| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Keiko Sakai, Rie Hasebe, Yusuke Takahashi, Chang-Hyun Song, Akio Suzuki, Takeshi Yamasaki, Motohiro Horiuch. Absence of CD14 delays progression of prion diseases accompanied by increased microglial activation. Journal of virology. vol 87. issue 24. 2014-02-05. PMID:24089559. |
prion diseases are fatal neurodegenerative disorders characterized by accumulation of prp(sc), vacuolation of neurons and neuropil, astrocytosis, and microglial activation. |
2014-02-05 |
2023-08-12 |
mouse |
| Keiko Sakai, Rie Hasebe, Yusuke Takahashi, Chang-Hyun Song, Akio Suzuki, Takeshi Yamasaki, Motohiro Horiuch. Absence of CD14 delays progression of prion diseases accompanied by increased microglial activation. Journal of virology. vol 87. issue 24. 2014-02-05. PMID:24089559. |
immunofluorescence staining that can distinguish normal prion protein from the disease-specific form of prion protein (prp(sc)) revealed that deposition of prp(sc) was delayed in cd14(-/-) mice compared with wt mice by the middle stage of the infection. |
2014-02-05 |
2023-08-12 |
mouse |
| Zhe Li, B Michael Silber, Satish Rao, Joel R Gever, Clifford Bryant, Alejandra Gallardo-Godoy, Elena Dolghih, Kartika Widjaja, Manuel Elepano, Matthew P Jacobson, Stanley B Prusiner, Adam R Rensl. 2-Aminothiazoles with improved pharmacotherapeutic properties for treatment of prion disease. ChemMedChem. vol 8. issue 5. 2014-01-23. PMID:23509039. |
despite its good pharmacokinetic properties, compound 1 exhibited only modest potency in mouse neuroblastoma cells overexpressing the disease-causing prion protein prp(sc) . |
2014-01-23 |
2023-08-12 |
mouse |
| Constanza J Cortes, Kefeng Qin, Eric M Norstrom, William N Green, Vytautas P Bindokas, James A Mastriann. Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy. International journal of cell biology. vol 2013. 2014-01-23. PMID:24454378. |
prion diseases are linked to the accumulation of a misfolded isoform (prp(sc)) of prion protein (prp). |
2014-01-23 |
2023-08-12 |
mouse |
| Constanza J Cortes, Kefeng Qin, Eric M Norstrom, William N Green, Vytautas P Bindokas, James A Mastriann. Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy. International journal of cell biology. vol 2013. 2014-01-23. PMID:24454378. |
evidence suggests that lysosomes are degradation endpoints and sites of the accumulation of prp(sc). |
2014-01-23 |
2023-08-12 |
mouse |
| Constanza J Cortes, Kefeng Qin, Eric M Norstrom, William N Green, Vytautas P Bindokas, James A Mastriann. Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy. International journal of cell biology. vol 2013. 2014-01-23. PMID:24454378. |
these findings suggest that autophagy might function as a quality control mechanism to limit the accumulation of misfolded prp that normally leads to the generation of prp(sc). |
2014-01-23 |
2023-08-12 |
mouse |
| Shanwei Xu, Tim Reuter, Brandon H Gilroyed, Lisa Tymensen, Yongxin Hao, Xiying Hao, Miodrag Belosevic, Jerry J Leonard, Tim A McAlliste. Microbial communities and greenhouse gas emissions associated with the biodegradation of specified risk material in compost. Waste management (New York, N.Y.). vol 33. issue 6. 2014-01-21. PMID:23490363. |
provided that infectious prions (prp(sc)) are inactivated, composting of specified risk material (srm) may be a viable alternative to rendering and landfilling. |
2014-01-21 |
2023-08-12 |
chicken |
| Shanwei Xu, Tim Reuter, Brandon H Gilroyed, Lisa Tymensen, Yongxin Hao, Xiying Hao, Miodrag Belosevic, Jerry J Leonard, Tim A McAlliste. Microbial communities and greenhouse gas emissions associated with the biodegradation of specified risk material in compost. Waste management (New York, N.Y.). vol 33. issue 6. 2014-01-21. PMID:23490363. |
although inclusion of feathers in compost increases greenhouse gas emissions, it may promote the establishment of microbial communities that are more adept at degrading srm and recalcitrant proteins such as keratin and prp(sc). |
2014-01-21 |
2023-08-12 |
chicken |
| Laura Manuelidi. Infectious particles, stress, and induced prion amyloids: a unifying perspective. Virulence. vol 4. issue 5. 2014-01-21. PMID:23633671. |
transmissible encephalopathies (tses) are believed by many to arise by spontaneous conversion of host prion protein (prp) into an infectious amyloid (prp-res, prp (sc) ) without nucleic acid. |
2014-01-21 |
2023-08-12 |
cattle |
| Yuzuru Taguchi, Arla M A Mistica, Tetsuyuki Kitamoto, Hermann M Schätz. Critical significance of the region between Helix 1 and 2 for efficient dominant-negative inhibition by conversion-incompetent prion protein. PLoS pathogens. vol 9. issue 6. 2014-01-17. PMID:23825952. |
prion diseases are fatal infectious neurodegenerative disorders in man and animals associated with the accumulation of the pathogenic isoform prp(sc) of the host-encoded prion protein (prp(c)). |
