| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Woosuk Kim, Kyu Ri Hahn, Hyo Young Jung, Hyun Jung Kwon, Sung Min Nam, Tae Hyeong Kim, Jong Whi Kim, Dae Young Yoo, Dae Won Kim, Jung Hoon Choi, Yeo Sung Yoon, In Koo Hwan. Cuprizone Affects Hypothermia-Induced Neuroprotection and Enhanced Neuroblast Differentiation in the Gerbil Hippocampus after Ischemia. Cells. vol 9. issue 6. 2021-03-18. PMID:32531881. |
cuprizone treatment for 8 weeks increased the number of astrocytes, microglia, and pro-inflammatory cytokine levels in the hippocampus. |
2021-03-18 |
2023-08-13 |
Not clear |
| Yanchao Liu, Shujuan Zhang, Xiaoguang Li, Enjie Liu, Xin Wang, Qiuzhi Zhou, Jinwang Ye, Jian-Zhi Wan. Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier. Bioscience reports. vol 40. issue 2. 2021-03-16. PMID:32043530. |
in the ad patients, the abnormal tau accumulation first appeared in entorhinal cortex (ec) and then propagated to the hippocampus with microglia activation and inflammation, but the mechanism is elusive. |
2021-03-16 |
2023-08-13 |
human |
| Una Avdic, Matilda Ahl, My Andersson, Christine T Ekdah. Levetiracetam and N-Cadherin Antibody Alleviate Brain Pathology Without Reducing Early Epilepsy Development After Focal Non-convulsive Status Epilepticus in Rats. Frontiers in neurology. vol 12. 2021-03-16. PMID:33716930. |
continuous levetiracetam treatment for 4 weeks post-fncse reduced microglia activation, including cell numbers and morphological changes, partly decreased neuronal cell loss, and excitatory post-synaptic scaffold protein psd-95 expression in selective hippocampal structures. |
2021-03-16 |
2023-08-13 |
rat |
| Daniele Lana, Filippo Ugolini, Maria Grazia Giovannin. Space-Dependent Glia-Neuron Interplay in the Hippocampus of Transgenic Models of β-Amyloid Deposition. International journal of molecular sciences. vol 21. issue 24. 2021-03-15. PMID:33322419. |
differential crosstalk between astrocytes and microglia in ca1 and ca3 areas of the hippocampus can be responsible for the differential sensitivity of the two areas to insults. |
2021-03-15 |
2023-08-13 |
Not clear |
| David Wegrzyn, Nadja Freund, Andreas Faissner, Georg Jucke. Poly I:C Activated Microglia Disrupt Perineuronal Nets and Modulate Synaptic Balance in Primary Hippocampal Neurons Frontiers in synaptic neuroscience. vol 13. 2021-03-13. PMID:33708102. |
poly i:c activated microglia disrupt perineuronal nets and modulate synaptic balance in primary hippocampal neurons perineuronal nets (pnns) are specialized, reticular structures of the extracellular matrix (ecm) that can be found covering the soma and proximal dendrites of a neuronal subpopulation. |
2021-03-13 |
2023-08-13 |
Not clear |
| David Wegrzyn, Nadja Freund, Andreas Faissner, Georg Jucke. Poly I:C Activated Microglia Disrupt Perineuronal Nets and Modulate Synaptic Balance in Primary Hippocampal Neurons Frontiers in synaptic neuroscience. vol 13. 2021-03-13. PMID:33708102. |
based on this knowledge, we analyzed the impact of activated microglia on hippocampal neuronal networks |
2021-03-13 |
2023-08-13 |
Not clear |
| Nannan Lan, Yongxin Liu, Zhaodong Juan, Rui Zhang, Baoyu Ma, Keliang Xie, Lina Sun, Hao Feng, Meng Sun, Jianfeng Li. The TSPO-specific Ligand PK11195 Protects Against LPS-Induced Cognitive Dysfunction by Inhibiting Cellular Autophagy. Frontiers in pharmacology. vol 11. 2021-03-13. PMID:33708121. |
the hippocampal microglia of pnd model rats also have severe mitochondrial damage, and a large number of autophagosomes and phagocytic vesicles can be seen. |
2021-03-13 |
2023-08-13 |
rat |
| Anna O Giarratana, Cynthia Zheng, Sahithi Reddi, Shavonne L Teng, David Berger, Derek Adler, Patrick Sullivan, Smita Thakker-Varia, Janet Alde. APOE4 genetic polymorphism results in impaired recovery in a repeated mild traumatic brain injury model and treatment with Bryostatin-1 improves outcomes. Scientific reports. vol 10. issue 1. 2021-03-11. PMID:33199792. |
