| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L C Yu, J S Ha. Habenula as a relay in the descending pathway from nucleus accumbens to periaqueductal grey subserving antinociception. The International journal of neuroscience. vol 54. issue 3-4. 1991-02-12. PMID:2265972. |
this antinociceptive effect of morphine was attenuated by naloxone or muscimol, and enhanced by bicuculline methochloride administered to periaqueductal grey, suggesting that morphine may act on habenula to activate a descending neural pathway extending to periaqueductal grey to induce an antinociceptive effect, which seems to utilize endogenous opioid peptides and gamma-aminobutyric acid as its mediators. |
1991-02-12 |
2023-08-11 |
rabbit |
| T Mennini, M Gobb. Regional distribution of low-affinity GABA receptors coupled to benzodiazepine receptor subtypes in rat brain: an autoradiographic evaluation. European journal of pharmacology. vol 189. issue 2-3. 1991-01-22. PMID:2174788. |
quantitative autoradiography of rat brain coronal sections show that maximum enhancement (more than 80%) of [3h]flunitrazepam binding by gaba occurs in brain regions particularly rich in type i benzodiazepine receptors (inferior colliculus, medium raphe, central gray and substantia nigra); conversely, brain areas where type ii predominates show the lowest enhancement by gaba (about 50%). |
1991-01-22 |
2023-08-11 |
rat |
| T Mennini, M Gobb. Regional distribution of low-affinity GABA receptors coupled to benzodiazepine receptor subtypes in rat brain: an autoradiographic evaluation. European journal of pharmacology. vol 189. issue 2-3. 1991-01-22. PMID:2174788. |
one possible explanation of these discrepancies is that the type ii receptors found in type i-enriched tissues (inferior colliculus, median raphe, central gray and substantia nigra) are associated with the alpha 3-subunit, while the type ii sites present in limbic and cortical regions represent a subpopulation carrying the alpha 2-subunit of the gabaa receptor, with lower gaba potentiation. |
1991-01-22 |
2023-08-11 |
rat |
| P M Beart, R J Summers, J A Stephenson, C J Cook, M J Christi. Excitatory amino acid projections to the periaqueductal gray in the rat: a retrograde transport study utilizing D[3H]aspartate and [3H]GABA. Neuroscience. vol 34. issue 1. 1990-05-21. PMID:2325847. |
excitatory amino acid projections to the periaqueductal gray in the rat: a retrograde transport study utilizing d[3h]aspartate and [3h]gaba. |
1990-05-21 |
2023-08-11 |
rat |
| P M Beart, R J Summers, J A Stephenson, C J Cook, M J Christi. Excitatory amino acid projections to the periaqueductal gray in the rat: a retrograde transport study utilizing D[3H]aspartate and [3H]GABA. Neuroscience. vol 34. issue 1. 1990-05-21. PMID:2325847. |
low densities of labelled cells were found after the injection of [3h]gaba into the periaqueductal gray, and the only regions in which a small number of perikarya were labelled by both [3h]gaba and d[3h]aspartate were the dorsal raphe and parabrachial nuclei. |
1990-05-21 |
2023-08-11 |
rat |
| Michael M Behbehani, Maorong Jiang, Sharon D Chandler, Matthew Enni. The effect of GABA and its antagonists on midbrain periaqueductal gray neurons in the rat. Pain. vol 40. issue 2. 1990-04-09. PMID:2308765. |
the effect of gaba and its antagonists on midbrain periaqueductal gray neurons in the rat. |
1990-04-09 |
2023-08-11 |
rat |
| Michael M Behbehani, Maorong Jiang, Sharon D Chandler, Matthew Enni. The effect of GABA and its antagonists on midbrain periaqueductal gray neurons in the rat. Pain. vol 40. issue 2. 1990-04-09. PMID:2308765. |
injection of gaba into the midbrain periaqueductal gray (pag) activates medullary neurons that are involved in pain inhibition and potentiates morphine-induced analgesia. |
