| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rodrigo Morales, Sandra Pritzkow, Ping Ping Hu, Claudia Duran-Aniotz, Claudio Sot. Lack of prion transmission by sexual or parental routes in experimentally infected hamsters. Prion. vol 7. issue 5. 2014-08-29. PMID:24121659. |
western blotting and pmca were unable to detect sub-clinical levels of prp(sc) in experimental subjects, suggesting a complete absence of prion transmission by these routes. |
2014-08-29 |
2023-08-12 |
human |
| Kristen Marciniuk, Pekka Määttänen, Ryan Taschuk, T Dean Airey, Andrew Potter, Neil R Cashman, Philip Griebel, Scott Nappe. Development of a multivalent, PrP(Sc)-specific prion vaccine through rational optimization of three disease-specific epitopes. Vaccine. vol 32. issue 17. 2014-08-24. PMID:24486363. |
development of a multivalent, prp(sc)-specific prion vaccine through rational optimization of three disease-specific epitopes. |
2014-08-24 |
2023-08-12 |
Not clear |
| Kristen Marciniuk, Pekka Määttänen, Ryan Taschuk, T Dean Airey, Andrew Potter, Neil R Cashman, Philip Griebel, Scott Nappe. Development of a multivalent, PrP(Sc)-specific prion vaccine through rational optimization of three disease-specific epitopes. Vaccine. vol 32. issue 17. 2014-08-24. PMID:24486363. |
prion diseases represent a novel form of infectivity caused by the propagated misfolding of a self-protein (prp(c)) into a pathological, infectious conformation (prp(sc)). |
2014-08-24 |
2023-08-12 |
Not clear |
| Kristen Marciniuk, Pekka Määttänen, Ryan Taschuk, T Dean Airey, Andrew Potter, Neil R Cashman, Philip Griebel, Scott Nappe. Development of a multivalent, PrP(Sc)-specific prion vaccine through rational optimization of three disease-specific epitopes. Vaccine. vol 32. issue 17. 2014-08-24. PMID:24486363. |
previously, we reported development of a prp(sc)-specific vaccine through empirical expansions of a yyr dse. |
2014-08-24 |
2023-08-12 |
Not clear |
| Kristen Marciniuk, Pekka Määttänen, Ryan Taschuk, T Dean Airey, Andrew Potter, Neil R Cashman, Philip Griebel, Scott Nappe. Development of a multivalent, PrP(Sc)-specific prion vaccine through rational optimization of three disease-specific epitopes. Vaccine. vol 32. issue 17. 2014-08-24. PMID:24486363. |
here we describe optimization of two additional prion dses, yml of β-sheet 1 and a rigid loop (rl) linking β-sheet 2 to α-helix 2, through in silico predictions of b cell epitopes and further translation of these epitopes into prp(sc)-specific vaccines. |
2014-08-24 |
2023-08-12 |
Not clear |
| Fabio Moda, Pierluigi Gambetti, Silvio Notari, Luis Concha-Marambio, Marcella Catania, Kyung-Won Park, Emanuela Maderna, Silvia Suardi, Stéphane Haïk, Jean-Philippe Brandel, James Ironside, Richard Knight, Fabrizio Tagliavini, Claudio Sot. Prions in the urine of patients with variant Creutzfeldt-Jakob disease. The New England journal of medicine. vol 371. issue 6. 2014-08-12. PMID:25099577. |
prions, the infectious agents responsible for transmissible spongiform encephalopathies, consist mainly of the misfolded prion protein (prp(sc)). |
2014-08-12 |
2023-08-13 |
cattle |
| Monique Antoinette David, Daryl Rhys Jones, Mourad Tayeb. Potential candidate camelid antibodies for the treatment of protein-misfolding diseases. Journal of neuroimmunology. vol 272. issue 1-2. 2014-07-31. PMID:24864011. |
these antibodies could prove to be a valuable tool for the neutralization/clearance of prp(sc), aβ and tau proteins in cellular compartments of affected neurons and could potentially have wider applicability for the treatment of pmds. |
2014-07-31 |
2023-08-13 |
Not clear |
| Justin J Greenlee, Jodi D Smith, Robert A Kunkl. White-tailed deer are susceptible to the agent of sheep scrapie by intracerebral inoculation. Veterinary research. vol 42. 2014-06-30. PMID:21988781. |
examinations of brain tissue for the presence of the disease-associated abnormal prion protein (prp(sc)) by western blot (wb) and immunohistochemistry (ihc) were negative whereas ihc of lymphoid tissues was positive. |
2014-06-30 |
2023-08-12 |
Not clear |
| Justin J Greenlee, Jodi D Smith, Robert A Kunkl. White-tailed deer are susceptible to the agent of sheep scrapie by intracerebral inoculation. Veterinary research. vol 42. 2014-06-30. PMID:21988781. |
tissues with prp(sc) immunoreactivity included brain (at levels of cerebrum, hippocampus, colliculus, cerebellum, and brainstem), trigeminal ganglion, neurohypophysis, retina, spinal cord, and various lymphoid tissues including tonsil, retropharyngeal and mesenteric lymph nodes, peyer's patches, and spleen. |
2014-06-30 |
2023-08-12 |
Not clear |
| Linda A Terry, Laurence Howells, Keith Bishop, Claire A Baker, Sally Everest, Leigh Thorne, Ben C Maddison, Kevin C Goug. Detection of prions in the faeces of sheep naturally infected with classical scrapie. Veterinary research. vol 42. 2014-06-30. PMID:21592355. |
