| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Cash, R Raisman, A Ploska, Y Agi. High and low affinity [3H]imipramine binding sites in control and parkinsonian brains. European journal of pharmacology. vol 117. issue 1. 1986-02-28. PMID:3002804. |
in parkinson's disease, where brain serotonin concentrations are decreased, there was a significant reduction in the density of the high affinity binding in the prefrontal cortex and putamen while the characteristics of the low affinity binding sites remained unchanged. |
1986-02-28 |
2023-08-11 |
human |
| S O Ogren, C Johansson, O Magnusso. Forebrain serotonergic involvement in avoidance learning. Neuroscience letters. vol 58. issue 3. 1985-11-06. PMID:2995878. |
injection of 5,7-dihydroxytryptamine (5,7-dht) into the forebrain in desipramine (20 mg/kg)-pretreated rats resulted in a 65-70% decrease in 5-ht concentrations in the prefrontal cortex and hippocampus without any significant effect on striatal 5-ht. |
1985-11-06 |
2023-08-11 |
rat |
| W Wouters, J Van Dun, J E Leysen, P M Laduro. Photoaffinity probes for serotonin and histamine receptors. Synthesis and characterization of two azide analogues of ketanserin. The Journal of biological chemistry. vol 260. issue 14. 1985-08-16. PMID:3874207. |
in the rat prefrontal cortex, irreversible blocking of serotonin receptors with 7-azidoketanserin could be inhibited by serotonin agonists or antagonists but not by histaminergic compounds. |
1985-08-16 |
2023-08-11 |
rat |
| J M Lakoski, G K Aghajania. Effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus. Neuropharmacology. vol 24. issue 4. 1985-07-09. PMID:3158835. |
effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus. |
1985-07-09 |
2023-08-11 |
rat |
| J M Lakoski, G K Aghajania. Effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus. Neuropharmacology. vol 24. issue 4. 1985-07-09. PMID:3158835. |
the ability of the putative serotonin2 (5-ht2) antagonist ketanserin, to alter serotonin (5-ht)-induced responses in cell firing was examined in the prefrontal cortex, the lateral geniculate nucleus and the dorsal raphe nucleus of the rat by microiontophoretic extracellular single unit recording techniques. |
1985-07-09 |
2023-08-11 |
rat |
| J M Lakoski, G K Aghajania. Effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus. Neuropharmacology. vol 24. issue 4. 1985-07-09. PMID:3158835. |
in the prefrontal cortex, ketanserin failed to antagonize the inhibitory effects of 5-ht recorded in cerveau isolé or preparations anesthetized with chloral hydrate (pure excitatory responses to 5-ht were not observed in either of these preparations). |
1985-07-09 |
2023-08-11 |
rat |
| J M Lakoski, G K Aghajania. Effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus. Neuropharmacology. vol 24. issue 4. 1985-07-09. PMID:3158835. |
in the lateral geniculate nucleus, as in the prefrontal cortex, ketanserin potentiated rather than attenuated, the inhibitory effect of 5-ht. |
1985-07-09 |
2023-08-11 |
rat |
| J M Lakoski, G K Aghajania. Effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus. Neuropharmacology. vol 24. issue 4. 1985-07-09. PMID:3158835. |
the observed potentiation by ketanserin of inhibitory responses to 5-ht but not those of gamma-aminobutyric acid, tryptamine or norepinephrine, recorded in the prefrontal cortex, may be consistent with the proposed interaction between ketanserin and a specific 5-ht2 binding site. |
1985-07-09 |
2023-08-11 |
rat |
| T Nishikawa, B Scatto. Inhibitory influence of GABA on central serotonergic transmission. Raphé nuclei as the neuroanatomical site of the GABAergic inhibition of cerebral serotonergic neurons. Brain research. vol 331. issue 1. 1985-06-14. PMID:2985201. |
the inhibition of serotonin (5-ht) synthesis induced by a single progabide administration was accentuated on repeated treatment in the striatum, prefrontal cortex and cerebellum but was similar to that seen after acute treatment in the other areas. |
1985-06-14 |
2023-08-11 |
Not clear |
| J C Jackson, R J Cross, R F Walker, W R Markesbery, W H Brooks, T L Roszma. Influence of serotonin on the immune response. Immunology. vol 54. issue 3. 1985-04-19. PMID:3156091. |
systemic administration of 5-ht (4-100 mg/kg) or its precursor, 5-hydroxytryptophan (5-htp, 50-400 mg/kg), 30-60 min before immunization resulted in dose-dependent suppression of both the igm and igg plaque-forming cell (pfc) response to srbc. |
1985-04-19 |
2023-08-11 |
mouse |
| M Boranić, D Pericić, M Poljak-Blazi, V Sverk. Suppression of the immune response by drugs interfering with the metabolism of serotonin. Experientia. vol 40. issue 10. 1984-11-30. PMID:6237931. |
treatment with pcpa also suppressed the pfc response, but this suppression was accompanied by decreased levels of brain serotonin and of 5-hiaa. |
1984-11-30 |
2023-08-12 |
rat |
| M H Bassant, D Fage, J Dedek, F Cathala, L Court, B Scatto. Monoamine abnormalities in the brain of scrapie-infected rats. Brain research. vol 308. issue 1. 1984-11-14. PMID:6206919. |
scrapie-infected rats showed a reduction in the levels of serotonin (prefrontal cortex, hippocampus, striatum) and dopamine (striatum) and an elevation of 5-hiaa levels (cerebral cortex, striatum, thalamus). |
1984-11-14 |
2023-08-12 |
mouse |
| F De Clerck, B Xhonneux, J Leysen, P A Jansse. Evidence for functional 5-HT2 receptor sites on human blood platelets. Biochemical pharmacology. vol 33. issue 17. 1984-09-19. PMID:6466388. |
the 5-ht induced platelet reaction is inhibited in a concentration-dependent way by various serotonergic antagonists; the potency of these compounds in this respect correlates strongly with their potential to inhibit the specific binding of [3h] ketanserin, a selective label for 5-ht2 binding sites, to rat prefrontal cortex and striatum and to cat platelet membranes. |
1984-09-19 |
2023-08-12 |
human |
| G Battaglia, M Shannon, M Titele. Modulation of brain S2 serotonin receptors by lithium, sodium and potassium chloride. Life sciences. vol 32. issue 22. 1983-07-15. PMID:6304441. |
the effect of licl, nacl, and kcl on serotonin competition for 3h-ketanserin binding to s2 serotonin receptors in homogenates of rat prefrontal cortex were investigated. |
1983-07-15 |
2023-08-12 |
rat |
| T A Reade. Distribution of catecholamines and serotonin in the rat cerebral cortex: absolute levels and relative proportions. Journal of neural transmission. vol 50. issue 1. 1981-05-26. PMID:7205246. |
the serotonin distribution was found to be non-homogeneous, with the highest values for the prefrontal cortex and ventral cortex lateral to the hypothalamus. |
1981-05-26 |
2023-08-12 |
rat |
| K B Franklin, A Robertso. 5HT blockade and the stimulant effects of D- and L-amphetamine: no interaction in self-stimulation of prefrontal cortex, hypothalamus, or dorsal tegmentum. unexpected lethality in hippocampal sites. Pharmacology, biochemistry, and behavior. vol 13. issue 3. 1980-12-18. PMID:7422692. |
5ht blockade and the stimulant effects of d- and l-amphetamine: no interaction in self-stimulation of prefrontal cortex, hypothalamus, or dorsal tegmentum. |
1980-12-18 |
2023-08-12 |
rat |