1990-04-09 |
2023-08-11 |
rat |
| N C Coimbra, P C Leão-Borges, M L Brandã. GABAergic fibers from substantia nigra pars reticulata modulate escape behavior induced by midbrain central gray stimulation. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 22. issue 1. 1989-09-18. PMID:2758165. |
electrical stimulation of microinjection of gaba antagonists into the dorsal periaqueductal gray (dpag) produces escape behavior. |
1989-09-18 |
2023-08-11 |
rat |
| M L Brandão, C Tomaz, P C Borges, N C Coimbra, A Bagr. Defense reaction induced by microinjections of bicuculline into the inferior colliculus. Physiology & behavior. vol 44. issue 3. 1989-03-23. PMID:2851846. |
these results suggest that in addition to the central gray and medial hypothalamus, gaba also exerts a tonic inhibitory action on neurons of the ic implicated in the generation or elaboration of aversive responses. |
1989-03-23 |
2023-08-11 |
rat |
| V A Krauz, V I Mamchu. [GABA-ergic mechanisms of the action of ketamine on the structures of the hippocampo-reticulo-neocortical system of the brain]. Farmakologiia i toksikologiia. vol 51. issue 1. 1988-05-27. PMID:2834220. |
in freely mobile rabbits with electrodes preliminarily implanted in the brain structures ketamine (5 mg/kg intravenously or 20 mg/kg intramuscularly) exhibited properties of gaba receptor agonist decreasing the direct excitability of the mesencephalic reticular formation and periaqueductal gray matter and reducing their activating effect on the frontal cortex (fc) and dorsal region of the hippocamp (dh). |
1988-05-27 |
2023-08-11 |
Not clear |
| A Depaulis, M M Morgan, J C Liebeskin. GABAergic modulation of the analgesic effects of morphine microinjected in the ventral periaqueductal gray matter of the rat. Brain research. vol 436. issue 2. 1988-03-25. PMID:3435824. |
microinjection of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin 3-ol (thip) (0.4 microgram in 0.2 microliter), a gaba agonist, in the ventral periaqueductal gray matter significantly reversed the increase of tail-flick latency induced by a prior injection of morphine sulfate (4 micrograms in 0.2 microliter) at the same site. |
1988-03-25 |
2023-08-11 |
rat |
| E Carstens, H Gilly, H Schreiber, M Zimmerman. Effects of midbrain stimulation and iontophoretic application of serotonin, noradrenaline, morphine and GABA on electrical thresholds of afferent C- and A-fibre terminals in cat spinal cord. Neuroscience. vol 21. issue 2. 1987-09-01. PMID:3614639. |
we have used the single-fibre excitability testing method to investigate whether electrical stimulation in midbrain periaqueductal gray or lateral reticular formation, as well as intraspinal iontophoretic application of the suspected inhibitory neurotransmitters serotonin (5-hydroxytryptamine), noradrenaline, the opiate morphine, or gamma-aminobutyric acid (gaba), exert presynaptic actions at the central terminals of cutaneous afferent unmyelinated or myelinated fibres. |
1987-09-01 |
2023-08-11 |
cat |
| E Carstens, H Gilly, H Schreiber, M Zimmerman. Effects of midbrain stimulation and iontophoretic application of serotonin, noradrenaline, morphine and GABA on electrical thresholds of afferent C- and A-fibre terminals in cat spinal cord. Neuroscience. vol 21. issue 2. 1987-09-01. PMID:3614639. |
thresholds to antidromically excited 42 single unmyelinated and 18 myelinated fibres in the sural nerve by intraspinal microstimulation were determined before and during periaqueductal gray or lateral reticular formation stimulation (3 100 ms trains/s at 100 hz; 100-900 microa) or intraspinal iontophoretic application (40-300 na) of 5-hydroxytryptamine, noradrenaline, morphine or gaba from a multibarrel micropipette. |
1987-09-01 |
2023-08-11 |
cat |
