| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| João S Gonçalves, Raquel M Seiça, João Laranjinha, Cátia F Lourenç. Impairment of neurovascular coupling in the hippocampus due to decreased nitric oxide bioavailability supports early cognitive dysfunction in type 2 diabetic rats. Free radical biology & medicine. 2022-11-13. PMID:36372286. |
impairment of neurovascular coupling in the hippocampus due to decreased nitric oxide bioavailability supports early cognitive dysfunction in type 2 diabetic rats. |
2022-11-13 |
2023-08-14 |
rat |
| Neda Fatahinezhad, Zahra Lorigooini, Mehran Arabi, Zahra Rabiei, Sedighe Kazemi Sheykhshabani, Mahmoud Rafieian-Kopae. Effects of Hyssopus Officinalis Hydroalcoholic Extract on Pentylenetetrazol-Induced Convulsive Seizures in Rat. Neurochemical research. 2022-10-26. PMID:36287300. |
blood and hippocampus samples were prepared to measure brain and serum antioxidant capacity, malondialdehyde (mda), and nitric oxide (no). |
2022-10-26 |
2023-08-14 |
rat |
| G Gambino, D Gallo, A Covelo, G Ferraro, P Sardo, G Gigli. TRPV1 channels in nitric oxide-mediated signalling: Insight on excitatory transmission in rat CA1 pyramidal neurons. Free radical biology & medicine. 2022-08-27. PMID:36029909. |
our data suggest that nitric oxide influences trpv1 hippocampal signalling since these channels are not constitutively active, but can be "on-demand" activated to modulate excitation in ca1 pyramidal neurons and that this effect is linked to nitric oxide production. |
2022-08-27 |
2023-08-14 |
rat |
| Amira A Sallam, Mohammed A El-Magd, Mona M Ahmed, Heba I Ghamry, Mohammad Y Alshahrani, Rabab A Hegazy, Ahmed Magdy, Magdy F Abou El-Foto. Quercetin alleviated multi-walled carbon nanotubes-induced neurotoxicity in mice through inhibition of oxidation, inflammation, and pyroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 151. 2022-05-23. PMID:35605300. |
however, treatment with que ameliorated mwcnts-induced neurotoxicity as revealed by 1) elevated acetylcholinesterase (ache) activity, 2) reduced lipid peroxidation biomarker malondialdehyde (mda), 3) improved antioxidant status as indicated by increased levels of reduced glutathione (gsh) and activities of superoxide dismutase (sod), catalase (cat), as well as upregulated expression of nuclear factor erythroid 2-related factor 2 (nrf2) and heme oxygenase-1 (ho-1) genes, 4) decreased levels and expression of inflammatory biomarkers [nitric oxide (no), interleukin 1 beta (il1ß), tumor necrosis factor-alpha (tnfα), and nuclear factor kappa b (nf-κb)], 5) downregulated expression of pyroptosis-related genes [nod-like receptor protein inflammasome 3 (nlrp3) and caspase 1 (casp1)] but with no effect on the apoptotic casp3 gene, 6) minimized axonal degeneration and number of microglia in the cerebral medulla, and 7) diminished the number of degenerated neurons in hippocampus and cerebellum. |
2022-05-23 |
2023-08-13 |
mouse |
| Marc Hemmerich, Nikolai Malorny, Andrea Lewen, Jan-Oliver Hollnagel, Bruno Chausse, Oliver Kan. Priming of microglia by type II interferon is lasting and resistant to modulation by interleukin-10 in situ. Journal of neuroimmunology. vol 368. 2022-05-10. PMID:35537331. |
we report that serial exposure of hippocampal slice cultures to ifn-γ and lipopolysaccharide (toll-like receptor 4 ligand) induces high release of il-6, tnf-α and nitric oxide, concomitant loss of electrical network activity (neuronal gamma oscillations) and neurodegeneration. |
2022-05-10 |
2023-08-13 |
Not clear |
| Qin Wu, Jiajun Dong, Xinying Bai, Yuan Jiang, Jinjin Li, Shiqi Fan, Yahong Cheng, Gaofeng Jian. Propionate ameliorates diabetes-induced neurological dysfunction through regulating the PI3K/Akt/eNOS signaling pathway. European journal of pharmacology. 2022-05-01. PMID:35490725. |
here, we show that propionate can markedly improve neurological function, which is correlated with its capabilities of stimulating nitrogen monoxide (no) production, increasing cerebral microcirculation, suppressing oxidative stress, and reducing neuron loss in the hippocampus. |
2022-05-01 |
2023-08-13 |
mouse |
| Md Mamun Al-Amin, Robert K P Sullivan, Suzy Alexander, David A Carter, DanaKai Bradford, Thomas H J Burn. Impaired spatial memory in adult vitamin D deficient BALB/c mice is associated with reductions in spine density, nitric oxide, and neural nitric oxide synthase in the hippocampus. AIMS neuroscience. vol 9. issue 1. 2022-04-18. PMID:35434279. |
