| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Koichiro Kawashima, Masato Mashimo, Atsuo Nomura, Takeshi Fuji. Contributions of Non-Neuronal Cholinergic Systems to the Regulation of Immune Cell Function, Highlighting the Role of α7 Nicotinic Acetylcholine Receptors. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38674149. |
it thus appears that non-neuronal cholinergic systems are expressed in a variety of mammalian cells, and that ach should now be recognized not only as a neurotransmitter, but also as a local regulator of non-neuronal cholinergic systems. |
2024-04-27 |
2024-04-29 |
Not clear |
| Xiyong Xiang, Siyu Xia, Shan Li, Yirong Zeng, Lixuan Wang, Yan Zho. Study on the role and mechanism of Tan IIA in Alzheimer's disease based on CREB-BDNF-TrkB pathway. Neuroscience letters. 2024-04-14. PMID:38616003. |
these data suggest that tan iia may upregulate the expression of the creb-bdnf-trkb signaling pathway in the hippocampus of brain tissue, produce anti-neuroinflammatory, antioxidant stress, inhibit neuronal apoptosis effects, and improve cholinergic neurotransmitter disorder induced by stz, reduce the neuronal damage and learning and memory impairment caused by stz in rats, and improve the cognitive function of rats. |
2024-04-14 |
2024-04-17 |
rat |
| Juan David Villeda-González, José Luis Gómez-Olivares, Luis Arturo Baiza-Gutma. New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl-and-butyrylcholinesterase. Journal of cellular physiology. 2024-04-12. PMID:38605655. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that belong to the neuromuscular cholinergic system, their main function is to hydrolyze the neurotransmitter acetylcholine (ach), through their hydrolysis these enzymes regulate the neuronal and neuromuscular cholinergic system. |
2024-04-12 |
2024-04-14 |
Not clear |
| Gumpeny R Sridhar, Lakshmi Gumpen. Emerging significance of butyrylcholinesterase. World journal of experimental medicine. vol 14. issue 1. 2024-04-09. PMID:38590305. |
its other functions include the ability to hydrolyze acetylcholine, the cholinergic neurotransmitter in the brain, when its primary hydrolytic enzyme, acetylcholinesterase, is absent. |
2024-04-09 |
2024-04-11 |
human |
| Érica Novaes Soares, Ana Carla Dos Santos Costa, Gabriel de Jesus Ferrolho, Rodrigo Portes Ureshino, Bruk Getachew, Silvia Lima Costa, Victor Diogenes Amaral da Silva, Yousef Tizab. Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson's Disease. Cells. vol 13. issue 6. 2024-03-27. PMID:38534318. |
dopamine (da) is the primary neurotransmitter involved in this disease, but cholinergic imbalance has also been implicated. |
2024-03-27 |
2024-03-29 |
Not clear |
| Arash Salehi, Behzad Zolfaghari, Mahmoud Aghaei, Hajar Sirous, Morteza Sadeghi, Mohammad Reza Gholami, Parham Reisi, Mustafa Ghanadia. New amide and diterpene alkaloids with anticholinesterase activity from Delphinium cyphoplectrum roots. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2024-03-18. PMID:38498253. |
the cholinergic hypothesis posits a robust correlation between the onset of alzheimer's disease and a pronounced deficit in acetylcholine, a pivotal neurotransmitter crucial for the central cholinergic nervous system's function, pivotal for memory and learning. |
2024-03-18 |
2024-03-21 |
Not clear |
| Shiho Taniguchi, Satoshi Nakayama, Rin Iguchi, Yasunori Sasakura, Honoo Satake, Shuichi Wada, Nobuo Suzuki, Michio Ogasawara, Toshio Sekiguch. Distribution of cionin, a cholecystokinin/gastrin family peptide, and its receptor in the central nervous system of Ciona intestinalis type A. Scientific reports. vol 14. issue 1. 2024-03-16. PMID:38491056. |
consequently, these results suggest that cionin interacts with cholinergic neurons as a neurotransmitter or neuromodulator via cior1. |
2024-03-16 |
2024-03-19 |
Not clear |
| F Javier Luque, Diego Muñoz-Torrer. Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets. Accounts of chemical research. 2024-02-09. PMID:38333993. |
conspectusthe enzyme acetylcholinesterase (ache) hydrolyzes the neurotransmitter acetylcholine (ach) at cholinergic synapses of the peripheral and central nervous system. |
2024-02-09 |
2024-02-11 |
human |
| Navneet Dhaliwal, Jatinder Dhaliwal, Kanwaljit Chopr. 7, 8-dihydroxyflavone Ameliorates Cholinergic Dysfunction, Inflammation, Oxidative Stress, and Apoptosis in a Rat Model of Vascular Dementia. Neurochemical research. 2024-02-01. PMID:38300457. |
p-akt, p-creb, bdnf, and neurotransmitter (nt) (glu, gaba, and ach) levels were also analyzed in the hippocampus of 2-vo rats. our results show that 7,8-dhf effectively improved memory performance and cholinergic dysfunction in 2-vo model rats. |
2024-02-01 |
2024-02-03 |
rat |
| Min Ha Kim, Hye Rim Suh, Hee Chul Ha. The effects of the cholinergic system on carrageenan-induced arthritis. Neuroscience letters. 2024-01-23. PMID:38262509. |
the cholinergic system has been found to make an anti-inflammatory effect through the cholinergic anti-inflammatory pathway (caip), which suppresses the production of pro-inflammatory cytokines by secreting acetylcholine, a major neurotransmitter. |