2014-01-17 |
2023-08-12 |
human |
| Yuzuru Taguchi, Arla M A Mistica, Tetsuyuki Kitamoto, Hermann M Schätz. Critical significance of the region between Helix 1 and 2 for efficient dominant-negative inhibition by conversion-incompetent prion protein. PLoS pathogens. vol 9. issue 6. 2014-01-17. PMID:23825952. |
a profound conformational change of prp(c) underlies formation of prp(sc) and prion propagation involves conversion of prp(c) substrate by direct interaction with prp(sc) template. |
2014-01-17 |
2023-08-12 |
human |
| Yuzuru Taguchi, Arla M A Mistica, Tetsuyuki Kitamoto, Hermann M Schätz. Critical significance of the region between Helix 1 and 2 for efficient dominant-negative inhibition by conversion-incompetent prion protein. PLoS pathogens. vol 9. issue 6. 2014-01-17. PMID:23825952. |
it also suggests that this region is involved in prp-prp interaction and conversion of prp(c) into prp(sc). |
2014-01-17 |
2023-08-12 |
human |
| Yuzuru Taguchi, Arla M A Mistica, Tetsuyuki Kitamoto, Hermann M Schätz. Critical significance of the region between Helix 1 and 2 for efficient dominant-negative inhibition by conversion-incompetent prion protein. PLoS pathogens. vol 9. issue 6. 2014-01-17. PMID:23825952. |
using autophagy pathways Δprps obtain access to the locale of prion conversion and prp(sc) recycling and can exert dni there. |
2014-01-17 |
2023-08-12 |
human |
| Mridula Swayampakula, Pravas Kumar Baral, Adriano Aguzzi, Nat N V Kav, Michael N G Jame. The crystal structure of an octapeptide repeat of the prion protein in complex with a Fab fragment of the POM2 antibody. Protein science : a publication of the Protein Society. vol 22. issue 7. 2014-01-16. PMID:23629842. |
prion diseases are progressive, infectious neurodegenerative disorders caused primarily by the misfolding of the cellular prion protein (prp(c)) into an insoluble, protease-resistant, aggregated isoform termed prp(sc). |
2014-01-16 |
2023-08-12 |
Not clear |
| Y Matsuura, Y Iwamaru, K Masujin, M Imamura, S Mohri, T Yokoyama, H Okad. Distribution of abnormal prion protein in a sheep affected with L-type bovine spongiform encephalopathy. Journal of comparative pathology. vol 149. issue 1. 2014-01-08. PMID:23273583. |
to investigate the topographical distribution and patterns of deposition of immunolabelled abnormal prion protein (prp(sc)), interspecies transmission of atypical l-type bovine spongiform encephalopathy (bse) to cheviot ewes (arq/arq genotype) was performed. |
2014-01-08 |
2023-08-12 |
cattle |
| Y Matsuura, Y Iwamaru, K Masujin, M Imamura, S Mohri, T Yokoyama, H Okad. Distribution of abnormal prion protein in a sheep affected with L-type bovine spongiform encephalopathy. Journal of comparative pathology. vol 149. issue 1. 2014-01-08. PMID:23273583. |
minimal vacuolar change was detected in the basal ganglia, thalamus and brainstem, and prp(sc) accumulated throughout the brain. |
2014-01-08 |
2023-08-12 |
cattle |
| Y Matsuura, Y Iwamaru, K Masujin, M Imamura, S Mohri, T Yokoyama, H Okad. Distribution of abnormal prion protein in a sheep affected with L-type bovine spongiform encephalopathy. Journal of comparative pathology. vol 149. issue 1. 2014-01-08. PMID:23273583. |
the l-type bse-affected sheep was characterized by conspicuous fine particulate deposits in the neuropil, particulate and/or granular intraneuronal and intraglial deposits, and the absence of prp(sc) plaques or stellate deposits. |
2014-01-08 |
2023-08-12 |
cattle |
| Y Matsuura, Y Iwamaru, K Masujin, M Imamura, S Mohri, T Yokoyama, H Okad. Distribution of abnormal prion protein in a sheep affected with L-type bovine spongiform encephalopathy. Journal of comparative pathology. vol 149. issue 1. 2014-01-08. PMID:23273583. |
in addition, immunohistochemical and western blot analyses revealed that prp(sc) accumulation was present in peripheral nervous tissues (including the trigeminal ganglia and dorsal root ganglion) and adrenal glands, but was absent in lymphoid tissues. |
2014-01-08 |
2023-08-12 |
cattle |
| Y Matsuura, Y Iwamaru, K Masujin, M Imamura, S Mohri, T Yokoyama, H Okad. Distribution of abnormal prion protein in a sheep affected with L-type bovine spongiform encephalopathy. Journal of comparative pathology. vol 149. issue 1. 2014-01-08. PMID:23273583. |
these results suggest that l-type bse has distinct and distinguishable characteristics as well as prp(sc) tissue tropism in sheep. |
2014-01-08 |
2023-08-12 |
cattle |
| James M McCarthy, Dietmar Appelhans, Jörg Tatzelt, Mark S Roger. Nanomedicine for prion disease treatment: new insights into the role of dendrimers. Prion. vol 7. issue 3. 2014-01-08. PMID:23764833. |
progress is hampered by the difficulty in identifying compounds that affect prp (sc) and the necessity of any potential therapeutic to gain access to the cns. |
2014-01-08 |
2023-08-12 |
Not clear |