impaired spatial memory in adult vitamin d deficient balb/c mice is associated with reductions in spine density, nitric oxide, and neural nitric oxide synthase in the hippocampus. |
2022-04-18 |
2023-08-13 |
mouse |
| Md Mamun Al-Amin, Robert K P Sullivan, Suzy Alexander, David A Carter, DanaKai Bradford, Thomas H J Burn. Impaired spatial memory in adult vitamin D deficient BALB/c mice is associated with reductions in spine density, nitric oxide, and neural nitric oxide synthase in the hippocampus. AIMS neuroscience. vol 9. issue 1. 2022-04-18. PMID:35434279. |
we examined spatial memory impairment in avd-deficient balb/c mice and its underlying mechanism by measuring spine density, long term potentiation (ltp), nitric oxide (no), neuronal nitric oxide synthase (nnos), and endothelial nos (enos) in the hippocampus. |
2022-04-18 |
2023-08-13 |
mouse |
| Ali Jaafari Suha, Seyed Shahabeddin Sadr, Mehrdad Roghani, Saeed Mohammadian Haftcheshmeh, Safoura Khamse, Amir Abbas Momtazi-Borojen. Ferulic acid attenuates kainate-induced neurodegeneration in a rat post-status epilepticus model. Current molecular pharmacology. 2022-03-02. PMID:35232370. |
histopathological evaluations including nissl staining and immunohistochemical staining of cyclooxygenase-2 (cox-2), and neural nitric oxide synthases (nnos) were performed for the ca3 region of the hippocampus. |
2022-03-02 |
2023-08-13 |
human |
| Amina E Essawy, Soad Ahmed El-Sayed, Ehab Tousson, Horeya S Abd El-Gawad, Reem Hasaballah Alhasani, Heba-Tallah Abd Elrahim Abd Elkade. Anti-kindling effect of Ginkgo biloba leaf extract and L-carnitine in the pentylenetetrazol model of epilepsy. Environmental science and pollution research international. 2022-02-23. PMID:35194715. |
the oxidative stress, antioxidant, and neurochemical parameters, viz., malondialdehyde (mda), nitric oxide (no), reduced glutathione (gsh), superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), acetylcholine esterase (ache), dopamine (da), norepinephrine (ne), and serotonin (5-ht), in the hippocampal and hypothalamic regions have been evaluated. |
2022-02-23 |
2023-08-13 |
rat |
| Mahboobeh Hashemi, Manizheh Karami, Mohammad Reza Zarrindas. The regulatory role of nitric oxide in morphine-induced analgesia in the descending path of pain from the dorsal hippocampus to the dorsolateral periaqueductal gray. European journal of pain (London, England). 2022-01-28. PMID:35090066. |
the regulatory role of nitric oxide in morphine-induced analgesia in the descending path of pain from the dorsal hippocampus to the dorsolateral periaqueductal gray. |
2022-01-28 |
2023-08-13 |
Not clear |
| Mahboobeh Hashemi, Manizheh Karami, Mohammad Reza Zarrindas. The regulatory role of nitric oxide in morphine-induced analgesia in the descending path of pain from the dorsal hippocampus to the dorsolateral periaqueductal gray. European journal of pain (London, England). 2022-01-28. PMID:35090066. |
nitric oxide (no) levels in brain nuclei, such as the hippocampus and brainstem, are involved in morphine analgesia, but the relationship between the dorsal hippocampus (dh) and the dorsolateral periaqueductal gray matter (dlpag) needs to be clarified, which is our goal. |
2022-01-28 |
2023-08-13 |
Not clear |
| Neveen A Noor, Eman N Hosny, Yasser A Khadrawy, Iman M Mourad, Amel I Othman, Heba S Aboul Ezz, Haitham S Mohamme. Effect of curcumin nanoparticles on streptozotocin-induced male Wistar rat model of Alzheimer's disease. Metabolic brain disease. 2022-01-20. PMID:35048324. |
the icv-stz microinjection produced cognitive impairment as evident from the behavioral morris water maze (mwm) test and induced oxidative stress in the cortex and hippocampus as indicated by the significant increases in lipid peroxidation and nitric oxide (no) levels and the significant decrease in reduced glutathione (gsh) levels. |
2022-01-20 |
2023-08-13 |
rat |
| Peng Ren, Bin Xiao, Lin-Ping Wang, Ying-Shun Li, Hua Jin, Qing-Hua Ji. Nitric oxide impairs spatial learning and memory in a rat model of Alzheimer's disease via disturbance of glutamate response in the hippocampal dentate gyrus during spatial learning. Behavioural brain research. 2022-01-16. PMID:35033612. |
nitric oxide impairs spatial learning and memory in a rat model of alzheimer's disease via disturbance of glutamate response in the hippocampal dentate gyrus during spatial learning. |
2022-01-16 |
2023-08-13 |
rat |
