factor, known to play a critical protective role in the development and survival of sympathetic, sensory and forebrain cholinergic neurons. |
2016-08-09 |
2023-08-13 |
human |
| Lara Eid, Martin Paren. Cholinergic neurons intrinsic to the primate external pallidum. Synapse (New York, N.Y.). vol 69. issue 8. 2016-03-21. PMID:25967898. |
the majority of these cholinergic pallidal neurons are devoid of nerve growth factor receptor (ngfr), which sets them apart from the population of corticopetal ngfr-rich neurons of the nucleus basalis of meynert and its ectopic elements that impinge dorsally upon the pallidum via the medullary laminae. |
2016-03-21 |
2023-08-13 |
monkey |
| Michael S Rafii, Tiffany L Baumann, Roy A E Bakay, Jeffrey M Ostrove, Joao Siffert, Adam S Fleisher, Christopher D Herzog, David Barba, Mary Pay, David P Salmon, Yaping Chu, Jeffrey H Kordower, Kathie Bishop, David Keator, Steven Potkin, Raymond T Bartu. A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 5. 2016-02-04. PMID:24411134. |
nerve growth factor (ngf) is an endogenous neurotrophic-factor protein with the potential to restore function and to protect degenerating cholinergic neurons in alzheimer's disease (ad), but safe and effective delivery has proved unsuccessful. |
2016-02-04 |
2023-08-12 |
Not clear |
| Sylvia E Perez, Bin He, Muhammad Nadeem, Joanne Wuu, Stephen W Scheff, Eric E Abrahamson, Milos D Ikonomovic, Elliott J Mufso. Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal Alzheimer's disease. Biological psychiatry. vol 77. issue 8. 2016-01-01. PMID:24529280. |
whether this cholinergic deficit is associated with alteration in nerve growth factor (ngf) signaling and its relation to aβ plaque and neurofibrillary tangle (nft) pathology during disease onset is unknown. |
2016-01-01 |
2023-08-12 |
Not clear |
| G Gu, W Zhang, M Li, J Ni, P Wan. Transplantation of NSC-derived cholinergic neuron-like cells improves cognitive function in APP/PS1 transgenic mice. Neuroscience. vol 291. 2015-12-21. PMID:25681520. |
first, green fluorescent protein (gfp)-nscs were induced to differentiate into cholinergic neuron-like cells (cnls) with retinoic acid (ra) pre-induction followed by nerve growth factor (ngf) induction. |
2015-12-21 |
2023-08-13 |
mouse |
| Daniel Ferreira, Eric Westman, Helga Eyjolfsdottir, Per Almqvist, Göran Lind, Bengt Linderoth, Ake Seiger, Kaj Blennow, Azadeh Karami, Taher Darreh-Shori, Maria Wiberg, Andrew Simmons, Lars-Olof Wahlund, Lars Wahlberg, Maria Eriksdotte. Brain changes in Alzheimer's disease patients with implanted encapsulated cells releasing nerve growth factor. Journal of Alzheimer's disease : JAD. vol 43. issue 3. 2015-08-21. PMID:25147108. |
nerve growth factor (ngf) protein has demonstrated regenerative and neuroprotective effects on basal forebrain cholinergic neurons in animal studies. |
2015-08-21 |
2023-08-13 |
Not clear |
| Erik Keimpema, Kang Zheng, Swapnali Shantaram Barde, Paul Berghuis, Márton B Dobszay, Robert Schnell, Jan Mulder, Paul G M Luiten, Zhiqing David Xu, Johan Runesson, Ülo Langel, Bai Lu, Tomas Hökfelt, Tibor Harkan. GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain. Cerebral cortex (New York, N.Y. : 1991). vol 24. issue 12. 2015-06-25. PMID:23897649. |
nerve growth factor (ngf), known to modulate cholinergic morphogenesis, increases galr2 expression. |
2015-06-25 |
2023-08-12 |
mouse |
| Lucy Norcliffe-Kaufmann, Stuart D Katz, Felicia Axelrod, Horacio Kaufman. Norepinephrine deficiency with normal blood pressure control in congenital insensitivity to pain with anhidrosis. Annals of neurology. vol 77. issue 5. 2015-06-22. PMID:25627679. |
this affects the development of nerve growth factor (ngf)-dependent neurons including sympathetic cholinergic neurons in the skin, causing anhidrosis. |
2015-06-22 |
2023-08-13 |
Not clear |
| Nina Daschil, Christian Humpe. Nifedipine and nimodipine protect dopaminergic substantia nigra neurons against axotomy-induced cell death in rat vibrosections via modulating inflammatory responses. Brain research. vol 1581. 2015-05-21. PMID:25038562. |
sagittal or coronal vibrosections (200 μm thick) of postnatal day 10 rats were cultured on 0.4 μm semipermeable membranes for 2 weeks with 10 ng/ml nerve growth factor (ngf) and/or glial-cell line derived neurotrophic factor (gdnf) to maintain survival of cholinergic or dopaminergic neurons, respectively. |
2015-05-21 |
2023-08-13 |
rat |
| Chang Yang, Yuli Liu, Xiuqin Ni, Ning Li, Baohui Zhang, Xiubin Fan. Enhancement of the nonamyloidogenic pathway by exogenous NGF in an Alzheimer transgenic mouse model. Neuropeptides. vol 48. issue 4. 2015-02-09. PMID:24813062. |
nerve growth factor (ngf) is an important nerve cell growth regulatory factor and has an indispensable role in the development, survival and regeneration of the cholinergic basal forebrain (cbf) neurons, and it has multiple targets when used for alzheimer's disease (ad) therapy. |
2015-02-09 |
2023-08-13 |
mouse |
| Kathrin M Kniewallner, Natalia Grimm, Christian Humpe. Platelet-derived nerve growth factor supports the survival of cholinergic neurons in organotypic rat brain slices. Neuroscience letters. vol 574. 2014-12-18. PMID:24861506. |
platelet-derived nerve growth factor supports the survival of cholinergic neurons in organotypic rat brain slices. |
2014-12-18 |
2023-08-13 |
rat |