2024-01-23 |
2024-01-26 |
rat |
| Tosin A Olasehinde, Oyinlola O Olaoku. The Beneficial Role of Apigenin against Cognitive and Neurobehavioural Dysfunction: A Systematic Review of Preclinical Investigations. Biomedicines. vol 12. issue 1. 2024-01-23. PMID:38255283. |
some of the molecular and biochemical mechanisms of apigenin include activation of the erk/creb/bdnf signalling pathway; modulation of neurotransmitter levels and monoaminergic, cholinergic, dopaminergic and serotonergic systems; inhibition of pro-inflammatory cytokine production; and attenuation of oxidative neuronal damage. |
2024-01-23 |
2024-01-25 |
mouse |
| b' Suzana \\xc5\\xbdunec, Donna Vadlja, Alma Rami\\xc4\\x87, Antonio Zandona, Nikola Marakovi\\xc4\\x87, Iva Brekalo, Ines Primo\\xc5\\xbei\\xc4\\x8d, Maja Katalini\\xc4\\x8. Profiling Novel Quinuclidine-Based Derivatives as Potential Anticholinesterase Drugs: Enzyme Inhibition and Effects on Cell Viability. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203326.' |
the cholinergic system, relying on the neurotransmitter acetylcholine (ach), plays a significant role in muscle contraction, cognition, and autonomic nervous system regulation. |
2024-01-11 |
2024-01-13 |
Not clear |
| Keontae Park, Chang Hyeon Kong, Woo Chang Kang, Mijin Jeon, Won Hyung Lee, Juyeon Lee, Sang Chul Kim, Seo Yun Jung, Jong Hoon Ry. LPC20K modified from krill oil ameliorates the scopolamine-induced cognitive impairment. Behavioural brain research. 2023-12-25. PMID:38145873. |
etiologically, dysfunction of cholinergic neurotransmitter system is prominent in ad. |
2023-12-25 |
2023-12-28 |
Not clear |
| Filippo Basagni, Jose A Ortega, Sine M Bertozzi, Andrea Armirotti, Maria Summa, Rosalia Bertorelli, Manuela Bartolini, Ian R Mellor, Martina Bedeschi, Giovanni Bottegoni, Vittorio Lembo, Anna Minarini, Andrea Cavalli, Michela Rosin. Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties. European journal of medicinal chemistry. vol 261. 2023-09-21. PMID:37734258. |
neurodegenerative processes characterizing alzheimer's disease (ad) are strictly related to the impairment of cholinergic and glutamatergic neurotransmitter systems which provoke synaptic loss. |
2023-09-21 |
2023-10-07 |
Not clear |
| Joseph V Martin, Pradip K Sarka. Nongenomic roles of thyroid hormones and their derivatives in adult brain: are these compounds putative neurotransmitters? Frontiers in endocrinology. vol 14. 2023-09-13. PMID:37701902. |
furthermore, thyronines bind specifically to other defined neurotransmitter receptors, including gabaergic, catecholaminergic, glutamatergic, serotonergic and cholinergic systems. |
2023-09-13 |
2023-10-07 |
Not clear |
| Ayokunle Olubode Ademosun, Olufunke Florence Ajeigbe, Bodun Oluwaseun Lawrence, Ganiyu Obo. Modulatory Effects of Cannabis Sativa Co-administration with Tramadol and Codeine on Cognitive Function in Male Rats. Neurotoxicology. 2023-08-31. PMID:37652187. |
this study reported the mechanism behind the neurotoxicity of cnb, tmd, and cde on rats' cognitive, cholinergic, purinergic, and antioxidant enzymes as a consequence of the drastic reduction in cholinesterase enzyme activities leading to neurotransmitter poisoning. |
2023-08-31 |
2023-09-07 |
rat |
| Francisco Nieto-Escamez, Esteban Obrero-Gaitán, Irene Cortés-Pére. Visual Dysfunction in Parkinson's Disease. Brain sciences. vol 13. issue 8. 2023-08-26. PMID:37626529. |
similarly, although the involvement of different neurotransmitter systems is controversial, data about neurochemical alterations related to visual impairments are presented, especially dopaminergic, cholinergic, and serotoninergic systems. |
2023-08-26 |
2023-09-07 |
Not clear |
| Moncef Zoual. Pharmacological and Electroceutical Targeting of the Cholinergic Anti-Inflammatory Pathway in Autoimmune Diseases. Pharmaceuticals (Basel, Switzerland). vol 16. issue 8. 2023-08-26. PMID:37631004. |
in the cholinergic anti-inflammatory pathway, the vagus nerve, its pivotal neurotransmitter acetylcholine, together with the corresponding receptors play a key role in modulating the immune response of mammals. |
2023-08-26 |
2023-09-07 |
Not clear |
| Yaoyao Ren, Shengtao Q. Constituent isoflavones of Puerariae radix as a potential neuroprotector in cognitive impairment: Evidence from preclinical studies. Ageing research reviews. 2023-08-24. PMID:37619620. |
these isoflavones prevent aβ aggregation, inhibit tau hyperphosphorylation, increase cholinergic neurotransmitter levels, reduce neuroinflammation and oxidative stress, improve synaptic plasticity, promote nerve regeneration, and prevent apoptosis. |
2023-08-24 |
2023-09-07 |
Not clear |
| A M Dzhafarova, M B Saidov, N K Klichkhano. The Time Profile of the Effects of Moderate Hypothermia on Synaptic Acetylcholinesterase in Rat Brain. Bulletin of experimental biology and medicine. 2023-07-18. PMID:37462806. |
hypothermia in homeotherms significantly affects the neurotransmitter systems of the brain, including the cholinergic system. |
2023-07-18 |
2023-08-14 |
rat |