| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shristi Baral, Hassan Hosseini, Kaushik More, Thomaz M C Fabrin, Jochen Braun, Matthias Prigg. Spike-Dependent Dynamic Partitioning of the Locus Coeruleus Network through Noradrenergic Volume Release in a Simulation of the Nucleus Core. Brain sciences. vol 12. issue 6. 2022-06-24. PMID:35741613. |
we determined the exact position of hundreds of lc neurons in the mouse brain stem via a tissue clearing approach and, based on this, further determined that 25 percent of noradrenergic neurons have a neighboring lc neuron within less than a 25-micrometer radius. |
2022-06-24 |
2023-08-14 |
mouse |
| Tatiana Bezdudnaya, Moin Vahora, David Giacobbo, Vitaliy Marchenk. Anatomical Basis of Interactions Between Locomotor and Respiratory Systems. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555670. |
in the brainstem, the double-labeled neurons were seen in the following structures: 1) midbrain - in all parts of periaqueductal gray substance (pag), dorsal raphe (dr) and deep mesncephalic (dme) nuclei; 2) pons - in kölliker-fuse and parabrachial nuclei (pb/kf), in areas of noradrenergic groups of cells (locus coeruleus and a5) and sub-coeruleus areas, in oral and caudal pontine nuclei (pno and pnc); 3) medulla - in all parts of raphe (obscurus, magnus and pallidus), gigantocellular reticular (gi), internal reticular (irt), and lateral paragigantocellular (lpgi) nuclei, in para-fascial/retrotrapezoid area (pf/rtn), and in bötzinger and pre-bötzinger complexes (bc and pbc). |
2022-05-13 |
2023-08-13 |
rat |
| Hiroki Toyoda, Jonghwa Won, Wheedong Kim, Hayun Kim, Oscar Davy, Mitsuru Saito, Doyun Kim, Takuma Tanaka, Youngnam Kang, Seog Bae O. The Nature of Noradrenergic Volume Transmission From Locus Coeruleus to Brainstem Mesencephalic Trigeminal Sensory Neurons. Frontiers in cellular neuroscience. vol 16. 2022-05-13. PMID:35558874. |
the nature of noradrenergic volume transmission from locus coeruleus to brainstem mesencephalic trigeminal sensory neurons. |
2022-05-13 |
2023-08-13 |
Not clear |
| Mateusz W Kucharczyk, Francesca Di Domenico, Kirsty Banniste. Distinct brainstem to spinal cord noradrenergic pathways inversely regulate spinal neuronal activity. Brain : a journal of neurology. 2022-03-04. PMID:35245374. |
distinct brainstem to spinal cord noradrenergic pathways inversely regulate spinal neuronal activity. |
2022-03-04 |
2023-08-13 |
Not clear |
| Mateusz W Kucharczyk, Francesca Di Domenico, Kirsty Banniste. Distinct brainstem to spinal cord noradrenergic pathways inversely regulate spinal neuronal activity. Brain : a journal of neurology. 2022-03-04. PMID:35245374. |
brainstem to spinal cord noradrenergic pathways include a locus coeruleus origin projection and diffuse noxious inhibitory controls. |
2022-03-04 |
2023-08-13 |
Not clear |
| Shai Porat, Francesca Sibilia, Josephine Yoon, Yonggang Shi, Martin J Dahl, Markus Werkle-Bergner, Sandra Düzel, Nils Bodammer, Ulman Lindenberger, Simone Kühn, Mara Mathe. Age Differences in Diffusivity in the Locus Coeruleus and its Ascending Noradrenergic Tract. NeuroImage. 2022-02-22. PMID:35192943. |
the noradrenergic locus coeruleus (lc) is a small brainstem nucleus that promotes arousal and attention. |
2022-02-22 |
2023-08-13 |
Not clear |
| Pauline Bornert, Sebastien Boure. Locus coeruleus neurons encode the subjective difficulty of triggering and executing actions. PLoS biology. vol 19. issue 12. 2021-12-07. PMID:34874935. |
the brain stem noradrenergic nucleus locus coeruleus (lc) is involved in various costly processes: arousal, stress, and attention. |
2021-12-07 |
2023-08-13 |
monkey |
