| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fabienne Leidel, Martin Eiden, Markus Geissen, Thomas Hirschberger, Paul Tavan, Armin Giese, Hans A Kretzschmar, Hermann Schätzl, Martin H Groschu. Piperazine derivatives inhibit PrP/PrP(res) propagation in vitro and in vivo. Biochemical and biophysical research communications. vol 445. issue 1. 2014-05-02. PMID:24502948. |
in search of compounds that have the potential to interfere with prp(sc) formation and propagation, we used a cell based assay for the screening of potential aggregation inhibitors. |
2014-05-02 |
2023-08-12 |
mouse |
| Fabienne Leidel, Martin Eiden, Markus Geissen, Thomas Hirschberger, Paul Tavan, Armin Giese, Hans A Kretzschmar, Hermann Schätzl, Martin H Groschu. Piperazine derivatives inhibit PrP/PrP(res) propagation in vitro and in vivo. Biochemical and biophysical research communications. vol 445. issue 1. 2014-05-02. PMID:24502948. |
we could detect six different classes of highly potent inhibitors of prp(sc) propagation in vitro and identified piperazine derivatives as a new inhibitory lead structure, which increased incubation time of scrapie infected mice. |
2014-05-02 |
2023-08-12 |
mouse |
| Takeshi Yamasaki, Gerald S Baron, Akio Suzuki, Rie Hasebe, Motohiro Horiuch. Characterization of intracellular dynamics of inoculated PrP-res and newly generated PrP(Sc) during early stage prion infection in Neuro2a cells. Virology. vol 450-451. 2014-05-02. PMID:24503096. |
characterization of intracellular dynamics of inoculated prp-res and newly generated prp(sc) during early stage prion infection in neuro2a cells. |
2014-05-02 |
2023-08-12 |
Not clear |
| Takeshi Yamasaki, Gerald S Baron, Akio Suzuki, Rie Hasebe, Motohiro Horiuch. Characterization of intracellular dynamics of inoculated PrP-res and newly generated PrP(Sc) during early stage prion infection in Neuro2a cells. Virology. vol 450-451. 2014-05-02. PMID:24503096. |
to clarify the cellular mechanisms for the establishment of prion infection, we analyzed the intracellular dynamics of inoculated and newly generated abnormal isoform of prion protein (prp(sc)) in neuro2a cells. |
2014-05-02 |
2023-08-12 |
Not clear |
| Takeshi Yamasaki, Gerald S Baron, Akio Suzuki, Rie Hasebe, Motohiro Horiuch. Characterization of intracellular dynamics of inoculated PrP-res and newly generated PrP(Sc) during early stage prion infection in Neuro2a cells. Virology. vol 450-451. 2014-05-02. PMID:24503096. |
within 24h after inoculation, the newly generated prp(sc) was evident at the plasma membrane, in early endosomes, and in late endosomes, but this prp(sc) was barely evident in lysosomes; in contrast, the majority of the inoculated prp(sc) was evident in late endosomes and lysosomes. |
2014-05-02 |
2023-08-12 |
Not clear |
| Takeshi Yamasaki, Gerald S Baron, Akio Suzuki, Rie Hasebe, Motohiro Horiuch. Characterization of intracellular dynamics of inoculated PrP-res and newly generated PrP(Sc) during early stage prion infection in Neuro2a cells. Virology. vol 450-451. 2014-05-02. PMID:24503096. |
however, during the subsequent 48 h, the newly generated prp(sc) increased remarkably in early endosomes and recycling endosomes. |
2014-05-02 |
2023-08-12 |
Not clear |
| Takeshi Yamasaki, Gerald S Baron, Akio Suzuki, Rie Hasebe, Motohiro Horiuch. Characterization of intracellular dynamics of inoculated PrP-res and newly generated PrP(Sc) during early stage prion infection in Neuro2a cells. Virology. vol 450-451. 2014-05-02. PMID:24503096. |