| Manar Mohammed El Tabaa, Samia Salem Sokkar, Ehab Sayed Ramdan, Inas Zakria Abd El Salam, Anis Ani. Does ( -)-epigallocatechin-3-gallate protects the neurotoxicity induced by bisphenol A in vivo? Environmental science and pollution research international. 2022-01-11. PMID:35013969. |
this study revealed that egcg was unable to abrogate the significant decrease in circulating adiponectin level and hippocampal superoxide dismutase activity as well as an increase in hippocampal levels of nitric oxide and malondialdehyde. |
2022-01-11 |
2023-08-13 |
rat |
| Mohammad Reza Safdari, Farzaneh Shakeri, Ameneh Mohammadi, Bahram Bibak, Peiman Alesheikh, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebka. Role of Herbal Medicines in the Management of Brain Injury. Advances in experimental medicine and biology. vol 1328. 2022-01-04. PMID:34981485. |
the different mechanisms for improvement in brain injury by these medicinal plants include hif-1 (hypoxia-inducible factor 1) signaling, free-radical scavenging, reduction of nitric oxide (no) toxicity and acetylcholine esterase (ache) activity, decrease of pakt and its downstream targets, downregulation of the aquaporin-4 (aqp-4) and tlr4/nf-ĸb/tnf-α signal, reduction in malondialdehyde and no levels, increasing neuronal density in the hippocampus, and inhibition of oxidative stress. |
2022-01-04 |
2023-08-13 |
Not clear |
| De-Ping Zhao, Da-Long Li, Yan-Hang Zhang, Yue Cui, Hong-Dan Xu, Bo Yang, Xia Lei, Ning Zhan. [Total flavonoids of Drynariae Rhizoma regulates ER-p38 MAPK signaling pathway to improve scopolamine-induced learning and memory impairments in model mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 22. 2021-12-24. PMID:34951183. |
the contents of malondia-ldehyde(mda), superoxide dismutase(sod), and nitric oxide(no) in the hippocampus were then determined using corresponding kits. |
2021-12-24 |
2023-08-13 |
mouse |
| Yuechen Guan, Junming Wang, Xiaohui Wu, Lingling Song, Yanmei Wang, Mingzhu Gong, Bingyin L. Quercetin reverses chronic unpredictable mild stress-induced depression-like behavior in vivo by involving nuclear factor-E2-related factor 2. Brain research. vol 1772. 2021-12-09. PMID:34529966. |
in addition, cums also caused significant reduction in the levels of antioxidants including superoxide dismutase (sod) and glutathione-s transferase (gst) in the mice hippocampus by 51.3%, 40.3% (both p < 0.01), while after chronic oral administration of high dose quercetin at 40 mg/kg, the abnormalities of the above indicators were significantly reversed by 69.2% and 49.5% (both p < 0.01), as well as significant elevation in the levels of lipid peroxide malondialdehyde (mda), inflammation medium nitric oxide (no) and inducible nitric oxide synthase (inos) by 156.4%, 255.4% and 72.7% (all p < 0.01), while after chronic oral administration of high dose quercetin at 40 mg/kg, the abnormalities of the above indicators were significantly reversed by 45.9%, 26.8% and 55.2% (all p < 0.01). |
2021-12-09 |
2023-08-13 |
mouse |
| Zahra Moradi, Zahra Rabiei, Maryam Anjomshoa, Zeinab Amini-Farsani, Vahid Massahzadeh, Samira Asgharzad. Neuroprotective effect of wild lowbush blueberry (Vaccinium angustifolium) on global cerebral ischemia/reperfusion injury in rats: Downregulation of iNOS/TNF-α and upregulation of miR-146a/miR-21 expression. Phytotherapy research : PTR. vol 35. issue 11. 2021-11-25. PMID:34580912. |
the findings showed that the bbe significantly decreased the levels of malondialdehyde (mda) and nitric oxide (no) and increased ferric ion reducing antioxidant power (frap) levels in the hippocampus and serum following the stroke. |
2021-11-25 |
2023-08-13 |
rat |
| Lingling Song, Xiaohui Wu, Junming Wang, Yuechen Guan, Yueyue Zhang, Mingzhu Gong, Yanmei Wang, Bingyin L. Antidepressant effect of catalpol on corticosterone-induced depressive-like behavior involves the inhibition of HPA axis hyperactivity, central inflammation and oxidative damage probably via dual regulation of NF-κB and Nrf2. Brain research bulletin. vol 177. 2021-11-18. PMID:34500039. |
furthermore, cort exposure dramatically augmented the levels of inflammatory factors (interleukin-1β, tumor necrosis factor-α, nitric oxide synthase, and nitric oxide) and lipid peroxidation product malondialdehyde, and attenuated the levels of antioxidants including reduced glutathione, glutathione s-transferase, total superoxide dismutase, and heme oxygenase-1 in the mouse hippocampus and frontal cortex. |
2021-11-18 |
2023-08-13 |
mouse |