| Nelson K Totah, Nikos K Logothetis, Oxana Eschenk. Synchronous spiking associated with prefrontal high γ oscillations evokes a 5-Hz rhythmic modulation of spiking in locus coeruleus. Journal of neurophysiology. vol 125. issue 4. 2021-11-23. PMID:33566743. |
the brainstem noradrenergic locus coeruleus (lc) is reciprocally connected with the prefrontal cortex (pfc). |
2021-11-23 |
2023-08-13 |
rat |
| Yasufumi Sakakibara, Yu Hirota, Kyoko Ibaraki, Kimi Takei, Sachie Chikamatsu, Yoko Tsubokawa, Takashi Saito, Takaomi C Saido, Michiko Sekiya, Koichi M Iijim. Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis. Journal of Alzheimer's disease : JAD. vol 82. issue 4. 2021-11-23. PMID:34180416. |
the locus coeruleus (lc), a brainstem nucleus comprising noradrenergic neurons, is one of the earliest regions affected by alzheimer's disease (ad). |
2021-11-23 |
2023-08-13 |
mouse |
| Adeline Orts-Del'Immagine, Mahalakshmi Dhanasekar, François-Xavier Lejeune, Julian Roussel, Claire Wyar. A norepinephrine-dependent glial calcium wave travels in the spinal cord upon acoustovestibular stimuli. Glia. 2021-11-13. PMID:34773299. |
altogether, our results revealed that a simple av stimulation is sufficient to recruit noradrenergic neurons in the brainstem that trigger in the rostral spinal cord two massive glial calcium waves, one traveling caudally in the spinal cord and another rostrally into the hindbrain. |
2021-11-13 |
2023-08-13 |
zebrafish |
| Jesse D Hoffmeister, Cynthia A Kelm-Nelson, Michelle R Ciucc. Quantification of brainstem norepinephrine relative to vocal impairment and anxiety in the Pink1-/- rat model of Parkinson disease. Behavioural brain research. vol 414. 2021-11-04. PMID:34358571. |
in order to address this gap in knowledge, we assessed vocal impairment and anxiety behavior relative to brainstem noradrenergic markers in a genetic rat model of early-onset pd (pink1-/-) and wild type controls (wt). |
2021-11-04 |
2023-08-13 |
rat |
| Jesse D Hoffmeister, Cynthia A Kelm-Nelson, Michelle R Ciucc. Quantification of brainstem norepinephrine relative to vocal impairment and anxiety in the Pink1-/- rat model of Parkinson disease. Behavioural brain research. vol 414. 2021-11-04. PMID:34358571. |
we hypothesized that 1) brainstem noradrenergic markers would be disrupted in pink1-/-, and 2) brainstem noradrenergic markers would be associated with vocal acoustic changes and anxiety level. |
2021-11-04 |
2023-08-13 |
rat |
| Jesse D Hoffmeister, Cynthia A Kelm-Nelson, Michelle R Ciucc. Quantification of brainstem norepinephrine relative to vocal impairment and anxiety in the Pink1-/- rat model of Parkinson disease. Behavioural brain research. vol 414. 2021-11-04. PMID:34358571. |
further, brainstem noradrenergic markers including th and α1 adrenoreceptor immunoreactivity in the locus coeruleus, and β1 adrenoreceptor immunoreactivity in vagal nuclei differed by genotype, and were associated with vocalization and anxiety behavior. |
2021-11-04 |
2023-08-13 |
rat |
| Gisele Vieira Rodovalho, Lucas Rios Drummond, Candido Celso Coimbr. Involvement of brainstem noradrenergic system in cutaneous heat loss during exercise. Brain research bulletin. vol 164. 2021-10-29. PMID:32890662. |
involvement of brainstem noradrenergic system in cutaneous heat loss during exercise. |
2021-10-29 |
2023-08-13 |
rat |
| Gisele Vieira Rodovalho, Lucas Rios Drummond, Candido Celso Coimbr. Involvement of brainstem noradrenergic system in cutaneous heat loss during exercise. Brain research bulletin. vol 164. 2021-10-29. PMID:32890662. |
the involvement of brainstem noradrenergic system in thermoregulation during exercise was evaluated by assessing the neuronal activation of a1, a2, locus coeruleus (lc) during exercise. |