| E A Audi, F G Graef. GABAA receptors in the midbrain central grey mediate the antiaversive action of GABA. European journal of pharmacology. vol 135. issue 2. 1987-07-01. PMID:3034627. |
gabaa receptors in the midbrain central grey mediate the antiaversive action of gaba. |
1987-07-01 |
2023-08-11 |
rat |
| E A Audi, F G Graef. GABAA receptors in the midbrain central grey mediate the antiaversive action of GABA. European journal of pharmacology. vol 135. issue 2. 1987-07-01. PMID:3034627. |
these results indicate that the antiaversive action of gaba in the midbrain central grey is mediated by gabaa but not by gabab receptors. |
1987-07-01 |
2023-08-11 |
rat |
| F G Graeff, M L Brandão, E A Audi, M T Schüt. Modulation of the brain aversive system by GABAergic and serotonergic mechanisms. Behavioural brain research. vol 22. issue 2. 1987-02-10. PMID:3024664. |
experiments performed in our laboratory, using electrical stimulation combined with microinjection of drugs in the dorsal midbrain central grey (cg) of the rat, evidenced that direct stimulation of gaba receptors with locally administered gamma-aminobutyric acid (gaba) or the gabaa receptor agonists 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol, isoguvacine and muscimol raised the aversive threshold, defined as the lowest electrical current intensity inducing flight or escape behaviour when applied to the dorsal cg. |
1987-02-10 |
2023-08-11 |
rat |
| F G Graeff, M L Brandão, E A Audi, M T Schüt. Modulation of the brain aversive system by GABAergic and serotonergic mechanisms. Behavioural brain research. vol 21. issue 1. 1986-10-02. PMID:3017372. |
experiments performed in our laboratory, using electrical stimulation combined with microinjection of drugs in the dorsal midbrain central grey (cg) of the rat, evidenced that direct stimulation of gaba receptors with locally administered gamma-aminobutyric acid (gaba) or the gabaa receptor agonists 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol, isoguvacine and muscimol raised the aversive threshold, defined as the lowest electrical current intensity inducing flight or escape behaviour when applied to the dorsal cg. |
1986-10-02 |
2023-08-11 |
rat |
| A Depaulis, M Vergne. Elicitation of intraspecific defensive behaviors in the rat by microinjection of picrotoxin, a gamma-aminobutyric acid antagonist, into the midbrain periaqueductal gray matter. Brain research. vol 367. issue 1-2. 1986-06-09. PMID:3697719. |
elicitation of intraspecific defensive behaviors in the rat by microinjection of picrotoxin, a gamma-aminobutyric acid antagonist, into the midbrain periaqueductal gray matter. |
1986-06-09 |
2023-08-11 |
rat |
| A Depaulis, M Vergne. Elicitation of intraspecific defensive behaviors in the rat by microinjection of picrotoxin, a gamma-aminobutyric acid antagonist, into the midbrain periaqueductal gray matter. Brain research. vol 367. issue 1-2. 1986-06-09. PMID:3697719. |
behavioral reactions induced in the rat by microinjections of a gamma-aminobutyric acid (gaba) antagonist (picrotoxin; 25 and 50 ng in 0.25 microliter) into the midbrain periaqueductal gray matter were measured in an open-field test and when the animal was confronted by a conspecific introduced into its cage (i.e. |
1986-06-09 |
2023-08-11 |
rat |
| M J Christie, L B James, P M Bear. An excitatory amino acid projection from rat prefrontal cortex to periaqueductal gray. Brain research bulletin. vol 16. issue 1. 1986-05-05. PMID:2869823. |
high affinity d-[3h]aspartate and [3h]gaba uptake, and amino acid concentrations were examined in synaptosome-enriched preparations of rat periaqueductal gray matter 6-7 days following n-methyl-d-aspartate lesions confined to medial prefrontal cortex. |
1986-05-05 |
2023-08-11 |
rat |