overexpression of wild-type and mutant rab proteins showed that membrane trafficking along not only the endocytic-recycling pathway but also the endo-lysosomal pathway is involved in de novo prp(sc) generation. |
2014-05-02 |
2023-08-12 |
Not clear |
| Takeshi Yamasaki, Gerald S Baron, Akio Suzuki, Rie Hasebe, Motohiro Horiuch. Characterization of intracellular dynamics of inoculated PrP-res and newly generated PrP(Sc) during early stage prion infection in Neuro2a cells. Virology. vol 450-451. 2014-05-02. PMID:24503096. |
these results suggest that the trafficking of exogenously introduced prp(sc) from the endo-lysosomal pathway to the endocytic-recycling pathway is important for the establishment of prion infection. |
2014-05-02 |
2023-08-12 |
Not clear |
| Yael Friedman-Levi, Michal Mizrahi, Kati Frid, Orli Binyamin, Ruth Gabizo. PrP(ST), a soluble, protease resistant and truncated PrP form features in the pathogenesis of a genetic prion disease. PloS one. vol 8. issue 7. 2014-04-29. PMID:23922744. |
while the conversion of prp(c) into prp(sc) in the transmissible form of prion disease requires a preexisting prp(sc) seed, in genetic prion disease accumulation of disease related prp could be associated with biochemical and metabolic modifications resulting from the designated prp mutation. |
2014-04-29 |
2023-08-12 |
mouse |
| Yael Friedman-Levi, Michal Mizrahi, Kati Frid, Orli Binyamin, Ruth Gabizo. PrP(ST), a soluble, protease resistant and truncated PrP form features in the pathogenesis of a genetic prion disease. PloS one. vol 8. issue 7. 2014-04-29. PMID:23922744. |
we next looked into brain samples from e200k patients and found that both pk resistant prps, prp(st) as in tgmhu2me199k mice, and "classical" prp(sc) as in infectious prion diseases, coincide in the patient's post mortem brains. |
2014-04-29 |
2023-08-12 |
mouse |
| Emmanuel A Asante, Jacqueline M Linehan, Michelle Smidak, Andrew Tomlinson, Andrew Grimshaw, Asif Jeelani, Tatiana Jakubcova, Shyma Hamdan, Caroline Powell, Sebastian Brandner, Jonathan D F Wadsworth, John Colling. Inherited prion disease A117V is not simply a proteinopathy but produces prions transmissible to transgenic mice expressing homologous prion protein. PLoS pathogens. vol 9. issue 9. 2014-04-28. PMID:24086135. |
multiple attempts to transmit a117v gss have been unsuccessful and typical protease-resistant prp (prp(sc)), pathognomonic of prion disease, is not detected in brain. |
2014-04-28 |
2023-08-12 |
mouse |
| Emmanuel A Asante, Jacqueline M Linehan, Michelle Smidak, Andrew Tomlinson, Andrew Grimshaw, Asif Jeelani, Tatiana Jakubcova, Shyma Hamdan, Caroline Powell, Sebastian Brandner, Jonathan D F Wadsworth, John Colling. Inherited prion disease A117V is not simply a proteinopathy but produces prions transmissible to transgenic mice expressing homologous prion protein. PLoS pathogens. vol 9. issue 9. 2014-04-28. PMID:24086135. |
we found that brain tissue from gss a117v patients did transmit disease to these mice and both the neuropathological features of prion disease and presence of prp(sc) was demonstrated in the brains of recipient transgenic mice. |
2014-04-28 |
2023-08-12 |
mouse |
| Emmanuel A Asante, Jacqueline M Linehan, Michelle Smidak, Andrew Tomlinson, Andrew Grimshaw, Asif Jeelani, Tatiana Jakubcova, Shyma Hamdan, Caroline Powell, Sebastian Brandner, Jonathan D F Wadsworth, John Colling. Inherited prion disease A117V is not simply a proteinopathy but produces prions transmissible to transgenic mice expressing homologous prion protein. PLoS pathogens. vol 9. issue 9. 2014-04-28. PMID:24086135. |