2021-10-29 |
2023-08-13 |
rat |
| Emanuele R G Plini, Erik O'Hanlon, Rory Boyle, Francesca Sibilia, Gaia Rikhye, Joanne Kenney, Robert Whelan, Michael C Melnychuk, Ian H Robertson, Paul M Dockre. Examining the Role of the Noradrenergic Locus Coeruleus for Predicting Attention and Brain Maintenance in Healthy Old Age and Disease: An MRI Structural Study for the Alzheimer's Disease Neuroimaging Initiative. Cells. vol 10. issue 7. 2021-10-27. PMID:34359997. |
the noradrenergic theory of cognitive reserve (robertson, 2013-2014) postulates that the upregulation of the locus coeruleus-noradrenergic system (lc-na) originating in the brainstem might facilitate cortical networks involved in attention, and protracted activation of this system throughout the lifespan may enhance cognitive stimulation contributing to reserve. |
2021-10-27 |
2023-08-13 |
human |
| Tiziana Carandini, Matteo Mancini, Iulia Bogdan, Charlotte L Rae, Andrew W Barritt, Marinella Clerico, Arjun Sethi, Neil Harrison, Waqar Rashid, Elio Scarpini, Daniela Galimberti, Marco Bozzali, Mara Cercignan. In vivo evidence of functional disconnection between brainstem monoaminergic nuclei and brain networks in multiple sclerosis. Multiple sclerosis and related disorders. vol 56. 2021-10-26. PMID:34461571. |
brainstem monoaminergic (dopaminergic, noradrenergic, and serotoninergic) nuclei (brmn) contain a variety of ascending neurons that diffusely project to the whole brain, crucially regulating normal brain function. |
2021-10-26 |
2023-08-13 |
Not clear |
| Kristyn N Borrelli, Emily J Yao, William W Yen, Rhushikesh A Phadke, Qiu T Ruan, Melanie M Chen, Julia C Kelliher, Carly R Langan, Julia L Scotellaro, Richard K Babbs, Jacob C Beierle, Ryan W Logan, William Evan Johnson, Elisha M Wachman, Alberto Cruz-Martín, Camron D Bryan. Sex Differences in Behavioral and Brainstem Transcriptomic Neuroadaptations following Neonatal Opioid Exposure in Outbred Mice. eNeuro. vol 8. issue 5. 2021-10-20. PMID:34479978. |
transcriptome analysis of the brainstem, an area implicated in opioid withdrawal and nows, identified pathways enriched for noradrenergic signaling in females and males. |
2021-10-20 |
2023-08-13 |
mouse |
| Richard A Gillis, Ghazaul Dezfuli, Lorenza Bellusci, Stefano Vicini, Niaz Sahibzad. Brainstem Neuronal Circuitries Controlling Gastric Tonic and Phasic Contractions: A Review. Cellular and molecular neurobiology. 2021-08-11. PMID:33813668. |
data obtained indicate the following: (1) nucleus tractus solitarius (nts)-dorsal motor nucleus of the vagus (dmv) noradrenergic connection is required for reflex control of the fundus; (2) second-order nitrergic neurons in the nts are also required for reflex control of the fundus; (3) a nts gabaergic connection is required for reflex control of the antrum; (4) a single dmv efferent pathway is involved in brainstem control of gastric mechanical function under most experimental conditions excluding the accommodation reflex. |
2021-08-11 |
2023-08-13 |
mouse |
| Tiziana Carandini, Matteo Mancini, Iulia Bogdan, Charlotte L Rae, Andrew W Barritt, Arjun Sethi, Neil Harrison, Waqar Rashid, Elio Scarpini, Daniela Galimberti, Marco Bozzali, Mara Cercignan. Disruption of brainstem monoaminergic fibre tracts in multiple sclerosis as a putative mechanism for cognitive fatigue: a fixel-based analysis. NeuroImage. Clinical. vol 30. 2021-07-30. PMID:33610097. |
we focused on ventral tegmental area, locus coeruleus, and raphe nuclei as the main source of dopaminergic, noradrenergic, and serotoninergic fibres within the brainstem, respectively. |
2021-07-30 |
2023-08-13 |
Not clear |