| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James M Kelley, Laura B Hughes, S Louis Bridge. Does gamma-aminobutyric acid (GABA) influence the development of chronic inflammation in rheumatoid arthritis? Journal of neuroinflammation. vol 5. 2008-02-26. PMID:18171484. |
integrating these data suggests that gaba may play a role in downregulating mechanisms that lead to the production of proinflammatory agents such as interleukin-1, interleukin-6, and matrix metalloproteinase 3 - agents implicated in the pathogenesis of rheumatoid arthritis (ra). |
2008-02-26 |
2023-08-12 |
Not clear |
| Teruo Inamoto, Haruhito Azuma, Takeshi Sakamoto, Satoshi Kiyama, Takanobu Ubai, Yatsugu Kotake, Masahito Watanabe, Yoji Katsuok. Invasive ability of human renal cell carcinoma cell line Caki-2 is accelerated by gamma-aminobutyric acid, via sustained activation of ERK1/2 inducible matrix metalloproteinases. Cancer investigation. vol 25. issue 7. 2007-12-06. PMID:18027151. |
invasive ability of human renal cell carcinoma cell line caki-2 is accelerated by gamma-aminobutyric acid, via sustained activation of erk1/2 inducible matrix metalloproteinases. |
2007-12-06 |
2023-08-12 |
human |
| Olena Bukalo, Melitta Schachner, Alexander Dityate. Hippocampal metaplasticity induced by deficiency in the extracellular matrix glycoprotein tenascin-R. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 22. 2007-06-13. PMID:17537973. |
tnr is a major extracellular matrix glycoprotein of the cns and carries the hnk-1 carbohydrate (human natural killer cell glycan), which has been identified as the functional epitope mediating regulation of gabaergic transmission via gaba(b) receptors. |
2007-06-13 |
2023-08-12 |
mouse |
| Lynette J Tippett, Henry J Waldvogel, Sally J Thomas, Virginia M Hogg, Willeke van Roon-Mom, Beth J Synek, Ann M Graybiel, Richard L M Faul. Striosomes and mood dysfunction in Huntington's disease. Brain : a journal of neurology. vol 130. issue Pt 1. 2007-02-01. PMID:17040921. |
to determine whether the phenotypic variability in huntington's disease is related to this compartmental organization, we carried out a double-blind study in which we used gaba(a) receptor immunohistochemistry to analyse the status of striosomes and matrix in the brains of 35 huntington's disease cases and 13 control cases, and collected detailed data on the clinical symptomatology expressed by the patients from family members and records. |
2007-02-01 |
2023-08-12 |
Not clear |
| Lynette J Tippett, Henry J Waldvogel, Sally J Thomas, Virginia M Hogg, Willeke van Roon-Mom, Beth J Synek, Ann M Graybiel, Richard L M Faul. Striosomes and mood dysfunction in Huntington's disease. Brain : a journal of neurology. vol 130. issue Pt 1. 2007-02-01. PMID:17040921. |
we suggest that variation in clinical symptomatology in huntington's disease is associated with variation in the relative abnormality of gaba(a) receptor expression in the striosome and matrix compartments of the striatum, and that striosome-related circuits may modulate mood functioning. |
2007-02-01 |
2023-08-12 |
Not clear |
| Agnes Zvara, Péter Bencsik, Gabriella Fodor, Tamás Csont, László Hackler, Mária Dux, Susanna Fürst, Gábor Jancsó, László G Puskás, Péter Ferdinand. Capsaicin-sensitive sensory neurons regulate myocardial function and gene expression pattern of rat hearts: a DNA microarray study. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 1. 2006-03-23. PMID:16278290. |
this is the first demonstration that gene expression changes in the heart due to capsaicin pretreatment included vanilloid receptor-1 (capsaicin receptor), transient receptor potential protein, gaba receptor rho-3 subunit, 5-hydroxytryptamine 3 receptor b, neurokinin receptor 2, endothelial nitric oxide synthase, matrix metalloproteinase-13, cytochrome p450, farnesyl-transferase, apob, and leptin. |
2006-03-23 |
2023-08-12 |
rat |