this prp(sc) rapidly degraded during laboratory analysis, suggesting that the difficulty in its detection in patients with gss a117v could relate to post-mortem proteolysis. |
2014-04-28 |
2023-08-12 |
mouse |
| Elin K Allard, Mirjana Grujic, Gilberto Fisone, Krister Kristensso. Prion formation correlates with activation of translation-regulating protein 4E-BP and neuronal transcription factor Elk1. Neurobiology of disease. vol 58. 2014-04-23. PMID:23742760. |
cellular mechanisms play a role in conversion of the normal prion protein prp(c) to the disease-associated protein prp(sc). |
2014-04-23 |
2023-08-12 |
Not clear |
| Elin K Allard, Mirjana Grujic, Gilberto Fisone, Krister Kristensso. Prion formation correlates with activation of translation-regulating protein 4E-BP and neuronal transcription factor Elk1. Neurobiology of disease. vol 58. 2014-04-23. PMID:23742760. |
in order to obtain a "flow-chart" of such pathways, we here studied the activation of mek/erk and mtorc1 downstream targets in relation to prp(sc) accumulation in gt1-1 cells infected with the rml or 22l prion strains. |
2014-04-23 |
2023-08-12 |
Not clear |
| Elin K Allard, Mirjana Grujic, Gilberto Fisone, Krister Kristensso. Prion formation correlates with activation of translation-regulating protein 4E-BP and neuronal transcription factor Elk1. Neurobiology of disease. vol 58. 2014-04-23. PMID:23742760. |
we show that inhibition of mtorc1 with rapamycin causes a reduction of prp(sc) accumulation at similar low levels as seen when the interaction between the translation initiation factors eif4e and eif4g downstream mtorc1 is inhibited using 4egi-1. |
2014-04-23 |
2023-08-12 |
Not clear |
| Elin K Allard, Mirjana Grujic, Gilberto Fisone, Krister Kristensso. Prion formation correlates with activation of translation-regulating protein 4E-BP and neuronal transcription factor Elk1. Neurobiology of disease. vol 58. 2014-04-23. PMID:23742760. |
this study shows that prion formation can be modulated by translational initiating factors, and suggests that mek/erk signaling plays a role in the conversion of prp(c) to prp(sc) via an elk1-mediated transcriptional control. |
2014-04-23 |
2023-08-12 |
Not clear |
| Xuesong Wang, Lei He, Cong Zhao, Weihong Du, Jun Li. Gold complexes inhibit the aggregation of prion neuropeptides. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 18. issue 7. 2014-04-23. PMID:23982344. |
prion diseases are characterized by conformational conversion of prion protein from a normal cellular form to an abnormal scrapie isoform (prp(sc)). |
2014-04-23 |
2023-08-12 |
Not clear |
| Xuesong Wang, Lei He, Cong Zhao, Weihong Du, Jun Li. Gold complexes inhibit the aggregation of prion neuropeptides. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 18. issue 7. 2014-04-23. PMID:23982344. |
prp106-126 is a prion neuropeptide and an accepted model used to study the characteristics of prp(sc) because such a model has biological and physiochemical properties similar to those of prp(sc). |
2014-04-23 |
2023-08-12 |
Not clear |
| Gianluigi Zanusso, Michele Fiorini, Sergio Ferrari, Kimberly Meade-White, Ilaria Barbieri, Emiliana Brocchi, Bernardino Ghetti, Salvatore Monac. Gerstmann-Sträussler-Scheinker disease and "anchorless prion protein" mice share prion conformational properties diverging from sporadic Creutzfeldt-Jakob disease. The Journal of biological chemistry. vol 289. issue 8. 2014-04-22. PMID:24398683. |
these findings show that anchorless prp(sc) generates gss-like prp fragments, and suggest a major role for unanchored prp in amyloidogenesis. |
2014-04-22 |
2023-08-12 |
mouse |