All Relations between microglial cell and nitrogen monoxide

Reference Sentence Publish Date Extraction Date Species
Jing Li, Peilin Zhu, Yue Li, Kai Xiao, Jing Tang, Xin Liang, Yanmin Luo, Jin Wang, Yuhui Deng, Lin Jiang, Qian Xiao, Yijing Guo, Yong Tang, Chunxia Huan. The liver X receptors agonist GW3965 attenuates depressive-like behaviors and suppresses microglial activation and neuroinflammation in hippocampal subregions in a mouse depression model. The Journal of comparative neurology vol issue 2022 35758275 to investigate the effects of lxrs agonist (gw3965) on neuroinflammation and microglia in the hippocampal formation of mice with chronic unpredictable stress (cus)-induced depression, depressive-like behaviors were evaluated by behavioral tests, hippocampal lxrs gene expression were evaluated by qrt-pcr, the protein expression levels of interleukin-1\xce\xb2, tumor necrosis factor-\xce\xb1, inducible nitric oxide synthase, nuclear factor kappa b, and cluster of differentiation 206 were estimated by western blotting, modern stereological methods were used to precisely quantify the total number of microglia in each hippocampal subregion, and immunofluorescence was used to detect the density of activated microglia and the morphology of microglia. 2022-06-27 2022-07-04 Not clear
Jinqiang Zhang, Dapeng Su, Qin Liu, Qingsong Yuan, Zhen Ouyang, Yuan Wei, Chenghong Xiao, Liangyuan Li, Changgui Yang, Weike Jiang, Lanping Guo, Tao Zho. Gasdermin D-mediated microglial pyroptosis exacerbates neurotoxicity of aflatoxins B1 and M1 in mouse primary microglia and neuronal cultures. Neurotoxicology vol issue 2022 35716928 blockade of gasdermin d activity in afb1- or afm1-treated primary microglia using dimethyl fumarate (dmf) reduced the release of il-1\xce\xb2, il-18 and nitric oxide, as well as the neurotoxicity of microglia-conditioned medium to neurons, astrocytes, oligodendrocytes and neural stem/precursor cells. 2022-06-18 2022-06-20 Not clear
Mengfan Li, Bingtian Xu, Xing Li, Yueqi Li, Shuqin Qiu, Kechun Chen, Zhuhe Liu, Yuewen Ding, Honghao Wang, Jiangping Xu, Haitao Wan. Mitofusin 2 confers the suppression of microglial activation by cannabidiol: insights from in vitro and in vivo models. Brain, behavior, and immunity vol issue 2022 35688339 we found that treatment with cbd decreased the levels of tumor necrosis factor \xce\xb1, interleukin 6, inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), and ionized calcium-binding adaptor molecule-1 (iba1) in lipopolysaccharide (lps)-challenged microglia. 2022-06-10 2022-06-13 Not clear
Hye-Rim Choi, Ji Sun Ha, Eun-A Kim, Sung-Woo Cho, Seung-Ju Yan. MiR-30a-5p and miR-153-3p regulate LPS-induced neuroinflammatory response and neuronal apoptosis by targeting NeuroD1. BMB reports vol issue 2022 35651331 in lps-induced microglia, mir-30a-5p and mir-153-3p suppressed pro-inflammatory cytokines, reactive oxygen species, the phosphorylation of c-jun n-terminal kinase, extracellular-signal-regulated kinase (erk), and p38, and the expression of cyclooxygenase and inducible nitric oxide synthase (inos) via the nf-\xce\xbab pathway. 2022-06-02 2022-06-13 Not clear