| Jingli Cai, Haipeng Xue, Ming Zhan, Mahendra S Ra. Characterization of progenitor-cell-specific genes identified by subtractive suppression hybridization. Developmental neuroscience. vol 26. issue 2-4. 2005-04-28. PMID:15711056. |
five of the grp-specific clones (tenascin c, cystatin c, gaba transporter 3, extracellular matrix molecule 2 and h2-4) were characterized further, and their glial specificity was confirmed by rt-pcr, in situ hybridization and immunocytochemistry. |
2005-04-28 |
2023-08-12 |
Not clear |
| Erminio Costa, Dennis R Grayson, Colin P Mitchell, Lucio Tremolizzo, Marin Veldic, Alessandro Guidott. GABAergic cortical neuron chromatin as a putative target to treat schizophrenia vulnerability. Critical reviews in neurobiology. vol 15. issue 2. 2004-04-12. PMID:14977367. |
these abnormalities include a decrease of gad67 and reelin expression, which result in a reduction of cortical inhibitory input to spine postsynaptic densities as a result of the decrease of gaba concentration at the synaptic cleft, and of neurotrophic stimuli as a result of the decrease of reelin secreted into the extracellular matrix. |
2004-04-12 |
2023-08-12 |
Not clear |
| Haruhito Azuma, Teruo Inamoto, Takeshi Sakamoto, Satoshi Kiyama, Takanobu Ubai, Yuko Shinohara, Kentaro Maemura, Motomu Tsuji, Naoki Segawa, Hiroshi Masuda, Kiyoshi Takahara, Yoji Katsuoka, Masahito Watanab. Gamma-aminobutyric acid as a promoting factor of cancer metastasis; induction of matrix metalloproteinase production is potentially its underlying mechanism. Cancer research. vol 63. issue 23. 2004-02-27. PMID:14678958. |
gamma-aminobutyric acid as a promoting factor of cancer metastasis; induction of matrix metalloproteinase production is potentially its underlying mechanism. |
2004-02-27 |
2023-08-12 |
human |
| Haruhito Azuma, Teruo Inamoto, Takeshi Sakamoto, Satoshi Kiyama, Takanobu Ubai, Yuko Shinohara, Kentaro Maemura, Motomu Tsuji, Naoki Segawa, Hiroshi Masuda, Kiyoshi Takahara, Yoji Katsuoka, Masahito Watanab. Gamma-aminobutyric acid as a promoting factor of cancer metastasis; induction of matrix metalloproteinase production is potentially its underlying mechanism. Cancer research. vol 63. issue 23. 2004-02-27. PMID:14678958. |
we investigated expression of gamma-aminobutyric acid (gaba), glutamate decarboxylase, and matrix metalloproteinase (mmp) in the prostates of patients with cancer or benign prostatic hypertrophy by immunohistochemical study. |
2004-02-27 |
2023-08-12 |
human |
| Erbo Dong, Hector Caruncho, Wen Sheng Liu, Neil R Smalheiser, Dennis R Grayson, Erminio Costa, Alessandro Guidott. A reelin-integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 9. 2003-06-11. PMID:12707415. |
reelin is synthesized and secreted into extracellular matrix by cortical gamma-aminobutyric acid (gaba)ergic interneurons and binds with high affinity to the extracellular domain of integrin receptors expressed in dendritic shaft and spine postsynaptic densities (dspsd) of pyramidal neurons. |
2003-06-11 |
2023-08-12 |
mouse |
| Alexander Nikonenko, Sandra Schmidt, Galina Skibo, Gert Brückner, Melitta Schachne. Tenascin-R-deficient mice show structural alterations of symmetric perisomatic synapses in the CA1 region of the hippocampus. The Journal of comparative neurology. vol 456. issue 4. 2003-04-10. PMID:12532406. |
our previous electrophysiologic study of mice deficient in the extracellular matrix glycoprotein tenascin-r (tn-r) showed an impaired gamma-aminobutyric acid release at perisomatic inhibitory synapses in the ca1 pyramidal cell layer of the hippocampus. |
2003-04-10 |
2023-08-12 |
mouse |
| Jan Joseph, Bernd Niggemann, Kurt S Zaenker, Frank Entschlade. The neurotransmitter gamma-aminobutyric acid is an inhibitory regulator for the migration of SW 480 colon carcinoma cells. Cancer research. vol 62. issue 22. 2002-12-17. PMID:12438237. |