we used serial protein misfolding cyclic amplification (spmca) along with two extraction methods to examine faeces from sheep during both the clinical and preclinical phases of the disease and showed amplification of prp(sc) in 7 of 15 and 14 of 14 sheep respectively. |
2014-06-30 |
2023-08-12 |
Not clear |
| Linda A Terry, Laurence Howells, Keith Bishop, Claire A Baker, Sally Everest, Leigh Thorne, Ben C Maddison, Kevin C Goug. Detection of prions in the faeces of sheep naturally infected with classical scrapie. Veterinary research. vol 42. 2014-06-30. PMID:21592355. |
however prp(sc) was not amplified from the faeces of 25 sheep not exposed to scrapie. |
2014-06-30 |
2023-08-12 |
Not clear |
| Alessio Cardinale, Silvia Biocc. Gene-based antibody strategies for prion diseases. International journal of cell biology. vol 2013. 2014-06-24. PMID:24027584. |
prion diseases or transmissible spongiform encephalopathies (tse) are a group of neurodegenerative and infectious disorders characterized by the conversion of a normal cellular protein prp(c) into a pathological abnormally folded form, termed prp(sc). |
2014-06-24 |
2023-08-12 |
Not clear |
| Michael B Miller, Daphne W Wang, Fei Wang, Geoffrey P Noble, Jiyan Ma, Virgil L Woods, Sheng Li, Surachai Supattapon. Cofactor molecules induce structural transformation during infectious prion formation. Structure (London, England : 1993). vol 21. issue 11. 2014-06-24. PMID:24120764. |
final conversion into the infectious prp(sc) form was accompanied by globally decreased solvent exposure, with persistence of the major cofactor-induced conformational features. |
2014-06-24 |
2023-08-12 |
Not clear |
| Isabelle Acquatella-Tran Van Ba, Thibaut Imberdis, Véronique Perrie. From prion diseases to prion-like propagation mechanisms of neurodegenerative diseases. International journal of cell biology. vol 2013. 2014-06-24. PMID:24222767. |
the hallmark of prion diseases is the deposition in the brain of prp(sc), an abnormal β -sheet-rich form of the cellular prion protein (prp(c)) (prusiner 1982). |
2014-06-24 |
2023-08-12 |
cattle |
| Isabelle Acquatella-Tran Van Ba, Thibaut Imberdis, Véronique Perrie. From prion diseases to prion-like propagation mechanisms of neurodegenerative diseases. International journal of cell biology. vol 2013. 2014-06-24. PMID:24222767. |
according to the prion hypothesis, prp(sc) can trigger the autocatalytic conversion of prp(c) into prp(sc), presumably in the presence of cofactors (lipids and small rnas) that have been recently identified. |
2014-06-24 |
2023-08-12 |
cattle |
| Isabelle Acquatella-Tran Van Ba, Thibaut Imberdis, Véronique Perrie. From prion diseases to prion-like propagation mechanisms of neurodegenerative diseases. International journal of cell biology. vol 2013. 2014-06-24. PMID:24222767. |
the new concept of "deformed templating" regarding a new mechanism of prp(sc) formation and replication will be exposed. |
2014-06-24 |
2023-08-12 |
cattle |
| Suzana Aulić, Maria Laura Bolognesi, Giuseppe Legnam. Small-molecule theranostic probes: a promising future in neurodegenerative diseases. International journal of cell biology. vol 2013. 2014-06-24. PMID:24324497. |
many lines of evidence suggest that prions (prp(sc)) act both as a template for this conversion and as a neurotoxic agent causing neuronal dysfunction and cell death. |
2014-06-24 |
2023-08-12 |
cattle |
| Suzana Aulić, Maria Laura Bolognesi, Giuseppe Legnam. Small-molecule theranostic probes: a promising future in neurodegenerative diseases. International journal of cell biology. vol 2013. 2014-06-24. PMID:24324497. |
as such, prp(sc) may be considered as both a neuropathological hallmark of the disease and a therapeutic target. |
2014-06-24 |
2023-08-12 |
cattle |
| Ilaria Poggiolini, Daniela Saverioni, Piero Parch. Prion protein misfolding, strains, and neurotoxicity: an update from studies on Mammalian prions. International journal of cell biology. vol 2013. 2014-06-24. PMID:24454379. |
the central event in tse pathogenesis is the conformational conversion of the cellular prion protein, prp(c), into the aggregate, β -sheet rich, amyloidogenic form, prp(sc). |
2014-06-24 |
2023-08-12 |
Not clear |
| Ilaria Poggiolini, Daniela Saverioni, Piero Parch. Prion protein misfolding, strains, and neurotoxicity: an update from studies on Mammalian prions. International journal of cell biology. vol 2013. 2014-06-24. PMID:24454379. |
increasing evidence indicates that distinct prp(sc) conformers, forming distinct ordered aggregates, can encipher the phenotypic tse variants related to prion strains. |
2014-06-24 |
2023-08-12 |
Not clear |