| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Claire Elena Manning, Michael Fritz, Julie Ann Kaue. Function of excitatory periaqueductal grey synapses in the ventral tegmental area following inflammatory injury. eNeuro. 2023-01-12. PMID:36635253. |
in this study, we used male and female mice in combination with identified dopamine and gaba neurons in the vta that receive excitatory inputs from the periaqueductal grey (pag), a nexus of ascending pain information. |
2023-01-12 |
2023-08-14 |
mouse |
| Carlos Blanco-Centurion, Aurelio Vidal-Ortiz, Takashi Sato, Priyattam J Shiroman. Activity of GABA neurons in the zona incerta and ventral lateral periaqueductal grey is biased towards sleep. Sleep. 2022-12-14. PMID:36516419. |
activity of gaba neurons in the zona incerta and ventral lateral periaqueductal grey is biased towards sleep. |
2022-12-14 |
2023-08-14 |
Not clear |
| Carlos Blanco-Centurion, Aurelio Vidal-Ortiz, Takashi Sato, Priyattam J Shiroman. Activity of GABA neurons in the zona incerta and ventral lateral periaqueductal grey is biased towards sleep. Sleep. 2022-12-14. PMID:36516419. |
because in various brain regions the activity of gaba neurons is largely unknown, we measured in-vivo changes in calcium fluorescence in gaba neurons in the zona incerta (zi) and the ventral lateral periaqueductal grey (vlpag), two areas that have been implicated in regulating sleep. |
2022-12-14 |
2023-08-14 |
Not clear |
| Kelsey E Hudson, James W Gra. Ionic Plasticity: Common Mechanistic Underpinnings of Pathology in Spinal Cord Injury and the Brain. Cells. vol 11. issue 18. 2022-09-23. PMID:36139484. |
spinal cord injury (sci) can bring about a modification that weakens the inhibitory effect of gaba in the central gray caudal to injury. |
2022-09-23 |
2023-08-14 |
Not clear |
| Gissell Sanchez, Emily M Jutkiewicz, Susan L Ingram, Alan V Smrck. Coincident Regulation of PLCβ Signaling by Gq-Coupled and μOpioid Receptors Opposes Opioid- Mediated Antinociception. Molecular pharmacology. 2022-09-18. PMID:36116788. |
knockout of plcβ3, or pharmacological inhibition of its upstream regulators, gβγ or gq, ex vivo in periaqueductal gray (pag) slices increased the potency of the selective mor agonist damgo in inhibiting presynaptic gaba release. |
2022-09-18 |
2023-08-14 |
mouse |
| Wei Wang, Xueyan Zhang, Xiaoyan Bai, Yingkui Zhang, Ziyu Yuan, Hefei Tang, Zhiye Li, Zhangxuan Hu, Yaqing Zhang, Xueying Yu, Binbin Sui, Yonggang Wan. Gamma-aminobutyric acid and glutamate/glutamine levels in the dentate nucleus and periaqueductal gray with episodic and chronic migraine: a proton magnetic resonance spectroscopy study. The journal of headache and pain. vol 23. issue 1. 2022-07-15. PMID:35840907. |
gamma-aminobutyric acid and glutamate/glutamine levels in the dentate nucleus and periaqueductal gray with episodic and chronic migraine: a proton magnetic resonance spectroscopy study. |
2022-07-15 |
2023-08-14 |
human |
| Ram Kandasamy, Todd M Hillhouse, Kathryn E Livingston, Kelsey E Kochan, Claire Meurice, Shainnel O Eans, Ming-Hua Li, Andrew D White, Bernard P Roques, Jay P McLaughlin, Susan L Ingram, Neil T Burford, Andrew Alt, John R Trayno. Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 16. 2021-11-23. PMID:33846240. |
moreover, bms-986122 increases the potency of met-enk to inhibit gaba release in the periaqueductal gray, an important site for antinociception. |
2021-11-23 |
2023-08-13 |
mouse |
| Tadanao Hiroki, Takashi Suto, Jo Ohta, Shigeru Saito, Hideaki Obat. Spinal γ-Aminobutyric Acid Interneuron Plasticity Is Involved in the Reduced Analgesic Effects of Morphine on Neuropathic Pain. The journal of pain. 2021-11-15. PMID:34678470. |
we hypothesized that dysfunction of the descending serotonergic system, including the periaqueductal gray (pag), contributes to attenuate the efficacy of morphine on neuropathic pain through spinal 5-ht3 receptors and gaba neurons. |
2021-11-15 |
2023-08-13 |
rat |
| Jocelyn M Breton, Annabelle R Charbit, Benjamin J Snyder, Peter T K Fong, Elayne V Dias, Patricia Himmels, Hagar Lock, Elyssa B Margoli. Relative contributions and mapping of ventral tegmental area dopamine and GABA neurons by projection target in the rat. The Journal of comparative neurology. vol 527. issue 5. 2020-07-28. PMID:30393861. |
in addition, gaba neurons contributed no more than 20% to each projection, with the exception of the projection to the ventrolateral periaqueductal gray, where the gabaergic contribution approached 50%. |
2020-07-28 |
2023-08-13 |
rat |
| Alana Tercino Frias, Gabriel Gripp Fernandes, Hélio Zangross. GABA Behavioural brain research. vol 364. 2020-03-09. PMID:30768992. |
gaba although the etiology of panic disorder (pd) remains elusive, accumulating evidence suggests a key role for the dorsal periaqueductal gray matter (dpag). |
2020-03-09 |
2023-08-13 |
Not clear |
