| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lars H Nelson, Pavan Peketi, Kathryn M Len. Microglia Regulate Cell Genesis in a Sex-dependent Manner in the Neonatal Hippocampus. Neuroscience. vol 453. 2021-05-14. PMID:33129890. |
we examined whether microglia support a known sex difference in neonatal hippocampal neurogenesis and whether juvenile hippocampal neurogenesis was impacted by the loss of neonatal microglia. |
2021-05-14 |
2023-08-13 |
rat |
| Lars H Nelson, Pavan Peketi, Kathryn M Len. Microglia Regulate Cell Genesis in a Sex-dependent Manner in the Neonatal Hippocampus. Neuroscience. vol 453. 2021-05-14. PMID:33129890. |
we used central infusion of liposomal clodronate to selectively deplete microglia and found decreased cell genesis in the male, but not female, dentate gyrus and hippocampus. |
2021-05-14 |
2023-08-13 |
rat |
| Lars H Nelson, Pavan Peketi, Kathryn M Len. Microglia Regulate Cell Genesis in a Sex-dependent Manner in the Neonatal Hippocampus. Neuroscience. vol 453. 2021-05-14. PMID:33129890. |
we found that expression of il1b and tnf were decreased in the hippocampus due to microglia depletion however, there were no sex differences in the expression of any immune genes. |
2021-05-14 |
2023-08-13 |
rat |
| Sana Chintamen, Fatima Imessadouene, Steven G Kerni. Immune Regulation of Adult Neurogenic Niches in Health and Disease. Frontiers in cellular neuroscience. vol 14. 2021-05-14. PMID:33551746. |
recent evidence demonstrates that in adulthood, microglia secrete factors which modulate adult hippocampal neurogenesis by inhibiting cell proliferation and survival both |
2021-05-14 |
2023-08-13 |
Not clear |
| Kenta Sakai, Fuyuko Takata, Gaku Yamanaka, Miho Yasunaga, Kana Hashiguchi, Kazuki Tominaga, Kouichi Itoh, Yasufumi Kataoka, Atsushi Yamauchi, Shinya Dohg. Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice. Journal of pharmacological sciences. vol 145. issue 1. 2021-05-13. PMID:33357774. |
histological analyses of brain pericytes, microglia and astrocytes were performed for up to 28 days after cci in the injured ipsilateral hippocampus. |
2021-05-13 |
2023-08-13 |
mouse |
| Hang Xu, Xiang Yang Zhang, Wei Wen Wang, Jiesi Wan. Hydroxychloroquine Increased Anxiety-Like Behaviors and Disrupted the Expression of Some Related Genes in the Mouse Brain. Frontiers in pharmacology. vol 12. 2021-05-08. PMID:33953673. |
furthermore, hcq decreased the mrna expression of interleukin-1beta, corticotropin-releasing hormone (crh), a serotonin transporter (slc6a4), and a microglia maker (aif1) in the hippocampus and decreased the mrna expression of brain-derived neurotrophic factor (bdnf) in both the hippocampus and amygdala. |
2021-05-08 |
2023-08-13 |
mouse |
| Azeez Olakunle Ishola, Aminu Imam, Moyosore Salihu Aja. Datumetine exposure alters hippocampal neurotransmitters system in C57BL/6 mice. Drug and chemical toxicology. 2021-05-07. PMID:32847421. |
immunofluorescence procedure was done to check the distribution of neurons, astrocytes, microglia and major neuronal subtypes in the hippocampus. |
2021-05-07 |
2023-08-13 |
mouse |
| Patrick Szu-Ying Yen, Yen-Chin Liu, Chun-Hsien Chu, Shiou-Lan Che. Upregulation of Glutamatergic Receptors in Hippocampus and Locomotor Hyperactivity in Aged Spontaneous Hypertensive Rat. Cellular and molecular neurobiology. 2021-05-06. PMID:33954807. |
moreover, a down-regulation of microglia in the hippocampus and mpfc was seen in the shr brain. |
2021-05-06 |
2023-08-13 |
rat |
| Anne-Marie Howe, Aoife Cosgrave, Maitiú Ó'Murchú, Conor Britchfield, Aoife Mulvagh, Iván Fernandez-Perez, Megan Dykstra, Aimée C Jones, Derek A Costell. Characterising lipoteichoic acid as an in vitro model of acute neuroinflammation. International immunopharmacology. vol 85. 2021-04-30. PMID:32485352. |
moreover, we find that exposure to lta can enhance sensitivity to subthreshold aβ, promoting an 'm1'-like phenotype in microglia and provoking dysregulation of neuronal activity in acute hippocampal slices. |
2021-04-30 |
2023-08-13 |
Not clear |
| David Val-Laillet, Ameni Kanzari, Sylvie Guérin, Gwénaëlle Randuineau, Nicolas Coquer. A maternal Western diet during gestation and lactation modifies offspring's microglial cell density and morphology in the hippocampus and prefrontal cortex in Yucatan minipigs. Neuroscience letters. vol 739. 2021-04-30. PMID:32950568. |
a maternal western diet during gestation and lactation modifies offspring's microglial cell density and morphology in the hippocampus and prefrontal cortex in yucatan minipigs. |
2021-04-30 |
2023-08-13 |
Not clear |
| Ying Guo, Jianping Xie, Lanchun Zhang, Lingli Yang, Jiaqing Ma, Yufan Bai, Wenjie Ma, Ling Wang, Haofei Yu, Yueqin Zeng, Haiyun Luo, Rongping Zhan. Ginsenoside Rb1 exerts antidepressant-like effects via suppression inflammation and activation of AKT pathway. Neuroscience letters. vol 744. 2021-04-30. PMID:33359924. |
taken together, the results indicate that grb1 prevents crs-induced depression-like behaviors in mice, which may be related to anti-inflammatory effects in hippocampus, serum and microglia and activation of akt pathway. |