relative to injured apoe3 tr mice, injured apoe4 tr mice had more inflammation, neurodegeneration, apoptosis, p-tau, and activated microglia and less total brain-derived neurotrophic factor (bdnf) in the cortex and/or hippocampus at 1 and/or 21 days post-injury. |
2021-03-11 |
2023-08-13 |
mouse |
| Sandra Bonfante, Larissa Joaquim, Maria Eduarda Fileti, Amanda Della Giustina, Mariana Pereira de Souza Goldim, Lucinéia Gainski Danielski, Evandro Cittadin, Raquel Jaconi De Carli, Bianca Xavier de Farias, Nicole Alessandra Engel, Naiana da Rosa, Jucélia Jeremias Fortunato, Vijayasree Giridharan, Giselli Scaini, Gislaine Tezza Rezin, Jaqueline Generoso, Rafael Mariano de Bitencourt, Silvia Terra, Tatiana Barichello, Fabricia Petronilh. Stanniocalcin 1 Inhibits the Inflammatory Response in Microglia and Protects Against Sepsis-Associated Encephalopathy. Neurotoxicity research. vol 39. issue 2. 2021-03-10. PMID:33025358. |
here, we demonstrated a protective role of stc-1 on inflammatory responses in vitro, in activated microglia stimulated with lps, and on neuroinflammation, oxidative stress, and mitochondrial function in the hippocampus of rats subjected to an animal model of sepsis by cecal ligation and puncture (clp), as well the consequences on long-term memory. |
2021-03-10 |
2023-08-13 |
human |
| Shouchao Wei, Wanjuan Peng, Yingren Mai, Kanglan Li, Wei Wei, Li Hu, Shaoping Zhu, Haihong Zhou, Wanxin Jie, Zhuangsheng Wei, Chenyao Kang, Ruikai Li, Zhou Liu, Bin Zhao, Zhiyou Ca. Outer membrane vesicles enhance tau phosphorylation and contribute to cognitive impairment. Journal of cellular physiology. vol 235. issue 5. 2021-03-08. PMID:31663118. |
omvs activated astrocytes and microglia, increased secretion of inflammatory cytokines (nuclear factor κb, interleukin-1β, and tumour necrosis factor-α) in the hippocampus. |
2021-03-08 |
2023-08-13 |
Not clear |
| Kinga Gawlińska, Małgorzata Frankowska, Dawid Gawliński, Marcin Piechota, Michał Korostyński, Małgorzata Fili. Cocaine Administration and Its Abstinence Conditions Modulate Neuroglia. International journal of molecular sciences. vol 21. issue 21. 2021-03-08. PMID:33120991. |
in addition, downregulation of gene expression associated with oligodendrocytes (cnp, myrf) and microglia regulator of g protein signaling 1 (rgs1) was observed in the hippocampus, regardless of the type of drug abstinence, while downregulation of myelin and lymphocyte protein (mal) expression was found only in rats exposed to abstinence in the home cage. |
2021-03-08 |
2023-08-13 |
rat |
| Bernadette Basilico, Barbara Cortese, Patrizia Ratano, Silvia Di Angelantonio, Davide Ragozzin. Time-lapse Whole-field Fluorescence Imaging of Microglia ProcessesMotility in Acute Mouse Hippocampal Slices and Analysis. Bio-protocol. vol 9. issue 8. 2021-03-05. PMID:33655009. |
time-lapse whole-field fluorescence imaging of microglia processesmotility in acute mouse hippocampal slices and analysis. |
2021-03-05 |
2023-08-13 |
mouse |
| Samantha L Hodges, Suzanne O Nolan, Lindsay A Tomac, Ilyasah D A Muhammad, Matthew S Binder, Joseph H Taube, Joaquin N Lug. Lipopolysaccharide-induced inflammation leads to acute elevations in pro-inflammatory cytokine expression in a mouse model of Fragile X syndrome. Physiology & behavior. vol 215. 2021-03-04. PMID:31838149. |
there were no differences in hippocampal protein expression between genotypes in microglia (iba1) or astrocyte (gfap) reactivity. |
2021-03-04 |
2023-08-13 |
mouse |
| Jing Wang, Gangadhara R Sareddy, Yujiao Lu, Uday P Pratap, Fulei Tang, Karah M Greene, Pornjittra L Meyre, Rajeshwar R Tekmal, Ratna K Vadlamudi, Darrell W Bran. Astrocyte-Derived Estrogen Regulates Reactive Astrogliosis and is Neuroprotective following Ischemic Brain Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 50. 2021-03-04. PMID:33158962. |