gaba reduced the norepinephrine-induced migratory activity of these cells within a three-dimensional collagen matrix to spontaneous migration levels, as was analyzed by time-lapse videomicroscopy. |
2002-12-17 |
2023-08-12 |
Not clear |
| K Szalisznyó, P Erd. Depolarizing/hyperpolarizing effects of the GABA(A) synapse have a beneficial role in synaptic weight resetting in the hippocampus. Neuroreport. vol 11. issue 16. 2001-05-31. PMID:11095518. |
considering the gaba(a) receptor-mediated complex effects on the membrane potential of adult mammalian central neurons we raised the question of the properties of the network, which has elements in the synaptic weight matrix with changing signs. |
2001-05-31 |
2023-08-12 |
Not clear |
| B Huang, C K Mitchell, D A Redburn-Johnso. GABA and GABA(A) receptor antagonists alter developing cone photoreceptor development in neonatal rabbit retina. Visual neuroscience. vol 17. issue 6. 2001-03-08. PMID:11193109. |
peanut agglutinin (pna), a plant lectin that specifically labels cone plasma membrane and extracellular matrix, was used to monitor cone development, and a gaba(a) receptor antibody against the beta2/3 subunits of the protein was used to label gaba(a) receptors. |
2001-03-08 |
2023-08-12 |
rabbit |
| J Vautrin, D Maric, M Sukhareva, A E Schaffner, J L Barke. Surface-accessible GABA supports tonic and quantal synaptic transmission. Synapse (New York, N.Y.). vol 37. issue 1. 2000-07-17. PMID:10842350. |
thus, we tested whether the synaptic transmitter gaba could also be held in a matrix before being released. |
2000-07-17 |
2023-08-12 |
rat |
| F Blanchet, C Gauchy, S Pérez, P Soubrié, J Glowinski, M L Keme. Control by GABA and tachykinins of the evoked release of acetylcholine in striatal compartments under different modalities of NMDA receptor stimulation. Brain research. vol 853. issue 1. 2000-03-07. PMID:10627318. |
the contribution of endogenously released dopamine, gaba and its co-transmitters, substance p (sp) and neurokinin a (nka), to the control of the evoked release of acetylcholine was investigated in vitro in the striosomes and the matrix of the rat striatum under various modalities of nmda receptor stimulation (nmda 50 microm or 1 mm without or with 10 microm d-serine). |
2000-03-07 |
2023-08-12 |
rat |
| F Blanchet, C Gauchy, S Pérez, P Soubrié, J Glowinski, M L Keme. Control by GABA and tachykinins of the evoked release of acetylcholine in striatal compartments under different modalities of NMDA receptor stimulation. Brain research. vol 853. issue 1. 2000-03-07. PMID:10627318. |
in the presence of d-serine, and depending on the nmda concentration, the facilitatory regulation of gaba was reduced (matrix) or suppressed (striosomes). |
2000-03-07 |
2023-08-12 |
rat |
| H J Waldvogel, Y Kubota, J Fritschy, H Mohler, R L Faul. Regional and cellular localisation of GABA(A) receptor subunits in the human basal ganglia: An autoradiographic and immunohistochemical study. The Journal of comparative neurology. vol 415. issue 3. 1999-12-15. PMID:10553118. |
high densities of gaba(a) receptors in the striosome compartment contained the alpha(2), alpha(3), beta(2, 3), and gamma(2) subunits, and lower densities of receptors in the matrix compartment contained the alpha(1), alpha(2), alpha(3), beta(2,3), and gamma(2) subunits. |
1999-12-15 |
2023-08-12 |
human |
| H J Waldvogel, J M Fritschy, H Mohler, R L Faul. GABA(A) receptors in the primate basal ganglia: an autoradiographic and a light and electron microscopic immunohistochemical study of the alpha1 and beta2,3 subunits in the baboon brain. The Journal of comparative neurology. vol 397. issue 3. 1998-09-24. PMID:9674559. |
these results show that the subunit composition of gaba(a) receptors varies between the striosome and the matrix compartments in the striatum and that there is receptor subunit homogeneity in the globus pallidus. |
1998-09-24 |
2023-08-12 |
Not clear |