| Hung-Chi Lu, Harvey Pollack, John J Lefante, Alea A Mills, Di Tia. Altered sleep architecture, rapid eye movement sleep, and neural oscillation in a mouse model of human chromosome 16p11.2 microdeletion. Sleep. vol 42. issue 3. 2020-02-17. PMID:30541142. |
in addition, whole-cell patch clamp recording of the ventrolateral periaqueductal gray (vlpag)-projecting gamma-aminobutyric acid (gaba)ergic neurons in the lateral paragigantocellular nucleus of ventral medulla of mutant mice reveal that these neurons, which are important for nrem-rem transition and rem maintenance, have hyperpolarized resting membrane potential and increased membrane resistance. |
2020-02-17 |
2023-08-13 |
mouse |
| Zhang, Tang, Yuan, Ji. Inhibitory effects of glutamate-induced activation of thalamic nucleus submedius are mediated by ventrolateral orbital cortex and periaqueductal gray in rats. European journal of pain (London, England). vol 2. issue 2. 2019-11-20. PMID:10700311. |
furthermore, micro-injections of gamma-aminobutyric acid (gaba) (100 mm) into the ipsilateral ventrolateral orbital cortex (vlo) (0.7 µl), or bilaterally into the lateral or ventrolateral parts of the periaqueductal gray (pag) (0.5 µl on each side), eliminated the sm-evoked inhibition. |
2019-11-20 |
2023-08-12 |
rat |
| Kylie B McPherson, Emily R Leff, Ming-Hua Li, Claire Meurice, Sherrica Tai, John R Traynor, Susan L Ingra. Regulators of G-Protein Signaling (RGS) Proteins Promote Receptor Coupling to G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 41. 2019-10-07. PMID:30150362. |
regulators of g-protein signaling (rgs) proteins negatively modulate presynaptic μ-opioid receptor inhibition of gaba release in the ventrolateral periaqueductal gray (vlpag). |
2019-10-07 |
2023-08-13 |
Not clear |
| Emily G Lowery-Gionta, Jeffrey DiBerto, Christopher M Mazzone, Thomas Louis Kas. GABA neurons of the ventral periaqueductal gray area modulate behaviors associated with anxiety and conditioned fear. Brain structure & function. vol 223. issue 8. 2019-01-25. PMID:30076467. |
gaba neurons of the ventral periaqueductal gray area modulate behaviors associated with anxiety and conditioned fear. |
2019-01-25 |
2023-08-13 |
mouse |
| Emily G Lowery-Gionta, Jeffrey DiBerto, Christopher M Mazzone, Thomas Louis Kas. GABA neurons of the ventral periaqueductal gray area modulate behaviors associated with anxiety and conditioned fear. Brain structure & function. vol 223. issue 8. 2019-01-25. PMID:30076467. |
here, we evaluate the role of gaba neurons of the ventral periaqueductal gray (vpag) in emotional behavioral responses related to anxiety and fear using a chemogenetic approach in vgat-ires-cre mice. |
2019-01-25 |
2023-08-13 |
mouse |
| Dongsheng Xu, Hui Zhao, Han Gao, Huiling Zhao, Dandan Liu, Jing L. Participation of pro-inflammatory cytokines in neuropathic pain evoked by chemotherapeutic oxaliplatin via central GABAergic pathway. Molecular pain. vol 14. 2018-10-22. PMID:29900804. |
in oxaliplatin rats, impaired inhibitory gamma-aminobutyric acid within the periaqueductal gray was accompanied with decreases in withdrawal thresholds to mechanical stimulus and % time spent on the cold plate. |
2018-10-22 |
2023-08-13 |
rat |
| Dongsheng Xu, Hui Zhao, Han Gao, Huiling Zhao, Dandan Liu, Jing L. Participation of pro-inflammatory cytokines in neuropathic pain evoked by chemotherapeutic oxaliplatin via central GABAergic pathway. Molecular pain. vol 14. 2018-10-22. PMID:29900804. |
our data further showed that the concentrations of gamma-aminobutyric acid were largely restored by blocking those pro-inflammatory cytokine receptors in periaqueductal gray of oxaliplatin rats; and mechanical hyperalgesia and cold hypersensitivity evoked by oxaliplatin were attenuated. |
2018-10-22 |
2023-08-13 |
rat |
| Dongsheng Xu, Hui Zhao, Han Gao, Huiling Zhao, Dandan Liu, Jing L. Participation of pro-inflammatory cytokines in neuropathic pain evoked by chemotherapeutic oxaliplatin via central GABAergic pathway. Molecular pain. vol 14. 2018-10-22. PMID:29900804. |
stimulation of gamma-aminobutyric acid receptors in the periaqueductal gray also blunted neuropathic pain in oxaliplatin rats. |
2018-10-22 |
2023-08-13 |
rat |
| Guangying Li, Caifeng Shao, Qian Chen, Qiang Wang, Kun Yan. Accumulated GABA activates presynaptic GABAB receptors and inhibits both excitatory and inhibitory synaptic transmission in rat midbrain periaqueductal gray. Neuroreport. vol 28. issue 6. 2018-01-10. PMID:28272262. |
accumulated gaba activates presynaptic gabab receptors and inhibits both excitatory and inhibitory synaptic transmission in rat midbrain periaqueductal gray. |
2018-01-10 |
2023-08-13 |
rat |
| Karin R Aubrey, Geoffrey M Drew, Hyo-Jin Jeong, Benjamin K Lau, Christopher W Vaugha. Endocannabinoids control vesicle release mode at midbrain periaqueductal grey inhibitory synapses. The Journal of physiology. vol 595. issue 1. 2017-09-25. PMID:27461371. |
the midbrain periaqueductal grey (pag) forms part of an endogenous analgesic system which is tightly regulated by the neurotransmitter gaba. |
2017-09-25 |
2023-08-13 |
rat |