Abdur Rauf, Himani Badoni, Tareq Abu-Izneid, Ahmed Olatunde, Md Mominur Rahman, Sakshi Painuli, Prabhakar Semwal, Polrat Wilairatana, Mohammad S Mubara. Neuroinflammatory Markers: Key Indicators in the Pathology of Neurodegenerative Diseases. Molecules (Basel, Switzerland) vol 27 issue 10 2022 35630670 entry of any foreign pathogen activates the glial cells (astrocytes and microglia) and overactivation of these cells triggers the release of various neuroinflammatory markers (nms), such as the tumor necrosis factor-\xce\xb1 (tnf-\xce\xb1), interleukin-1\xce\xb2 (il-1\xce\xb2), interleukin-1\xce\xb2 (il-10), nitric oxide (no), and cyclooxygenase-2 (cox-2), among others. 2022-05-28 2022-06-13 Not clear
Amira A Sallam, Mohammed A El-Magd, Mona M Ahmed, Heba I Ghamry, Mohammad Y Alshahrani, Rabab A Hegazy, Ahmed Magdy, Magdy F Abou El-Foto. Quercetin alleviated multi-walled carbon nanotubes-induced neurotoxicity in mice through inhibition of oxidation, inflammation, and pyroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol 151 issue 2022 35605300 however, treatment with que ameliorated mwcnts-induced neurotoxicity as revealed by 1) elevated acetylcholinesterase (ache) activity, 2) reduced lipid peroxidation biomarker malondialdehyde (mda), 3) improved antioxidant status as indicated by increased levels of reduced glutathione (gsh) and activities of superoxide dismutase (sod), catalase (cat), as well as upregulated expression of nuclear factor erythroid 2-related factor 2 (nrf2) and heme oxygenase-1 (ho-1) genes, 4) decreased levels and expression of inflammatory biomarkers [nitric oxide (no), interleukin 1 beta (il1\xc3\x9f), tumor necrosis factor-alpha (tnf\xce\xb1), and nuclear factor kappa b (nf-\xce\xbab)], 5) downregulated expression of pyroptosis-related genes [nod-like receptor protein inflammasome 3 (nlrp3) and caspase 1 (casp1)] but with no effect on the apoptotic casp3 gene, 6) minimized axonal degeneration and number of microglia in the cerebral medulla, and 7) diminished the number of degenerated neurons in hippocampus and cerebellum. 2022-05-23 2022-06-13 Not clear
Kimberly Barber, Patricia Mendonca, Karam F Solima. Cardamonin Antioxidant Effects Through the Modulation of Proteins and Genes Expressions in LPS-Activated BV-2 Microglial Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 36 Suppl 1 issue 2022 35559544 continuous activation of microglia cells, known as the resident, innate immune cells in the brain, participates in producing numerous neurotoxic factors, including nitric oxide and reactive oxygen species (ros), which induce neurodegeneration. 2022-05-13 2022-06-13 Not clear
Jung-Eun Park, Yea-Hyun Leem, Jin-Sun Park, Do-Yeon Kim, Jihee Lee Kang, Hee-Sun Ki. Anti-Inflammatory and Neuroprotective Mechanisms of GTS-21, an \\xce\\xb17 Nicotinic Acetylcholine Receptor Agonist, in Neuroinflammation and Parkinson's Disease Mouse Models. International journal of molecular sciences vol 23 issue 8 2022 35457238 gts-21 inhibited the expression of inducible nitric oxide synthase (inos) and proinflammatory cytokines in lipopolysaccharide (lps)-stimulated bv2 microglial cells and primary microglia. 2022-04-23 2022-04-25 Not clear
Jamal Ahmad Ansari, Shubhendra K Mishra, Rajib K Dey, Opalina Roy, Shaivya Kushwaha, Vikas Singh, Satyakam Patnaik, Debabrata Ghos. Minocycline reverses developmental arsenic exposure-induced microglia activation and functional alteration in BALB/c mice. Environmental toxicology and pharmacology vol issue 2022 35351628 primary microglial were isolated (ex vivo microglia) from experimental animals and used to measure reactive oxygen species (ros), nitric oxide (no), cytokine production and phagocytosis. 2022-03-30 2022-04-14 Not clear