in contrast, after gci, gfap-aro-ko mice: (1) lacked the normal elevation of astrocyte aromatase and hippocampal e2 levels; (2) had significantly attenuated reactive astrogliosis; and (3) displayed enhanced neuronal damage, microglia activation, and cognitive deficits. |
2021-03-04 |
2023-08-13 |
mouse |
| Jorge Miguel Amaya, Ernst Suidgeest, Isabelle Sahut-Barnola, Typhanie Dumontet, Nathanaëlle Montanier, Guilhem Pagès, Cécile Keller, Louise van der Weerd, Alberto M Pereira, Antoine Martinez, Onno C Meije. Effects of Long-Term Endogenous Corticosteroid Exposure on Brain Volume and Glial Cells in the AdKO Mouse. Frontiers in neuroscience. vol 15. 2021-03-03. PMID:33642975. |
we also observed a decrease in the expression of glial fibrillary acidic protein (gfap, a marker for reactive astrocytes) and ionized calcium-binding adapter molecule 1 (iba1, a marker for activated microglia) in the cingulate regions of the anterior corpus callosum and the hippocampus. |
2021-03-03 |
2023-08-13 |
mouse |
| Zhang Yuan, Shi Yi-Yun, Yu Hai-Ya. Triad3A displays a critical role in suppression of cerebral ischemic/reperfusion (I/R) injury by regulating necroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 128. 2021-03-01. PMID:32460187. |
triad3a and necroptosis were triggered in mouse microglia cells treated with oxygen and glucose deprivation (ogd), and in tnfα-incubated mouse hippocampal neuronal cells treated with z-vad-fmk, known as a pan-caspase inhibitor. |
2021-03-01 |
2023-08-13 |
mouse |
| Zhong-Fu Mao, Shu-Hua Ouyang, Qiong-Yi Zhang, Yan-Ping Wu, Guo-En Wang, Long-Fang Tu, Zhuo Luo, Wei-Xi Li, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong H. New insights into the effects of caffeine on adult hippocampal neurogenesis in stressed mice: Inhibition of CORT-induced microglia activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 8. 2021-02-25. PMID:32619083. |
new insights into the effects of caffeine on adult hippocampal neurogenesis in stressed mice: inhibition of cort-induced microglia activation. |
2021-02-25 |
2023-08-13 |
mouse |
| Zhong-Fu Mao, Shu-Hua Ouyang, Qiong-Yi Zhang, Yan-Ping Wu, Guo-En Wang, Long-Fang Tu, Zhuo Luo, Wei-Xi Li, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong H. New insights into the effects of caffeine on adult hippocampal neurogenesis in stressed mice: Inhibition of CORT-induced microglia activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 8. 2021-02-25. PMID:32619083. |
notably, microglia activation-evoked brain inflammation and inhibited neurogenesis were also observed in the hippocampus of stressed mice. |
2021-02-25 |
2023-08-13 |
mouse |
| Zhong-Fu Mao, Shu-Hua Ouyang, Qiong-Yi Zhang, Yan-Ping Wu, Guo-En Wang, Long-Fang Tu, Zhuo Luo, Wei-Xi Li, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong H. New insights into the effects of caffeine on adult hippocampal neurogenesis in stressed mice: Inhibition of CORT-induced microglia activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 8. 2021-02-25. PMID:32619083. |
in comparison, intragastric administration of caffeine (10 and 20 mg/kg, 28 days) significantly reverted cwirs-induced depressive behaviors, neurogenesis recession and microglia activation in the hippocampus. |
2021-02-25 |
2023-08-13 |
mouse |
| Tatiana Anan'ina, Alena Kisel, Marina Kudabaeva, Galina Chernysheva, Vera Smolyakova, Konstantin Usov, Elena Krutenkova, Mark Plotnikov, Marina Khodanovic. Neurodegeneration, Myelin Loss and Glial Response in the Three-Vessel Global Ischemia Model in Rat. International journal of molecular sciences. vol 21. issue 17. 2021-02-24. PMID:32872364. |
in addition, we investigated the relationships between demyelination and changes in microglia and astrocytes, as well as oligodendrogenesis in the hippocampus; (2) methods: adult male wistar rats ( |
2021-02-24 |
2023-08-13 |
human |