2021-04-30 |
2023-08-13 |
mouse |
| Heping Shen, Qiaobing Guan, Xiaoling Zhang, Chao Yuan, Zhengye Tan, Liping Zhai, Yanan Hao, Yanling Gu, Chenyang Ha. New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota. Progress in neuro-psychopharmacology & biological psychiatry. vol 100. 2021-04-28. PMID:32032696. |
consistently, the cognitive impairment was more severe in mice receiving gut microbiota from ad patients than those did not, with activation of microglia in the central hippocampus of mice, and increased expression of neuroinflammatory factors. |
2021-04-28 |
2023-08-13 |
mouse |
| Heping Shen, Qiaobing Guan, Xiaoling Zhang, Chao Yuan, Zhengye Tan, Liping Zhai, Yanan Hao, Yanling Gu, Chenyang Ha. New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota. Progress in neuro-psychopharmacology & biological psychiatry. vol 100. 2021-04-28. PMID:32032696. |
consequently, the intestinal expression of nlrp3 was down-regulated, the cognitive ability of mice was improved, the activation of microglia in central hippocampus was suppressed and the expression of neuroinflammatory factors was also down-regulated. |
2021-04-28 |
2023-08-13 |
mouse |
| Heping Shen, Qiaobing Guan, Xiaoling Zhang, Chao Yuan, Zhengye Tan, Liping Zhai, Yanan Hao, Yanling Gu, Chenyang Ha. New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota. Progress in neuro-psychopharmacology & biological psychiatry. vol 100. 2021-04-28. PMID:32032696. |
although the cognitive ability of mice was not significantly changed, the microglia in the hippocampus of mice were still activated and the expression of inflammatory factors was up-regulated. |
2021-04-28 |
2023-08-13 |
mouse |
| Lídia Cantacorps, Sandra Montagud-Romero, Olga Valverd. Curcumin treatment attenuates alcohol-induced alterations in a mouse model of foetal alcohol spectrum disorders. Progress in neuro-psychopharmacology & biological psychiatry. vol 100. 2021-04-28. PMID:32109509. |
we focused on inflammatory and epigenetic mechanisms by analysing the expression of pro-inflammatory mediators, such as il-6, tnf-α, and nf-κb, in the hippocampus and prefrontal cortex, as well as microglia and astrocyte activation in the dentate gyrus. |
2021-04-28 |
2023-08-13 |
mouse |
| Yue Han, Jiutai Wang, Qiuying Zhao, Xiaofang Xie, Rui Song, Ying Xiao, Xixi Kang, Lijuan Zhang, Yue Zhang, Cheng Peng, Zili Yo. Pioglitazone alleviates maternal sleep deprivation-induced cognitive deficits in male rat offspring by enhancing microglia-mediated neurogenesis. Brain, behavior, and immunity. vol 87. 2021-04-27. PMID:32032783. |
in msd rat offspring, microglial density as determined by immunofluorescence was higher, microglia showed fewer and shorter processes, and neurogenesis in the hippocampus was significantly reduced. |
2021-04-27 |
2023-08-13 |
rat |
| Michael J Butler, Rachel M Cole, Nicholas P Deems, Martha A Belury, Ruth M Barriento. Fatty food, fatty acids, and microglial priming in the adult and aged hippocampus and amygdala. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32544595. |
our results indicate that hfd increased gene expression of microglial markers of activation indicative of microglial priming, including cd11b, mhcii, cx3cr1, and nlrp3, as well as the pro-inflammatory marker il-1β in both hippocampus and amygdala-derived microglia. |
2021-04-27 |
2023-08-13 |
rat |
| Michael J Butler, Rachel M Cole, Nicholas P Deems, Martha A Belury, Ruth M Barriento. Fatty food, fatty acids, and microglial priming in the adult and aged hippocampus and amygdala. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32544595. |
in a separate cohort of young and aged animals, isolated microglia from the hippocampus and amygdala exposed to palmitate in vitro induced an inflammatory gene expression profile mimicking the effects of hfd in vivo. |
2021-04-27 |
2023-08-13 |
rat |
| Okito Hashimoto, Hiroshi Kuniishi, Yuko Nakatake, Mitsuhiko Yamada, Keiji Wada, Masayuki Sekiguch. Early life stress from allergic dermatitis causes depressive-like behaviors in adolescent male mice through neuroinflammatory priming. Brain, behavior, and immunity. vol 90. 2021-04-27. PMID:32950622. |
although ox-treated pd40 mice showed neither behavioral abnormalities nor increases in pro-inflammatory cytokine expression in the brain, this study revealed that they experienced downregulation of cd200r1 expression in the amygdala under basal conditions and that additional lipopolysaccharide (lps) administration induced enhanced neuroinflammatory reaction as the priming effect was accompanied by an increase of iba-1-positive microglia in the amygdala and hippocampus. |
2021-04-27 |
2023-08-13 |
mouse |
| Daniele Lana, Filippo Ugolini, Daniele Nosi, Gary L Wenk, Maria Grazia Giovannin. The Emerging Role of the Interplay Among Astrocytes, Microglia, and Neurons in the Hippocampus in Health and Disease. Frontiers in aging neuroscience. vol 13. 2021-04-24. PMID:33889084. |
the emerging role of the interplay among astrocytes, microglia, and neurons in the hippocampus in health and disease. |
2021-04-24 |
2023-08-13 |
rat |