Wenhao Qu, Ying Cheng, Wei Peng, Yan Wu, Tongyu Rui, Chengliang Luo, Jian Zhan. Targeting iNOS Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage via Promoting Ferroptosis of M1 Microglia and Reducing Neuroinflammation. Molecular neurobiology vol issue 2022 35262869 previous studies have found that inducible nitric oxide synthase (inos/no\xe2\x80\xa2) plays an essential role in promoting the survival of m1 microglia by blocking ferroptosis. 2022-03-09 2022-04-14 Not clear
Suresh B Rangasamy, Sumita Raha, Sridevi Dasarathy, Kalipada Paha. Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Improves Cognitive Functions in Mice after Controlled Cortical Impact Injury. International journal of molecular sciences vol 23 issue 1 2022 35008615 oral treatment with nab, but not sodium formate (nafo), was found to decrease the activation of microglia and astrocytes and to inhibit the expression of inducible nitric oxide synthase (inos) in the hippocampus and cortex of cci-insulted mice. 2022-02-03 2022-01-13 Not clear
Alessandra Quarta, Tim Meese, Zo\\xc3\\xab Pieters, Elise Van Breedam, Debbie Le Blon, Jana Van Broeckhoven, Sven Hendrix, Herman Goossens, Niel Hens, Zwi Berneman, Filip Van Nieuwerburgh, Peter Ponsaert. Murine induced pluripotent stem cell-derived neuroimmune cell culture models emphasize opposite immune-effector functions of interleukin 13-primed microglia and macrophages in terms of neuroimmune toxicity. Glia vol 69 issue 2 2021 32865285 finally, the striking il13-induced upregulation of no secretion by microglia under pro-inflammatory conditions was confirmed in vivo, where intracerebral delivery of il13 increased inducible nitric oxide synthase mrna expression. 2022-02-02 2022-01-13 Not clear
Lanqiu Zhang, Xiaolin Jiang, Jinlu Zhang, Hejun Gao, Lei Yang, Dihua Li, Qi Zhang, Botao Wang, Lihua Cui, Ximo Wan. (-)-Syringaresinol suppressed LPS-induced microglia activation via downregulation of NF-\\xce\\xbaB p65 signaling and interaction with ER\\xce\\xb2. International immunopharmacology vol 99 issue 2021 34303280 as a result, (-)-syr significantly reduced lipopolysaccharide (lps)-induced production of interleukin - 6 (il-6), tumor necrosis factor \xce\xb1 (tnf-\xce\xb1), interleukin -1 beta (il-1\xce\xb2), cycloxygenase-2 (cox-2), and nitric oxide (no) in bv2 microglia cells. 2022-01-31 2022-01-13 Not clear
Anne-Marie Howe, Sin\\xc3\\xa9ad Burke, Marcella E O'Reilly, Fiona C McGillicuddy, Derek A Costell. Palmitic Acid and Oleic Acid Differently Modulate TLR2-Mediated Inflammatory Responses in Microglia and Macrophages. Molecular neurobiology vol issue 2022 35079937 using the tlr2 agonist lipoteichoic acid (lta), we report that pre-exposure to either palmitic acid (pa) or oleic acid (oa) attenuated cytokine secretion from microglia, but heightened sensitivity to nitric oxide (no) production. 2022-01-26 2022-01-27 Not clear
Anna Starinets, Anna Tyrtyshnaia, Yulia Kipryushina, Igor Manzhul. Analgesic Activity of Synaptamide in a Rat Sciatic Nerve Chronic Constriction Injury Model. Cells, tissues, organs vol 211 issue 1 2022 34510045 further, synaptamide suppressed the cci-induced increase in the activity of microglia (13.1 \xc2\xb1 0.5% in cci+syn, compared to 15.3 \xc2\xb1 0.7% in the cci group) and the number of nitric oxide synthase-positive neurons (58,307 \xc2\xb1 5,206 cells/mm3 in cci+syn, compared to 80,288 \xc2\xb1 4,287 cells/mm3 in the cci group) in the dorsal horns of the spinal cord, and also reduced the concentration of interleukin 1 beta in the spinal cord (169.3 \xc2\xb1 4 pg/mg of protein in cci+syn, compared to 236.9 \xc2\xb1 9.3 pg/mg of protein in cci group) 35 days after surgery. 2022-01-19 2022-01-27 Not clear
Suresh B Rangasamy, Sumita Raha, Sridevi Dasarathy, Kalipada Paha. Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Improves Cognitive Functions in Mice after Controlled Cortical Impact Injury. International journal of molecular sciences vol 23 issue 1 2022 35008615 oral treatment with nab, but not sodium formate (nafo), was found to decrease the activation of microglia and astrocytes and to inhibit the expression of inducible nitric oxide synthase (inos) in the hippocampus and cortex of cci-insulted mice. 2022-01-11 2022-01-13 Not clear
Meiyun Cai, Wenxin Zhuang, E Lv, Zhan Liu, Yanqiang Wang, Wenyi Zhang, Wenyu F. Kaemperfol alleviates pyroptosis and microglia-mediated neuroinflammation in Parkinson's disease via inhibiting p38MAPK/NF-\\xce\\xbaB signaling pathway. Neurochemistry international vol 152 issue 2021 34780806 the results showed kae could ameliorate the behavioral deficits of parkinson's disease (pd) rats, inhibit the activation of microglia and astrocytes, reduce the loss of th-positive neurons, down-regulate levels of pyroptosis-related nod-like receptor family pyrin domain containing 3 (nlrp3), gasdermind-n term (gsdmd-nt), caspase1, apoptosis-associated speck-like protein containing a caspase-recruitment domain (asc), interleukin (il)-1\xce\xb2, and il-18, and decrease the levels of inflammatory molecules (inducible nitric oxide synthase (inos) and cyclooxygenase-2 (cox-2)) and p38 mitogen-activated protein kinase/nuclear factor-kappab (p38mapk/nf-\xce\xbab) signaling pathway molecules (p38mapk, p-p38mapk, nf-\xce\xbab, and p-nf-\xce\xbab) in the substantia nigra of pd rats. 2021-12-11 2022-01-13 Not clear
Yingjie Wang, Gang Chen, Qingqi Meng, Xiaohu Yao, Yang Li, Honglin Cao, Bin Lin, Yue Hou, Di Zhou, Ning L. Potential inhibitors of microglial activation from the roots of Vernicia montana Lour. Phytochemistry vol 194 issue 2021 34826794 during our continuous investigation of natural, herbal inhibitors of microglial over-activation in the euphorbiaceae family, two plants of the vernicia genus showed remarkable inhibitory effects on nitric oxide (no) production in over-activated microglia. 2021-12-09 2022-01-13 Not clear
Rishika Dhapola, Subhendu Shekhar Hota, Phulen Sarma, Anusuya Bhattacharyya, Bikash Medhi, Dibbanti HariKrishna Redd. Recent advances in molecular pathways and therapeutic implications targeting neuroinflammation for Alzheimer's disease. Inflammopharmacology vol 29 issue 6 2021 34813026 various pathways like nf\xce\xbab, p38 mapk, akt/mtor, caspase, nitric oxide and cox trigger microglia to release inflammatory cytokines. 2021-12-08 2022-01-13 Not clear
Pan M Liy, Nur Nabilah A Puzi, Shinsmon Jose, Sharmili Vidyadara. Nitric oxide modulation in neuroinflammation and the role of mesenchymal stem cells. Experimental biology and medicine (Maywood, N.J.) vol 246 issue 22 2021 33715528 within the inflamed brain, microglia and astrocytes produce large amounts of nitric oxide during inflammation. 2021-12-07 2022-01-13 Not clear
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